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Items: 30


Multi-scale Predictions of Drug Resistance Epidemiology Identify Design Principles for Rational Drug Design.

Leighow SM, Liu C, Inam H, Zhao B, Pritchard JR.

Cell Rep. 2020 Mar 24;30(12):3951-3963.e4. doi: 10.1016/j.celrep.2020.02.108.


The primary mechanism of cytotoxicity of the chemotherapeutic agent CX-5461 is topoisomerase II poisoning.

Bruno PM, Lu M, Dennis KA, Inam H, Moore CJ, Sheehe J, Elledge SJ, Hemann MT, Pritchard JR.

Proc Natl Acad Sci U S A. 2020 Feb 25;117(8):4053-4060. doi: 10.1073/pnas.1921649117. Epub 2020 Feb 10.


Evolution of the nonsense-mediated decay pathway is associated with decreased cytolytic immune infiltration.

Zhao B, Pritchard JR.

PLoS Comput Biol. 2019 Oct 28;15(10):e1007467. doi: 10.1371/journal.pcbi.1007467. eCollection 2019 Oct.


The risks of perpetuating an evolutionary arms race in drug discovery.

Leighow SM, Pritchard JR.

Evol Med Public Health. 2019 May 21;2019(1):64-65. doi: 10.1093/emph/eoz013. eCollection 2019. No abstract available.


Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.

Schmitt MW, Pritchard JR, Leighow SM, Aminov BI, Beppu L, Kim DS, Hodgson JG, Rivera VM, Loeb LA, Radich JP.

Clin Cancer Res. 2018 Nov 1;24(21):5321-5334. doi: 10.1158/1078-0432.CCR-18-0167. Epub 2018 Jul 24.


A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.

Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, Pritchard JR, Pommier Y, Lippard SJ, Hemann MT.

Nat Med. 2017 Apr;23(4):461-471. doi: 10.1038/nm.4291. Epub 2017 Feb 27.


Programmable transcriptional repression in mycobacteria using an orthogonal CRISPR interference platform.

Rock JM, Hopkins FF, Chavez A, Diallo M, Chase MR, Gerrick ER, Pritchard JR, Church GM, Rubin EJ, Sassetti CM, Schnappinger D, Fortune SM.

Nat Microbiol. 2017 Feb 6;2:16274. doi: 10.1038/nmicrobiol.2016.274.


Inherited Disease Genetics Improves the Identification of Cancer-Associated Genes.

Zhao B, Pritchard JR.

PLoS Genet. 2016 Jun 15;12(6):e1006081. doi: 10.1371/journal.pgen.1006081. eCollection 2016 Jun.


Exploiting Temporal Collateral Sensitivity in Tumor Clonal Evolution.

Zhao B, Sedlak JC, Srinivas R, Creixell P, Pritchard JR, Tidor B, Lauffenburger DA, Hemann MT.

Cell. 2016 Mar 24;165(1):234-246. doi: 10.1016/j.cell.2016.01.045. Epub 2016 Feb 25.


A genome-scale in vivo loss-of-function screen identifies Phf6 as a lineage-specific regulator of leukemia cell growth.

Meacham CE, Lawton LN, Soto-Feliciano YM, Pritchard JR, Joughin BA, Ehrenberger T, Fenouille N, Zuber J, Williams RT, Young RA, Hemann MT.

Genes Dev. 2015 Mar 1;29(5):483-8. doi: 10.1101/gad.254151.114.


ARTIST: high-resolution genome-wide assessment of fitness using transposon-insertion sequencing.

Pritchard JR, Chao MC, Abel S, Davis BM, Baranowski C, Zhang YJ, Rubin EJ, Waldor MK.

PLoS Genet. 2014 Nov 6;10(11):e1004782. doi: 10.1371/journal.pgen.1004782. eCollection 2014 Nov.


Disruption of Mycobacterium avium subsp. paratuberculosis-specific genes impairs in vivo fitness.

Wang J, Pritchard JR, Kreitmann L, Montpetit A, Behr MA.

BMC Genomics. 2014 May 31;15:415. doi: 10.1186/1471-2164-15-415.


Addressing genetic tumor heterogeneity through computationally predictive combination therapy.

Zhao B, Pritchard JR, Lauffenburger DA, Hemann MT.

Cancer Discov. 2014 Feb;4(2):166-74. doi: 10.1158/2159-8290.CD-13-0465. Epub 2013 Dec 6.


High-resolution definition of the Vibrio cholerae essential gene set with hidden Markov model-based analyses of transposon-insertion sequencing data.

Chao MC, Pritchard JR, Zhang YJ, Rubin EJ, Livny J, Davis BM, Waldor MK.

Nucleic Acids Res. 2013 Oct;41(19):9033-48. doi: 10.1093/nar/gkt654. Epub 2013 Jul 30.


Predicting cancer drug mechanisms of action using molecular network signatures.

Pritchard JR, Bruno PM, Hemann MT, Lauffenburger DA.

Mol Biosyst. 2013 Jul;9(7):1604-19. doi: 10.1039/c2mb25459j. Epub 2013 Jan 4.


Defining principles of combination drug mechanisms of action.

Pritchard JR, Bruno PM, Gilbert LA, Capron KL, Lauffenburger DA, Hemann MT.

Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E170-9. doi: 10.1073/pnas.1210419110. Epub 2012 Dec 18.


Understanding resistance to combination chemotherapy.

Pritchard JR, Lauffenburger DA, Hemann MT.

Drug Resist Updat. 2012 Oct;15(5-6):249-57. doi: 10.1016/j.drup.2012.10.003. Epub 2012 Nov 17. Review.


21 cm cosmology in the 21st century.

Pritchard JR, Loeb A.

Rep Prog Phys. 2012 Aug;75(8):086901. doi: 10.1088/0034-4885/75/8/086901. Epub 2012 Jul 24. Review.


Down-regulation of Glucan, Water-Dikinase activity in wheat endosperm increases vegetative biomass and yield.

Ral JP, Bowerman AF, Li Z, Sirault X, Furbank R, Pritchard JR, Bloemsma M, Cavanagh CR, Howitt CA, Morell MK.

Plant Biotechnol J. 2012 Sep;10(7):871-82. doi: 10.1111/j.1467-7652.2012.00711.x. Epub 2012 Jun 6. Erratum in: Plant Biotechnol J. 2013 Apr;11(3):390-1.


Bcl-2 family genetic profiling reveals microenvironment-specific determinants of chemotherapeutic response.

Pritchard JR, Gilbert LA, Meacham CE, Ricks JL, Jiang H, Lauffenburger DA, Hemann MT.

Cancer Res. 2011 Sep 1;71(17):5850-8. doi: 10.1158/0008-5472.CAN-11-1014. Epub 2011 Jul 22.


A survey of β-glucan and arabinoxylan content in wheat.

Pritchard JR, Lawrence GJ, Larroque O, Li Z, Laidlaw HK, Morell MK, Rahman S.

J Sci Food Agric. 2011 May;91(7):1298-303. doi: 10.1002/jsfa.4316. Epub 2011 Feb 24.


Predicting problematic Internet use in men and women: the contributions of psychological distress, coping style, and body esteem.

Hetzel-Riggin MD, Pritchard JR.

Cyberpsychol Behav Soc Netw. 2011 Sep;14(9):519-25. doi: 10.1089/cyber.2010.0314. Epub 2011 Feb 22.


A mammalian functional-genetic approach to characterizing cancer therapeutics.

Jiang H, Pritchard JR, Williams RT, Lauffenburger DA, Hemann MT.

Nat Chem Biol. 2011 Feb;7(2):92-100. doi: 10.1038/nchembio.503. Epub 2010 Dec 26.


Three-kinase inhibitor combination recreates multipathway effects of a geldanamycin analogue on hepatocellular carcinoma cell death.

Pritchard JR, Cosgrove BD, Hemann MT, Griffith LG, Wands JR, Lauffenburger DA.

Mol Cancer Ther. 2009 Aug;8(8):2183-92. doi: 10.1158/1535-7163.MCT-08-1203. Epub 2009 Aug 11.


An inducible autocrine cascade regulates rat hepatocyte proliferation and apoptosis responses to tumor necrosis factor-alpha.

Cosgrove BD, Cheng C, Pritchard JR, Stolz DB, Lauffenburger DA, Griffith LG.

Hepatology. 2008 Jul;48(1):276-88. doi: 10.1002/hep.22335.


[A comparison between L-4F and SC-4F in preventing low density lipoprotein induced endothelial cell dysfunction in cell culture].

Ou ZJ, Ou JS, Ma H, Su CJ, Pritchard KA Jr.

Zhonghua Xin Xue Guan Bing Za Zhi. 2005 May;33(5):411-4. Chinese. Erratum in: Zhonghua Xin Xue Guan Bing Za Zhi. 2006 Feb;34(2):163. Kirkwood A [corrected to Pritchard, Kirkwood A Jr];Pritchard Jr [corrected to Pritchard, Kirkwood A Jr].


Large cystic granulosa cell tumor: case report.

Choi CH, Pritchard JR.

Am J Obstet Gynecol. 1990 Jul;163(1 Pt 1):74-6.


Sudden death by Lepomis macrochirus (the killer fish).

Pritchard JR.

Am J Forensic Med Pathol. 1989 Sep;10(3):245-6.


Gingival crevice depth. I. Predictability of probing deepest points.

Pritchard JR, Laws AJ.

Aust Dent J. 1984 Dec;29(6):404-10. No abstract available.


The periodontal probe: screening for periodontal disease.

Pritchard JR.

J N Z Soc Periodontol. 1981 Nov;(52):21-2. No abstract available.


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