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Items: 1 to 50 of 1108

1.

Profile of a Highly Selective Quaternized Pyrrolidine Betaine αvβ6 Integrin Inhibitor-(3S)-3-(3-(3,5-Dimethyl-1H-pyrazol-1-yl)phenyl)-4-((1S and 1R,3R)-1-methyl-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-ium-1-yl)butanoate Synthesized by Stereoselective Methylation.

Barrett TN, Taylor JA, Barker D, Procopiou PA, Thompson JDF, Barrett J, Le J, Lynn SM, Pogany P, Pratley C, Pritchard JM, Roper JA, Rowedder JE, Slack RJ, Vitulli G, Macdonald SJF, Kerr WJ.

J Med Chem. 2019 Aug 5. doi: 10.1021/acs.jmedchem.9b00819. [Epub ahead of print]

PMID:
31381331
2.

Public Discussion Affects Question Asking at Academic Conferences.

Telis N, Glassberg EC, Pritchard JK, Gunter C.

Am J Hum Genet. 2019 Jul 3;105(1):189-197. doi: 10.1016/j.ajhg.2019.06.004. Epub 2019 Jun 27.

PMID:
31256875
3.

Mucoid Pseudomonas aeruginosa infection in a cat with severe chronic rhinosinusitis.

Sharma D, Pakravan N, Pritchard JC, Hartmann FA, Young KM.

Vet Clin Pathol. 2019 Jun;48(2):300-304. doi: 10.1111/vcp.12749. Epub 2019 Jun 18.

PMID:
31210366
4.

The risks of perpetuating an evolutionary arms race in drug discovery.

Leighow SM, Pritchard JR.

Evol Med Public Health. 2019 May 21;2019(1):64-65. doi: 10.1093/emph/eoz013. eCollection 2019. No abstract available.

5.

Trans Effects on Gene Expression Can Drive Omnigenic Inheritance.

Liu X, Li YI, Pritchard JK.

Cell. 2019 May 2;177(4):1022-1034.e6. doi: 10.1016/j.cell.2019.04.014.

PMID:
31051098
6.

Ancient Mammalian and Plant DNA from Late Quaternary Stalagmite Layers at Solkota Cave, Georgia.

Stahlschmidt MC, Collin TC, Fernandes DM, Bar-Oz G, Belfer-Cohen A, Gao Z, Jakeli N, Matskevich Z, Meshveliani T, Pritchard JK, McDermott F, Pinhasi R.

Sci Rep. 2019 Apr 29;9(1):6628. doi: 10.1038/s41598-019-43147-0.

7.

Evaluation of vaccine delivery systems for inducing long-lived antibody responses to Dermanyssus gallinae antigen in laying hens.

Price DRG, Küster T, Øines Ø, Oliver EM, Bartley K, Nunn F, Lima Barbero JF, Pritchard J, Karp-Tatham E, Hauge H, Blake DP, Tomley FM, Nisbet AJ.

Avian Pathol. 2019 Jul 2:1-15. doi: 10.1080/03079457.2019.1612514. [Epub ahead of print]

PMID:
31032631
8.

Reduced signal for polygenic adaptation of height in UK Biobank.

Berg JJ, Harpak A, Sinnott-Armstrong N, Joergensen AM, Mostafavi H, Field Y, Boyle EA, Zhang X, Racimo F, Pritchard JK, Coop G.

Elife. 2019 Mar 21;8. pii: e39725. doi: 10.7554/eLife.39725.

9.

Interpreting polygenic scores, polygenic adaptation, and human phenotypic differences.

Rosenberg NA, Edge MD, Pritchard JK, Feldman MW.

Evol Med Public Health. 2018 Dec 27;2019(1):26-34. doi: 10.1093/emph/eoy036. eCollection 2019. Review.

10.

The Short Performance Physical Battery Is Associated with One-Year Emergency Department Visits and Hospitalization.

Negm AM, Kennedy CC, Pritchard JM, Ioannidis G, Vastis V, Marr S, Patterson C, Misiaszek B, Woo TKW, Thabane L, Papaioannou A.

Can J Aging. 2019 Mar 4:1-5. doi: 10.1017/S0714980819000011. [Epub ahead of print]

PMID:
30829183
11.

A randomised, open-label, cross-over clinical study to evaluate the pharmacokinetic profiles of cigarettes and e-cigarettes with nicotine salt formulations in US adult smokers.

O'Connell G, Pritchard JD, Prue C, Thompson J, Verron T, Graff D, Walele T.

Intern Emerg Med. 2019 Feb 2. doi: 10.1007/s11739-019-02025-3. [Epub ahead of print]

PMID:
30712148
12.

High-resolution mapping of cancer cell networks using co-functional interactions.

Boyle EA, Pritchard JK, Greenleaf WJ.

Mol Syst Biol. 2018 Dec 20;14(12):e8594. doi: 10.15252/msb.20188594.

13.

Evidence for Weak Selective Constraint on Human Gene Expression.

Glassberg EC, Gao Z, Harpak A, Lan X, Pritchard JK.

Genetics. 2019 Feb;211(2):757-772. doi: 10.1534/genetics.118.301833. Epub 2018 Dec 15.

14.

Draft Genome Assembly of the Poultry Red Mite, Dermanyssus gallinae.

Burgess STG, Bartley K, Nunn F, Wright HW, Hughes M, Gemmell M, Haldenby S, Paterson S, Rombauts S, Tomley FM, Blake DP, Pritchard J, Schicht S, Strube C, Øines Ø, Van Leeuwen T, Van de Peer Y, Nisbet AJ.

Microbiol Resour Announc. 2018 Nov 8;7(18). pii: e01221-18. doi: 10.1128/MRA.01221-18. eCollection 2018 Nov.

15.

Does Late Maturity Alpha-Amylase Impact Wheat Baking Quality?

Newberry M, Zwart AB, Whan A, Mieog JC, Sun M, Leyne E, Pritchard J, Daneri-Castro SN, Ibrahim K, Diepeveen D, Howitt CA, Ral JF.

Front Plant Sci. 2018 Sep 7;9:1356. doi: 10.3389/fpls.2018.01356. eCollection 2018.

16.

Functional Genetic Variants Revealed by Massively Parallel Precise Genome Editing.

Sharon E, Chen SA, Khosla NM, Smith JD, Pritchard JK, Fraser HB.

Cell. 2018 Oct 4;175(2):544-557.e16. doi: 10.1016/j.cell.2018.08.057. Epub 2018 Sep 20.

PMID:
30245013
17.

Hot topic: Management of cull dairy cows-Consensus of an expert consultation in Canada.

Stojkov J, Bowers G, Draper M, Duffield T, Duivenvoorden P, Groleau M, Haupstein D, Peters R, Pritchard J, Radom C, Sillett N, Skippon W, Trépanier H, Fraser D.

J Dairy Sci. 2018 Dec;101(12):11170-11174. doi: 10.3168/jds.2018-14919. Epub 2018 Sep 20.

18.

Discovery of ( S)-3-(3-(3,5-Dimethyl-1 H-pyrazol-1-yl)phenyl)-4-(( R)-3-(2-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)ethyl)pyrrolidin-1-yl)butanoic Acid, a Nonpeptidic αvβ6 Integrin Inhibitor for the Inhaled Treatment of Idiopathic Pulmonary Fibrosis.

Procopiou PA, Anderson NA, Barrett J, Barrett TN, Crawford MHJ, Fallon BJ, Hancock AP, Le J, Lemma S, Marshall RP, Morrell J, Pritchard JM, Rowedder JE, Saklatvala P, Slack RJ, Sollis SL, Suckling CJ, Thorp LR, Vitulli G, Macdonald SJF.

J Med Chem. 2018 Sep 27;61(18):8417-8443. doi: 10.1021/acs.jmedchem.8b00959. Epub 2018 Sep 14.

PMID:
30215258
19.

Single-Molecule Sequencing Reveals Patterns of Preexisting Drug Resistance That Suggest Treatment Strategies in Philadelphia-Positive Leukemias.

Schmitt MW, Pritchard JR, Leighow SM, Aminov BI, Beppu L, Kim DS, Hodgson JG, Rivera VM, Loeb LA, Radich JP.

Clin Cancer Res. 2018 Nov 1;24(21):5321-5334. doi: 10.1158/1078-0432.CCR-18-0167. Epub 2018 Jul 24.

PMID:
30042204
20.

RET fusions observed in lung and colorectal cancers are sensitive to ponatinib.

Gozgit JM, Chen TH, Song Y, Wardwell S, Wang F, Cai J, Li H, Edgren H, Rivera VM, Pritchard J.

Oncotarget. 2018 Jul 3;9(51):29654-29664. doi: 10.18632/oncotarget.25664. eCollection 2018 Jul 3.

21.

Post-translational buffering leads to convergent protein expression levels between primates.

Wang SH, Hsiao CJ, Khan Z, Pritchard JK.

Genome Biol. 2018 Jun 27;19(1):83. doi: 10.1186/s13059-018-1451-z.

22.

Participation of Women in Behavior Analysis Research: Some Recent and Relevant Data.

Li A, Curiel H, Pritchard J, Poling A.

Behav Anal Pract. 2018 Feb 7;11(2):160-164. doi: 10.1007/s40617-018-0211-6. eCollection 2018 Jun.

23.

Determining the genetic basis of anthracycline-cardiotoxicity by molecular response QTL mapping in induced cardiomyocytes.

Knowles DA, Burrows CK, Blischak JD, Patterson KM, Serie DJ, Norton N, Ober C, Pritchard JK, Gilad Y.

Elife. 2018 May 8;7. pii: e33480. doi: 10.7554/eLife.33480.

24.

Fetal overgrowth in pregnancies complicated by diabetes: development of a clinical prediction index.

Tomlinson TM, Mostello DJ, Lim KH, Pritchard JS, Gross G.

Arch Gynecol Obstet. 2018 Jul;298(1):67-74. doi: 10.1007/s00404-018-4758-9. Epub 2018 Apr 26.

PMID:
29700600
25.

Large-Scale Clonal Analysis Resolves Aging of the Mouse Hematopoietic Stem Cell Compartment.

Yamamoto R, Wilkinson AC, Ooehara J, Lan X, Lai CY, Nakauchi Y, Pritchard JK, Nakauchi H.

Cell Stem Cell. 2018 Apr 5;22(4):600-607.e4. doi: 10.1016/j.stem.2018.03.013.

26.

Creation of a national emergency medicine enhanced competency directory for residency training.

Argintaru N, Baylis J, Pritchard J, Mulla A, Gray A, Hart A, Bova C, Armstrong TL, Taher A.

CJEM. 2018 Jul;20(4):634-637. doi: 10.1017/cem.2018.25. Epub 2018 Mar 4.

PMID:
29501069
27.

Remodeling the Specificity of an Endosomal CORVET Tether Underlies Formation of Regulated Secretory Vesicles in the Ciliate Tetrahymena thermophila.

Sparvoli D, Richardson E, Osakada H, Lan X, Iwamoto M, Bowman GR, Kontur C, Bourland WA, Lynn DH, Pritchard JK, Haraguchi T, Dacks JB, Turkewitz AP.

Curr Biol. 2018 Mar 5;28(5):697-710.e13. doi: 10.1016/j.cub.2018.01.047. Epub 2018 Feb 22.

28.

Improving working equine welfare in 'hard-win' situations, where gains are difficult, expensive or marginal.

Pritchard J, Upjohn M, Hirson T.

PLoS One. 2018 Feb 6;13(2):e0191950. doi: 10.1371/journal.pone.0191950. eCollection 2018.

29.

Outbreak of Escherichia coli O157:H7 Infections Linked to Aged Raw Milk Gouda Cheese, Canada, 2013.

Currie A, Galanis E, Chacon PA, Murray R, Wilcott L, Kirkby P, Honish L, Franklin K, Farber J, Parker R, Shyng S, Sharma D, Tschetter L, Hoang L, Chui L, Pacagnella A, Wong J, Pritchard J, Kerr A, Taylor M, Mah V, Flint J; Investigative Team.

J Food Prot. 2018 Feb;81(2):325-331. doi: 10.4315/0362-028X.JFP-17-283.

PMID:
29369688
30.

Deterministic Nanopatterning of Diamond Using Electron Beams.

Bishop J, Fronzi M, Elbadawi C, Nikam V, Pritchard J, Fröch JE, Duong NMH, Ford MJ, Aharonovich I, Lobo CJ, Toth M.

ACS Nano. 2018 Mar 27;12(3):2873-2882. doi: 10.1021/acsnano.8b00354. Epub 2018 Feb 5.

PMID:
29365264
31.

Identification of genes required for Mycobacterium abscessus growth in vivo with a prominent role of the ESX-4 locus.

Laencina L, Dubois V, Le Moigne V, Viljoen A, Majlessi L, Pritchard J, Bernut A, Piel L, Roux AL, Gaillard JL, Lombard B, Loew D, Rubin EJ, Brosch R, Kremer L, Herrmann JL, Girard-Misguich F.

Proc Natl Acad Sci U S A. 2018 Jan 30;115(5):E1002-E1011. doi: 10.1073/pnas.1713195115. Epub 2018 Jan 17.

32.

Mesh nebulizers have become the first choice for new nebulized pharmaceutical drug developments.

Pritchard JN, Hatley RH, Denyer J, Hollen DV.

Ther Deliv. 2018 Feb;9(2):121-136. doi: 10.4155/tde-2017-0102. Review.

33.

Does Early Coronary Angiography Improve Survival After out-of-Hospital Cardiac Arrest? A Systematic Review With Meta-Analysis.

Welsford M, Bossard M, Shortt C, Pritchard J, Natarajan MK, Belley-Côté EP.

Can J Cardiol. 2018 Feb;34(2):180-194. doi: 10.1016/j.cjca.2017.09.012. Epub 2017 Sep 18. Review.

PMID:
29275998
34.

Enhancing the Promise of Drug Repositioning through Genetics.

Pritchard JE, O'Mara TA, Glubb DM.

Front Pharmacol. 2017 Dec 6;8:896. doi: 10.3389/fphar.2017.00896. eCollection 2017. Review.

35.

Annotation-free quantification of RNA splicing using LeafCutter.

Li YI, Knowles DA, Humphrey J, Barbeira AN, Dickinson SP, Im HK, Pritchard JK.

Nat Genet. 2018 Jan;50(1):151-158. doi: 10.1038/s41588-017-0004-9. Epub 2017 Dec 11.

36.

Impact of regulatory variation across human iPSCs and differentiated cells.

Banovich NE, Li YI, Raj A, Ward MC, Greenside P, Calderon D, Tung PY, Burnett JE, Myrthil M, Thomas SM, Burrows CK, Romero IG, Pavlovic BJ, Kundaje A, Pritchard JK, Gilad Y.

Genome Res. 2018 Jan;28(1):122-131. doi: 10.1101/gr.224436.117. Epub 2017 Dec 5.

37.

Delay Between Shaking and Actuation of a Hydrofluoroalkane Fluticasone Pressurized Metered-Dose Inhaler.

Berlinski A, von Hollen D, Pritchard JN, Hatley RH.

Respir Care. 2018 Mar;63(3):289-293. doi: 10.4187/respcare.05782. Epub 2017 Nov 21.

38.

Frequent nonallelic gene conversion on the human lineage and its effect on the divergence of gene duplicates.

Harpak A, Lan X, Gao Z, Pritchard JK.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):12779-12784. doi: 10.1073/pnas.1708151114. Epub 2017 Nov 14.

39.

Randomly polarised beam produced by magnetooptically Q-switched laser.

Morimoto R, Goto T, Taira T, Pritchard J, Mina M, Takagi H, Nakamura Y, Lim PB, Uchida H, Inoue M.

Sci Rep. 2017 Nov 13;7(1):15398. doi: 10.1038/s41598-017-15826-3.

40.

Measuring frailty in clinical practice: a comparison of physical frailty assessment methods in a geriatric out-patient clinic.

Pritchard JM, Kennedy CC, Karampatos S, Ioannidis G, Misiaszek B, Marr S, Patterson C, Woo T, Papaioannou A.

BMC Geriatr. 2017 Nov 13;17(1):264. doi: 10.1186/s12877-017-0623-0.

41.

Inferring Relevant Cell Types for Complex Traits by Using Single-Cell Gene Expression.

Calderon D, Bhaskar A, Knowles DA, Golan D, Raj T, Fu AQ, Pritchard JK.

Am J Hum Genet. 2017 Nov 2;101(5):686-699. doi: 10.1016/j.ajhg.2017.09.009. Epub 2017 Oct 26.

42.

Supported nickel-rhenium catalysts for selective hydrogenation of methyl esters to alcohols.

Liu K, Pritchard J, Lu L, van Putten R, Tiny Verhoeven MWGM, Schmitkamp M, Huang X, Lefort L, Kiely CJ, Hensen EJM, Pidko EA.

Chem Commun (Camb). 2017 Aug 29;53(70):9761-9764. doi: 10.1039/c7cc04759b.

PMID:
28813041
43.

Quantification of transplant-derived circulating cell-free DNA in absence of a donor genotype.

Sharon E, Shi H, Kharbanda S, Koh W, Martin LR, Khush KK, Valantine H, Pritchard JK, De Vlaminck I.

PLoS Comput Biol. 2017 Aug 3;13(8):e1005629. doi: 10.1371/journal.pcbi.1005629. eCollection 2017 Aug.

44.

An Expanded View of Complex Traits: From Polygenic to Omnigenic.

Boyle EA, Li YI, Pritchard JK.

Cell. 2017 Jun 15;169(7):1177-1186. doi: 10.1016/j.cell.2017.05.038. Review.

45.

Scoping review of indicators and methods of measurement used to evaluate the impact of dog population management interventions.

Hiby E, Atema KN, Brimley R, Hammond-Seaman A, Jones M, Rowan A, Fogelberg E, Kennedy M, Balaram D, Nel L, Cleaveland S, Hampson K, Townsend S, Lembo T, Rooney N, Whay HR, Pritchard J, Murray J, van Dijk L, Waran N, Bacon H, Knobel D, Tasker L, Baker C, Hiby L.

BMC Vet Res. 2017 May 30;13(1):143. doi: 10.1186/s12917-017-1051-2. Review.

46.

Comprehensive list of metabolites measured by DI-FTICR mass spectrometry in thyme plants with contrasting tolerance to drought.

Moradi P, Ford-Lloyd B, Pritchard J.

Data Brief. 2017 Apr 29;12:438-441. doi: 10.1016/j.dib.2017.04.039. eCollection 2017 Jun.

47.

Nebulized drug delivery in respiratory medicine: what does the future hold?

Pritchard JN.

Ther Deliv. 2017 Jun;8(6):391-399. doi: 10.4155/tde-2017-0015. Epub 2017 May 4.

PMID:
28470113
48.

Oil Accumulation in Transgenic Potato Tubers Alters Starch Quality and Nutritional Profile.

Mitchell M, Pritchard J, Okada S, Larroque O, Yulia D, Pettolino F, Szydlowski N, Singh S, Liu Q, Ral JP.

Front Plant Sci. 2017 Apr 12;8:554. doi: 10.3389/fpls.2017.00554. eCollection 2017.

49.

Rapid evolution of the human mutation spectrum.

Harris K, Pritchard JK.

Elife. 2017 Apr 25;6. pii: e24284. doi: 10.7554/eLife.24284.

50.

A subset of platinum-containing chemotherapeutic agents kills cells by inducing ribosome biogenesis stress.

Bruno PM, Liu Y, Park GY, Murai J, Koch CE, Eisen TJ, Pritchard JR, Pommier Y, Lippard SJ, Hemann MT.

Nat Med. 2017 Apr;23(4):461-471. doi: 10.1038/nm.4291. Epub 2017 Feb 27.

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