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Proteomics-Based Comparative Mapping of the Secretomes of Human Brown and White Adipocytes Reveals EPDR1 as a Novel Batokine.

Deshmukh AS, Peijs L, Beaudry JL, Jespersen NZ, Nielsen CH, Ma T, Brunner AD, Larsen TJ, Bayarri-Olmos R, Prabhakar BS, Helgstrand C, Severinsen MCK, Holst B, Kjaer A, Tang-Christensen M, Sanfridson A, Garred P, Privé GG, Pedersen BK, Gerhart-Hines Z, Nielsen S, Drucker DJ, Mann M, Scheele C.

Cell Metab. 2019 Nov 5;30(5):963-975.e7. doi: 10.1016/j.cmet.2019.10.001. Epub 2019 Oct 24.


Lysosomal integral membrane protein-2 (LIMP-2/SCARB2) is involved in lysosomal cholesterol export.

Heybrock S, Kanerva K, Meng Y, Ing C, Liang A, Xiong ZJ, Weng X, Ah Kim Y, Collins R, Trimble W, Pomès R, Privé GG, Annaert W, Schwake M, Heeren J, Lüllmann-Rauch R, Grinstein S, Ikonen E, Saftig P, Neculai D.

Nat Commun. 2019 Aug 6;10(1):3521. doi: 10.1038/s41467-019-11425-0.


Molecular models should not be published without the corresponding atomic coordinates.

Graham SC, Nagar B, Privé GG, Deane JE.

Proc Natl Acad Sci U S A. 2019 Jun 4;116(23):11099-11100. doi: 10.1073/pnas.1904409116. No abstract available.


BCL6 Evolved to Enable Stress Tolerance in Vertebrates and Is Broadly Required by Cancer Cells to Adapt to Stress.

Fernando TM, Marullo R, Pera Gresely B, Phillip JM, Yang SN, Lundell-Smith G, Torregroza I, Ahn H, Evans T, Győrffy B, Privé GG, Hirano M, Melnick AM, Cerchietti L.

Cancer Discov. 2019 May;9(5):662-679. doi: 10.1158/2159-8290.CD-17-1444. Epub 2019 Feb 18.


Crystal structures of human lysosomal EPDR1 reveal homology with the superfamily of bacterial lipoprotein transporters.

Wei Y, Xiong ZJ, Li J, Zou C, Cairo CW, Klassen JS, Privé GG.

Commun Biol. 2019 Feb 5;2:52. doi: 10.1038/s42003-018-0262-9. eCollection 2019.


Detecting Protein-Glycolipid Interactions Using CaR-ESI-MS and Model Membranes: Comparison of Pre-loaded and Passively Loaded Picodiscs.

Li J, Han L, Li J, Kitova EN, Xiong ZJ, Privé GG, Klassen JS.

J Am Soc Mass Spectrom. 2018 Jul;29(7):1493-1504. doi: 10.1007/s13361-018-1936-8. Epub 2018 Apr 13.


Mutations in the Fusion Protein of Measles Virus That Confer Resistance to the Membrane Fusion Inhibitors Carbobenzoxy-d-Phe-l-Phe-Gly and 4-Nitro-2-Phenylacetyl Amino-Benzamide.

Ha MN, Delpeut S, Noyce RS, Sisson G, Black KM, Lin LT, Bilimoria D, Plemper RK, Privé GG, Richardson CD.

J Virol. 2017 Nov 14;91(23). pii: e01026-17. doi: 10.1128/JVI.01026-17. Print 2017 Dec 1.


Characterizing the Size and Composition of Saposin A Lipoprotein Picodiscs.

Li J, Richards MR, Bagal D, Campuzano ID, Kitova EN, Xiong ZJ, Privé GG, Klassen JS.

Anal Chem. 2016 Oct 4;88(19):9524-9531. Epub 2016 Sep 13.


Structure of Human Acid Sphingomyelinase Reveals the Role of the Saposin Domain in Activating Substrate Hydrolysis.

Xiong ZJ, Huang J, Poda G, Pomès R, Privé GG.

J Mol Biol. 2016 Jul 31;428(15):3026-42. doi: 10.1016/j.jmb.2016.06.012. Epub 2016 Jun 24.


Higher-order oligomerization promotes localization of SPOP to liquid nuclear speckles.

Marzahn MR, Marada S, Lee J, Nourse A, Kenrick S, Zhao H, Ben-Nissan G, Kolaitis RM, Peters JL, Pounds S, Errington WJ, Privé GG, Taylor JP, Sharon M, Schuck P, Ogden SK, Mittag T.

EMBO J. 2016 Jun 15;35(12):1254-75. doi: 10.15252/embj.201593169. Epub 2016 May 23.


Screening Glycolipids Against Proteins in Vitro Using Picodiscs and Catch-and-Release Electrospray Ionization-Mass Spectrometry.

Li J, Fan X, Kitova EN, Zou C, Cairo CW, Eugenio L, Ng KK, Xiong ZJ, Privé GG, Klassen JS.

Anal Chem. 2016 May 3;88(9):4742-50. doi: 10.1021/acs.analchem.6b00043. Epub 2016 Apr 20.


Structural Insights into KCTD Protein Assembly and Cullin3 Recognition.

Ji AX, Chu A, Nielsen TK, Benlekbir S, Rubinstein JL, Privé GG.

J Mol Biol. 2016 Jan 16;428(1):92-107. doi: 10.1016/j.jmb.2015.08.019. Epub 2015 Aug 31.


Crystal structure of GnsA from Escherichia coli.

Wei Y, Zhan L, Gao Z, Privé GG, Dong Y.

Biochem Biophys Res Commun. 2015 Jun 19;462(1):1-7. doi: 10.1016/j.bbrc.2015.03.133. Epub 2015 Apr 1.


Picodiscs for facile protein-glycolipid interaction analysis.

Leney AC, Rezaei Darestani R, Li J, Nikjah S, Kitova EN, Zou C, Cairo CW, Xiong ZJ, Privé GG, Klassen JS.

Anal Chem. 2015 Apr 21;87(8):4402-8. doi: 10.1021/acs.analchem.5b00170. Epub 2015 Apr 9.


Prostate cancer. Ubiquitylome analysis identifies dysregulation of effector substrates in SPOP-mutant prostate cancer.

Theurillat JP, Udeshi ND, Errington WJ, Svinkina T, Baca SC, Pop M, Wild PJ, Blattner M, Groner AC, Rubin MA, Moch H, Prive GG, Carr SA, Garraway LA.

Science. 2014 Oct 3;346(6205):85-89. doi: 10.1126/science.1250255. Epub 2014 Oct 2.


PKA signaling drives mammary tumorigenesis through Src.

Beristain AG, Molyneux SD, Joshi PA, Pomroy NC, Di Grappa MA, Chang MC, Kirschner LS, Privé GG, Pujana MA, Khokha R.

Oncogene. 2015 Feb 26;34(9):1160-73. doi: 10.1038/onc.2014.41. Epub 2014 Mar 24.


The integrated landscape of driver genomic alterations in glioblastoma.

Frattini V, Trifonov V, Chan JM, Castano A, Lia M, Abate F, Keir ST, Ji AX, Zoppoli P, Niola F, Danussi C, Dolgalev I, Porrati P, Pellegatta S, Heguy A, Gupta G, Pisapia DJ, Canoll P, Bruce JN, McLendon RE, Yan H, Aldape K, Finocchiaro G, Mikkelsen T, Privé GG, Bigner DD, Lasorella A, Rabadan R, Iavarone A.

Nat Genet. 2013 Oct;45(10):1141-9. doi: 10.1038/ng.2734. Epub 2013 Aug 5.


A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

Hatzi K, Jiang Y, Huang C, Garrett-Bakelman F, Gearhart MD, Giannopoulou EG, Zumbo P, Kirouac K, Bhaskara S, Polo JM, Kormaksson M, MacKerell AD Jr, Xue F, Mason CE, Hiebert SW, Prive GG, Cerchietti L, Bardwell VJ, Elemento O, Melnick A.

Cell Rep. 2013 Aug 15;4(3):578-88. doi: 10.1016/j.celrep.2013.06.016. Epub 2013 Aug 1.


Systemic ceramide accumulation leads to severe and varied pathological consequences.

Alayoubi AM, Wang JC, Au BC, Carpentier S, Garcia V, Dworski S, El-Ghamrasni S, Kirouac KN, Exertier MJ, Xiong ZJ, Privé GG, Simonaro CM, Casas J, Fabrias G, Schuchman EH, Turner PV, Hakem R, Levade T, Medin JA.

EMBO Mol Med. 2013 Jun;5(6):827-42. doi: 10.1002/emmm.201202301. Epub 2013 May 16.


Crystal structure of KLHL3 in complex with Cullin3.

Ji AX, Privé GG.

PLoS One. 2013;8(4):e60445. doi: 10.1371/journal.pone.0060445. Epub 2013 Apr 3.


Detergent-mediated protein aggregation.

Neale C, Ghanei H, Holyoake J, Bishop RE, Privé GG, Pomès R.

Chem Phys Lipids. 2013 Apr;169:72-84. doi: 10.1016/j.chemphyslip.2013.02.005. Epub 2013 Mar 4. Review.


Adaptor protein self-assembly drives the control of a cullin-RING ubiquitin ligase.

Errington WJ, Khan MQ, Bueler SA, Rubinstein JL, Chakrabartty A, Privé GG.

Structure. 2012 Jul 3;20(7):1141-53. doi: 10.1016/j.str.2012.04.009. Epub 2012 May 24.


Structure of saposin A lipoprotein discs.

Popovic K, Holyoake J, Pomès R, Privé GG.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):2908-12. doi: 10.1073/pnas.1115743109. Epub 2012 Feb 2.


PagP crystallized from SDS/cosolvent reveals the route for phospholipid access to the hydrocarbon ruler.

Cuesta-Seijo JA, Neale C, Khan MA, Moktar J, Tran CD, Bishop RE, Pomès R, Privé GG.

Structure. 2010 Sep 8;18(9):1210-9. doi: 10.1016/j.str.2010.06.014.


Kelch-like homologue 9 mutation is associated with an early onset autosomal dominant distal myopathy.

Cirak S, von Deimling F, Sachdev S, Errington WJ, Herrmann R, Bönnemann C, Brockmann K, Hinderlich S, Lindner TH, Steinbrecher A, Hoffmann K, Privé GG, Hannink M, Nürnberg P, Voit T.

Brain. 2010 Jul;133(Pt 7):2123-35. doi: 10.1093/brain/awq108. Epub 2010 Jun 16.


Insights into strand exchange in BTB domain dimers from the crystal structures of FAZF and Miz1.

Stogios PJ, Cuesta-Seijo JA, Chen L, Pomroy NC, Privé GG.

J Mol Biol. 2010 Jul 30;400(5):983-97. doi: 10.1016/j.jmb.2010.05.028. Epub 2010 May 21.


A small-molecule inhibitor of BCL6 kills DLBCL cells in vitro and in vivo.

Cerchietti LC, Ghetu AF, Zhu X, Da Silva GF, Zhong S, Matthews M, Bunting KL, Polo JM, Farès C, Arrowsmith CH, Yang SN, Garcia M, Coop A, Mackerell AD Jr, Privé GG, Melnick A.

Cancer Cell. 2010 Apr 13;17(4):400-11. doi: 10.1016/j.ccr.2009.12.050.


Assessing the stability of membrane proteins to detect ligand binding using differential static light scattering.

Senisterra GA, Ghanei H, Khutoreskaya G, Dobrovetsky E, Edwards AM, Privé GG, Vedadi M.

J Biomol Screen. 2010 Mar;15(3):314-20. doi: 10.1177/1087057109357117. Epub 2010 Feb 11.


Lipopeptide detergents for membrane protein studies.

Privé GG.

Curr Opin Struct Biol. 2009 Aug;19(4):379-85. doi: 10.1016/ Epub 2009 Aug 12. Review.


Crystal structure of a self-assembling lipopeptide detergent at 1.20 A.

Ho DN, Pomroy NC, Cuesta-Seijo JA, Privé GG.

Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12861-6. doi: 10.1073/pnas.0801941105. Epub 2008 Aug 27.


Protecting role of cosolvents in protein denaturation by SDS: a structural study.

Michaux C, Pouyez J, Wouters J, Privé GG.

BMC Struct Biol. 2008 Jun 3;8:29. doi: 10.1186/1472-6807-8-29.


Structures of the human ceramide activator protein saposin D.

Popovic K, Privé GG.

Acta Crystallogr D Biol Crystallogr. 2008 May;64(Pt 5):589-94. doi: 10.1107/S0907444908003120. Epub 2008 Apr 19.


Therapeutic targeting of the BCL6 oncogene for diffuse large B-cell lymphomas.

Parekh S, Privé G, Melnick A.

Leuk Lymphoma. 2008 May;49(5):874-82. doi: 10.1080/10428190801895345. Review.


Structure of a BCOR corepressor peptide in complex with the BCL6 BTB domain dimer.

Ghetu AF, Corcoran CM, Cerchietti L, Bardwell VJ, Melnick A, Privé GG.

Mol Cell. 2008 Feb 15;29(3):384-91. doi: 10.1016/j.molcel.2007.12.026.


Refolding SDS-denatured proteins by the addition of amphipathic cosolvents.

Michaux C, Pomroy NC, Privé GG.

J Mol Biol. 2008 Feb 1;375(5):1477-88. Epub 2007 Nov 19.


Molecular imaging of membrane interfaces reveals mode of beta-glucosidase activation by saposin C.

Alattia JR, Shaw JE, Yip CM, Privé GG.

Proc Natl Acad Sci U S A. 2007 Oct 30;104(44):17394-9. Epub 2007 Oct 22.


Gauging a hydrocarbon ruler by an intrinsic exciton probe.

Khan MA, Neale C, Michaux C, Pomès R, Privé GG, Woody RW, Bishop RE.

Biochemistry. 2007 Apr 17;46(15):4565-79. Epub 2007 Mar 22.


Detergents for the stabilization and crystallization of membrane proteins.

Privé GG.

Methods. 2007 Apr;41(4):388-97. Review.


Crystal structure of the BTB domain from the LRF/ZBTB7 transcriptional regulator.

Stogios PJ, Chen L, Privé GG.

Protein Sci. 2007 Feb;16(2):336-42. Epub 2006 Dec 22.


Structural characterization of a blue chromoprotein and its yellow mutant from the sea anemone Cnidopus japonicus.

Chan MC, Karasawa S, Mizuno H, Bosanac I, Ho D, Privé GG, Miyawaki A, Ikura M.

J Biol Chem. 2006 Dec 8;281(49):37813-9. Epub 2006 Oct 6.


Direct visualization of saposin remodelling of lipid bilayers.

Alattia JR, Shaw JE, Yip CM, Privé GG.

J Mol Biol. 2006 Oct 6;362(5):943-53. Epub 2006 Aug 9.


Crystal structures of saposins A and C.

Ahn VE, Leyko P, Alattia JR, Chen L, Privé GG.

Protein Sci. 2006 Aug;15(8):1849-57. Epub 2006 Jul 5.


Mechanisms of antimicrobial peptide action: studies of indolicidin assembly at model membrane interfaces by in situ atomic force microscopy.

Shaw JE, Alattia JR, Verity JE, Privé GG, Yip CM.

J Struct Biol. 2006 Apr;154(1):42-58. Epub 2006 Jan 13.


Specific peptides for the therapeutic targeting of oncogenes.

Privé GG, Melnick A.

Curr Opin Genet Dev. 2006 Feb;16(1):71-7. Epub 2005 Dec 27. Review.


Sequence and structural analysis of BTB domain proteins.

Stogios PJ, Downs GS, Jauhal JJ, Nandra SK, Privé GG.

Genome Biol. 2005;6(10):R82. Epub 2005 Sep 15.


Molecular models of lipopeptide detergents: large coiled-coils with hydrocarbon interiors.

Kelly E, Privé GG, Tieleman DP.

J Am Chem Soc. 2005 Oct 5;127(39):13446-7.


A novel mass spectrometric assay for the cerebroside sulfate activator protein (saposin B) and arylsulfatase A.

Norris AJ, Whitelegge JP, Yaghoubian A, Alattia JR, Privé GG, Toyokuni T, Sun H, Brooks MN, Panza L, Matto P, Compostella F, Remmel N, Klingenstein R, Sandhoff K, Fluharty C, Fluharty A, Faull KF.

J Lipid Res. 2005 Oct;46(10):2254-64. Epub 2005 Aug 1.


The BACK domain in BTB-kelch proteins.

Stogios PJ, Privé GG.

Trends Biochem Sci. 2004 Dec;29(12):634-7. Review.


Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells.

Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF, Prive GG, Licht JD, Melnick A.

Nat Med. 2004 Dec;10(12):1329-35. Epub 2004 Nov 7.


A hydrocarbon ruler measures palmitate in the enzymatic acylation of endotoxin.

Ahn VE, Lo EI, Engel CK, Chen L, Hwang PM, Kay LE, Bishop RE, Privé GG.

EMBO J. 2004 Aug 4;23(15):2931-41. Epub 2004 Jul 22.

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