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Items: 1 to 50 of 113

1.

NF-κB2 signalling in enteroids modulates enterocyte responses to secreted factors from bone marrow-derived dendritic cells.

Jones LG, Vaida A, Thompson LM, Ikuomola FI, Caamaño JH, Burkitt MD, Miyajima F, Williams JM, Campbell BJ, Pritchard DM, Duckworth CA.

Cell Death Dis. 2019 Nov 26;10(12):896. doi: 10.1038/s41419-019-2129-5.

2.

Corrigendum to "IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas." [Cancer Lett. 458C (2019) 29-38].

Mihajluk K, Simms C, Reay M, Madureira PA, Howarth A, Murray P, Nasser S, Duckworth CA, Pritchard DM, Pilkington GJ, Hill R.

Cancer Lett. 2020 Jan 28;469:524-525. doi: 10.1016/j.canlet.2019.10.002. Epub 2019 Oct 8. No abstract available.

PMID:
31604579
3.

Macrophage-Specific NF-κB Activation Dynamics Can Segregate Inflammatory Bowel Disease Patients.

Papoutsopoulou S, Burkitt MD, Bergey F, England H, Hough R, Schmidt L, Spiller DG, White MHR, Paszek P, Jackson DA, Martins Dos Santos VAP, Sellge G, Pritchard DM, Campbell BJ, Müller W, Probert CS.

Front Immunol. 2019 Sep 11;10:2168. doi: 10.3389/fimmu.2019.02168. eCollection 2019.

4.

British Society of Gastroenterology guidelines on the diagnosis and management of patients at risk of gastric adenocarcinoma.

Banks M, Graham D, Jansen M, Gotoda T, Coda S, di Pietro M, Uedo N, Bhandari P, Pritchard DM, Kuipers EJ, Rodriguez-Justo M, Novelli MR, Ragunath K, Shepherd N, Dinis-Ribeiro M.

Gut. 2019 Sep;68(9):1545-1575. doi: 10.1136/gutjnl-2018-318126. Epub 2019 Jul 5.

5.

Replication of Crohn's Disease Mucosal E. coli Isolates inside Macrophages Correlates with Resistance to Superoxide and Is Dependent on Macrophage NF-kappa B Activation.

Tawfik A, Knight P, Duckworth CA, Pritchard DM, Rhodes JM, Campbell BJ.

Pathogens. 2019 Jun 8;8(2). pii: E74. doi: 10.3390/pathogens8020074.

6.

IP1867B suppresses the insulin-like growth factor 1 receptor (IGF1R) ablating epidermal growth factor receptor inhibitor resistance in adult high grade gliomas.

Mihajluk K, Simms C, Reay M, Madureira PA, Howarth A, Murray P, Nasser S, Duckworth CA, Pritchard DM, Pilkington GJ, Hill R.

Cancer Lett. 2019 Aug 28;458:29-38. doi: 10.1016/j.canlet.2019.05.028. Epub 2019 May 23. Erratum in: Cancer Lett. 2020 Jan 28;469:524-525.

PMID:
31129148
7.

Recharacterization data for a geriatric gastrin polycolonal antibody.

Dodd S, Varro A, Pritchard DM, Dockray GJ.

Data Brief. 2019 Apr 1;24:103886. doi: 10.1016/j.dib.2019.103886. eCollection 2019 Jun.

8.

Author Correction: Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.

Burkitt MD, Williams JM, Townsend T, Hough R, Duckworth CA, Pritchard DM.

Cell Death Dis. 2019 Apr 18;10(5):334. doi: 10.1038/s41419-019-1534-0.

9.

Correction: The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR.

Oncotarget. 2019 Jan 18;10(6):685. doi: 10.18632/oncotarget.26625. eCollection 2019 Jan 18.

10.

Development of an orthotopic syngeneic murine model of colorectal cancer for use in translational research.

Evans JP, Winiarski BK, Sutton PA, Ressel L, Duckworth CA, Pritchard DM, Palmer DH, Goldring CE, Kitteringham NR.

Lab Anim. 2019 Dec;53(6):598-609. doi: 10.1177/0023677219826165. Epub 2019 Feb 13.

11.

A cohort study of local excision followed by adjuvant therapy incorporating a contact X-ray brachytherapy boost instead of radical resection in 180 patients with rectal cancer.

Smith FM, Pritchard DM, Wong H, Whitmarsh K, Hershman MJ, Sun Myint A.

Colorectal Dis. 2019 Jun;21(6):663-670. doi: 10.1111/codi.14584. Epub 2019 Mar 8.

PMID:
30742736
12.

Potential role of fecal volatile organic compounds as biomarkers of chemically induced intestinal inflammation in mice.

Reade S, Williams JM, Aggio R, Duckworth CA, Mahalhal A, Hough R, Pritchard DM, Probert CS.

FASEB J. 2019 Mar;33(3):3129-3136. doi: 10.1096/fj.201800076RR. Epub 2018 Oct 25.

PMID:
30359099
13.

Oral iron exacerbates colitis and influences the intestinal microbiome.

Mahalhal A, Williams JM, Johnson S, Ellaby N, Duckworth CA, Burkitt MD, Liu X, Hold GL, Campbell BJ, Pritchard DM, Probert CS.

PLoS One. 2018 Oct 11;13(10):e0202460. doi: 10.1371/journal.pone.0202460. eCollection 2018.

14.

Contact X-ray Brachytherapy as an Adjunct to a Watch and Wait Approach is an Affordable Alternative to Standard Surgical Management of Rectal Cancer for Patients with a Partial Clinical Response to Chemoradiotherapy.

Rao C, Stewart A, Martin AP, Collins B, Pritchard DM, Athanasiou T, Sun Myint A.

Clin Oncol (R Coll Radiol). 2018 Oct;30(10):625-633. doi: 10.1016/j.clon.2018.06.010. Epub 2018 Jul 7.

PMID:
30196845
15.

Application of a quantum cascade laser aperture scanning near-field optical microscope to the study of a cancer cell.

Smith CI, Siggel-King MRF, Ingham J, Harrison P, Martin DS, Varro A, Pritchard DM, Surman M, Barrett S, Weightman P.

Analyst. 2018 Dec 3;143(24):5912-5917. doi: 10.1039/c8an01183d.

PMID:
30191233
16.

The Nrf2 inhibitor brusatol is a potent antitumour agent in an orthotopic mouse model of colorectal cancer.

Evans JP, Winiarski BK, Sutton PA, Jones RP, Ressel L, Duckworth CA, Pritchard DM, Lin ZX, Fretwell VL, Tweedle EM, Costello E, Goldring CE, Copple IM, Park BK, Palmer DH, Kitteringham NR.

Oncotarget. 2018 Jun 5;9(43):27104-27116. doi: 10.18632/oncotarget.25497. eCollection 2018 Jun 5. Erratum in: Oncotarget. 2019 Jan 18;10(6):685. Vicky, Fretwell L [corrected to Fretwell, Vicky L].

17.

In Reply to Habr-Gama et al.

Sun Myint A, Smith FM, Gollins S, Rao C, Pritchard DM.

Int J Radiat Oncol Biol Phys. 2018 Jul 1;101(3):743-744. doi: 10.1016/j.ijrobp.2018.03.033. No abstract available.

PMID:
29893284
18.

Matrix metalloproteinase (MMP)-7 in Barrett's esophagus and esophageal adenocarcinoma: expression, metabolism, and functional significance.

Garalla HM, Lertkowit N, Tiszlavicz L, Reisz Z, Holmberg C, Beynon R, Simpson D, Varga A, Kumar JD, Dodd S, Pritchard DM, Moore AR, Rosztóczy AI, Wittman T, Simpson A, Dockray GJ, Varro A.

Physiol Rep. 2018 May;6(10):e13683. doi: 10.14814/phy2.13683.

19.

Dose Escalation Using Contact X-ray Brachytherapy After External Beam Radiotherapy as Nonsurgical Treatment Option for Rectal Cancer: Outcomes From a Single-Center Experience.

Sun Myint A, Smith FM, Gollins S, Wong H, Rao C, Whitmarsh K, Sripadam R, Rooney P, Hershman M, Pritchard DM.

Int J Radiat Oncol Biol Phys. 2018 Mar 1;100(3):565-573. doi: 10.1016/j.ijrobp.2017.10.022. Epub 2017 Oct 20.

PMID:
29229327
20.

Comparison of the human gastric microbiota in hypochlorhydric states arising as a result of Helicobacter pylori-induced atrophic gastritis, autoimmune atrophic gastritis and proton pump inhibitor use.

Parsons BN, Ijaz UZ, D'Amore R, Burkitt MD, Eccles R, Lenzi L, Duckworth CA, Moore AR, Tiszlavicz L, Varro A, Hall N, Pritchard DM.

PLoS Pathog. 2017 Nov 2;13(11):e1006653. doi: 10.1371/journal.ppat.1006653. eCollection 2017 Nov.

21.

Dose escalation using contact X-ray brachytherapy (Papillon) for rectal cancer: does it improve the chance of organ preservation?

Sun Myint A, Smith FM, Gollins SW, Wong H, Rao C, Whitmarsh K, Sripadam R, Rooney P, Hershman MJ, Fekete Z, Perkins K, Pritchard DM.

Br J Radiol. 2017 Dec;90(1080):20170175. doi: 10.1259/bjr.20170175. Epub 2017 Nov 10.

22.

Quality standards in upper gastrointestinal endoscopy: a position statement of the British Society of Gastroenterology (BSG) and Association of Upper Gastrointestinal Surgeons of Great Britain and Ireland (AUGIS).

Beg S, Ragunath K, Wyman A, Banks M, Trudgill N, Pritchard DM, Riley S, Anderson J, Griffiths H, Bhandari P, Kaye P, Veitch A.

Gut. 2017 Nov;66(11):1886-1899. doi: 10.1136/gutjnl-2017-314109. Epub 2017 Aug 18. Erratum in: Gut. 2017 Dec;66(12 ):2188.

23.

Mice lacking NF-κB1 exhibit marked DNA damage responses and more severe gastric pathology in response to intraperitoneal tamoxifen administration.

Burkitt MD, Williams JM, Townsend T, Hough R, Duckworth CA, Pritchard DM.

Cell Death Dis. 2017 Jul 20;8(7):e2939. doi: 10.1038/cddis.2017.332. Erratum in: Cell Death Dis. 2019 Apr 18;10(5):334. Duckworth, Carrie A [added].

24.

68Gallium DOTANOC-PET Imaging in Lung Carcinoids: Impact on Patients' Management.

Lamarca A, Pritchard DM, Westwood T, Papaxoinis G, Nonaka D, Vinjamuri S, Valle JW, Manoharan P, Mansoor W.

Neuroendocrinology. 2018;106(2):128-138. doi: 10.1159/000472717. Epub 2017 Apr 12.

PMID:
28399530
25.

Hexane Extracts of Calophyllum brasiliense Inhibit the Development of Gastric Preneoplasia in Helicobacter felis Infected INS-Gas Mice.

Lemos LM, Miyajima F, Castilho GR, Martins DT, Pritchard DM, Burkitt MD.

Front Pharmacol. 2017 Feb 27;8:92. doi: 10.3389/fphar.2017.00092. eCollection 2017.

26.

Helicobacter pylori-induced gastric pathology: insights from in vivo and ex vivo models.

Burkitt MD, Duckworth CA, Williams JM, Pritchard DM.

Dis Model Mech. 2017 Feb 1;10(2):89-104. doi: 10.1242/dmm.027649. Review.

27.

Towards better models and mechanistic biomarkers for drug-induced gastrointestinal injury.

Carr DF, Ayehunie S, Davies A, Duckworth CA, French S, Hall N, Hussain S, Mellor HR, Norris A, Park BK, Penrose A, Pritchard DM, Probert CS, Ramaiah S, Sadler C, Schmitt M, Shaw A, Sidaway JE, Vries RG, Wagoner M, Pirmohamed M.

Pharmacol Ther. 2017 Apr;172:181-194. doi: 10.1016/j.pharmthera.2017.01.002. Epub 2017 Jan 27. Review.

PMID:
28132905
28.

Potential clinical indications for a CCK2 receptor antagonist.

Boyce M, Lloyd KA, Pritchard DM.

Curr Opin Pharmacol. 2016 Dec;31:68-75. doi: 10.1016/j.coph.2016.09.002. Epub 2016 Oct 3. Review.

PMID:
27710813
29.

Netazepide, a gastrin/cholecystokinin-2 receptor antagonist, can eradicate gastric neuroendocrine tumours in patients with autoimmune chronic atrophic gastritis.

Boyce M, Moore AR, Sagatun L, Parsons BN, Varro A, Campbell F, Fossmark R, Waldum HL, Pritchard DM.

Br J Clin Pharmacol. 2017 Mar;83(3):466-475. doi: 10.1111/bcp.13146. Epub 2016 Nov 21.

30.

A knockin mouse model for human ATP4aR703C mutation identified in familial gastric neuroendocrine tumors recapitulates the premalignant condition of the human disease and suggests new therapeutic strategies.

Calvete O, Varro A, Pritchard DM, Barroso A, Oteo M, Morcillo MÁ, Vargiu P, Dodd S, Garcia M, Reyes J, Ortega S, Benitez J.

Dis Model Mech. 2016 Sep 1;9(9):975-84. doi: 10.1242/dmm.025890. Epub 2016 Aug 4.

31.

Gastrin-induced miR-222 promotes gastric tumor development by suppressing p27kip1.

Lloyd KA, Moore AR, Parsons BN, O'Hara A, Boyce M, Dockray GJ, Varro A, Pritchard DM.

Oncotarget. 2016 Jul 19;7(29):45462-45478. doi: 10.18632/oncotarget.9990.

32.

Intestinal Preparation Techniques for Histological Analysis in the Mouse.

Williams JM, Duckworth CA, Vowell K, Burkitt MD, Pritchard DM.

Curr Protoc Mouse Biol. 2016 Jun 1;6(2):148-168. doi: 10.1002/cpmo.2.

PMID:
27248432
33.

Importance of the alternative NF-κB activation pathway in inflammation-associated gastrointestinal carcinogenesis.

Merga YJ, O'Hara A, Burkitt MD, Duckworth CA, Probert CS, Campbell BJ, Pritchard DM.

Am J Physiol Gastrointest Liver Physiol. 2016 Jun 1;310(11):G1081-90. doi: 10.1152/ajpgi.00026.2016. Epub 2016 Apr 21. Review.

34.

Letter: gastric cancer and pernicious anaemia--only a minority of UK pernicious anaemia patients have had a gastroscopy.

Pritchard DM, Hooper M.

Aliment Pharmacol Ther. 2016 May;43(10):1106-7. doi: 10.1111/apt.13595. No abstract available.

35.

Murine Models of Helicobacter (pylori or felis)-associated Gastric Cancer.

Duckworth CA, Burkitt MD, Williams JM, Parsons BN, Tang JMF, Pritchard DM.

Curr Protoc Pharmacol. 2015 Jun 1;69:14.34.1-14.34.35. doi: 10.1002/0471141755.ph1434s69.

PMID:
26344212
36.

The stomach in health and disease.

Hunt RH, Camilleri M, Crowe SE, El-Omar EM, Fox JG, Kuipers EJ, Malfertheiner P, McColl KE, Pritchard DM, Rugge M, Sonnenberg A, Sugano K, Tack J.

Gut. 2015 Oct;64(10):1650-68. doi: 10.1136/gutjnl-2014-307595. Epub 2015 Sep 4. Review.

37.

Helicobacter pylori, HIV and Gastric Hypochlorhydria in the Malawian Population.

Geraghty J, Thumbs A, Kankwatira A, Andrews T, Moore A, Malamba R, Mtunthama N, Hellberg K, Kalongolera L, O'Toole P, Varro A, Pritchard DM, Gordon M.

PLoS One. 2015 Aug 5;10(8):e0132043. doi: 10.1371/journal.pone.0132043. eCollection 2015.

38.

Chemically modified, non-anticoagulant heparin derivatives are potent galectin-3 binding inhibitors and inhibit circulating galectin-3-promoted metastasis.

Duckworth CA, Guimond SE, Sindrewicz P, Hughes AJ, French NS, Lian LY, Yates EA, Pritchard DM, Rhodes JM, Turnbull JE, Yu LG.

Oncotarget. 2015 Sep 15;6(27):23671-87.

39.

bak deletion stimulates gastric epithelial proliferation and enhances Helicobacter felis-induced gastric atrophy and dysplasia in mice.

Duckworth CA, Abuderman AA, Burkitt MD, Williams JM, O'Reilly LA, Pritchard DM.

Am J Physiol Gastrointest Liver Physiol. 2015 Sep 15;309(6):G420-30. doi: 10.1152/ajpgi.00404.2014. Epub 2015 Jul 9.

40.

PAK1 modulates a PPARγ/NF-κB cascade in intestinal inflammation.

Dammann K, Khare V, Lang M, Claudel T, Harpain F, Granofszky N, Evstatiev R, Williams JM, Pritchard DM, Watson A, Gasche C.

Biochim Biophys Acta. 2015 Oct;1853(10 Pt A):2349-60. doi: 10.1016/j.bbamcr.2015.05.031. Epub 2015 May 31.

41.

Gastrin stimulates MMP-1 expression in gastric epithelial cells: putative role in gastric epithelial cell migration.

Kumar JD, Steele I, Moore AR, Murugesan SV, Rakonczay Z, Venglovecz V, Pritchard DM, Dimaline R, Tiszlavicz L, Varro A, Dockray GJ.

Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G78-86. doi: 10.1152/ajpgi.00084.2015. Epub 2015 May 14.

42.

NF-κB1, NF-κB2 and c-Rel differentially regulate susceptibility to colitis-associated adenoma development in C57BL/6 mice.

Burkitt MD, Hanedi AF, Duckworth CA, Williams JM, Tang JM, O'Reilly LA, Putoczki TL, Gerondakis S, Dimaline R, Caamano JH, Pritchard DM.

J Pathol. 2015 Jul;236(3):326-36. doi: 10.1002/path.4527. Epub 2015 Apr 21.

43.

Exome sequencing identifies ATP4A gene as responsible of an atypical familial type I gastric neuroendocrine tumour.

Calvete O, Reyes J, Zuñiga S, Paumard-Hernández B, Fernández V, Bujanda L, Rodriguez-Pinilla MS, Palacios J, Heine-Suñer D, Banka S, Newman WG, Cañamero M, Pritchard DM, Benítez J.

Hum Mol Genet. 2015 May 15;24(10):2914-22. doi: 10.1093/hmg/ddv054. Epub 2015 Feb 11.

PMID:
25678551
44.

Epithelial cell shedding and barrier function: a matter of life and death at the small intestinal villus tip.

Williams JM, Duckworth CA, Burkitt MD, Watson AJ, Campbell BJ, Pritchard DM.

Vet Pathol. 2015 May;52(3):445-55. doi: 10.1177/0300985814559404. Epub 2014 Nov 26.

45.

Peanut agglutinin appearance in the blood circulation after peanut ingestion mimics the action of endogenous galectin-3 to promote metastasis by interaction with cancer-associated MUC1.

Zhao Q, Duckworth CA, Wang W, Guo X, Barrow H, Pritchard DM, Rhodes JM, Yu LG.

Carcinogenesis. 2014 Dec;35(12):2815-21. doi: 10.1093/carcin/bgu216. Epub 2014 Oct 17.

PMID:
25326505
46.

Serial surveillance of carcinoid heart disease: factors associated with echocardiographic progression and mortality.

Dobson R, Burgess MI, Valle JW, Pritchard DM, Vora J, Wong C, Chadwick C, Keevi B, Adaway J, Hofmann U, Poston GJ, Cuthbertson DJ.

Br J Cancer. 2014 Oct 28;111(9):1703-9. doi: 10.1038/bjc.2014.468. Epub 2014 Sep 11.

47.

Analysis of clinical isolates of Helicobacter pylori in Pakistan reveals high degrees of pathogenicity and high frequencies of antibiotic resistance.

Rasheed F, Campbell BJ, Alfizah H, Varro A, Zahra R, Yamaoka Y, Pritchard DM.

Helicobacter. 2014 Oct;19(5):387-99. doi: 10.1111/hel.12142. Epub 2014 May 14.

48.

The clinical presentation and management of carcinoid heart disease.

Dobson R, Burgess MI, Pritchard DM, Cuthbertson DJ.

Int J Cardiol. 2014 Apr 15;173(1):29-32. doi: 10.1016/j.ijcard.2014.02.037. Epub 2014 Feb 28. Review.

PMID:
24636550
49.

Circulating galectins -2, -4 and -8 in cancer patients make important contributions to the increased circulation of several cytokines and chemokines that promote angiogenesis and metastasis.

Chen C, Duckworth CA, Fu B, Pritchard DM, Rhodes JM, Yu LG.

Br J Cancer. 2014 Feb 4;110(3):741-52. doi: 10.1038/bjc.2013.793. Epub 2014 Jan 2.

50.

Netazepide, a gastrin receptor antagonist, normalises tumour biomarkers and causes regression of type 1 gastric neuroendocrine tumours in a nonrandomised trial of patients with chronic atrophic gastritis.

Moore AR, Boyce M, Steele IA, Campbell F, Varro A, Pritchard DM.

PLoS One. 2013 Oct 1;8(10):e76462. doi: 10.1371/journal.pone.0076462. eCollection 2013.

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