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Development of a conditional localization approach to control apicoplast protein trafficking in malaria parasites.

Roberts AD, Nair SC, Guerra AJ, Prigge ST.

Traffic. 2019 Aug;20(8):571-582. doi: 10.1111/tra.12656. Epub 2019 Jun 17.


Short-term metabolic adjustments in Plasmodium falciparum counter hypoxanthine deprivation at the expense of long-term viability.

Tewari SG, Rajaram K, Schyman P, Swift R, Reifman J, Prigge ST, Wallqvist A.

Malar J. 2019 Mar 19;18(1):86. doi: 10.1186/s12936-019-2720-3.


Using Lipoamidase as a Novel Probe To Interrogate the Importance of Lipoylation in Plasmodium falciparum.

Jhun H, Walters MS, Prigge ST.

MBio. 2018 Nov 20;9(6). pii: e01872-18. doi: 10.1128/mBio.01872-18.


Amylase increases energy and nutrient density of Super Cereal Plus porridge as prepared and accepted by Rwandan caregivers.

Broersen B, Sinamo S, Nsabimana J, Mahamadou T, Gatete E, Prigge S, Van Hoan N, de Pee S.

Matern Child Nutr. 2019 Apr;15(2):e12742. doi: 10.1111/mcn.12742. Epub 2018 Dec 11.


Host biotin is required for liver stage development in malaria parasites.

Dellibovi-Ragheb TA, Jhun H, Goodman CD, Walters MS, Ragheb DRT, Matthews KA, Rajaram K, Mishra S, McFadden GI, Sinnis P, Prigge ST.

Proc Natl Acad Sci U S A. 2018 Mar 13;115(11):E2604-E2613. doi: 10.1073/pnas.1800717115. Epub 2018 Feb 26.


A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.

Afanador GA, Guerra AJ, Swift RP, Rodriguez RE, Bartee D, Matthews KA, Schön A, Freire E, Freel Meyers CL, Prigge ST.

Mol Microbiol. 2017 Nov;106(3):439-451. doi: 10.1111/mmi.13776. Epub 2017 Sep 8.


Crystal structure of lipoate-bound lipoate ligase 1, LipL1, from Plasmodium falciparum.

Guerra AJ, Afanador GA, Prigge ST.

Proteins. 2017 Sep;85(9):1777-1783. doi: 10.1002/prot.25324. Epub 2017 Jun 7.


Using a genome-scale metabolic network model to elucidate the mechanism of chloroquine action in Plasmodium falciparum.

Tewari SG, Prigge ST, Reifman J, Wallqvist A.

Int J Parasitol Drugs Drug Resist. 2017 Aug;7(2):138-146. doi: 10.1016/j.ijpddr.2017.03.004. Epub 2017 Mar 22.


Detection of pathogen-specific antibodies by loop-mediated isothermal amplification.

Burbulis IE, Yamaguchi K, Nikolskaia OV, Prigge ST, Magez S, Bisser S, Reller ME, Grab DJ.

Clin Vaccine Immunol. 2015 Apr;22(4):374-80. doi: 10.1128/CVI.00811-14. Epub 2015 Feb 4.


Redox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparum.

Afanador GA, Matthews KA, Bartee D, Gisselberg JE, Walters MS, Freel Meyers CL, Prigge ST.

Mol Microbiol. 2014 Oct;94(1):156-71. doi: 10.1111/mmi.12753. Epub 2014 Sep 1.


The benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme target.

Wilkinson C, McPhillie MJ, Zhou Y, Woods S, Afanador GA, Rawson S, Khaliq F, Prigge ST, Roberts CW, Rice DW, McLeod R, Fishwick CW, Muench SP.

Bioorg Med Chem Lett. 2014 Feb 1;24(3):911-6. doi: 10.1016/j.bmcl.2013.12.066. Epub 2013 Dec 22.


Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.

Afanador GA, Muench SP, McPhillie M, Fomovska A, Schön A, Zhou Y, Cheng G, Stec J, Freundlich JS, Shieh HM, Anderson JW, Jacobus DP, Fidock DA, Kozikowski AP, Fishwick CW, Rice DW, Freire E, McLeod R, Prigge ST.

Biochemistry. 2013 Dec 23;52(51):9155-66. doi: 10.1021/bi400945y. Epub 2013 Dec 13.


The suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasites.

Gisselberg JE, Dellibovi-Ragheb TA, Matthews KA, Bosch G, Prigge ST.

PLoS Pathog. 2013;9(9):e1003655. doi: 10.1371/journal.ppat.1003655. Epub 2013 Sep 26.


Modification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.

Stec J, Fomovska A, Afanador GA, Muench SP, Zhou Y, Lai BS, El Bissati K, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Sommervile C, Woods S, Roberts CW, Rice D, Prigge ST, McLeod R, Kozikowski AP.

ChemMedChem. 2013 Jul;8(7):1138-60. doi: 10.1002/cmdc.201300050. Epub 2013 Jun 14.


Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.

Muench SP, Stec J, Zhou Y, Afanador GA, McPhillie MJ, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Prigge ST, Rice DW, McLeod R.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3551-5. doi: 10.1016/j.bmcl.2013.04.035. Epub 2013 Apr 24.


Parasites FeS up: iron-sulfur cluster biogenesis in eukaryotic pathogens.

Dellibovi-Ragheb TA, Gisselberg JE, Prigge ST.

PLoS Pathog. 2013;9(4):e1003227. doi: 10.1371/journal.ppat.1003227. Epub 2013 Apr 4. No abstract available.


A key role for lipoic acid synthesis during Plasmodium liver stage development.

Falkard B, Kumar TR, Hecht LS, Matthews KA, Henrich PP, Gulati S, Lewis RE, Manary MJ, Winzeler EA, Sinnis P, Prigge ST, Heussler V, Deschermeier C, Fidock D.

Cell Microbiol. 2013 Sep;15(9):1585-604. doi: 10.1111/cmi.12137. Epub 2013 Apr 5.


Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.

Cheng G, Muench SP, Zhou Y, Afanador GA, Mui EJ, Fomovska A, Lai BS, Prigge ST, Woods S, Roberts CW, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Rice DW, McLeod R.

Bioorg Med Chem Lett. 2013 Apr 1;23(7):2035-43. doi: 10.1016/j.bmcl.2013.02.019. Epub 2013 Feb 13.


Rice fortification: an emerging opportunity to contribute to the elimination of vitamin and mineral deficiency worldwide.

Muthayya S, Hall J, Bagriansky J, Sugimoto J, Gundry D, Matthias D, Prigge S, Hindle P, Moench-Pfanner R, Maberly G.

Food Nutr Bull. 2012 Dec;33(4):296-307.


Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agents.

Schrader FC, Glinca S, Sattler JM, Dahse HM, Afanador GA, Prigge ST, Lanzer M, Mueller AK, Klebe G, Schlitzer M.

ChemMedChem. 2013 Mar;8(3):442-61. doi: 10.1002/cmdc.201200407. Epub 2013 Jan 22.


Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.

Fomovska A, Huang Q, El Bissati K, Mui EJ, Witola WH, Cheng G, Zhou Y, Sommerville C, Roberts CW, Bettis S, Prigge ST, Afanador GA, Hickman MR, Lee PJ, Leed SE, Auschwitz JM, Pieroni M, Stec J, Muench SP, Rice DW, Kozikowski AP, McLeod R.

Antimicrob Agents Chemother. 2012 May;56(5):2666-82. doi: 10.1128/AAC.06450-11. Epub 2012 Feb 21.


Plasmodium falciparum apicoplast transit peptides are unstructured in vitro and during apicoplast import.

Gallagher JR, Matthews KA, Prigge ST.

Traffic. 2011 Sep;12(9):1124-38. doi: 10.1111/j.1600-0854.2011.01232.x. Epub 2011 Jul 7.


Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.

Bankeu JJ, Khayala R, Lenta BN, Noungoué DT, Ngouela SA, Mustafa SA, Asaad K, Choudhary MI, Prigge ST, Hasanov R, Nkengfack AE, Tsamo E, Ali MS.

J Nat Prod. 2011 Jun 24;74(6):1370-8. doi: 10.1021/np100896w. Epub 2011 May 27.


Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae).

Bankeu JJ, Mustafa SA, Gojayev AS, Lenta BD, Tchamo Noungoué D, Ngouela SA, Asaad K, Choudhary MI, Prigge S, Guliyev AA, Nkengfack AE, Tsamo E, Shaiq Ali M.

Chem Pharm Bull (Tokyo). 2010 Dec;58(12):1661-5.


Increased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya.

Spalding MD, Eyase FL, Akala HM, Bedno SA, Prigge ST, Coldren RL, Moss WJ, Waters NC.

Malar J. 2010 Nov 24;9:338. doi: 10.1186/1475-2875-9-338.


Differential reactivity between two copper sites in peptidylglycine α-hydroxylating monooxygenase.

Chufán EE, Prigge ST, Siebert X, Eipper BA, Mains RE, Amzel LM.

J Am Chem Soc. 2010 Nov 10;132(44):15565-72. doi: 10.1021/ja103117r.


Overexpression of biotin synthase and biotin ligase is required for efficient generation of sulfur-35 labeled biotin in E. coli.

Delli-Bovi TA, Spalding MD, Prigge ST.

BMC Biotechnol. 2010 Oct 11;10:73. doi: 10.1186/1472-6750-10-73.


Identification and development of novel inhibitors of Toxoplasma gondii enoyl reductase.

Tipparaju SK, Muench SP, Mui EJ, Ruzheinikov SN, Lu JZ, Hutson SL, Kirisits MJ, Prigge ST, Roberts CW, Henriquez FL, Kozikowski AP, Rice DW, McLeod RL.

J Med Chem. 2010 Sep 9;53(17):6287-300. doi: 10.1021/jm9017724.


Targeting the Lipid Metabolic Pathways for the Treatment of Malaria.

Ben Mamoun C, Prigge ST, Vial H.

Drug Dev Res. 2010 Feb;71(1):44-55.


Lipoic acid metabolism in microbial pathogens.

Spalding MD, Prigge ST.

Microbiol Mol Biol Rev. 2010 Jun;74(2):200-28. doi: 10.1128/MMBR.00008-10. Review.


Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener.

Du Y, Gisselberg JE, Johnson JD, Lee PJ, Prigge ST, Bachmann BO.

Appl Environ Microbiol. 2010 Jun;76(12):3959-66. doi: 10.1128/AEM.00170-10. Epub 2010 Apr 23.


Validation of a modified method for Bxb1 mycobacteriophage integrase-mediated recombination in Plasmodium falciparum by localization of the H-protein of the glycine cleavage complex to the mitochondrion.

Spalding MD, Allary M, Gallagher JR, Prigge ST.

Mol Biochem Parasitol. 2010 Aug;172(2):156-60. doi: 10.1016/j.molbiopara.2010.04.005. Epub 2010 Apr 18.


An update on the rapid advances in malaria parasite cell biology.

Coppens I, Sullivan DJ, Prigge ST.

Trends Parasitol. 2010 Jun;26(6):305-10. doi: 10.1016/ Epub 2010 Apr 9.


The amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo.

Spalding MD, Prigge ST.

PLoS One. 2009 Oct 8;4(10):e7392. doi: 10.1371/journal.pone.0007392.


Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.

Lee PJ, Bhonsle JB, Gaona HW, Huddler DP, Heady TN, Kreishman-Deitrick M, Bhattacharjee A, McCalmont WF, Gerena L, Lopez-Sanchez M, Roncal NE, Hudson TH, Johnson JD, Prigge ST, Waters NC.

J Med Chem. 2009 Feb 26;52(4):952-63. doi: 10.1021/jm8008103.


Malaria pulls a FASt one.

Spalding MD, Prigge ST.

Cell Host Microbe. 2008 Dec 11;4(6):509-11. doi: 10.1016/j.chom.2008.11.006.


The tail of mycolic acids.

Lu JZ, Prigge ST.

Chem Biol. 2008 Apr;15(4):309-10. doi: 10.1016/j.chembiol.2008.04.001.


Type I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structure.

Lu JZ, Muench SP, Allary M, Campbell S, Roberts CW, Mui E, McLeod RL, Rice DW, Prigge ST.

Parasitology. 2007 Dec;134(Pt.14):1949-62. Epub 2007 Aug 13.


Studies of Toxoplasma gondii and Plasmodium falciparum enoyl acyl carrier protein reductase and implications for the development of antiparasitic agents.

Muench SP, Prigge ST, McLeod R, Rafferty JB, Kirisits MJ, Roberts CW, Mui EJ, Rice DW.

Acta Crystallogr D Biol Crystallogr. 2007 Mar;63(Pt 3):328-38. Epub 2007 Feb 21.


Scavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparum.

Allary M, Lu JZ, Zhu L, Prigge ST.

Mol Microbiol. 2007 Mar;63(5):1331-44. Epub 2007 Jan 22.


Enzymes of type II fatty acid synthesis and apicoplast differentiation and division in Eimeria tenella.

Ferguson DJ, Campbell SA, Henriquez FL, Phan L, Mui E, Richards TA, Muench SP, Allary M, Lu JZ, Prigge ST, Tomley F, Shirley MW, Rice DW, McLeod R, Roberts CW.

Int J Parasitol. 2007 Jan;37(1):33-51. Epub 2006 Oct 30.


Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase.

Muench SP, Prigge ST, Zhu L, Kirisits MJ, Roberts CW, Wernimont S, McLeod R, Rice DW.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2006 Jun 1;62(Pt 6):604-6. Epub 2006 May 31.


Identification of an effector protein and gain-of-function mutants that activate Pfmrk, a malarial cyclin-dependent protein kinase.

Chen Y, Jirage D, Caridha D, Kathcart AK, Cortes EA, Dennull RA, Geyer JA, Prigge ST, Waters NC.

Mol Biochem Parasitol. 2006 Sep;149(1):48-57. Epub 2006 May 15.


Prognostic value of tissue inhibitor of metalloproteinase-1 for cardiovascular death among patients with cardiovascular disease: results from the AtheroGene study.

Lubos E, Schnabel R, Rupprecht HJ, Bickel C, Messow CM, Prigge S, Cambien F, Tiret L, Münzel T, Blankenberg S.

Eur Heart J. 2006 Jan;27(2):150-6. Epub 2005 Oct 17.


Targeting malaria with specific CDK inhibitors.

Geyer JA, Prigge ST, Waters NC.

Biochim Biophys Acta. 2005 Dec 30;1754(1-2):160-70. Epub 2005 Sep 9. Review.


The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural role.

Siebert X, Eipper BA, Mains RE, Prigge ST, Blackburn NJ, Amzel LM.

Biophys J. 2005 Nov;89(5):3312-9. Epub 2005 Aug 12.


Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.

Ferguson DJ, Henriquez FL, Kirisits MJ, Muench SP, Prigge ST, Rice DW, Roberts CW, McLeod RL.

Eukaryot Cell. 2005 Apr;4(4):814-26.


Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.

Keenan SM, Geyer JA, Welsh WJ, Prigge ST, Waters NC.

Comb Chem High Throughput Screen. 2005 Feb;8(1):27-38. Review.


Fatty Acid synthesis as a target for antimalarial drug discovery.

Lu JZ, Lee PJ, Waters NC, Prigge ST.

Comb Chem High Throughput Screen. 2005 Feb;8(1):15-26. Review.


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