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Items: 1 to 50 of 267

1.

The clinical KRAS(G12C) inhibitor AMG 510 drives anti-tumour immunity.

Canon J, Rex K, Saiki AY, Mohr C, Cooke K, Bagal D, Gaida K, Holt T, Knutson CG, Koppada N, Lanman BA, Werner J, Rapaport AS, San Miguel T, Ortiz R, Osgood T, Sun JR, Zhu X, McCarter JD, Volak LP, Houk BE, Fakih MG, O'Neil BH, Price TJ, Falchook GS, Desai J, Kuo J, Govindan R, Hong DS, Ouyang W, Henary H, Arvedson T, Cee VJ, Lipford JR.

Nature. 2019 Nov;575(7781):217-223. doi: 10.1038/s41586-019-1694-1. Epub 2019 Oct 30.

PMID:
31666701
2.

Alleviation of paclitaxel-induced mechanical hypersensitivity and hyperalgesic priming with AMPK activators in male and female mice.

Inyang KE, McDougal TA, Ramirez ED, Williams M, Laumet G, Kavelaars A, Heijnen CJ, Burton M, Dussor G, Price TJ.

Neurobiol Pain. 2019 Sep 27;6:100037. doi: 10.1016/j.ynpai.2019.100037. eCollection 2019 Aug-Dec.

3.

Prolactin Regulates Pain Responses via a Female-Selective Nociceptor-Specific Mechanism.

Patil M, Belugin S, Mecklenburg J, Wangzhou A, Paige C, Barba-Escobedo PA, Boyd JT, Goffin V, Grattan D, Boehm U, Dussor G, Price TJ, Akopian AN.

iScience. 2019 Oct 25;20:449-465. doi: 10.1016/j.isci.2019.09.039. Epub 2019 Oct 1.

4.

Transient Photoinactivation of Cell Membrane Protein Activity without Genetic Modification by Molecular Hyperthermia.

Kang P, Li X, Liu Y, Shiers SI, Xiong H, Giannotta M, Dejana E, Price TJ, Randrianalisoa J, Nielsen SO, Qin Z.

ACS Nano. 2019 Oct 24. doi: 10.1021/acsnano.9b01993. [Epub ahead of print]

PMID:
31613606
5.

Druggable Molecular Targets for the Treatment of Triple Negative Breast Cancer.

Nakhjavani M, Hardingham JE, Palethorpe HM, Price TJ, Townsend AR.

J Breast Cancer. 2019 Sep 2;22(3):341-361. doi: 10.4048/jbc.2019.22.e39. eCollection 2019 Sep. Review.

6.

Reversal of peripheral nerve injury-induced neuropathic pain and cognitive dysfunction via genetic and tomivosertib targeting of MNK.

Shiers S, Mwirigi J, Pradhan G, Kume M, Black B, Barragan-Iglesias P, Moy JK, Dussor G, Pancrazio JJ, Kroener S, Price TJ.

Neuropsychopharmacology. 2019 Oct 7. doi: 10.1038/s41386-019-0537-y. [Epub ahead of print]

PMID:
31590180
7.

Bacopasides I and II Act in Synergy to Inhibit the Growth, Migration and Invasion of Breast Cancer Cell Lines.

Palethorpe HM, Smith E, Tomita Y, Nakhjavani M, Yool AJ, Price TJ, Young JP, Townsend AR, Hardingham JE.

Molecules. 2019 Sep 30;24(19). pii: E3539. doi: 10.3390/molecules24193539.

8.

MNK-eIF4E signalling is a highly conserved mechanism for sensory neuron axonal plasticity: evidence from Aplysia californica.

Mihail SM, Wangzhou A, Kunjilwar KK, Moy JK, Dussor G, Walters ET, Price TJ.

Philos Trans R Soc Lond B Biol Sci. 2019 Nov 11;374(1785):20190289. doi: 10.1098/rstb.2019.0289. Epub 2019 Sep 23.

PMID:
31544610
9.

Challenges of international oncology trial collaboration-a call to action.

Tang M, Joensuu H, Simes RJ, Price TJ, Yip S, Hague W, Sjoquist KM, Zalcberg J.

Br J Cancer. 2019 Oct;121(7):515-521. doi: 10.1038/s41416-019-0532-4. Epub 2019 Aug 5. Review.

PMID:
31378784
10.

Stereoselective Anti-Cancer Activities of Ginsenoside Rg3 on Triple Negative Breast Cancer Cell Models.

Nakhjavani M, Palethorpe HM, Tomita Y, Smith E, Price TJ, Yool AJ, Pei JV, Townsend AR, Hardingham JE.

Pharmaceuticals (Basel). 2019 Aug 1;12(3). pii: E117. doi: 10.3390/ph12030117.

11.

Indirect AMP-Activated Protein Kinase Activators Prevent Incision-Induced Hyperalgesia and Block Hyperalgesic Priming, Whereas Positive Allosteric Modulators Block Only Priming in Mice.

Inyang KE, Burton MD, Szabo-Pardi T, Wentworth E, McDougal TA, Ramirez ED, Pradhan G, Dussor G, Price TJ.

J Pharmacol Exp Ther. 2019 Oct;371(1):138-150. doi: 10.1124/jpet.119.258400. Epub 2019 Jul 19.

12.

Differences between Dorsal Root and Trigeminal Ganglion Nociceptors in Mice Revealed by Translational Profiling.

Megat S, Ray PR, Tavares-Ferreira D, Moy JK, Sankaranarayanan I, Wanghzou A, Fang Lou T, Barragan-Iglesias P, Campbell ZT, Dussor G, Price TJ.

J Neurosci. 2019 Aug 28;39(35):6829-6847. doi: 10.1523/JNEUROSCI.2663-18.2019. Epub 2019 Jun 28.

PMID:
31253755
13.

Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent.

Patil M, Hovhannisyan AH, Wangzhou A, Mecklenburg J, Koek W, Goffin V, Grattan D, Boehm U, Dussor G, Price TJ, Akopian AN.

J Neuroendocrinol. 2019 Aug;31(8):e12759. doi: 10.1111/jne.12759. Epub 2019 Jul 4.

PMID:
31231869
14.

Translation regulation and pain special issue editorial for neurobiology of pain.

Price TJ.

Neurobiol Pain. 2018 May 30;4:1. doi: 10.1016/j.ynpai.2018.05.001. eCollection 2018 Aug-Dec. No abstract available.

15.

Temporal and sex differences in the role of BDNF/TrkB signaling in hyperalgesic priming in mice and rats.

Moy JK, Szabo-Pardi T, Tillu DV, Megat S, Pradhan G, Kume M, Asiedu MN, Burton MD, Dussor G, Price TJ.

Neurobiol Pain. 2018 Oct 19;5:100024. doi: 10.1016/j.ynpai.2018.10.001. eCollection 2019 Jan-Jul.

16.

A Genetic Locus on Chromosome 2q24 Predicting Peripheral Neuropathy Risk in Type 2 Diabetes: Results From the ACCORD and BARI 2D Studies.

Tang Y, Lenzini PA, Pop-Busui R, Ray PR, Campbell H, Perkins BA, Callaghan B, Wagner MJ, Motsinger-Reif AA, Buse JB, Price TJ, Mychaleckyj JC, Cresci S, Shah H, Doria A.

Diabetes. 2019 Aug;68(8):1649-1662. doi: 10.2337/db19-0109. Epub 2019 May 24.

PMID:
31127053
17.

Moving miRNAs to therapeutic targets in colorectal cancer.

McGregor M, Price TJ.

EBioMedicine. 2019 May;43:13-14. doi: 10.1016/j.ebiom.2019.04.051. Epub 2019 May 3. No abstract available.

18.

Authors' Reply to Yu: "Outcomes for Metastatic Colorectal Cancer Based on Microsatellite Instability: Results from the South Australian Metastatic Colorectal Cancer Registry".

Chong LC, Karapetis C, Roy A, Padbury R, Price TJ.

Target Oncol. 2019 Jun;14(3):367-368. doi: 10.1007/s11523-019-00640-w. No abstract available.

PMID:
31020602
19.

Bumetanide-Derived Aquaporin 1 Inhibitors, AqB013 and AqB050 Inhibit Tube Formation of Endothelial Cells through Induction of Apoptosis and Impaired Migration In Vitro.

Tomita Y, Palethorpe HM, Smith E, Nakhjavani M, Townsend AR, Price TJ, Yool AJ, Hardingham JE.

Int J Mol Sci. 2019 Apr 12;20(8). pii: E1818. doi: 10.3390/ijms20081818.

20.

Dural Calcitonin Gene-Related Peptide Produces Female-Specific Responses in Rodent Migraine Models.

Avona A, Burgos-Vega C, Burton MD, Akopian AN, Price TJ, Dussor G.

J Neurosci. 2019 May 29;39(22):4323-4331. doi: 10.1523/JNEUROSCI.0364-19.2019. Epub 2019 Apr 8.

PMID:
30962278
21.

Transcriptome Analysis of the Human Tibial Nerve Identifies Sexually Dimorphic Expression of Genes Involved in Pain, Inflammation, and Neuro-Immunity.

Ray PR, Khan J, Wangzhou A, Tavares-Ferreira D, Akopian AN, Dussor G, Price TJ.

Front Mol Neurosci. 2019 Mar 5;12:37. doi: 10.3389/fnmol.2019.00037. eCollection 2019. Erratum in: Front Mol Neurosci. 2019 May 22;12:127.

22.

Electrophysiological and transcriptomic correlates of neuropathic pain in human dorsal root ganglion neurons.

North RY, Li Y, Ray P, Rhines LD, Tatsui CE, Rao G, Johansson CA, Zhang H, Kim YH, Zhang B, Dussor G, Kim TH, Price TJ, Dougherty PM.

Brain. 2019 May 1;142(5):1215-1226. doi: 10.1093/brain/awz063.

PMID:
30887021
23.

Reduced aquaporin-1 transcript expression in colorectal carcinoma is associated with promoter hypermethylation.

Smith E, Tomita Y, Palethorpe HM, Howell S, Nakhjavani M, Townsend AR, Price TJ, Young JP, Hardingham JE.

Epigenetics. 2019 Feb;14(2):158-170. doi: 10.1080/15592294.2019.1580112. Epub 2019 Feb 20.

PMID:
30739527
24.

Ginsenoside Rg3: Potential Molecular Targets and Therapeutic Indication in Metastatic Breast Cancer.

Nakhjavani M, Hardingham JE, Palethorpe HM, Tomita Y, Smith E, Price TJ, Townsend AR.

Medicines (Basel). 2019 Jan 23;6(1). pii: E17. doi: 10.3390/medicines6010017. Review.

25.

Neuroscience: A Male-Specific Pain Memory Mechanism.

Shiers S, Price TJ.

Curr Biol. 2019 Jan 21;29(2):R50-R52. doi: 10.1016/j.cub.2018.11.062.

PMID:
30668946
26.

Outcomes for Metastatic Colorectal Cancer Based on Microsatellite Instability: Results from the South Australian Metastatic Colorectal Cancer Registry.

Chong LC, Townsend AR, Young J, Roy A, Piantadosi C, Hardingham JE, Roder D, Karapetis C, Padbury R, Maddern G, Moore J, Price TJ.

Target Oncol. 2019 Feb;14(1):85-91. doi: 10.1007/s11523-018-0615-9.

PMID:
30659494
27.

Outcomes of Older Patients (≥ 70 Years) Treated With Targeted Therapy in Metastatic Chemorefractory Colorectal Cancer: Retrospective Analysis of NCIC CTG CO.17 and CO.20.

Wells JC, Tu D, Siu LL, Shapiro JD, Jonker DJ, Karapetis C, Simes J, Liu G, Price TJ, Tebbutt NC, O'Callaghan CJ.

Clin Colorectal Cancer. 2019 Mar;18(1):e140-e149. doi: 10.1016/j.clcc.2018.11.006. Epub 2018 Nov 28.

PMID:
30595557
28.

Emerging neurotechnology for antinoceptive mechanisms and therapeutics discovery.

Black BJ, Atmaramani R, Plagens S, Campbell ZT, Dussor G, Price TJ, Pancrazio JJ.

Biosens Bioelectron. 2019 Feb 1;126:679-689. doi: 10.1016/j.bios.2018.11.015. Epub 2018 Nov 13. Review.

PMID:
30544081
29.

Cetuximab Alone or With Irinotecan for Resistant KRAS-, NRAS-, BRAF- and PIK3CA-wild-type Metastatic Colorectal Cancer: The AGITG Randomized Phase II ICECREAM Study.

Shapiro JD, Thavaneswaran S, Underhill CR, Robledo KP, Karapetis CS, Day FL, Nott LM, Jefford M, Chantrill LA, Pavlakis N, Tebbutt NC, Price TJ, Khasraw M, Van Hazel GA, Waring PM, Tejpar S, Simes J, Gebski VJ, Desai J, Segelov E.

Clin Colorectal Cancer. 2018 Dec;17(4):313-319. doi: 10.1016/j.clcc.2018.06.002. Epub 2018 Jun 8.

PMID:
30463680
30.

eIF4E-Dependent Translational Control: A Central Mechanism for Regulation of Pain Plasticity.

Uttam S, Wong C, Price TJ, Khoutorsky A.

Front Genet. 2018 Oct 24;9:470. doi: 10.3389/fgene.2018.00470. eCollection 2018. Review.

31.

Nociceptor Translational Profiling Reveals the Ragulator-Rag GTPase Complex as a Critical Generator of Neuropathic Pain.

Megat S, Ray PR, Moy JK, Lou TF, Barragán-Iglesias P, Li Y, Pradhan G, Wanghzou A, Ahmad A, Burton MD, North RY, Dougherty PM, Khoutorsky A, Sonenberg N, Webster KR, Dussor G, Campbell ZT, Price TJ.

J Neurosci. 2019 Jan 16;39(3):393-411. doi: 10.1523/JNEUROSCI.2661-18.2018. Epub 2018 Nov 20.

32.

The antidiabetic drug metformin prevents and reverses neuropathic pain and spinal cord microglial activation in male but not female mice.

Inyang KE, Szabo-Pardi T, Wentworth E, McDougal TA, Dussor G, Burton MD, Price TJ.

Pharmacol Res. 2019 Jan;139:1-16. doi: 10.1016/j.phrs.2018.10.027. Epub 2018 Nov 1.

PMID:
30391353
33.

Fc-gamma receptor polymorphisms, cetuximab therapy, and overall survival in the CCTG CO.20 trial of metastatic colorectal cancer.

Shepshelovich D, Townsend AR, Espin-Garcia O, Latifovic L, O'Callaghan CJ, Jonker DJ, Tu D, Chen E, Morgen E, Price TJ, Shapiro J, Siu LL, Kubo M, Dobrovic A, Ratain MJ, Xu W, Mushiroda T, Liu G.

Cancer Med. 2018 Nov;7(11):5478-5487. doi: 10.1002/cam4.1819. Epub 2018 Oct 14.

34.

Semiclassical Treatment of High-Lying Electronic States of H2.

Price TJ, Greene CH.

J Phys Chem A. 2018 Nov 1;122(43):8565-8575. doi: 10.1021/acs.jpca.8b07878. Epub 2018 Oct 22.

PMID:
30299945
35.

The prognostic impact of consensus molecular subtypes (CMS) and its predictive effects for bevacizumab benefit in metastatic colorectal cancer: molecular analysis of the AGITG MAX clinical trial.

Mooi JK, Wirapati P, Asher R, Lee CK, Savas P, Price TJ, Townsend A, Hardingham J, Buchanan D, Williams D, Tejpar S, Mariadason JM, Tebbutt NC.

Ann Oncol. 2018 Nov 1;29(11):2240-2246. doi: 10.1093/annonc/mdy410.

PMID:
30247524
36.

eIF4E phosphorylation regulates ongoing pain, independently of inflammation, and hyperalgesic priming in the mouse CFA model.

Moy JK, Kuhn JL, Szabo-Pardi TA, Pradhan G, Price TJ.

Neurobiol Pain. 2018 Aug-Dec;4:45-50. doi: 10.1016/j.ynpai.2018.03.001. Epub 2018 Mar 15.

37.

Therapeutic opportunities for pain medicines via targeting of specific translation signaling mechanisms.

Megat S, Price TJ.

Neurobiol Pain. 2018 Aug-Dec;4:8-19. doi: 10.1016/j.ynpai.2018.02.001. Epub 2018 Feb 23.

38.

Activation of the integrated stress response in nociceptors drives methylglyoxal-induced pain.

Barragán-Iglesias P, Kuhn J, Vidal-Cantú GC, Salinas-Abarca AB, Granados-Soto V, Dussor GO, Campbell ZT, Price TJ.

Pain. 2019 Jan;160(1):160-171. doi: 10.1097/j.pain.0000000000001387.

PMID:
30157134
39.

Pancreatic, periampullary and biliary cancer with liver metastases: Should we consider resection in selected cases?

Lee RC, Kanhere H, Trochsler M, Broadbridge V, Maddern G, Price TJ.

World J Gastrointest Oncol. 2018 Aug 15;10(8):211-220. doi: 10.4251/wjgo.v10.i8.211.

40.

The Purified Extract from the Medicinal Plant Bacopa monnieri, Bacopaside II, Inhibits Growth of Colon Cancer Cells In Vitro by Inducing Cell Cycle Arrest and Apoptosis.

Smith E, Palethorpe HM, Tomita Y, Pei JV, Townsend AR, Price TJ, Young JP, Yool AJ, Hardingham JE.

Cells. 2018 Jul 21;7(7). pii: E81. doi: 10.3390/cells7070081.

41.

Targeted therapy for metastatic colorectal cancer.

Price TJ, Tang M, Gibbs P, Haller DG, Peeters M, Arnold D, Segelov E, Roy A, Tebbutt N, Pavlakis N, Karapetis C, Burge M, Shapiro J.

Expert Rev Anticancer Ther. 2018 Oct;18(10):991-1006. doi: 10.1080/14737140.2018.1502664. Epub 2018 Aug 3. Review.

PMID:
30019590
42.

Angiotensin II Triggers Peripheral Macrophage-to-Sensory Neuron Redox Crosstalk to Elicit Pain.

Shepherd AJ, Copits BA, Mickle AD, Karlsson P, Kadunganattil S, Haroutounian S, Tadinada SM, de Kloet AD, Valtcheva MV, McIlvried LA, Sheahan TD, Jain S, Ray PR, Usachev YM, Dussor G, Krause EG, Price TJ, Gereau RW 4th, Mohapatra DP.

J Neurosci. 2018 Aug 8;38(32):7032-7057. doi: 10.1523/JNEUROSCI.3542-17.2018. Epub 2018 Jul 5.

43.

Adult mouse sensory neurons on microelectrode arrays exhibit increased spontaneous and stimulus-evoked activity in the presence of interleukin-6.

Black BJ, Atmaramani R, Kumaraju R, Plagens S, Romero-Ortega M, Dussor G, Price TJ, Campbell ZT, Pancrazio JJ.

J Neurophysiol. 2018 Sep 1;120(3):1374-1385. doi: 10.1152/jn.00158.2018. Epub 2018 Jun 27.

44.

Consensus statement on essential patient characteristics in systemic treatment trials for metastatic colorectal cancer: Supported by the ARCAD Group.

Goey KKH, Sørbye H, Glimelius B, Adams RA, André T, Arnold D, Berlin JD, Bodoky G, de Gramont A, Díaz-Rubio E, Eng C, Falcone A, Grothey A, Heinemann V, Hochster HS, Kaplan RS, Kopetz S, Labianca R, Lieu CH, Meropol NJ, Price TJ, Schilsky RL, Schmoll HJ, Shacham-Shmueli E, Shi Q, Sobrero AF, Souglakos J, Van Cutsem E, Zalcberg J, van Oijen MGH, Punt CJA, Koopman M.

Eur J Cancer. 2018 Sep;100:35-45. doi: 10.1016/j.ejca.2018.05.010. Epub 2018 Jun 22.

PMID:
29936065
45.

Protease activated receptor 2 (PAR2) activation causes migraine-like pain behaviors in mice.

Hassler SN, Ahmad FB, Burgos-Vega CC, Boitano S, Vagner J, Price TJ, Dussor G.

Cephalalgia. 2019 Jan;39(1):111-122. doi: 10.1177/0333102418779548. Epub 2018 May 31.

PMID:
29848111
46.

Non-invasive dural stimulation in mice: A novel preclinical model of migraine.

Burgos-Vega CC, Quigley LD, Trevisan Dos Santos G, Yan F, Asiedu M, Jacobs B, Motina M, Safdar N, Yousuf H, Avona A, Price TJ, Dussor G.

Cephalalgia. 2019 Jan;39(1):123-134. doi: 10.1177/0333102418779557. Epub 2018 May 31.

PMID:
29848109
47.

Do we know what to do with our nonagenarian and centenarian patients with metastatic colorectal cancer (mCRC)? Results from the South Australian mCRC registry.

Tapia Rico G, Karapetis C, Townsend AR, Piantadosi C, Padbury R, Roy A, Maddern G, Moore J, Carruthers S, Roder D, Price TJ.

Acta Oncol. 2018 Nov;57(11):1455-1457. doi: 10.1080/0284186X.2018.1473640. Epub 2018 May 18. No abstract available.

PMID:
29775123
48.

Transition to chronic pain: opportunities for novel therapeutics.

Price TJ, Basbaum AI, Bresnahan J, Chambers JF, De Koninck Y, Edwards RR, Ji RR, Katz J, Kavelaars A, Levine JD, Porter L, Schechter N, Sluka KA, Terman GW, Wager TD, Yaksh TL, Dworkin RH.

Nat Rev Neurosci. 2018 Jul;19(7):383-384. doi: 10.1038/s41583-018-0012-5. No abstract available.

49.

Panitumumab in the treatment of metastatic colorectal cancer, including wild-type RAS, KRAS and NRAS mCRC.

McGregor M, Price TJ.

Future Oncol. 2018 Oct;14(24):2437-2459. doi: 10.2217/fon-2017-0711. Epub 2018 May 8. Review.

PMID:
29737864
50.

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