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Items: 1 to 50 of 175


LAP-like non-canonical autophagy and evolution of endocytic vacuoles in pancreatic acinar cells.

De Faveri F, Chvanov M, Voronina S, Moore D, Pollock L, Haynes L, Awais M, Beckett AJ, Mayer U, Sutton R, Criddle DN, Prior IA, Wileman T, Tepikin AV.

Autophagy. 2019 Oct 25:1-18. doi: 10.1080/15548627.2019.1679514. [Epub ahead of print]


ER stress-linked autophagy stabilizes apoptosis effector PERP and triggers its co-localization with SERCA2b at ER-plasma membrane junctions.

McDonnell SJ, Spiller DG, White MRH, Prior IA, Paraoan L.

Cell Death Discov. 2019 Sep 3;5:132. doi: 10.1038/s41420-019-0212-4. eCollection 2019.


Targeting centrosome amplification, an Achilles' heel of cancer.

Sabat-Pośpiech D, Fabian-Kolpanowicz K, Prior IA, Coulson JM, Fielding AB.

Biochem Soc Trans. 2019 Oct 31;47(5):1209-1222. doi: 10.1042/BST20190034.


Concentric lamellae - novel microanatomical structures in the articular calcified cartilage of mice.

Keenan CM, Beckett AJ, Sutherland H, Ranganath LR, Jarvis JC, Prior IA, Gallagher JA.

Sci Rep. 2019 Aug 1;9(1):11188. doi: 10.1038/s41598-019-47545-2.


DRP-1 functions independently of mitochondrial structural perturbations to facilitate BH3 mimetic-mediated apoptosis.

Milani M, Beckett AJ, Al-Zebeeby A, Luo X, Prior IA, Cohen GM, Varadarajan S.

Cell Death Discov. 2019 Jul 17;5:117. doi: 10.1038/s41420-019-0199-x. eCollection 2019.


SuperCLEM: an accessible correlative light and electron microscopy approach for investigation of neurons and glia in vitro.

Booth DG, Beckett AJ, Prior IA, Meijer D.

Biol Open. 2019 May 30;8(5). pii: bio042085. doi: 10.1242/bio.042085.


Isoform-specific Ras signaling is growth factor dependent.

Hood FE, Klinger B, Newlaczyl AU, Sieber A, Dorel M, Oliver SP, Coulson JM, Blüthgen N, Prior IA.

Mol Biol Cell. 2019 Apr 15;30(9):1108-1117. doi: 10.1091/mbc.E18-10-0676. Epub 2019 Feb 20.


Fibroblast Growth Factor 2 lethally sensitizes cancer cells to stress-targeted therapeutic inhibitors.

Dias MH, Fonseca CS, Zeidler JD, Albuquerque LL, da Silva MS, Cararo-Lopes E, Reis MS, Noël V, Dos Santos EO, Prior IA, Armelin HA.

Mol Oncol. 2019 Feb;13(2):290-306. doi: 10.1002/1878-0261.12402. Epub 2018 Dec 3.


RAS variant signalling.

Mo SP, Coulson JM, Prior IA.

Biochem Soc Trans. 2018 Oct 19;46(5):1325-1332. doi: 10.1042/BST20180173. Epub 2018 Oct 3. Review.


Long-Chain n-3 Fatty Acids Attenuate Oncogenic KRas-Driven Proliferation by Altering Plasma Membrane Nanoscale Proteolipid Composition.

Fuentes NR, Mlih M, Barhoumi R, Fan YY, Hardin P, Steele TJ, Behmer S, Prior IA, Karpac J, Chapkin RS.

Cancer Res. 2018 Jul 15;78(14):3899-3912. doi: 10.1158/0008-5472.CAN-18-0324. Epub 2018 May 16.


The deubiquitylase USP15 regulates topoisomerase II alpha to maintain genome integrity.

Fielding AB, Concannon M, Darling S, Rusilowicz-Jones EV, Sacco JJ, Prior IA, Clague MJ, Urbé S, Coulson JM.

Oncogene. 2018 Apr;37(17):2326-2342. doi: 10.1038/s41388-017-0092-0. Epub 2018 Feb 12.


New Perspectives, Opportunities, and Challenges in Exploring the Human Protein Kinome.

Wilson LJ, Linley A, Hammond DE, Hood FE, Coulson JM, MacEwan DJ, Ross SJ, Slupsky JR, Smith PD, Eyers PA, Prior IA.

Cancer Res. 2018 Jan 1;78(1):15-29. doi: 10.1158/0008-5472.CAN-17-2291. Epub 2017 Dec 18. Review.


Regulation of the cell cycle and centrosome biology by deubiquitylases.

Darling S, Fielding AB, Sabat-Pośpiech D, Prior IA, Coulson JM.

Biochem Soc Trans. 2017 Oct 15;45(5):1125-1136. doi: 10.1042/BST20170087. Epub 2017 Sep 12. Review.


Modulating Protein-Protein Interactions of the Mitotic Polo-like Kinases to Target Mutant KRAS.

Narvaez AJ, Ber S, Crooks A, Emery A, Hardwick B, Guarino Almeida E, Huggins DJ, Perera D, Roberts-Thomson M, Azzarelli R, Hood FE, Prior IA, Walker DW, Boyce R, Boyle RG, Barker SP, Torrance CJ, McKenzie GJ, Venkitaraman AR.

Cell Chem Biol. 2017 Aug 17;24(8):1017-1028.e7. doi: 10.1016/j.chembiol.2017.07.009. Epub 2017 Aug 10.


Modular approach for bimodal antibacterial surfaces combining photo-switchable activity and sustained biocidal release.

Pallavicini P, Bassi B, Chirico G, Collini M, Dacarro G, Fratini E, Grisoli P, Patrini M, Sironi L, Taglietti A, Moritz M, Sorzabal-Bellido I, Susarrey-Arce A, Latter E, Beckett AJ, Prior IA, Raval R, Diaz Fernandez YA.

Sci Rep. 2017 Jul 12;7(1):5259. doi: 10.1038/s41598-017-05693-3.


Microtubule organization within mitotic spindles revealed by serial block face scanning electron microscopy and image analysis.

Nixon FM, Honnor TR, Clarke NI, Starling GP, Beckett AJ, Johansen AM, Brettschneider JA, Prior IA, Royle SJ.

J Cell Sci. 2017 May 15;130(10):1845-1855. doi: 10.1242/jcs.203877. Epub 2017 Apr 7.


Serial block-face scanning electron microscopy applied to study the trafficking of 8D3-coated gold nanoparticles at the blood-brain barrier.

Cabezón I, Augé E, Bosch M, Beckett AJ, Prior IA, Pelegrí C, Vilaplana J.

Histochem Cell Biol. 2017 Jul;148(1):3-12. doi: 10.1007/s00418-017-1553-9. Epub 2017 Mar 10.


Quantification of spatiotemporal patterns of Ras isoform expression during development.

Newlaczyl AU, Coulson JM, Prior IA.

Sci Rep. 2017 Jan 24;7:41297. doi: 10.1038/srep41297.


3D-CLEM Reveals that a Major Portion of Mitotic Chromosomes Is Not Chromatin.

Booth DG, Beckett AJ, Molina O, Samejima I, Masumoto H, Kouprina N, Larionov V, Prior IA, Earnshaw WC.

Mol Cell. 2016 Nov 17;64(4):790-802. doi: 10.1016/j.molcel.2016.10.009. Epub 2016 Nov 10.


The endoplasmic reticulum remains functionally connected by vesicular transport after its fragmentation in cells expressing Z-α1-antitrypsin.

Dickens JA, Ordóñez A, Chambers JE, Beckett AJ, Patel V, Malzer E, Dominicus CS, Bradley J, Peden AA, Prior IA, Lomas DA, Marciniak SJ.

FASEB J. 2016 Dec;30(12):4083-4097. Epub 2016 Sep 6.


Feedback activation of neurofibromin terminates growth factor-induced Ras activation.

Hennig A, Markwart R, Wolff K, Schubert K, Cui Y, Prior IA, Esparza-Franco MA, Ladds G, Rubio I.

Cell Commun Signal. 2016 Feb 9;14:5. doi: 10.1186/s12964-016-0128-z.


Comparative proteomic analysis of compartmentalised Ras signalling.

Hernandez-Valladares M, Prior IA.

Sci Rep. 2015 Dec 1;5:17307. doi: 10.1038/srep17307.


Absolute Quantification of Endogenous Ras Isoform Abundance.

Mageean CJ, Griffiths JR, Smith DL, Clague MJ, Prior IA.

PLoS One. 2015 Nov 11;10(11):e0142674. doi: 10.1371/journal.pone.0142674. eCollection 2015.


The mesh is a network of microtubule connectors that stabilizes individual kinetochore fibers of the mitotic spindle.

Nixon FM, Gutiérrez-Caballero C, Hood FE, Booth DG, Prior IA, Royle SJ.

Elife. 2015 Jun 19;4. doi: 10.7554/eLife.07635.


Differential reprogramming of isogenic colorectal cancer cells by distinct activating KRAS mutations.

Hammond DE, Mageean CJ, Rusilowicz EV, Wickenden JA, Clague MJ, Prior IA.

J Proteome Res. 2015 Mar 6;14(3):1535-46. doi: 10.1021/pr501191a. Epub 2015 Feb 4.


The role of Ca2+ influx in endocytic vacuole formation in pancreatic acinar cells.

Voronina S, Collier D, Chvanov M, Middlehurst B, Beckett AJ, Prior IA, Criddle DN, Begg M, Mikoshiba K, Sutton R, Tepikin AV.

Biochem J. 2015 Feb 1;465(3):405-12. doi: 10.1042/BJ20140398.


Electron microscopy methods for studying plasma membranes.

Beckett AJ, Prior IA.

Methods Mol Biol. 2015;1232:137-51. doi: 10.1007/978-1-4939-1752-5_12.


Plasticity of mammary cell boundaries governed by EGF and actin remodeling.

Tang WYY, Beckett AJ, Prior IA, Coulson JM, Urbé S, Clague MJ.

Cell Rep. 2014 Sep 25;8(6):1722-1730. doi: 10.1016/j.celrep.2014.08.026. Epub 2014 Sep 18.


Decoding RAS isoform and codon-specific signalling.

Newlaczyl AU, Hood FE, Coulson JM, Prior IA.

Biochem Soc Trans. 2014 Aug;42(4):742-6. doi: 10.1042/BST20140057. Review.


Quantitative proteomic analysis of compartmentalized signaling networks.

Hernandez-Valladares M, Aran V, Prior IA.

Methods Enzymol. 2014;535:309-25. doi: 10.1016/B978-0-12-397925-4.00018-3.


Studying kinetochore-fiber ultrastructure using correlative light-electron microscopy.

Booth DG, Cheeseman LP, Prior IA, Royle SJ.

Methods Cell Biol. 2013;115:327-342. doi: 10.1016/B978-0-12-407757-7.00020-7.


Ras palmitoylation is necessary for N-Ras activation and signal propagation in growth factor signalling.

Song SP, Hennig A, Schubert K, Markwart R, Schmidt P, Prior IA, Böhmer FD, Rubio I.

Biochem J. 2013 Sep 1;454(2):323-32. doi: 10.1042/BJ20121799.


Compartmentalized Ras signaling differentially contributes to phenotypic outputs.

Aran V, Prior IA.

Cell Signal. 2013 Sep;25(9):1748-53. doi: 10.1016/j.cellsig.2013.05.004. Epub 2013 May 22.


Specific removal of TACC3-ch-TOG-clathrin at metaphase deregulates kinetochore fiber tension.

Cheeseman LP, Harry EF, McAinsh AD, Prior IA, Royle SJ.

J Cell Sci. 2013 May 1;126(Pt 9):2102-13. doi: 10.1242/jcs.124834. Epub 2013 Mar 26.


The role of palmitoylation in regulating Ras localization and function.

Eisenberg S, Laude AJ, Beckett AJ, Mageean CJ, Aran V, Hernandez-Valladares M, Henis YI, Prior IA.

Biochem Soc Trans. 2013 Feb 1;41(1):79-83. doi: 10.1042/BST20120268. Review.


Global snapshot of the influence of endocytosis upon EGF receptor signaling output.

Omerovic J, Hammond DE, Prior IA, Clague MJ.

J Proteome Res. 2012 Nov 2;11(11):5157-66. doi: 10.1021/pr3007304. Epub 2012 Sep 28.


Transport of fibroblast growth factor 2 in the pericellular matrix is controlled by the spatial distribution of its binding sites in heparan sulfate.

Duchesne L, Octeau V, Bearon RN, Beckett A, Prior IA, Lounis B, Fernig DG.

PLoS Biol. 2012 Jul;10(7):e1001361. doi: 10.1371/journal.pbio.1001361. Epub 2012 Jul 17.


A comprehensive survey of Ras mutations in cancer.

Prior IA, Lewis PD, Mattos C.

Cancer Res. 2012 May 15;72(10):2457-67. doi: 10.1158/0008-5472.CAN-11-2612.


Putting signalling into context.

Prior IA.

Semin Cell Dev Biol. 2012 Apr;23(2):125. doi: 10.1016/j.semcdb.2012.02.008. Epub 2012 Mar 1. No abstract available.


Mercaptocarborane-capped gold nanoparticles: electron pools and ion traps with switchable hydrophilicity.

Cioran AM, Musteti AD, Teixidor F, Krpetić Ž, Prior IA, He Q, Kiely CJ, Brust M, Viñas C.

J Am Chem Soc. 2012 Jan 11;134(1):212-21. doi: 10.1021/ja203367h. Epub 2011 Dec 27.


Aurora A kinase activity is required for localization of TACC3/ch-TOG/clathrin inter-microtubule bridges.

Cheeseman LP, Booth DG, Hood FE, Prior IA, Royle SJ.

Commun Integr Biol. 2011 Jul;4(4):409-12. doi: 10.4161/cib.4.4.15250. Epub 2011 Jul 1.


Ras trafficking, localization and compartmentalized signalling.

Prior IA, Hancock JF.

Semin Cell Dev Biol. 2012 Apr;23(2):145-53. doi: 10.1016/j.semcdb.2011.09.002. Epub 2011 Sep 8. Review.


Intracellular mapping with SERS-encoded gold nanostars.

Rodríguez-Lorenzo L, Krpetic Z, Barbosa S, Alvarez-Puebla RA, Liz-Marzán LM, Prior IA, Brust M.

Integr Biol (Camb). 2011 Sep;3(9):922-6. doi: 10.1039/c1ib00029b. Epub 2011 Aug 10.


Raft protein clustering alters N-Ras membrane interactions and activation pattern.

Eisenberg S, Beckett AJ, Prior IA, Dekker FJ, Hedberg C, Waldmann H, Ehrlich M, Henis YI.

Mol Cell Biol. 2011 Oct;31(19):3938-52. doi: 10.1128/MCB.05570-11. Epub 2011 Aug 1.


Acrylate-facilitated cellular uptake of gold nanoparticles.

Krpetić Ž, Nativo P, Prior IA, Brust M.

Small. 2011 Jul 18;7(14):1982-6. doi: 10.1002/smll.201100462. Epub 2011 Jun 7. No abstract available.


Negotiation of intracellular membrane barriers by TAT-modified gold nanoparticles.

Krpetić Z, Saleemi S, Prior IA, Sée V, Qureshi R, Brust M.

ACS Nano. 2011 Jun 28;5(6):5195-201. doi: 10.1021/nn201369k. Epub 2011 May 31.


A TACC3/ch-TOG/clathrin complex stabilises kinetochore fibres by inter-microtubule bridging.

Booth DG, Hood FE, Prior IA, Royle SJ.

EMBO J. 2011 Mar 2;30(5):906-19. doi: 10.1038/emboj.2011.15. Epub 2011 Feb 4.


Magnetic CoPt nanoparticles as MRI contrast agent for transplanted neural stem cells detection.

Meng X, Seton HC, Lu le T, Prior IA, Thanh NT, Song B.

Nanoscale. 2011 Mar;3(3):977-84. doi: 10.1039/c0nr00846j. Epub 2011 Feb 4.


Inflicting controlled nonthermal damage to subcellular structures by laser-activated gold nanoparticles.

Krpetić Z, Nativo P, Sée V, Prior IA, Brust M, Volk M.

Nano Lett. 2010 Nov 10;10(11):4549-54. doi: 10.1021/nl103142t.


Ultrastructural examination of tissue in a patient with alkaptonuric arthropathy reveals a distinct pattern of binding of ochronotic pigment.

Taylor AM, Wlodarski B, Prior IA, Wilson PJ, Jarvis JC, Ranganath LR, Gallagher JA.

Rheumatology (Oxford). 2010 Jul;49(7):1412-4. doi: 10.1093/rheumatology/keq027. Epub 2010 Feb 24. No abstract available.


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