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Clinical Effectiveness of Intravitreal Therapy With Ranibizumab vs Aflibercept vs Bevacizumab for Macular Edema Secondary to Central Retinal Vein Occlusion: A Randomized Clinical Trial.

Hykin P, Prevost AT, Vasconcelos JC, Murphy C, Kelly J, Ramu J, Hounsome B, Yang Y, Harding SP, Lotery A, Chakravarthy U, Sivaprasad S; LEAVO Study Group.

JAMA Ophthalmol. 2019 Aug 29. doi: 10.1001/jamaophthalmol.2019.3305. [Epub ahead of print]


Arthritis prevention in the pre-clinical phase of RA with abatacept (the APIPPRA study): a multi-centre, randomised, double-blind, parallel-group, placebo-controlled clinical trial protocol.

Al-Laith M, Jasenecova M, Abraham S, Bosworth A, Bruce IN, Buckley CD, Ciurtin C, D'Agostino MA, Emery P, Gaston H, Isaacs JD, Filer A, Fisher BA, Huizinga TWJ, Ho P, Jacklin C, Lempp H, McInnes IB, Pratt AG, Östor A, Raza K, Taylor PC, van Schaardenburg D, Shivapatham D, Wright AJ, Vasconcelos JC, Kelly J, Murphy C, Prevost AT, Cope AP.

Trials. 2019 Jul 15;20(1):429. doi: 10.1186/s13063-019-3403-7.


Combined GLP-1, Oxyntomodulin, and Peptide YY Improves Body Weight and Glycemia in Obesity and Prediabetes/Type 2 Diabetes: A Randomized, Single-Blinded, Placebo-Controlled Study.

Behary P, Tharakan G, Alexiadou K, Johnson N, Wewer Albrechtsen NJ, Kenkre J, Cuenco J, Hope D, Anyiam O, Choudhury S, Alessimii H, Poddar A, Minnion J, Doyle C, Frost G, Le Roux C, Purkayastha S, Moorthy K, Dhillo W, Holst JJ, Ahmed AR, Prevost AT, Bloom SR, Tan TM.

Diabetes Care. 2019 Aug;42(8):1446-1453. doi: 10.2337/dc19-0449. Epub 2019 Jun 8.


Heterogeneity of treatment effect by baseline risk of mortality in critically ill patients: re-analysis of three recent sepsis and ARDS randomised controlled trials.

Santhakumaran S, Gordon A, Prevost AT, O'Kane C, McAuley DF, Shankar-Hari M.

Crit Care. 2019 May 3;23(1):156. doi: 10.1186/s13054-019-2446-1.


Electronically delivered interventions to reduce antibiotic prescribing for respiratory infections in primary care: cluster RCT using electronic health records and cohort study.

Gulliford MC, Juszczyk D, Prevost AT, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore M, Yardley L, Ashworth M, Charlton J.

Health Technol Assess. 2019 Mar;23(11):1-70. doi: 10.3310/hta23110.


Lightmasks that prevent dark adaptation for non-central diabetic macular oedema: the CLEOPATRA RCT.

Sivaprasad S, Vasconcelos J, Holmes H, Murphy C, Kelly J, Hykin P, Prevost AT.

Southampton (UK): NIHR Journals Library; 2019 Feb.


Effectiveness and safety of electronically delivered prescribing feedback and decision support on antibiotic use for respiratory illness in primary care: REDUCE cluster randomised trial.

Gulliford MC, Prevost AT, Charlton J, Juszczyk D, Soames J, McDermott L, Sultana K, Wright M, Fox R, Hay AD, Little P, Moore MV, Yardley L, Ashworth M.

BMJ. 2019 Feb 12;364:l236. doi: 10.1136/bmj.l236.


Mechanistic Evaluation of Panretinal Photocoagulation Versus Aflibercept in Proliferative Diabetic Retinopathy: CLARITY Substudy.

Nicholson L, Crosby-Nwaobi R, Vasconcelos JC, Prevost AT, Ramu J, Riddell A, Bainbridge JW, Hykin PG, Sivaprasad S.

Invest Ophthalmol Vis Sci. 2018 Aug 1;59(10):4277-4284. doi: 10.1167/iovs.17-23509.


Intravitreal aflibercept compared with panretinal photocoagulation for proliferative diabetic retinopathy: the CLARITY non-inferiority RCT.

Sivaprasad S, Hykin P, Prevost AT, Vasconcelos J, Riddell A, Ramu J, Murphy C, Kelly J, Edwards RT, Yeo ST, Bainbridge J, Hopkins D, White-Alao B.

Southampton (UK): NIHR Journals Library; 2018 Oct.


Clinical efficacy and safety of a light mask for prevention of dark adaptation in treating and preventing progression of early diabetic macular oedema at 24 months (CLEOPATRA): a multicentre, phase 3, randomised controlled trial.

Sivaprasad S, Vasconcelos JC, Prevost AT, Holmes H, Hykin P, George S, Murphy C, Kelly J, Arden GB; CLEOPATRA Study Group.

Lancet Diabetes Endocrinol. 2018 May;6(5):382-391. doi: 10.1016/S2213-8587(18)30036-6. Epub 2018 Mar 5.


Nutritional labelling for healthier food or non-alcoholic drink purchasing and consumption.

Crockett RA, King SE, Marteau TM, Prevost AT, Bignardi G, Roberts NW, Stubbs B, Hollands GJ, Jebb SA.

Cochrane Database Syst Rev. 2018 Feb 27;2:CD009315. doi: 10.1002/14651858.CD009315.pub2. Review.


Intravitreal aflibercept for proliferative diabetic retinopathy - Authors' reply.

Sivaprasad S, Prevost AT, Vasconcelos J, Riddell A, Hykin P.

Lancet. 2017 Nov 11;390(10108):2141-2142. doi: 10.1016/S0140-6736(17)32422-4. Epub 2017 Nov 9. No abstract available.


Clinical efficacy of intravitreal aflibercept versus panretinal photocoagulation for best corrected visual acuity in patients with proliferative diabetic retinopathy at 52 weeks (CLARITY): a multicentre, single-blinded, randomised, controlled, phase 2b, non-inferiority trial.

Sivaprasad S, Prevost AT, Vasconcelos JC, Riddell A, Murphy C, Kelly J, Bainbridge J, Tudor-Edwards R, Hopkins D, Hykin P; CLARITY Study Group.

Lancet. 2017 Jun 3;389(10085):2193-2203. doi: 10.1016/S0140-6736(17)31193-5. Epub 2017 May 7.


A randomised controlled trial of three very brief interventions for physical activity in primary care.

Pears S, Bijker M, Morton K, Vasconcelos J, Parker RA, Westgate K, Brage S, Wilson E, Prevost AT, Kinmonth AL, Griffin S, Sutton S, Hardeman W; VBI Programme Team.

BMC Public Health. 2016 Sep 30;16(1):1033.


Safety and patient response as indicated by biomarker changes to binding immunoglobulin protein in the phase I/IIA RAGULA clinical trial in rheumatoid arthritis.

Kirkham B, Chaabo K, Hall C, Garrood T, Mant T, Allen E, Vincent A, Vasconcelos JC, Prevost AT, Panayi GS, Corrigall VM.

Rheumatology (Oxford). 2016 Nov;55(11):1993-2000. Epub 2016 Aug 7.


Electronically delivered, multicomponent intervention to reduce unnecessary antibiotic prescribing for respiratory infections in primary care: a cluster randomised trial using electronic health records-REDUCE Trial study original protocol.

Juszczyk D, Charlton J, McDermott L, Soames J, Sultana K, Ashworth M, Fox R, Hay AD, Little P, Moore MV, Yardley L, Prevost AT, Gulliford MC.

BMJ Open. 2016 Aug 4;6(8):e010892. doi: 10.1136/bmjopen-2015-010892.


Safety of reduced antibiotic prescribing for self limiting respiratory tract infections in primary care: cohort study using electronic health records.

Gulliford MC, Moore MV, Little P, Hay AD, Fox R, Prevost AT, Juszczyk D, Charlton J, Ashworth M.

BMJ. 2016 Jul 4;354:i3410. doi: 10.1136/bmj.i3410.


Effectiveness and cost-effectiveness of a very brief physical activity intervention delivered in NHS Health Checks (VBI Trial): study protocol for a randomised controlled trial.

Mitchell J, Hardeman W, Pears S, Vasconcelos JC, Prevost AT, Wilson E, Sutton S; VBI Research Team.

Trials. 2016 Jun 27;17(1):303. doi: 10.1186/s13063-016-1413-2.


A systematic review of randomised controlled trials in rheumatoid arthritis: the reporting and handling of missing data in composite outcomes.

Ibrahim F, Tom BD, Scott DL, Prevost AT.

Trials. 2016 Jun 2;17(1):272. doi: 10.1186/s13063-016-1402-5. Review.


Costs and outcomes of increasing access to bariatric surgery for obesity: cohort study and cost-effectiveness analysis using electronic health records.

Gulliford MC, Charlton J, Booth HP, Fildes A, Khan O, Reddy M, Ashworth M, Littlejohns P, Prevost AT, Rudisill C.

Southampton (UK): NIHR Journals Library; 2016 May.


Unbiased estimation in seamless phase II/III trials with unequal treatment effect variances and hypothesis-driven selection rules.

Robertson DS, Prevost AT, Bowden J.

Stat Med. 2016 Sep 30;35(22):3907-22. doi: 10.1002/sim.6974. Epub 2016 Apr 21.


The clinical and cost effectiveness of a Breathlessness Intervention Service for patients with advanced non-malignant disease and their informal carers: mixed findings of a mixed method randomised controlled trial.

Farquhar MC, Prevost AT, McCrone P, Brafman-Price B, Bentley A, Higginson IJ, Todd CJ, Booth S.

Trials. 2016 Apr 4;17:185. doi: 10.1186/s13063-016-1304-6.


Accounting for selection and correlation in the analysis of two-stage genome-wide association studies.

Robertson DS, Prevost AT, Bowden J.

Biostatistics. 2016 Oct;17(4):634-49. doi: 10.1093/biostatistics/kxw012. Epub 2016 Mar 18.


The impact of communicating genetic risks of disease on risk-reducing health behaviour: systematic review with meta-analysis.

Hollands GJ, French DP, Griffin SJ, Prevost AT, Sutton S, King S, Marteau TM.

BMJ. 2016 Mar 15;352:i1102. doi: 10.1136/bmj.i1102. Review.


Effect of Contemporary Bariatric Surgical Procedures on Type 2 Diabetes Remission. A Population-Based Matched Cohort Study.

Gulliford MC, Booth HP, Reddy M, Charlton J, Fildes A, Prevost AT, Khan O; King’s Bariatric Surgery Study Group.

Obes Surg. 2016 Oct;26(10):2308-15. doi: 10.1007/s11695-016-2103-6.


Changing Epidemiology of Bariatric Surgery in the UK: Cohort Study Using Primary Care Electronic Health Records.

Booth HP, Khan O, Fildes A, Prevost AT, Reddy M, Charlton J, Gulliford MC; King’s Bariatric Surgery Study Group.

Obes Surg. 2016 Aug;26(8):1900-5. doi: 10.1007/s11695-015-2032-9.


A randomized clinical trial comparing fixed vs pro-re-nata dosing of Ozurdex in refractory diabetic macular oedema (OZDRY study).

Ramu J, Yang Y, Menon G, Bailey C, Narendran N, Bunce C, Quartilho A, Prevost AT, Hykin P, Sivaprasad S; OZDRY Study Group.

Eye (Lond). 2015 Dec;29(12):1603-12. doi: 10.1038/eye.2015.214. Epub 2015 Oct 23.


Clinical efficacy and mechanistic evaluation of aflibercept for proliferative diabetic retinopathy (acronym CLARITY): a multicentre phase IIb randomised active-controlled clinical trial.

Sivaprasad S, Prevost AT, Bainbridge J, Edwards RT, Hopkins D, Kelly J, Luthert P, Murphy C, Ramu J, Sarafraz-Shekary N, Vasconcelos J, White-Alao B, Hykin P.

BMJ Open. 2015 Sep 14;5(9):e008405. doi: 10.1136/bmjopen-2015-008405.


Probability of an Obese Person Attaining Normal Body Weight: Cohort Study Using Electronic Health Records.

Fildes A, Charlton J, Rudisill C, Littlejohns P, Prevost AT, Gulliford MC.

Am J Public Health. 2015 Sep;105(9):e54-9. doi: 10.2105/AJPH.2015.302773. Epub 2015 Jul 16.


Severity of obesity and management of hypertension, hypercholesterolaemia and smoking in primary care: population-based cohort study.

Booth HP, Prevost AT, Gulliford MC.

J Hum Hypertens. 2016 Jan;30(1):40-5. doi: 10.1038/jhh.2015.23. Epub 2015 Mar 26.


Impact of community based peer support in type 2 diabetes: a cluster randomised controlled trial of individual and/or group approaches.

Simmons D, Prevost AT, Bunn C, Holman D, Parker RA, Cohn S, Donald S, Paddison CA, Ward C, Robins P, Graffy J.

PLoS One. 2015 Mar 18;10(3):e0120277. doi: 10.1371/journal.pone.0120277. eCollection 2015.


Long-term effect of population screening for diabetes on cardiovascular morbidity, self-rated health, and health behavior.

Echouffo-Tcheugui JB, Simmons RK, Prevost AT, Williams KM, Kinmonth AL, Wareham NJ, Griffin SJ.

Ann Fam Med. 2015 Mar;13(2):149-57. doi: 10.1370/afm.1737.


Correcting for bias in the selection and validation of informative diagnostic tests.

Robertson DS, Prevost AT, Bowden J.

Stat Med. 2015 Apr 15;34(8):1417-37. doi: 10.1002/sim.6413. Epub 2015 Feb 1.


Access to weight reduction interventions for overweight and obese patients in UK primary care: population-based cohort study.

Booth HP, Prevost AT, Gulliford MC.

BMJ Open. 2015 Jan 13;5(1):e006642. doi: 10.1136/bmjopen-2014-006642.


Impact of bariatric surgery on clinical depression. Interrupted time series study with matched controls.

Booth H, Khan O, Prevost AT, Reddy M, Charlton J, Gulliford MC; King׳s Bariatric Surgery Study Group.

J Affect Disord. 2015 Mar 15;174:644-9. doi: 10.1016/j.jad.2014.12.050. Epub 2014 Dec 29.


Sleep duration and cardiometabolic risk factors among individuals with type 2 diabetes.

Cooper AJ, Westgate K, Brage S, Prevost AT, Griffin SJ, Simmons RK.

Sleep Med. 2015 Jan;16(1):119-25. doi: 10.1016/j.sleep.2014.10.006. Epub 2014 Oct 23.


Is a specialist breathlessness service more effective and cost-effective for patients with advanced cancer and their carers than standard care? Findings of a mixed-method randomised controlled trial.

Farquhar MC, Prevost AT, McCrone P, Brafman-Price B, Bentley A, Higginson IJ, Todd C, Booth S.

BMC Med. 2014 Oct 31;12:194. doi: 10.1186/s12916-014-0194-2.


Predicting adverse drug reactions in older adults; a systematic review of the risk prediction models.

Stevenson JM, Williams JL, Burnham TG, Prevost AT, Schiff R, Erskine SD, Davies JG.

Clin Interv Aging. 2014 Sep 19;9:1581-93. doi: 10.2147/CIA.S65475. eCollection 2014. Review.


Development and validation of a family history screening questionnaire in Australian primary care.

Emery JD, Reid G, Prevost AT, Ravine D, Walter FM.

Ann Fam Med. 2014 May-Jun;12(3):241-9. doi: 10.1370/afm.1617.


Which behavior change techniques are associated with changes in physical activity, diet and body mass index in people with recently diagnosed diabetes?

Hankonen N, Sutton S, Prevost AT, Simmons RK, Griffin SJ, Kinmonth AL, Hardeman W.

Ann Behav Med. 2015 Feb;49(1):7-17. doi: 10.1007/s12160-014-9624-9.


Multiple behaviour change intervention and outcomes in recently diagnosed type 2 diabetes: the ADDITION-Plus randomised controlled trial.

Griffin SJ, Simmons RK, Prevost AT, Williams KM, Hardeman W, Sutton S, Brage S, Ekelund U, Parker RA, Wareham NJ, Kinmonth AL; ADDITION-Plus study team.

Diabetologia. 2014 Jul;57(7):1308-19. doi: 10.1007/s00125-014-3236-6. Epub 2014 Apr 24.


Psychological impact of family history risk assessment in primary care: a mixed methods study.

Birt L, Emery JD, Prevost AT, Sutton S, Walter FM.

Fam Pract. 2014 Aug;31(4):409-18. doi: 10.1093/fampra/cmu012. Epub 2014 Apr 12.


Randomized controlled trial to assess the short-term effectiveness of tailored web- and text-based facilitation of smoking cessation in primary care (iQuit in practice).

Naughton F, Jamison J, Boase S, Sloan M, Gilbert H, Prevost AT, Mason D, Smith S, Brimicombe J, Evans R, Sutton S.

Addiction. 2014 Jul;109(7):1184-93. doi: 10.1111/add.12556. Epub 2014 Apr 24.


Does electronic monitoring influence adherence to medication? Randomized controlled trial of measurement reactivity.

Sutton S, Kinmonth AL, Hardeman W, Hughes D, Boase S, Prevost AT, Kellar I, Graffy J, Griffin S, Farmer A.

Ann Behav Med. 2014 Dec;48(3):293-9. doi: 10.1007/s12160-014-9595-x.


Effectiveness of interventions to promote healthy diet in primary care: systematic review and meta-analysis of randomised controlled trials.

Bhattarai N, Prevost AT, Wright AJ, Charlton J, Rudisill C, Gulliford MC.

BMC Public Health. 2013 Dec 20;13:1203. doi: 10.1186/1471-2458-13-1203. Review.


Impact of body mass index on prevalence of multimorbidity in primary care: cohort study.

Booth HP, Prevost AT, Gulliford MC.

Fam Pract. 2014 Feb;31(1):38-43. doi: 10.1093/fampra/cmt061. Epub 2013 Oct 16.


Changes in diet, cardiovascular risk factors and modelled cardiovascular risk following diagnosis of diabetes: 1-year results from the ADDITION-Cambridge trial cohort.

Savory LA, Griffin SJ, Williams KM, Prevost AT, Kinmonth AL, Wareham NJ, Simmons RK.

Diabet Med. 2014 Feb;31(2):148-55. doi: 10.1111/dme.12316. Epub 2013 Oct 21.


Pars plana vitrectomy for vitreomacular traction syndrome: a systematic review and metaanalysis of safety and efficacy.

Jackson TL, Nicod E, Angelis A, Grimaccia F, Prevost AT, Simpson AR, Kanavos P.

Retina. 2013 Nov-Dec;33(10):2012-7. doi: 10.1097/IAE.0b013e3182a6b3e2. Review.


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