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Items: 1 to 50 of 53

1.

Targeting VLA4 integrin and CXCR2 mobilizes serially repopulating hematopoietic stem cells.

Karpova D, Rettig MP, Ritchey J, Cancilla D, Christ S, Gehrs L, Chendamarai E, Evbuomwan MO, Holt M, Zhang J, Abou-Ezzi G, Celik H, Wiercinska E, Yang W, Gao F, Eissenberg LG, Heier RF, Arnett SD, Meyers MJ, Prinsen MJ, Griggs DW, Trumpp A, Ruminski PG, Morrow DM, Bonig HB, Link DC, DiPersio JF.

J Clin Invest. 2019 May 14;130. pii: 124738. doi: 10.1172/JCI124738.

2.

Identification of druggable small molecule antagonists of the Plasmodium falciparum hexose transporter PfHT and assessment of ligand access to the glucose permeation pathway via FLAG-mediated protein engineering.

Heitmeier MR, Hresko RC, Edwards RL, Prinsen MJ, Ilagan MXG, Odom John AR, Hruz PW.

PLoS One. 2019 May 9;14(5):e0216457. doi: 10.1371/journal.pone.0216457. eCollection 2019.

3.

Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017.

Uitdehaag JCM, Kooijman JJ, de Roos JADM, Prinsen MBW, Dylus J, Willemsen-Seegers N, Kawase Y, Sawa M, de Man J, van Gerwen SJC, Buijsman RC, Zaman GJR.

Mol Cancer Ther. 2019 Feb;18(2):470-481. doi: 10.1158/1535-7163.MCT-18-0877. Epub 2018 Oct 31.

PMID:
30381447
4.

Discovery of 3-Cyano- N-(3-(1-isobutyrylpiperidin-4-yl)-1-methyl-4-(trifluoromethyl)-1 H-pyrrolo[2,3- b]pyridin-5-yl)benzamide: A Potent, Selective, and Orally Bioavailable Retinoic Acid Receptor-Related Orphan Receptor C2 Inverse Agonist.

Schnute ME, Wennerstål M, Alley J, Bengtsson M, Blinn JR, Bolten CW, Braden T, Bonn T, Carlsson B, Caspers N, Chen M, Choi C, Collis LP, Crouse K, Färnegårdh M, Fennell KF, Fish S, Flick AC, Goos-Nilsson A, Gullberg H, Harris PK, Heasley SE, Hegen M, Hromockyj AE, Hu X, Husman B, Janosik T, Jones P, Kaila N, Kallin E, Kauppi B, Kiefer JR, Knafels J, Koehler K, Kruger L, Kurumbail RG, Kyne RE Jr, Li W, Löfstedt J, Long SA, Menard CA, Mente S, Messing D, Meyers MJ, Napierata L, Nöteberg D, Nuhant P, Pelc MJ, Prinsen MJ, Rhönnstad P, Backström-Rydin E, Sandberg J, Sandström M, Shah F, Sjöberg M, Sundell A, Taylor AP, Thorarensen A, Trujillo JI, Trzupek JD, Unwalla R, Vajdos FF, Weinberg RA, Wood DC, Xing L, Zamaratski E, Zapf CW, Zhao Y, Wilhelmsson A, Berstein G.

J Med Chem. 2018 Dec 13;61(23):10415-10439. doi: 10.1021/acs.jmedchem.8b00392. Epub 2018 Sep 9.

PMID:
30130103
5.

TTK Inhibitors as a Targeted Therapy for CTNNB1 (β-catenin) Mutant Cancers.

Zaman GJR, de Roos JADM, Libouban MAA, Prinsen MBW, de Man J, Buijsman RC, Uitdehaag JCM.

Mol Cancer Ther. 2017 Nov;16(11):2609-2617. doi: 10.1158/1535-7163.MCT-17-0342. Epub 2017 Jul 27.

6.

Target Residence Time-Guided Optimization on TTK Kinase Results in Inhibitors with Potent Anti-Proliferative Activity.

Uitdehaag JCM, de Man J, Willemsen-Seegers N, Prinsen MBW, Libouban MAA, Sterrenburg JG, de Wit JJP, de Vetter JRF, de Roos JADM, Buijsman RC, Zaman GJR.

J Mol Biol. 2017 Jul 7;429(14):2211-2230. doi: 10.1016/j.jmb.2017.05.014. Epub 2017 May 21.

PMID:
28539250
7.

The Isolated Chicken Eye test to replace the Draize test in rabbits.

Prinsen MK, Hendriksen CFM, Krul CAM, Woutersen RA.

Regul Toxicol Pharmacol. 2017 Apr;85:132-149. doi: 10.1016/j.yrtph.2017.01.009. Epub 2017 Feb 10.

8.

Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice.

Ulmasov B, Neuschwander-Tetri BA, Lai J, Monastyrskiy V, Bhat T, Yates MP, Oliva J, Prinsen MJ, Ruminski PG, Griggs DW.

Cell Mol Gastroenterol Hepatol. 2016 Mar 16;2(4):499-518. doi: 10.1016/j.jcmgh.2016.03.004. eCollection 2016 Jul.

9.

Compound Selectivity and Target Residence Time of Kinase Inhibitors Studied with Surface Plasmon Resonance.

Willemsen-Seegers N, Uitdehaag JCM, Prinsen MBW, de Vetter JRF, de Man J, Sawa M, Kawase Y, Buijsman RC, Zaman GJR.

J Mol Biol. 2017 Feb 17;429(4):574-586. doi: 10.1016/j.jmb.2016.12.019. Epub 2016 Dec 30.

PMID:
28043854
10.

Cell Panel Profiling Reveals Conserved Therapeutic Clusters and Differentiates the Mechanism of Action of Different PI3K/mTOR, Aurora Kinase and EZH2 Inhibitors.

Uitdehaag JC, de Roos JA, Prinsen MB, Willemsen-Seegers N, de Vetter JR, Dylus J, van Doornmalen AM, Kooijman J, Sawa M, van Gerwen SJ, de Man J, Buijsman RC, Zaman GJ.

Mol Cancer Ther. 2016 Dec;15(12):3097-3109. Epub 2016 Sep 1.

11.

Non-clinical safety assessment of single and repeated administration of gE/AS01 zoster vaccine in rabbits.

Giordano G, Segal L, Prinsen M, Wijnands MV, Garçon N, Destexhe E.

J Appl Toxicol. 2017 Feb;37(2):132-141. doi: 10.1002/jat.3329. Epub 2016 May 12.

PMID:
27172098
12.

Pharmacologic Comparison of Clinical Neutral Endopeptidase Inhibitors in a Rat Model of Acute Secretory Diarrhea.

Griggs DW, Prinsen MJ, Oliva J, Campbell MA, Arnett SD, Tajfirouz D, Ruminski PG, Yu Y, Bond BR, Ji Y, Neckermann G, Choy RK, de Hostos E, Meyers MJ.

J Pharmacol Exp Ther. 2016 May;357(2):423-31. doi: 10.1124/jpet.115.231167. Epub 2016 Feb 23.

13.

Inhibition of the spindle assembly checkpoint kinase TTK enhances the efficacy of docetaxel in a triple-negative breast cancer model.

Maia AR, de Man J, Boon U, Janssen A, Song JY, Omerzu M, Sterrenburg JG, Prinsen MB, Willemsen-Seegers N, de Roos JA, van Doornmalen AM, Uitdehaag JC, Kops GJ, Jonkers J, Buijsman RC, Zaman GJ, Medema RH.

Ann Oncol. 2015 Oct;26(10):2180-92. doi: 10.1093/annonc/mdv293. Epub 2015 Jul 7.

PMID:
26153498
14.

Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs.

Uitdehaag JC, de Roos JA, van Doornmalen AM, Prinsen MB, Spijkers-Hagelstein JA, de Vetter JR, de Man J, Buijsman RC, Zaman GJ.

PLoS One. 2015 May 27;10(5):e0125021. doi: 10.1371/journal.pone.0125021. eCollection 2015. Erratum in: PLoS One. 2015;10(6):e0132230.

15.

Evaluation of spiropiperidine hydantoins as a novel class of antimalarial agents.

Meyers MJ, Anderson EJ, McNitt SA, Krenning TM, Singh M, Xu J, Zeng W, Qin L, Xu W, Zhao S, Qin L, Eickhoff CS, Oliva J, Campbell MA, Arnett SD, Prinsen MJ, Griggs DW, Ruminski PG, Goldberg DE, Ding K, Liu X, Tu Z, Tortorella MD, Sverdrup FM, Chen X.

Bioorg Med Chem. 2015 Aug 15;23(16):5144-50. doi: 10.1016/j.bmc.2015.02.050. Epub 2015 Mar 4.

16.

Suitability of the isolated chicken eye test for classification of extreme pH detergents and cleaning products.

Cazelle E, Eskes C, Hermann M, Jones P, McNamee P, Prinsen M, Taylor H, Wijnands MV.

Toxicol In Vitro. 2015 Apr;29(3):609-16. doi: 10.1016/j.tiv.2014.12.020. Epub 2015 Jan 19.

PMID:
25614451
17.

Rb and FZR1/Cdh1 determine CDK4/6-cyclin D requirement in C. elegans and human cancer cells.

The I, Ruijtenberg S, Bouchet BP, Cristobal A, Prinsen MB, van Mourik T, Koreth J, Xu H, Heck AJ, Akhmanova A, Cuppen E, Boxem M, Muñoz J, van den Heuvel S.

Nat Commun. 2015 Jan 6;6:5906. doi: 10.1038/ncomms6906.

18.

Evaluation of aminohydantoins as a novel class of antimalarial agents.

Meyers MJ, Tortorella MD, Xu J, Qin L, He Z, Lang X, Zeng W, Xu W, Qin L, Prinsen MJ, Sverdrup FM, Eickhoff CS, Griggs DW, Oliva J, Ruminski PG, Jacobsen EJ, Campbell MA, Wood DC, Goldberg DE, Liu X, Lu Y, Lu X, Tu Z, Lu X, Ding K, Chen X.

ACS Med Chem Lett. 2013 Dec 6;5(1):89-93. doi: 10.1021/ml400412x. eCollection 2014 Jan 9.

19.

Comparison of the cancer gene targeting and biochemical selectivities of all targeted kinase inhibitors approved for clinical use.

Uitdehaag JC, de Roos JA, van Doornmalen AM, Prinsen MB, de Man J, Tanizawa Y, Kawase Y, Yoshino K, Buijsman RC, Zaman GJ.

PLoS One. 2014 Mar 20;9(3):e92146. doi: 10.1371/journal.pone.0092146. eCollection 2014.

20.

Suitability of histopathology as an additional endpoint to the Isolated Chicken Eye Test for classification of non-extreme pH detergent and cleaning products.

Cazelle E, Eskes C, Hermann M, Jones P, McNamee P, Prinsen M, Taylor H, Wijnands MV.

Toxicol In Vitro. 2014 Jun;28(4):657-66. doi: 10.1016/j.tiv.2014.01.010. Epub 2014 Feb 6.

PMID:
24509046
21.

Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs.

Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D.

Nat Med. 2013 Dec;19(12):1617-24. doi: 10.1038/nm.3282. Epub 2013 Nov 10.

22.

Evaluation of C-reactive protein as an inflammatory biomarker in rabbits for vaccine nonclinical safety studies.

Destexhe E, Prinsen MK, van Schöll I, Kuper CF, Garçon N, Veenstra S, Segal L.

J Pharmacol Toxicol Methods. 2013 Nov-Dec;68(3):367-73. doi: 10.1016/j.vascn.2013.04.003. Epub 2013 Apr 23.

PMID:
23624216
23.

Growing dairy heifers prefer supplementary long straw when fed a nutrient-dense ration in a limited amount.

Greter AM, Prinsen M, Duffield TF, McBride BW, Widowski TM, Devries TJ.

J Dairy Sci. 2013 Jun;96(6):3950-8. doi: 10.3168/jds.2013-6625. Epub 2013 Apr 12.

24.

Caenorhabditis elegans cyclin D/CDK4 and cyclin E/CDK2 induce distinct cell cycle re-entry programs in differentiated muscle cells.

Korzelius J, The I, Ruijtenberg S, Prinsen MB, Portegijs V, Middelkoop TC, Groot Koerkamp MJ, Holstege FC, Boxem M, van den Heuvel S.

PLoS Genet. 2011 Nov;7(11):e1002362. doi: 10.1371/journal.pgen.1002362. Epub 2011 Nov 10.

25.

Histopathology in the isolated chicken eye test and comparison of different stainings of the cornea.

Prinsen MK, Schipper ME, Wijnands MV.

Toxicol In Vitro. 2011 Oct;25(7):1475-9. doi: 10.1016/j.tiv.2011.04.028. Epub 2011 May 14.

PMID:
21575711
26.

Exploring the Flynn effect in mentally retarded adults by using a nonverbal intelligence test for children.

Nijman EE, Scheirs JG, Prinsen MJ, Abbink CD, Blok JB.

Res Dev Disabil. 2010 Nov-Dec;31(6):1404-11. doi: 10.1016/j.ridd.2010.06.018. Epub 2010 Jul 17.

PMID:
20638821
27.

A novel autotaxin inhibitor reduces lysophosphatidic acid levels in plasma and the site of inflammation.

Gierse J, Thorarensen A, Beltey K, Bradshaw-Pierce E, Cortes-Burgos L, Hall T, Johnston A, Murphy M, Nemirovskiy O, Ogawa S, Pegg L, Pelc M, Prinsen M, Schnute M, Wendling J, Wene S, Weinberg R, Wittwer A, Zweifel B, Masferrer J.

J Pharmacol Exp Ther. 2010 Jul;334(1):310-7. doi: 10.1124/jpet.110.165845. Epub 2010 Apr 14.

PMID:
20392816
28.

A proposed eye irritation testing strategy to reduce and replace in vivo studies using Bottom-Up and Top-Down approaches.

Scott L, Eskes C, Hoffmann S, Adriaens E, Alepée N, Bufo M, Clothier R, Facchini D, Faller C, Guest R, Harbell J, Hartung T, Kamp H, Varlet BL, Meloni M, McNamee P, Osborne R, Pape W, Pfannenbecker U, Prinsen M, Seaman C, Spielmann H, Stokes W, Trouba K, Berghe CV, Goethem FV, Vassallo M, Vinardell P, Zuang V.

Toxicol In Vitro. 2010 Feb;24(1):1-9. doi: 10.1016/j.tiv.2009.05.019. Epub 2009 May 31. Review.

PMID:
19490935
29.

The isolated chicken eye test as a suitable in vitro method for determining the eye irritation potential of household cleaning products.

Schutte K, Prinsen MK, McNamee PM, Roggeband R.

Regul Toxicol Pharmacol. 2009 Aug;54(3):272-81. doi: 10.1016/j.yrtph.2009.05.008. Epub 2009 May 19.

PMID:
19460408
30.

Accuracy of bedside glucose measurement from three glucometers in critically ill patients.

Hoedemaekers CW, Klein Gunnewiek JM, Prinsen MA, Willems JL, Van der Hoeven JG.

Crit Care Med. 2008 Nov;36(11):3062-6. doi: 10.1097/CCM.0b013e318186ffe6.

PMID:
18824915
31.

The contact allergen dinitrochlorobenzene (DNCB) and respiratory allergy in the Th2-prone Brown Norway rat.

Kuper CF, Stierum RH, Boorsma A, Schijf MA, Prinsen M, Bruijntjes JP, Bloksma N, Arts JH.

Toxicology. 2008 Apr 18;246(2-3):213-21. doi: 10.1016/j.tox.2008.01.013. Epub 2008 Feb 2.

PMID:
18316151
32.

Eye irritation.

Eskes C, Bessou S, Bruner L, Curren R, Harbell J, Jones P, Kreiling R, Liebsch M, McNamee P, Pape W, Prinsen MK, Seidle T, Vanparys P, Worth A, Zuang V.

Altern Lab Anim. 2005 Jul;33 Suppl 1:47-81. No abstract available.

PMID:
16194141
33.

The Draize Eye Test and in vitro alternatives; a left-handed marriage?

Prinsen MK.

Toxicol In Vitro. 2006 Feb;20(1):78-81. Epub 2005 Aug 1. No abstract available.

PMID:
16055303
34.

Human volunteer study with PGME: eye irritation during vapour exposure.

Emmen HH, Muijser H, Arts JH, Prinsen MK.

Toxicol Lett. 2003 Apr 11;140-141:249-59.

PMID:
12676472
35.

Marine natural products as prototype agrochemical agents.

Peng J, Shen X, El Sayed KA, Dunbar DC, Perry TL, Wilkins SP, Hamann MT, Bobzin S, Huesing J, Camp R, Prinsen M, Krupa D, Wideman MA.

J Agric Food Chem. 2003 Apr 9;51(8):2246-52.

36.

Comparison of dose-responses of contact allergens using the guinea pig maximization test and the local lymph node assay.

van Och FM, Vandebriel RJ, Prinsen MK, De Jong WH, Slob W, van Loveren H.

Toxicology. 2001 Oct 30;167(3):207-15. Erratum in: Toxicology 2002 Jan 25;170(3):228-30.

PMID:
11578800
38.

Inulin glasses for the stabilization of therapeutic proteins.

Hinrichs WL, Prinsen MG, Frijlink HW.

Int J Pharm. 2001 Mar 14;215(1-2):163-74.

PMID:
11250102
39.

Eye Irritation Testing: The Way Forward. The Report and Recommendations of ECVAM Workshop 34.

Balls M, Berg N, Bruner LH, Curren RD, de Silva O, Earl LK, Esdaile DJ, Fentem JH, Liebsch M, Ohno Y, Prinsen MK, Spielmann H, Worth AP.

Altern Lab Anim. 1999 Jan-Feb;27(1):53-77.

PMID:
25423402
41.

Preliminary safety assessment of an arachidonic acid-enriched oil derived from Mortierella alpina: summary of toxicological data.

Hempenius RA, Van Delft JM, Prinsen M, Lina BA.

Food Chem Toxicol. 1997 Jun;35(6):573-81.

PMID:
9225015
42.

Acute and subacute toxicity of tyramine, spermidine, spermine, putrescine and cadaverine in rats.

Til HP, Falke HE, Prinsen MK, Willems MI.

Food Chem Toxicol. 1997 Mar-Apr;35(3-4):337-48.

PMID:
9207896
43.

IRAG working group 1. Organotypic models for the assessment/prediction of ocular irritation. Interagency Regulatory Alternatives Group.

Chamberlain M, Gad SC, Gautheron P, Prinsen MK.

Food Chem Toxicol. 1997 Jan;35(1):23-37.

PMID:
9100813
45.

Validation-Lessons learned from practical experience.

Fentem JH, Prinsen MK, Spielmann H, Walum E, Botham PA.

Toxicol In Vitro. 1995 Dec;9(6):857-62.

PMID:
20650167
46.

Interlaboratory assessment of the bovine corneal opacity and permeability (BCOP) assay.

Gautheron P, Giroux J, Cottin M, Audegond L, Morilla A, Mayordomo-Blanco L, Tortajada A, Haynes G, Vericat JA, Pirovano R, Gillio Tos E, Hagemann C, Vanparys P, Deknudt G, Jacobs G, Prinsen M, Kalweit S, Spielmann H.

Toxicol In Vitro. 1994 Jun;8(3):381-92.

PMID:
20692929
47.

Cholesterol oxidase: a potent insecticidal protein active against boll weevil larvae.

Purcell JP, Greenplate JT, Jennings MG, Ryerse JS, Pershing JC, Sims SR, Prinsen MJ, Corbin DR, Tran M, Sammons RD, et al.

Biochem Biophys Res Commun. 1993 Nov 15;196(3):1406-13.

PMID:
8250897

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