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Items: 39

1.

Chikungunya virus drug discovery: still a long way to go?

Pérez-Pérez MJ, Delang L, Ng LFP, Priego EM.

Expert Opin Drug Discov. 2019 Sep;14(9):855-866. doi: 10.1080/17460441.2019.1629413. Epub 2019 Jun 14.

PMID:
31177861
2.

Metabolic Control of Dendritic Cell Functions: Digesting Information.

Wculek SK, Khouili SC, Priego E, Heras-Murillo I, Sancho D.

Front Immunol. 2019 Apr 25;10:775. doi: 10.3389/fimmu.2019.00775. eCollection 2019. Review.

3.

Chalcones and Chalcone-mimetic Derivatives as Notch Inhibitors in a Model of T-cell Acute Lymphoblastic Leukemia.

Quaglio D, Zhdanovskaya N, Tobajas G, Cuartas V, Balducci S, Christodoulou MS, Fabrizi G, Gargantilla M, Priego EM, Carmona Pestaña Á, Passarella D, Screpanti I, Botta B, Palermo R, Mori M, Ghirga F, Pérez-Pérez MJ.

ACS Med Chem Lett. 2019 Feb 26;10(4):639-643. doi: 10.1021/acsmedchemlett.8b00608. eCollection 2019 Apr 11.

PMID:
30996810
4.

Diphenyl ether derivatives occupy the expanded binding site of cyclohexanedione compounds at the colchicine site in tubulin by movement of the αT5 loop.

Bueno O, Gargantilla M, Estévez-Gallego J, Martins S, Díaz JF, Camarasa MJ, Liekens S, Pérez-Pérez MJ, Priego EM.

Eur J Med Chem. 2019 Jun 1;171:195-208. doi: 10.1016/j.ejmech.2019.03.045. Epub 2019 Mar 21.

PMID:
30921759
5.

Von Hippel-Lindau Protein Is Required for Optimal Alveolar Macrophage Terminal Differentiation, Self-Renewal, and Function.

Izquierdo HM, Brandi P, Gómez MJ, Conde-Garrosa R, Priego E, Enamorado M, Martínez-Cano S, Sánchez I, Conejero L, Jimenez-Carretero D, Martín-Puig S, Guilliams M, Sancho D.

Cell Rep. 2018 Aug 14;24(7):1738-1746. doi: 10.1016/j.celrep.2018.07.034.

6.

Identification of a novel 2-oxindole fluorinated derivative as in vivo antitumor agent for prostate cancer acting via AMPK activation.

Bort A, Quesada S, Ramos-Torres Á, Gargantilla M, Priego EM, Raynal S, Lepifre F, Gasalla JM, Rodriguez-Henche N, Castro A, Díaz-Laviada I.

Sci Rep. 2018 Mar 12;8(1):4370. doi: 10.1038/s41598-018-22690-2.

7.

High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design.

Bueno O, Estévez Gallego J, Martins S, Prota AE, Gago F, Gómez-SanJuan A, Camarasa MJ, Barasoain I, Steinmetz MO, Díaz JF, Pérez-Pérez MJ, Liekens S, Priego EM.

Sci Rep. 2018 Mar 9;8(1):4242. doi: 10.1038/s41598-018-22382-x.

8.

Conformational mimetics of the α-methyl chalcone TUB091 binding tubulin: Design, synthesis and antiproliferative activity.

Bueno O, Tobajas G, Quesada E, Estévez-Gallego J, Noppen S, Camarasa MJ, Díaz JF, Liekens S, Priego EM, Pérez-Pérez MJ.

Eur J Med Chem. 2018 Mar 25;148:337-348. doi: 10.1016/j.ejmech.2018.02.019. Epub 2018 Feb 10.

PMID:
29471122
9.

Inhibition of the Replication of Different Strains of Chikungunya Virus by 3-Aryl-[1,2,3]triazolo[4,5- d]pyrimidin-7(6 H)-ones.

Gómez-SanJuan A, Gamo AM, Delang L, Pérez-Sánchez A, Amrun SN, Abdelnabi R, Jacobs S, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Ng LFP, Querat G, Neyts J, Pérez-Pérez MJ.

ACS Infect Dis. 2018 Apr 13;4(4):605-619. doi: 10.1021/acsinfecdis.7b00219. Epub 2018 Feb 14.

PMID:
29406692
10.

Enhanced anti-tumour immunity requires the interplay between resident and circulating memory CD8+ T cells.

Enamorado M, Iborra S, Priego E, Cueto FJ, Quintana JA, Martínez-Cano S, Mejías-Pérez E, Esteban M, Melero I, Hidalgo A, Sancho D.

Nat Commun. 2017 Jul 17;8:16073. doi: 10.1038/ncomms16073.

11.

Antiviral activity of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones against chikungunya virus targeting the viral capping nsP1.

Gigante A, Gómez-SanJuan A, Delang L, Li C, Bueno O, Gamo AM, Priego EM, Camarasa MJ, Jochmans D, Leyssen P, Decroly E, Coutard B, Querat G, Neyts J, Pérez-Pérez MJ.

Antiviral Res. 2017 Aug;144:216-222. doi: 10.1016/j.antiviral.2017.06.003. Epub 2017 Jun 12.

12.

Blocking Blood Flow to Solid Tumors by Destabilizing Tubulin: An Approach to Targeting Tumor Growth.

Pérez-Pérez MJ, Priego EM, Bueno O, Martins MS, Canela MD, Liekens S.

J Med Chem. 2016 Oct 13;59(19):8685-8711. Epub 2016 Jun 27.

13.

Antivascular and antitumor properties of the tubulin-binding chalcone TUB091.

Canela MD, Noppen S, Bueno O, Prota AE, Bargsten K, Sáez-Calvo G, Jimeno ML, Benkheil M, Ribatti D, Velázquez S, Camarasa MJ, Díaz JF, Steinmetz MO, Priego EM, Pérez-Pérez MJ, Liekens S.

Oncotarget. 2017 Feb 28;8(9):14325-14342. doi: 10.18632/oncotarget.9527.

14.

Synthesis and antiproliferative activity of 6-phenylaminopurines.

Canela MD, Liekens S, Camarasa MJ, Priego EM, Pérez-Pérez MJ.

Eur J Med Chem. 2014 Nov 24;87:421-8. doi: 10.1016/j.ejmech.2014.09.093. Epub 2014 Sep 30.

PMID:
25282265
15.

Microwave-assisted synthesis of C-8 aryl and heteroaryl inosines and determination of their inhibitory activities against Plasmodium falciparum purine nucleoside phosphorylase.

Gigante A, Priego EM, Sánchez-Carrasco P, Ruiz-Pérez LM, Vande Voorde J, Camarasa MJ, Balzarini J, González-Pacanowska D, Pérez-Pérez MJ.

Eur J Med Chem. 2014 Jul 23;82:459-65. doi: 10.1016/j.ejmech.2014.05.073. Epub 2014 Jun 2.

16.

Identification of [1,2,3]triazolo[4,5-d]pyrimidin-7(6H)-ones as novel inhibitors of Chikungunya virus replication.

Gigante A, Canela MD, Delang L, Priego EM, Camarasa MJ, Querat G, Neyts J, Leyssen P, Pérez-Pérez MJ.

J Med Chem. 2014 May 22;57(10):4000-8. doi: 10.1021/jm401844c. Epub 2014 May 6.

PMID:
24800626
17.

Novel colchicine-site binders with a cyclohexanedione scaffold identified through a ligand-based virtual screening approach.

Canela MD, Pérez-Pérez MJ, Noppen S, Sáez-Calvo G, Díaz JF, Camarasa MJ, Liekens S, Priego EM.

J Med Chem. 2014 May 22;57(10):3924-38. doi: 10.1021/jm401939g. Epub 2014 May 9.

18.

CRDOCK: an ultrafast multipurpose protein-ligand docking tool.

Cortés Cabrera Á, Klett J, Dos Santos HG, Perona A, Gil-Redondo R, Francis SM, Priego EM, Gago F, Morreale A.

J Chem Inf Model. 2012 Aug 27;52(8):2300-9. doi: 10.1021/ci300194a. Epub 2012 Jul 19.

PMID:
22764680
19.

Recent advances in thymidine kinase 2 (TK2) inhibitors and new perspectives for potential applications.

Priego EM, Karlsson A, Gago F, Camarasa MJ, Balzarini J, Pérez-Pérez MJ.

Curr Pharm Des. 2012;18(20):2981-94. Review.

PMID:
22571666
20.

Efficient synthesis and anti-enteroviral activity of 9-arylpurines.

Aguado L, Canela MD, Thibaut HJ, Priego EM, Camarasa MJ, Leyssen P, Neyts J, Pérez-Pérez MJ.

Eur J Med Chem. 2012 Mar;49:279-88. doi: 10.1016/j.ejmech.2012.01.022. Epub 2012 Jan 17.

PMID:
22305341
21.

Intramolecular cation-pi interactions as the driving force to restrict the conformation of certain nucleosides.

Casanova E, Priego EM, Jimeno ML, Aguado L, Negri A, Gago F, Camarasa MJ, Pérez-Pérez MJ.

J Org Chem. 2010 Mar 19;75(6):1974-81. doi: 10.1021/jo902677s.

PMID:
20192191
22.

9-Arylpurines as a novel class of enterovirus inhibitors.

Aguado L, Thibaut HJ, Priego EM, Jimeno ML, Camarasa MJ, Neyts J, Pérez-Pérez MJ.

J Med Chem. 2010 Jan 14;53(1):316-24. doi: 10.1021/jm901240p.

PMID:
19924996
23.

Targeting LMO2 with a peptide aptamer establishes a necessary function in overt T-cell neoplasia.

Appert A, Nam CH, Lobato N, Priego E, Miguel RN, Blundell T, Drynan L, Sewell H, Tanaka T, Rabbitts T.

Cancer Res. 2009 Jun 1;69(11):4784-90. doi: 10.1158/0008-5472.CAN-08-4774.

24.

Structure, physiological role, and specific inhibitors of human thymidine kinase 2 (TK2): present and future.

Pérez-Pérez MJ, Priego EM, Hernández AI, Familiar O, Camarasa MJ, Negri A, Gago F, Balzarini J.

Med Res Rev. 2008 Sep;28(5):797-820. doi: 10.1002/med.20124. Review.

PMID:
18459168
25.

Selective human adenosine A3 antagonists based on pyrido[2,1-f]purine-2,4-diones: novel features of hA3 antagonist binding.

Priego EM, Pérez-Pérez MJ, von Frijtag Drabbe Kuenzel JK, de Vries H, Ijzerman AP, Camarasa MJ, Martín-Santamaría S.

ChemMedChem. 2008 Jan;3(1):111-9.

PMID:
18000937
26.

Genome bioinformatic analysis of nonsynonymous SNPs.

Burke DF, Worth CL, Priego EM, Cheng T, Smink LJ, Todd JA, Blundell TL.

BMC Bioinformatics. 2007 Aug 20;8:301.

27.

Synthesis and radical coupling of pyridine-bridged pi-extended tetrathiafulvalene (TTF)-type donors and push-pull analogues.

Priego EM, Sánchez L, Angeles Herranz M, Martín N, Viruela R, Ortí E.

Org Biomol Chem. 2007 Apr 21;5(8):1201-9. Epub 2007 Mar 20.

PMID:
17406718
28.

Thymidine phosphorylase is noncompetitively inhibited by 5'-O-trityl-inosine (KIN59) and related compounds.

Liekens S, Balzarini J, Hernández AI, De Clercq E, Priego EM, Camarasa MJ, Pérez-Pérez MJ.

Nucleosides Nucleotides Nucleic Acids. 2006;25(9-11):975-80.

PMID:
17065049
29.

The crystal structure of the BAR domain from human Bin1/amphiphysin II and its implications for molecular recognition.

Casal E, Federici L, Zhang W, Fernandez-Recio J, Priego EM, Miguel RN, DuHadaway JB, Prendergast GC, Luisi BF, Laue ED.

Biochemistry. 2006 Oct 31;45(43):12917-28.

30.

5'-O-tritylinosine and analogues as allosteric inhibitors of human thymidine phosphorylase.

Casanova E, Hernandez AI, Priego EM, Liekens S, Camarasa MJ, Balzarini J, Pérez-Pérez MJ.

J Med Chem. 2006 Sep 7;49(18):5562-70.

PMID:
16942029
31.

5'-O-tritylated nucleoside derivatives: inhibition of thymidine phosphorylase and angiogenesis.

Liekens S, Bronckaers A, Hernández AI, Priego EM, Casanova E, Camarasa MJ, Pérez-Pérez MJ, Balzarini J.

Mol Pharmacol. 2006 Aug;70(2):501-9. Epub 2006 May 4.

PMID:
16675660
32.

Thymidine phosphorylase inhibitors: recent developments and potential therapeutic applications.

Pérez-Pérez MJ, Priego EM, Hernández AI, Camarasa MJ, Balzarini J, Liekens S.

Mini Rev Med Chem. 2005 Dec;5(12):1113-23. Review.

PMID:
16375757
33.

Mitochondrial thymidine kinase inhibitors.

Pérez-Pérez MJ, Hernández AI, Priego EM, Rodríguez-Barrios F, Gago F, Camarasa MJ, Balzarini J.

Curr Top Med Chem. 2005;5(13):1205-19. Review.

PMID:
16305527
34.

Synthesis and evaluation of thymine-derived carboxamides against mitochondrial thymidine kinase (TK-2) and related enzymes.

Priego EM, Balzarini J, Karlsson A, Camarasa MJ, Pérez-Pérez MJ.

Bioorg Med Chem. 2004 Oct 1;12(19):5079-90.

PMID:
15351391
35.

Role of histidine-85 in the catalytic mechanism of thymidine phosphorylase as assessed by targeted molecular dynamics simulations and quantum mechanical calculations.

Mendieta J, Martín-Santamaría S, Priego EM, Balzarini J, Camarasa MJ, Pérez-Pérez MJ, Gago F.

Biochemistry. 2004 Jan 20;43(2):405-14.

PMID:
14717594
36.

Towards new thymidine phosphorylase/PD-ECGF inhibitors based on the transition state of the enzyme reaction.

Priego EM, Mendieta J, Gago F, Balzarini J, De Clercq E, Camarasa MJ, Pérez-Pérez MJ.

Nucleosides Nucleotides Nucleic Acids. 2003 May-Aug;22(5-8):951-3.

PMID:
14565319
37.

Pyrido[2,1-f]purine-2,4-dione derivatives as a novel class of highly potent human A(3) adenosine receptor antagonists.

Priego EM, von Frijtag Drabbe Kuenzel J, IJzerman AP, Camarasa MJ, Pérez-Pérez MJ.

J Med Chem. 2002 Aug 1;45(16):3337-44.

PMID:
12139445
38.

Anti-angiogenic activity of a novel multi-substrate analogue inhibitor of thymidine phosphorylase.

Liekens S, Bilsen F, De Clercq E, Priego EM, Camarasa MJ, Pérez-Pérez MJ, Balzarini J.

FEBS Lett. 2002 Jan 2;510(1-2):83-8.

39.

A new photoactive and highly soluble C(60)-TTF-C(60) dimer: charge separation and recombination

Segura JL, Priego EM, Martin N, Luo C, Guldi DM.

Org Lett. 2000 Dec 14;2(25):4021-4.

PMID:
11112633

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