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Items: 8


Nanoscale coupling of junctophilin-2 and ryanodine receptors regulates vascular smooth muscle cell contractility.

Pritchard HAT, Griffin CS, Yamasaki E, Thakore P, Lane C, Greenstein AS, Earley S.

Proc Natl Acad Sci U S A. 2019 Oct 22;116(43):21874-21881. doi: 10.1073/pnas.1911304116. Epub 2019 Oct 7.


Nanoscale remodeling of ryanodine receptor cluster size underlies cerebral microvascular dysfunction in Duchenne muscular dystrophy.

Pritchard HAT, Pires PW, Yamasaki E, Thakore P, Earley S.

Proc Natl Acad Sci U S A. 2018 Oct 9;115(41):E9745-E9752. doi: 10.1073/pnas.1804593115. Epub 2018 Sep 4.


Microtubule structures underlying the sarcoplasmic reticulum support peripheral coupling sites to regulate smooth muscle contractility.

Pritchard HAT, Gonzales AL, Pires PW, Drumm BT, Ko EA, Sanders KM, Hennig GW, Earley S.

Sci Signal. 2017 Sep 19;10(497). pii: eaan2694. doi: 10.1126/scisignal.aan2694.


The angiotensin II receptor type 1b is the primary sensor of intraluminal pressure in cerebral artery smooth muscle cells.

Pires PW, Ko EA, Pritchard HAT, Rudokas M, Yamasaki E, Earley S.

J Physiol. 2017 Jul 15;595(14):4735-4753. doi: 10.1113/JP274310. Epub 2017 Jun 1.


Unitary TRPV3 channel Ca2+ influx events elicit endothelium-dependent dilation of cerebral parenchymal arterioles.

Pires PW, Sullivan MN, Pritchard HA, Robinson JJ, Earley S.

Am J Physiol Heart Circ Physiol. 2015 Dec 15;309(12):H2031-41. doi: 10.1152/ajpheart.00140.2015. Epub 2015 Oct 9.


Molecular and functional significance of Ca(2+)-activated Cl(-) channels in pulmonary arterial smooth muscle.

Leblanc N, Forrest AS, Ayon RJ, Wiwchar M, Angermann JE, Pritchard HA, Singer CA, Valencik ML, Britton F, Greenwood IA.

Pulm Circ. 2015 Jun;5(2):244-68. doi: 10.1086/680189. Review.


Inhibitory role of phosphatidylinositol 4,5-bisphosphate on TMEM16A-encoded calcium-activated chloride channels in rat pulmonary artery.

Pritchard HA, Leblanc N, Albert AP, Greenwood IA.

Br J Pharmacol. 2014 Sep;171(18):4311-21. doi: 10.1111/bph.12778.


Potent vasorelaxant activity of the TMEM16A inhibitor T16A(inh) -A01.

Davis AJ, Shi J, Pritchard HA, Chadha PS, Leblanc N, Vasilikostas G, Yao Z, Verkman AS, Albert AP, Greenwood IA.

Br J Pharmacol. 2013 Feb;168(3):773-84. doi: 10.1111/j.1476-5381.2012.02199.x.

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