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Items: 28


TGFβ Blockade Augments PD-1 Inhibition to Promote T-Cell Mediated Regression of Pancreatic Cancer.

Principe DR, Park A, Dorman MJ, Kumar S, Viswakarma N, Rubin J, Torres C, McKinney R, Munshi HG, Grippo PJ, Rana A.

Mol Cancer Ther. 2018 Dec 26. pii: molcanther.0850.2018. doi: 10.1158/1535-7163.MCT-18-0850. [Epub ahead of print]


Of Mice, Dogs, Pigs, and Men: Choosing the Appropriate Model for Immuno-Oncology Research.

Overgaard NH, Fan TM, Schachtschneider KM, Principe DR, Schook LB, Jungersen G.

ILAR J. 2018 Nov 22. doi: 10.1093/ilar/ily014. [Epub ahead of print]


Loss of Sirt2 increases and prolongs a caerulein-induced pancreatitis permissive phenotype and induces spontaneous oncogenic Kras mutations in mice.

Quan S, Principe DR, Dean AE, Park SH, Grippo PJ, Gius D, Horikoshi N.

Sci Rep. 2018 Nov 7;8(1):16501. doi: 10.1038/s41598-018-34792-y.


Interplay between interferon regulatory factor 1 and BRD4 in the regulation of PD-L1 in pancreatic stellate cells.

Ebine K, Kumar K, Pham TN, Shields MA, Collier KA, Shang M, DeCant BT, Urrutia R, Hwang RF, Grimaldo S, Principe DR, Grippo PJ, Bentrem DJ, Munshi HG.

Sci Rep. 2018 Sep 5;8(1):13225. doi: 10.1038/s41598-018-31658-1.


KRASG12D and TP53R167H Cooperate to Induce Pancreatic Ductal Adenocarcinoma in Sus scrofa Pigs.

Principe DR, Overgaard NH, Park AJ, Diaz AM, Torres C, McKinney R, Dorman MJ, Castellanos K, Schwind R, Dawson DW, Rana A, Maker A, Munshi HG, Rund LA, Grippo PJ, Schook LB.

Sci Rep. 2018 Aug 22;8(1):12548. doi: 10.1038/s41598-018-30916-6.


Genetically Induced Tumors in the Oncopig Model Invoke an Antitumor Immune Response Dominated by Cytotoxic CD8β+ T Cells and Differentiated γδ T Cells Alongside a Regulatory Response Mediated by FOXP3+ T Cells and Immunoregulatory Molecules.

Overgaard NH, Principe DR, Schachtschneider KM, Jakobsen JT, Rund LA, Grippo PJ, Schook LB, Jungersen G.

Front Immunol. 2018 Jun 7;9:1301. doi: 10.3389/fimmu.2018.01301. eCollection 2018.


A validated, transitional and translational porcine model of hepatocellular carcinoma.

Schachtschneider KM, Schwind RM, Darfour-Oduro KA, De AK, Rund LA, Singh K, Principe DR, Guzman G, Ray CE Jr, Ozer H, Gaba RC, Schook LB.

Oncotarget. 2017 Jun 29;8(38):63620-63634. doi: 10.18632/oncotarget.18872. eCollection 2017 Sep 8.


The Oncopig Cancer Model: An Innovative Large Animal Translational Oncology Platform.

Schachtschneider KM, Schwind RM, Newson J, Kinachtchouk N, Rizko M, Mendoza-Elias N, Grippo P, Principe DR, Park A, Overgaard NH, Jungersen G, Garcia KD, Maker AV, Rund LA, Ozer H, Gaba RC, Schook LB.

Front Oncol. 2017 Aug 23;7:190. doi: 10.3389/fonc.2017.00190. eCollection 2017. Review.


The Complexity of Omega-3 Fatty Acid Modulation of Signaling Pathways Related to Pancreatic Cancer.

Torres C, Diaz AM, Principe DR, Grippo PJ.

Curr Med Chem. 2018;25(22):2608-2623. doi: 10.2174/0929867324666170616111225. Review.


TGFβ engages MEK/ERK to differentially regulate benign and malignant pancreas cell function.

Principe DR, Diaz AM, Torres C, Mangan RJ, DeCant B, McKinney R, Tsao MS, Lowy A, Munshi HG, Jung B, Grippo PJ.

Oncogene. 2017 Jul 27;36(30):4336-4348. doi: 10.1038/onc.2016.500. Epub 2017 Apr 3.


SIRT2 deletion enhances KRAS-induced tumorigenesis in vivo by regulating K147 acetylation status.

Song HY, Biancucci M, Kang HJ, O'Callaghan C, Park SH, Principe DR, Jiang H, Yan Y, Satchell KF, Raparia K, Gius D, Vassilopoulos A.

Oncotarget. 2016 Dec 6;7(49):80336-80349. doi: 10.18632/oncotarget.12015.


Loss of TGFβ signaling promotes colon cancer progression and tumor-associated inflammation.

Principe DR, DeCant B, Staudacher J, Vitello D, Mangan RJ, Wayne EA, Mascariñas E, Diaz AM, Bauer J, McKinney RD, Khazaie K, Pasche B, Dawson DW, Munshi HG, Grippo PJ, Jung B.

Oncotarget. 2017 Jan 17;8(3):3826-3839. doi: 10.18632/oncotarget.9830.


SIRT2-Mediated Deacetylation and Tetramerization of Pyruvate Kinase Directs Glycolysis and Tumor Growth.

Park SH, Ozden O, Liu G, Song HY, Zhu Y, Yan Y, Zou X, Kang HJ, Jiang H, Principe DR, Cha YI, Roh M, Vassilopoulos A, Gius D.

Cancer Res. 2016 Jul 1;76(13):3802-12. doi: 10.1158/0008-5472.CAN-15-2498. Epub 2016 Apr 27.


PEDF inhibits pancreatic tumorigenesis by attenuating the fibro-inflammatory reaction.

Principe DR, DeCant B, Diaz AM, Mangan RJ, Hwang R, Lowy A, Shetuni BB, Sreekumar BK, Chung C, Bentrem DJ, Munshi HG, Jung B, Grippo PJ, Bishehsari F.

Oncotarget. 2016 May 10;7(19):28218-34. doi: 10.18632/oncotarget.8587.


TGFβ Signaling in the Pancreatic Tumor Microenvironment Promotes Fibrosis and Immune Evasion to Facilitate Tumorigenesis.

Principe DR, DeCant B, Mascariñas E, Wayne EA, Diaz AM, Akagi N, Hwang R, Pasche B, Dawson DW, Fang D, Bentrem DJ, Munshi HG, Jung B, Grippo PJ.

Cancer Res. 2016 May 1;76(9):2525-39. doi: 10.1158/0008-5472.CAN-15-1293. Epub 2016 Mar 15.


HDAC3 mediates smoking-induced pancreatic cancer.

Edderkaoui M, Xu S, Chheda C, Morvaridi S, Hu RW, Grippo PJ, Mascariñas E, Principe DR, Knudsen B, Xue J, Habtezion A, Uyeminami D, Pinkerton KE, Pandol SJ.

Oncotarget. 2016 Feb 16;7(7):7747-60. doi: 10.18632/oncotarget.6820.


Activin and TGFβ use diverging mitogenic signaling in advanced colon cancer.

Bauer J, Ozden O, Akagi N, Carroll T, Principe DR, Staudacher JJ, Spehlmann ME, Eckmann L, Grippo PJ, Jung B.

Mol Cancer. 2015 Oct 24;14:182. doi: 10.1186/s12943-015-0456-4.


Characterization of Mouse Models of Early Pancreatic Lesions Induced by Alcohol and Chronic Pancreatitis.

Xu S, Chheda C, Ouhaddi Y, Benhaddou H, Bourhim M, Grippo PJ, Principe DR, Mascariñas E, DeCant B, Tsukamoto H, Pandol SJ, Edderkaoui M.

Pancreas. 2015 Aug;44(6):882-7. doi: 10.1097/MPA.0000000000000380.


Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models.

DeCant BT, Principe DR, Guerra C, Pasca di Magliano M, Grippo PJ.

Front Physiol. 2014 Dec 4;5:464. doi: 10.3389/fphys.2014.00464. eCollection 2014. Review.


Ablation of 5-lipoxygenase mitigates pancreatic lesion development.

Knab LM, Schultz M, Principe DR, Mascarinas WE, Gounaris E, Munshi HG, Grippo PJ, Bentrem DJ.

J Surg Res. 2015 Apr;194(2):481-7. doi: 10.1016/j.jss.2014.10.021. Epub 2014 Oct 22.


SIRT3 and SIRT4 are mitochondrial tumor suppressor proteins that connect mitochondrial metabolism and carcinogenesis.

Zhu Y, Yan Y, Principe DR, Zou X, Vassilopoulos A, Gius D.

Cancer Metab. 2014 Oct 20;2:15. doi: 10.1186/2049-3002-2-15. eCollection 2014. Review.


TGF-β: duality of function between tumor prevention and carcinogenesis.

Principe DR, Doll JA, Bauer J, Jung B, Munshi HG, Bartholin L, Pasche B, Lee C, Grippo PJ.

J Natl Cancer Inst. 2014 Feb;106(2):djt369. doi: 10.1093/jnci/djt369. Review.


Prion protein fragment 106-126 induces a p38 MAP kinase-dependent apoptosis in SH-SY5Y neuroblastoma cells independently from the amyloid fibril formation.

Corsaro A, Thellung S, Villa V, Principe DR, Paludi D, Arena S, Millo E, Schettini D, Damonte G, Aceto A, Schettini G, Florio T.

Ann N Y Acad Sci. 2003 Dec;1010:610-22.


Contribution of two conserved glycine residues to fibrillogenesis of the 106-126 prion protein fragment. Evidence that a soluble variant of the 106-126 peptide is neurotoxic.

Florio T, Paludi D, Villa V, Principe DR, Corsaro A, Millo E, Damonte G, D'Arrigo C, Russo C, Schettini G, Aceto A.

J Neurochem. 2003 Apr;85(1):62-72.


Contribution of glycine 146 to a conserved folding module affecting stability and refolding of human glutathione transferase p1-1.

Kong GK, Polekhina G, McKinstry WJ, Parker MW, Dragani B, Aceto A, Paludi D, Principe DR, Mannervik B, Stenberg G.

J Biol Chem. 2003 Jan 10;278(2):1291-302. Epub 2002 Oct 31.


A novel glutathione transferase from Haemophilus influenzae which has high affinity towards antibiotics.

Dainelli B, Paludi D, Dragani B, Cocco R, Principe DR, Petrucci M, Mucilli F, Faraone A, Aceto A.

Int J Biochem Cell Biol. 2002 Aug;34(8):916-20.


Conformational properties of five peptides corresponding to the entire sequence of glutathione transferase domain II.

Dragani B, Cocco R, Principe DR, Paludi D, Aceto A.

Arch Biochem Biophys. 2001 May 1;389(1):15-21.


Structural characterization of acid-induced intermediates of human glutathione transferase P1-1.

Dragani B, Cocco R, Principe DR, Cicconetti M, Aceto A.

Int J Biochem Cell Biol. 2000 Jul;32(7):725-36.


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