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Items: 1 to 50 of 451

1.

Two-stain immunohistochemical screening for Lynch syndrome in colorectal cancer may fail to detect mismatch repair deficiency.

Pearlman R, Markow M, Knight D, Chen W, Arnold CA, Pritchard CC, Hampel H, Frankel WL.

Mod Pathol. 2018 Jul 2. doi: 10.1038/s41379-018-0058-y. [Epub ahead of print]

PMID:
29967423
2.

A five-CpG DNA methylation score to predict metastatic-lethal outcomes in men treated with radical prostatectomy for localized prostate cancer.

Zhao S, Leonardson A, Geybels MS, McDaniel AS, Yu M, Kolb S, Zong H, Carter K, Siddiqui J, Cheng A, Wright JL, Pritchard CC, Lance R, Troyer D, Fan JB, Ostrander EA, Dai JY, Tomlins SA, Feng Z, Stanford JL.

Prostate. 2018 Jun 28. doi: 10.1002/pros.23667. [Epub ahead of print]

PMID:
29956356
3.

Using Somatic Mutations from Tumors to Classify Variants in Mismatch Repair Genes.

Shirts BH, Konnick EQ, Upham S, Walsh T, Ranola JMO, Jacobson AL, King MC, Pearlman R, Hampel H, Pritchard CC.

Am J Hum Genet. 2018 Jul 5;103(1):19-29. doi: 10.1016/j.ajhg.2018.05.001. Epub 2018 Jun 7.

PMID:
29887214
4.

Efficient Detection of Copy Number Mutations in PMS2 Exons with a Close Homolog.

Herman DS, Smith C, Liu C, Vaughn CP, Palaniappan S, Pritchard CC, Shirts BH.

J Mol Diagn. 2018 Jul;20(4):512-521. doi: 10.1016/j.jmoldx.2018.03.010. Epub 2018 May 22.

PMID:
29792936
5.

Significance and implications of FDA approval of pembrolizumab for biomarker-defined disease.

Boyiadzis MM, Kirkwood JM, Marshall JL, Pritchard CC, Azad NS, Gulley JL.

J Immunother Cancer. 2018 May 14;6(1):35. doi: 10.1186/s40425-018-0342-x.

6.

Mps1 inhibitors synergise with low doses of taxanes in promoting tumour cell death by enhancement of errors in cell division.

Maia ARR, Linder S, Song JY, Vaarting C, Boon U, Pritchard CEJ, Velds A, Huijbers IJ, van Tellingen O, Jonkers J, Medema RH.

Br J Cancer. 2018 May 8. doi: 10.1038/s41416-018-0081-2. [Epub ahead of print]

PMID:
29736010
7.

Histology of colorectal adenocarcinoma with double somatic mismatch repair mutations is indistinguishable from those caused by lynch syndrome.

Hemminger JA, Pearlman R, Haraldsdottir S, Knight D, Jonasson JG, Pritchard CC, Hampel H, Frankel WL.

Hum Pathol. 2018 Apr 30. pii: S0046-8177(18)30146-1. doi: 10.1016/j.humpath.2018.04.017. [Epub ahead of print]

PMID:
29723603
8.

Microsatellite instability in prostate cancer by PCR or next-generation sequencing.

Hempelmann JA, Lockwood CM, Konnick EQ, Schweizer MT, Antonarakis ES, Lotan TL, Montgomery B, Nelson PS, Klemfuss N, Salipante SJ, Pritchard CC.

J Immunother Cancer. 2018 Apr 17;6(1):29. doi: 10.1186/s40425-018-0341-y.

9.

Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types.

Hause RJ, Pritchard CC, Shendure J, Salipante SJ.

Nat Med. 2018 Apr 10;24(4):525. doi: 10.1038/nm0418-525a.

PMID:
29634692
10.

Accurate Pan-Cancer Molecular Diagnosis of Microsatellite Instability by Single-Molecule Molecular Inversion Probe Capture and High-Throughput Sequencing.

Waalkes A, Smith N, Penewit K, Hempelmann J, Konnick EQ, Hause RJ, Pritchard CC, Salipante SJ.

Clin Chem. 2018 Jun;64(6):950-958. doi: 10.1373/clinchem.2017.285981. Epub 2018 Apr 9.

PMID:
29632127
11.

The long tail of oncogenic drivers in prostate cancer.

Armenia J, Wankowicz SAM, Liu D, Gao J, Kundra R, Reznik E, Chatila WK, Chakravarty D, Han GC, Coleman I, Montgomery B, Pritchard C, Morrissey C, Barbieri CE, Beltran H, Sboner A, Zafeiriou Z, Miranda S, Bielski CM, Penson AV, Tolonen C, Huang FW, Robinson D, Wu YM, Lonigro R, Garraway LA, Demichelis F, Kantoff PW, Taplin ME, Abida W, Taylor BS, Scher HI, Nelson PS, de Bono JS, Rubin MA, Sawyers CL, Chinnaiyan AM; PCF/SU2C International Prostate Cancer Dream Team, Schultz N, Van Allen EM; PCF/SU2C International Prostate Cancer Dream Team.

Nat Genet. 2018 May;50(5):645-651. doi: 10.1038/s41588-018-0078-z. Epub 2018 Apr 2.

PMID:
29610475
12.

Assessment of Tumor Sequencing as a Replacement for Lynch Syndrome Screening and Current Molecular Tests for Patients With Colorectal Cancer.

Hampel H, Pearlman R, Beightol M, Zhao W, Jones D, Frankel WL, Goodfellow PJ, Yilmaz A, Miller K, Bacher J, Jacobson A, Paskett E, Shields PG, Goldberg RM, de la Chapelle A, Shirts BH, Pritchard CC; Ohio Colorectal Cancer Prevention Initiative Study Group.

JAMA Oncol. 2018 Jun 1;4(6):806-813. doi: 10.1001/jamaoncol.2018.0104.

PMID:
29596542
13.

Genetic Mechanisms of Immune Evasion in Colorectal Cancer.

Grasso CS, Giannakis M, Wells DK, Hamada T, Mu XJ, Quist M, Nowak JA, Nishihara R, Qian ZR, Inamura K, Morikawa T, Nosho K, Abril-Rodriguez G, Connolly C, Escuin-Ordinas H, Geybels MS, Grady WM, Hsu L, Hu-Lieskovan S, Huyghe JR, Kim YJ, Krystofinski P, Leiserson MDM, Montoya DJ, Nadel BB, Pellegrini M, Pritchard CC, Puig-Saus C, Quist EH, Raphael BJ, Salipante SJ, Shin DS, Shinbrot E, Shirts B, Shukla S, Stanford JL, Sun W, Tsoi J, Upfill-Brown A, Wheeler DA, Wu CJ, Yu M, Zaidi SH, Zaretsky JM, Gabriel SB, Lander ES, Garraway LA, Hudson TJ, Fuchs CS, Ribas A, Ogino S, Peters U.

Cancer Discov. 2018 Jun;8(6):730-749. doi: 10.1158/2159-8290.CD-17-1327. Epub 2018 Mar 6.

PMID:
29510987
14.

The Rap2c GTPase facilitates B cell receptor-induced reorientation of the microtubule-organizing center.

Wang JC, Lee JY, Dang-Lawson M, Pritchard C, Gold MR.

Small GTPases. 2018 Feb 19:1-11. doi: 10.1080/21541248.2018.1441626. [Epub ahead of print]

PMID:
29457987
15.

Clinical Outcome of Prostate Cancer Patients with Germline DNA Repair Mutations: Retrospective Analysis from an International Study.

Mateo J, Cheng HH, Beltran H, Dolling D, Xu W, Pritchard CC, Mossop H, Rescigno P, Perez-Lopez R, Sailer V, Kolinsky M, Balasopoulou A, Bertan C, Nanus DM, Tagawa ST, Thorne H, Montgomery B, Carreira S, Sandhu S, Rubin MA, Nelson PS, de Bono JS.

Eur Urol. 2018 May;73(5):687-693. doi: 10.1016/j.eururo.2018.01.010. Epub 2018 Feb 8.

16.

DNA Repair Pathway Alterations in Metastatic Castration-resistant Prostate Cancer Responders to Radium-223.

Ramos JD, Mostaghel EA, Pritchard CC, Yu EY.

Clin Genitourin Cancer. 2018 Apr;16(2):106-110. doi: 10.1016/j.clgc.2017.11.009. Epub 2017 Dec 6. No abstract available.

PMID:
29287968
17.

Targeted Sequencing of Malignant Supratentorial Pediatric Brain Tumors Demonstrates a High Frequency of Clinically Relevant Mutations.

Cole BL, Pritchard CC, Anderson M, Leary SE.

Pediatr Dev Pathol. 2017 Jan 1:1093526617743905. doi: 10.1177/1093526617743905. [Epub ahead of print]

PMID:
29173061
18.

Profiling tumour heterogeneity through circulating tumour DNA in patients with pancreatic cancer.

Adamo P, Cowley CM, Neal CP, Mistry V, Page K, Dennison AR, Isherwood J, Hastings R, Luo J, Moore DA, Howard PJ, Miguel ML, Pritchard C, Manson M, Shaw JA.

Oncotarget. 2017 Aug 14;8(50):87221-87233. doi: 10.18632/oncotarget.20250. eCollection 2017 Oct 20.

19.

Pilot parallel randomised controlled trial of protective socks against usual care to reduce skin tears in high risk people: 'STOPCUTS'.

Powell RJ, Hayward CJ, Snelgrove CL, Polverino K, Park L, Chauhan R, Evans PH, Byford R, Charman C, Foy CJW, Pritchard C, Kingsley A.

Pilot Feasibility Stud. 2017 Oct 17;3:43. doi: 10.1186/s40814-017-0182-3. eCollection 2017.

20.

Corrigendum: Classification and characterization of microsatellite instability across 18 cancer types.

Hause RJ, Pritchard CC, Shendure J, Salipante SJ.

Nat Med. 2017 Oct 6;23(10):1241. doi: 10.1038/nm1017-1241a.

PMID:
28985213
21.

Child mortality and poverty in three world regions (the West, Asia and Sub-Saharan Africa) 1988-2010: Evidence of relative intra-regional neglect?

Pritchard C, Keen S.

Scand J Public Health. 2016 Dec;44(8):734-741. doi: 10.1177/1403494816675550. Epub 2016 Oct 22.

PMID:
28929930
22.

On the ferries: the unmet health care needs of transiting refugees in Greece.

Shortall CK, Glazik R, Sornum A, Pritchard C.

Int Health. 2017 Sep 1;9(5):272-280. doi: 10.1093/inthealth/ihx032. Review.

PMID:
28911130
23.

An economic evaluation of the healthcare cost of tinnitus management in the UK.

Stockdale D, McFerran D, Brazier P, Pritchard C, Kay T, Dowrick C, Hoare DJ.

BMC Health Serv Res. 2017 Aug 22;17(1):577. doi: 10.1186/s12913-017-2527-2.

24.

Direct Generation of Conditional Alleles Using CRISPR/Cas9 in Mouse Zygotes.

Pritchard CEJ, Kroese LJ, Huijbers IJ.

Methods Mol Biol. 2017;1642:21-35. doi: 10.1007/978-1-4939-7169-5_2.

PMID:
28815491
25.

MSH2 Loss in Primary Prostate Cancer.

Guedes LB, Antonarakis ES, Schweizer MT, Mirkheshti N, Almutairi F, Park JC, Glavaris S, Hicks J, Eisenberger MA, De Marzo AM, Epstein JI, Isaacs WB, Eshleman JR, Pritchard CC, Lotan TL.

Clin Cancer Res. 2017 Nov 15;23(22):6863-6874. doi: 10.1158/1078-0432.CCR-17-0955. Epub 2017 Aug 8.

PMID:
28790115
26.

Prostate Cancer Screening in a New Era of Genetics.

Cheng HH, Pritchard CC, Montgomery B, Lin DW, Nelson PS.

Clin Genitourin Cancer. 2017 Dec;15(6):625-628. doi: 10.1016/j.clgc.2017.05.024. Epub 2017 May 31. Review.

PMID:
28697982
27.

Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017.

Gillessen S, Attard G, Beer TM, Beltran H, Bossi A, Bristow R, Carver B, Castellano D, Chung BH, Clarke N, Daugaard G, Davis ID, de Bono J, Borges Dos Reis R, Drake CG, Eeles R, Efstathiou E, Evans CP, Fanti S, Feng F, Fizazi K, Frydenberg M, Gleave M, Halabi S, Heidenreich A, Higano CS, James N, Kantoff P, Kellokumpu-Lehtinen PL, Khauli RB, Kramer G, Logothetis C, Maluf F, Morgans AK, Morris MJ, Mottet N, Murthy V, Oh W, Ost P, Padhani AR, Parker C, Pritchard CC, Roach M, Rubin MA, Ryan C, Saad F, Sartor O, Scher H, Sella A, Shore N, Smith M, Soule H, Sternberg CN, Suzuki H, Sweeney C, Sydes MR, Tannock I, Tombal B, Valdagni R, Wiegel T, Omlin A.

Eur Urol. 2018 Feb;73(2):178-211. doi: 10.1016/j.eururo.2017.06.002. Epub 2017 Jun 24.

28.

Controlled population-based comparative study of USA and international adult [55-74] neurological deaths 1989-2014.

Pritchard C, Rosenorn-Lanng E, Silk A, Hansen L.

Acta Neurol Scand. 2017 Dec;136(6):698-707. doi: 10.1111/ane.12789. Epub 2017 Jun 18.

PMID:
28626907
29.

Personalizing Therapy for Metastatic Prostate Cancer: The Role of Solid and Liquid Tumor Biopsies.

Friedlander TW, Pritchard CC, Beltran H.

Am Soc Clin Oncol Educ Book. 2017;37:358-369. doi: 10.14694/EDBK_175510. Review.

30.

KRASG12D expression in lung-resident myeloid cells promotes pulmonary LCH-like neoplasm sensitive to statin treatment.

Kamata T, Giblett S, Pritchard C.

Blood. 2017 Jul 27;130(4):514-526. doi: 10.1182/blood-2017-02-770149. Epub 2017 May 26.

31.

The cost-effectiveness of patient-controlled analgesia vs. standard care in patients presenting to the Emergency Department in pain, who are subsequently admitted to hospital.

Pritchard C, Smith JE, Creanor S, Squire R, Barton A, Benger J, Cocking L, Ewings P, Rockett M; PASTIES writing group.

Anaesthesia. 2017 Aug;72(8):953-960. doi: 10.1111/anae.13932. Epub 2017 May 26.

PMID:
28547753
32.

Comprehensive population-wide analysis of Lynch syndrome in Iceland reveals founder mutations in MSH6 and PMS2.

Haraldsdottir S, Rafnar T, Frankel WL, Einarsdottir S, Sigurdsson A, Hampel H, Snaebjornsson P, Masson G, Weng D, Arngrimsson R, Kehr B, Yilmaz A, Haraldsson S, Sulem P, Stefansson T, Shields PG, Sigurdsson F, Bekaii-Saab T, Moller PH, Steinarsdottir M, Alexiusdottir K, Hitchins M, Pritchard CC, de la Chapelle A, Jonasson JG, Goldberg RM, Stefansson K.

Nat Commun. 2017 May 3;8:14755. doi: 10.1038/ncomms14755.

33.

Analysis of Circulating Cell-Free DNA Identifies Multiclonal Heterogeneity of BRCA2 Reversion Mutations Associated with Resistance to PARP Inhibitors.

Quigley D, Alumkal JJ, Wyatt AW, Kothari V, Foye A, Lloyd P, Aggarwal R, Kim W, Lu E, Schwartzman J, Beja K, Annala M, Das R, Diolaiti M, Pritchard C, Thomas G, Tomlins S, Knudsen K, Lord CJ, Ryan C, Youngren J, Beer TM, Ashworth A, Small EJ, Feng FY.

Cancer Discov. 2017 Sep;7(9):999-1005. doi: 10.1158/2159-8290.CD-17-0146. Epub 2017 Apr 27.

34.

Cyp24a1 Attenuation Limits Progression of BrafV600E -Induced Papillary Thyroid Cancer Cells and Sensitizes Them to BRAFV600E Inhibitor PLX4720.

Zou M, Baitei EY, BinEssa HA, Al-Mohanna FA, Parhar RS, St-Arnaud R, Kimura S, Pritchard C, Alzahrani AS, Assiri AM, Meyer BF, Shi Y.

Cancer Res. 2017 Apr 15;77(8):2161-2172. doi: 10.1158/0008-5472.CAN-16-2066. Epub 2017 Feb 27.

35.

Features of Patients With Hereditary Mixed Polyposis Syndrome Caused by Duplication of GREM1 and Implications for Screening and Surveillance.

Lieberman S, Walsh T, Schechter M, Adar T, Goldin E, Beeri R, Sharon N, Baris H, Ben Avi L, Half E, Lerer I, Shirts BH, Pritchard CC, Tomlinson I, King MC, Levy-Lahad E, Peretz T, Goldberg Y.

Gastroenterology. 2017 Jun;152(8):1876-1880.e1. doi: 10.1053/j.gastro.2017.02.014. Epub 2017 Feb 24.

PMID:
28242209
36.

Ex Vivo Explant Cultures of Non-Small Cell Lung Carcinoma Enable Evaluation of Primary Tumor Responses to Anticancer Therapy.

Karekla E, Liao WJ, Sharp B, Pugh J, Reid H, Quesne JL, Moore D, Pritchard C, MacFarlane M, Pringle JH.

Cancer Res. 2017 Apr 15;77(8):2029-2039. doi: 10.1158/0008-5472.CAN-16-1121. Epub 2017 Feb 15.

37.

The Rap1-cofilin-1 pathway coordinates actin reorganization and MTOC polarization at the B cell immune synapse.

Wang JC, Lee JY, Christian S, Dang-Lawson M, Pritchard C, Freeman SA, Gold MR.

J Cell Sci. 2017 Mar 15;130(6):1094-1109. doi: 10.1242/jcs.191858. Epub 2017 Feb 6.

38.

Biodegradable scaffolds promote tissue remodeling and functional improvement in non-human primates with acute spinal cord injury.

Slotkin JR, Pritchard CD, Luque B, Ye J, Layer RT, Lawrence MS, O'Shea TM, Roy RR, Zhong H, Vollenweider I, Edgerton VR, Courtine G, Woodard EJ, Langer R.

Biomaterials. 2017 Apr;123:63-76. doi: 10.1016/j.biomaterials.2017.01.024. Epub 2017 Jan 25.

PMID:
28167393
39.

Raf Kinases Are Essential for Phosphate Induction of ERK1/2 Phosphorylation in Hypertrophic Chondrocytes and Normal Endochondral Bone Development.

Papaioannou G, Petit ET, Liu ES, Baccarini M, Pritchard C, Demay MB.

J Biol Chem. 2017 Feb 24;292(8):3164-3171. doi: 10.1074/jbc.M116.763342. Epub 2017 Jan 10.

40.

Autographa californica Multiple Nucleopolyhedrovirus AC83 is a Per Os Infectivity Factor (PIF) Protein Required for Occlusion-Derived Virus (ODV) and Budded Virus Nucleocapsid Assembly as well as Assembly of the PIF Complex in ODV Envelopes.

Javed MA, Biswas S, Willis LG, Harris S, Pritchard C, van Oers MM, Donly BC, Erlandson MA, Hegedus DD, Theilmann DA.

J Virol. 2017 Feb 14;91(5). pii: e02115-16. doi: 10.1128/JVI.02115-16. Print 2017 Mar 1.

41.

Prevalence and Spectrum of Germline Cancer Susceptibility Gene Mutations Among Patients With Early-Onset Colorectal Cancer.

Pearlman R, Frankel WL, Swanson B, Zhao W, Yilmaz A, Miller K, Bacher J, Bigley C, Nelsen L, Goodfellow PJ, Goldberg RM, Paskett E, Shields PG, Freudenheim JL, Stanich PP, Lattimer I, Arnold M, Liyanarachchi S, Kalady M, Heald B, Greenwood C, Paquette I, Prues M, Draper DJ, Lindeman C, Kuebler JP, Reynolds K, Brell JM, Shaper AA, Mahesh S, Buie N, Weeman K, Shine K, Haut M, Edwards J, Bastola S, Wickham K, Khanduja KS, Zacks R, Pritchard CC, Shirts BH, Jacobson A, Allen B, de la Chapelle A, Hampel H; Ohio Colorectal Cancer Prevention Initiative Study Group.

JAMA Oncol. 2017 Apr 1;3(4):464-471. doi: 10.1001/jamaoncol.2016.5194.

42.

Western medical acupuncture in a group setting for knee osteoarthritis: results of a pilot randomised controlled trial.

White A, Tough L, Eyre V, Vickery J, Asprey A, Quinn C, Warren F, Pritchard C, Foster NE, Taylor RS, Underwood M, Dieppe P.

Pilot Feasibility Stud. 2016 Feb 16;2:10. doi: 10.1186/s40814-016-0051-5. eCollection 2016.

43.

An ecological study of excess winter mortality in England and deprivation.

Stacey D, Pritchard C.

Public Health. 2016 Dec;141:207-209. doi: 10.1016/j.puhe.2016.09.023. Epub 2016 Oct 27. No abstract available.

PMID:
27932002
44.

DNA-Repair Gene Mutations in Metastatic Prostate Cancer.

Pritchard CC, Offit K, Nelson PS.

N Engl J Med. 2016 Nov 3;375(18):1804-5. doi: 10.1056/NEJMc1611137. No abstract available.

PMID:
27806229
45.

Genetic features of myelodysplastic syndrome and aplastic anemia in pediatric and young adult patients.

Keel SB, Scott A, Sanchez-Bonilla M, Ho PA, Gulsuner S, Pritchard CC, Abkowitz JL, King MC, Walsh T, Shimamura A.

Haematologica. 2016 Nov;101(11):1343-1350. Epub 2016 Jul 14.

46.

Classification and characterization of microsatellite instability across 18 cancer types.

Hause RJ, Pritchard CC, Shendure J, Salipante SJ.

Nat Med. 2016 Nov;22(11):1342-1350. doi: 10.1038/nm.4191. Epub 2016 Oct 3. Erratum in: Nat Med. 2017 Oct 6;23 (10 ):1241. Nat Med. 2018 Apr 10;24(4):525.

PMID:
27694933
47.

DNA Repair in Prostate Cancer: Biology and Clinical Implications.

Mateo J, Boysen G, Barbieri CE, Bryant HE, Castro E, Nelson PS, Olmos D, Pritchard CC, Rubin MA, de Bono JS.

Eur Urol. 2017 Mar;71(3):417-425. doi: 10.1016/j.eururo.2016.08.037. Epub 2016 Aug 31. Review.

48.

Mismatch repair deficiency may be common in ductal adenocarcinoma of the prostate.

Schweizer MT, Cheng HH, Tretiakova MS, Vakar-Lopez F, Klemfuss N, Konnick EQ, Mostaghel EA, Nelson PS, Yu EY, Montgomery B, True LD, Pritchard CC.

Oncotarget. 2016 Dec 13;7(50):82504-82510. doi: 10.18632/oncotarget.12697.

49.

Jumping translocations in myelodysplastic syndromes.

Yeung CCS, Deeg HJ, Pritchard C, Wu D, Fang M.

Cancer Genet. 2016 Sep;209(9):395-402. doi: 10.1016/j.cancergen.2016.08.002. Epub 2016 Aug 8.

50.

Family-Specific Variants and the Limits of Human Genetics.

Shirts BH, Pritchard CC, Walsh T.

Trends Mol Med. 2016 Nov;22(11):925-934. doi: 10.1016/j.molmed.2016.09.007. Epub 2016 Oct 11. Review.

PMID:
27742414

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