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Items: 32


Inhibition of ErbB kinase signalling promotes resolution of neutrophilic inflammation.

Rahman A, Henry KM, Herman KD, Thompson AA, Isles HM, Tulotta C, Sammut D, Rougeot JJ, Khoshaein N, Reese AE, Higgins K, Tabor C, Sabroe I, Zuercher WJ, Savage CO, Meijer AH, Whyte MK, Dockrell DH, Renshaw SA, Prince LR.

Elife. 2019 Oct 15;8. pii: e50990. doi: 10.7554/eLife.50990.


The CXCL12/CXCR4 Signaling Axis Retains Neutrophils at Inflammatory Sites in Zebrafish.

Isles HM, Herman KD, Robertson AL, Loynes CA, Prince LR, Elks PM, Renshaw SA.

Front Immunol. 2019 Jul 31;10:1784. doi: 10.3389/fimmu.2019.01784. eCollection 2019.


Pellino-1 Regulates Immune Responses to Haemophilus influenzae in Models of Inflammatory Lung Disease.

Hughes BM, Burton CS, Reese A, Jabeen MF, Wright C, Willis J, Khoshaein N, Marsh EK, Peachell P, Sun SC, Dockrell DH, Marriott HM, Sabroe I, Condliffe AM, Prince LR.

Front Immunol. 2019 Jul 31;10:1721. doi: 10.3389/fimmu.2019.01721. eCollection 2019.


Sources of Stress and Psychological Health Outcomes Among U.S. Air Force Total Force Distributed Common Ground System Operators.

Chappelle WL, Prince LR, Goodman TM.

Mil Med. 2019 Mar 1;184(Suppl 1):451-460. doi: 10.1093/milmed/usy398.


A Genome-Wide Screen Identifies Factors Involved in S. aureus-Induced Human Neutrophil Cell Death and Pathogenesis.

Yang D, Ho YX, Cowell LM, Jilani I, Foster SJ, Prince LR.

Front Immunol. 2019 Jan 31;10:45. doi: 10.3389/fimmu.2019.00045. eCollection 2019.


Effect of Hypoglycemia on Inflammatory Responses and the Response to Low-Dose Endotoxemia in Humans.

Iqbal A, Prince LR, Novodvorsky P, Bernjak A, Thomas MR, Birch L, Lambert D, Kay LJ, Wright FJ, Macdonald IA, Jacques RM, Storey RF, McCrimmon RJ, Francis S, Heller SR, Sabroe I.

J Clin Endocrinol Metab. 2019 Apr 1;104(4):1187-1199. doi: 10.1210/jc.2018-01168.


Identification of Staphylococcus aureus Factors Required for Pathogenicity and Growth in Human Blood.

Connolly J, Boldock E, Prince LR, Renshaw SA, Whyte MK, Foster SJ.

Infect Immun. 2017 Oct 18;85(11). pii: e00337-17. doi: 10.1128/IAI.00337-17. Print 2017 Nov.


NR4A orphan nuclear receptor family members, NR4A2 and NR4A3, regulate neutrophil number and survival.

Prince LR, Prosseda SD, Higgins K, Carlring J, Prestwich EC, Ogryzko NV, Rahman A, Basran A, Falciani F, Taylor P, Renshaw SA, Whyte MKB, Sabroe I.

Blood. 2017 Aug 24;130(8):1014-1025. doi: 10.1182/blood-2017-03-770164. Epub 2017 Jun 21.


Ticagrelor potentiates adenosine-induced stimulation of neutrophil chemotaxis and phagocytosis.

Alsharif KF, Thomas MR, Judge HM, Khan H, Prince LR, Sabroe I, Ridger VC, Storey RF.

Vascul Pharmacol. 2015 Aug;71:201-7. doi: 10.1016/j.vph.2015.02.006. Epub 2015 Apr 11.


Macrophage phenotype is associated with disease severity in preterm infants with chronic lung disease.

Prince LR, Maxwell NC, Gill SK, Dockrell DH, Sabroe I, McGreal EP, Kotecha S, Whyte MK.

PLoS One. 2014 Aug 12;9(8):e103059. doi: 10.1371/journal.pone.0103059. eCollection 2014.


A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.

Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MK, Renshaw SA.

Sci Transl Med. 2014 Feb 26;6(225):225ra29. doi: 10.1126/scitranslmed.3007672.


Serum and glucocorticoid-regulated kinase 1 regulates neutrophil clearance during inflammation resolution.

Burgon J, Robertson AL, Sadiku P, Wang X, Hooper-Greenhill E, Prince LR, Walker P, Hoggett EE, Ward JR, Farrow SN, Zuercher WJ, Jeffrey P, Savage CO, Ingham PW, Hurlstone AF, Whyte MK, Renshaw SA.

J Immunol. 2014 Feb 15;192(4):1796-805. doi: 10.4049/jimmunol.1300087. Epub 2014 Jan 15.


Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra.

Sabroe RA, Stokes CA, Parker LC, Higgins K, Prince LR, Sabroe I.

Clin Exp Dermatol. 2013 Dec;38(8):874-7. doi: 10.1111/ced.12186. Epub 2013 Jul 25.


Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.

Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MK, Walmsley SR, Higgins KR, Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC, Sabroe I.

J Leukoc Biol. 2013 Jan;93(1):7-19. doi: 10.1189/jlb.0512250. Epub 2012 Aug 17.


Pellino-1 selectively regulates epithelial cell responses to rhinovirus.

Bennett JA, Prince LR, Parker LC, Stokes CA, de Bruin HG, van den Berge M, Heijink IH, Whyte MK, Sabroe I.

J Virol. 2012 Jun;86(12):6595-604. doi: 10.1128/JVI.06755-11. Epub 2012 Apr 18.


Staphylococcus aureus induces eosinophil cell death mediated by α-hemolysin.

Prince LR, Graham KJ, Connolly J, Anwar S, Ridley R, Sabroe I, Foster SJ, Whyte MK.

PLoS One. 2012;7(2):e31506. doi: 10.1371/journal.pone.0031506. Epub 2012 Feb 15.


The role of TLRs in neutrophil activation.

Prince LR, Whyte MK, Sabroe I, Parker LC.

Curr Opin Pharmacol. 2011 Aug;11(4):397-403. doi: 10.1016/j.coph.2011.06.007. Epub 2011 Jul 6. Review.


Prosurvival activity for airway neutrophils in severe asthma.

Uddin M, Nong G, Ward J, Seumois G, Prince LR, Wilson SJ, Cornelius V, Dent G, Djukanovic R.

Thorax. 2010 Aug;65(8):684-9. doi: 10.1136/thx.2009.120741.


The rise and rise of Staphylococcus aureus: laughing in the face of granulocytes.

Anwar S, Prince LR, Foster SJ, Whyte MK, Sabroe I.

Clin Exp Immunol. 2009 Aug;157(2):216-24. doi: 10.1111/j.1365-2249.2009.03950.x. Review.


The generation of highly purified primary human neutrophils and assessment of apoptosis in response to Toll-like receptor ligands.

Parker LC, Prince LR, Buttle DJ, Sabroe I.

Methods Mol Biol. 2009;517:191-204. doi: 10.1007/978-1-59745-541-1_12.


Pathways regulating lipopolysaccharide-induced neutrophil survival revealed by lentiviral transduction of primary human neutrophils.

Dick EP, Prince LR, Prestwich EC, Renshaw SA, Whyte MK, Sabroe I.

Immunology. 2009 Jun;127(2):249-55. doi: 10.1111/j.1365-2567.2008.02949.x. Epub 2008 Oct 28.


Ex vivo-expanded bone marrow CD34+ derived neutrophils have limited bactericidal ability.

Dick EP, Prince LR, Sabroe I.

Stem Cells. 2008 Oct;26(10):2552-63. doi: 10.1634/stemcells.2008-0328. Epub 2008 Jul 31.


Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.

Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle DJ, Sabroe I, Dockrell DH, Whyte MK.

J Immunol. 2008 Mar 1;180(5):3502-11.


Inhibition of neutrophil apoptosis by ATP is mediated by the P2Y11 receptor.

Vaughan KR, Stokes L, Prince LR, Marriott HM, Meis S, Kassack MU, Bingle CD, Sabroe I, Surprenant A, Whyte MK.

J Immunol. 2007 Dec 15;179(12):8544-53.


Impairment of apoptotic cell engulfment by pyocyanin, a toxic metabolite of Pseudomonas aeruginosa.

Bianchi SM, Prince LR, McPhillips K, Allen L, Marriott HM, Taylor GW, Hellewell PG, Sabroe I, Dockrell DH, Henson PW, Whyte MK.

Am J Respir Crit Care Med. 2008 Jan 1;177(1):35-43. Epub 2007 Oct 4.


Endotoxin tolerance induces selective alterations in neutrophil function.

Parker LC, Jones EC, Prince LR, Dower SK, Whyte MK, Sabroe I.

J Leukoc Biol. 2005 Dec;78(6):1301-5. Epub 2005 Oct 21.


The role of interleukin-1beta in direct and toll-like receptor 4-mediated neutrophil activation and survival.

Prince LR, Allen L, Jones EC, Hellewell PG, Dower SK, Whyte MK, Sabroe I.

Am J Pathol. 2004 Nov;165(5):1819-26.


What can we learn from highly purified neutrophils?

Sabroe I, Prince LR, Dower SK, Walmsley SR, Chilvers ER, Whyte MK.

Biochem Soc Trans. 2004 Jun;32(Pt3):468-9. Review.


Alveolar macrophage apoptosis contributes to pneumococcal clearance in a resolving model of pulmonary infection.

Dockrell DH, Marriott HM, Prince LR, Ridger VC, Ince PG, Hellewell PG, Whyte MK.

J Immunol. 2003 Nov 15;171(10):5380-8.


The role of neutrophil apoptosis in the resolution of acute lung injury in newborn infants.

Kotecha S, Mildner RJ, Prince LR, Vyas JR, Currie AE, Lawson RA, Whyte MK.

Thorax. 2003 Nov;58(11):961-7.


Selective roles for Toll-like receptor (TLR)2 and TLR4 in the regulation of neutrophil activation and life span.

Sabroe I, Prince LR, Jones EC, Horsburgh MJ, Foster SJ, Vogel SN, Dower SK, Whyte MK.

J Immunol. 2003 May 15;170(10):5268-75.

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