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HDL Flux is Higher in Patients with Nonalcoholic Fatty Liver Disease.

McCullough A, Previs SF, Dasarathy J, Lee K, Osme A, Kim C, Ilchenko S, Lorkowski SW, Smith JD, Dasarathy S, Kasumov T.

Am J Physiol Endocrinol Metab. 2019 Sep 10. doi: 10.1152/ajpendo.00193.2019. [Epub ahead of print]


Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Chaurasia B, Tippetts TS, Mayoral Monibas R, Liu J, Li Y, Wang L, Wilkerson JL, Sweeney CR, Pereira RF, Sumida DH, Maschek JA, Cox JE, Kaddai V, Lancaster GI, Siddique MM, Poss A, Pearson M, Satapati S, Zhou H, McLaren DG, Previs SF, Chen Y, Qian Y, Petrov A, Wu M, Shen X, Yao J, Nunes CN, Howard AD, Wang L, Erion MD, Rutter J, Holland WL, Kelley DE, Summers SA.

Science. 2019 Jul 26;365(6451):386-392. doi: 10.1126/science.aav3722. Epub 2019 Jul 4.


Spatial and temporal studies of metabolic activity: contrasting biochemical kinetics in tissues and pathways during fasted and fed states.

Daurio NA, Wang Y, Chen Y, Zhou H, Carballo-Jane E, Mane J, Rodriguez CG, Zafian P, Houghton A, Addona G, McLaren DG, Zhang R, Shyong BJ, Bateman K, Downes DP, Webb M, Kelley DE, Previs SF.

Am J Physiol Endocrinol Metab. 2019 Jun 1;316(6):E1105-E1117. doi: 10.1152/ajpendo.00459.2018. Epub 2019 Mar 26.


Pharmacological AMPK activation induces transcriptional responses congruent to exercise in skeletal and cardiac muscle, adipose tissues and liver.

Muise ES, Guan HP, Liu J, Nawrocki AR, Yang X, Wang C, RodrĂ­guez CG, Zhou D, Gorski JN, Kurtz MM, Feng D, Leavitt KJ, Wei L, Wilkening RR, Apgar JM, Xu S, Lu K, Feng W, Li Y, He H, Previs SF, Shen X, van Heek M, Souza SC, Rosenbach MJ, Biftu T, Erion MD, Kelley DE, Kemp DM, Myers RW, Sebhat IK.

PLoS One. 2019 Feb 27;14(2):e0211568. doi: 10.1371/journal.pone.0211568. eCollection 2019.


DGAT2 Inhibition Alters Aspects of Triglyceride Metabolism in Rodents but Not in Non-human Primates.

McLaren DG, Han S, Murphy BA, Wilsie L, Stout SJ, Zhou H, Roddy TP, Gorski JN, Metzger DE, Shin MK, Reilly DF, Zhou HH, Tadin-Strapps M, Bartz SR, Cumiskey AM, Graham TH, Shen DM, Akinsanya KO, Previs SF, Imbriglio JE, Pinto S.

Cell Metab. 2018 Jun 5;27(6):1236-1248.e6. doi: 10.1016/j.cmet.2018.04.004. Epub 2018 Apr 26.


Superior Glycemic Control With a Glucose-Responsive Insulin Analog: Hepatic and Nonhepatic Impacts.

Moore MC, Kelley DE, Camacho RC, Zafian P, Ye T, Lin S, Kaarsholm NC, Nargund R, Kelly TM, Van Heek M, Previs SF, Moyes C, Smith MS, Farmer B, Williams P, Cherrington AD.

Diabetes. 2018 Jun;67(6):1173-1181. doi: 10.2337/db18-0099. Epub 2018 Mar 14.


Quantifying ceramide kinetics in vivo using stable isotope tracers and LC-MS/MS.

Chen Y, Berejnaia O, Liu J, Wang SP, Daurio NA, Yin W, Mayoral R, Petrov A, Kasumov T, Zhang GF, Previs SF, Kelley DE, McLaren DG.

Am J Physiol Endocrinol Metab. 2018 Sep 1;315(3):E416-E424. doi: 10.1152/ajpendo.00457.2017. Epub 2018 Mar 6.


Using [2H]water to quantify the contribution of de novo palmitate synthesis in plasma: enabling back-to-back studies.

Previs SF, Herath K, Nawrocki AR, Rodriguez CG, Slipetz D, Singh SB, Kang L, Bhat G, Roddy TP, Conarello S, Terebetski J, Erion MD, Kelley DE.

Am J Physiol Endocrinol Metab. 2018 Jul 1;315(1):E63-E71. doi: 10.1152/ajpendo.00010.2017. Epub 2018 Jan 2.


Glycation Reduces the Stability of ApoAI and Increases HDL Dysfunction in Diet-Controlled Type 2 Diabetes.

Kashyap SR, Osme A, Ilchenko S, Golizeh M, Lee K, Wang S, Bena J, Previs SF, Smith JD, Kasumov T.

J Clin Endocrinol Metab. 2018 Feb 1;103(2):388-396. doi: 10.1210/jc.2017-01551.


Reply to Letter to the Editor: "The art of quantifying glucose metabolism".

Wang SP, Satapati S, Daurio NA, Kelley DE, Previs SF.

Am J Physiol Endocrinol Metab. 2017 Aug 1;313(2):E259-E261. doi: 10.1152/ajpendo.00121.2017. No abstract available.


CETP (Cholesteryl Ester Transfer Protein) Inhibition With Anacetrapib Decreases Production of Lipoprotein(a) in Mildly Hypercholesterolemic Subjects.

Thomas T, Zhou H, Karmally W, Ramakrishnan R, Holleran S, Liu Y, Jumes P, Wagner JA, Hubbard B, Previs SF, Roddy T, Johnson-Levonas AO, Gutstein DE, Marcovina SM, Rader DJ, Ginsberg HN, Millar JS, Reyes-Soffer G.

Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1770-1775. doi: 10.1161/ATVBAHA.117.309549. Epub 2017 Jul 20.


Enhancing Studies of Pharmacodynamic Mechanisms via Measurements of Metabolic Flux: Fundamental Concepts and Guiding Principles for Using Stable Isotope Tracers.

Daurio NA, Wang SP, Chen Y, Zhou H, McLaren DG, Roddy TP, Johns DG, Milot D, Kasumov T, Erion MD, Kelley DE, Previs SF.

J Pharmacol Exp Ther. 2017 Oct;363(1):80-91. doi: 10.1124/jpet.117.241091. Epub 2017 Jul 19. Review.


GPR120 suppresses adipose tissue lipolysis and synergizes with GPR40 in antidiabetic efficacy.

Satapati S, Qian Y, Wu MS, Petrov A, Dai G, Wang SP, Zhu Y, Shen X, Muise ES, Chen Y, Zycband E, Weinglass A, Di Salvo J, Debenham JS, Cox JM, Lan P, Shah V, Previs SF, Erion M, Kelley DE, Wang L, Howard AD, Shang J.

J Lipid Res. 2017 Aug;58(8):1561-1578. doi: 10.1194/jlr.M075044. Epub 2017 Jun 5.


siRNA-mediated inhibition of SREBP cleavage-activating protein reduces dyslipidemia in spontaneously dysmetabolic rhesus monkeys.

Murphy BA, Tadin-Strapps M, Jensen K, Mogg R, Liaw A, Herath K, Bhat G, McLaren DG, Previs SF, Pinto S.

Metabolism. 2017 Jun;71:202-212. doi: 10.1016/j.metabol.2017.02.015. Epub 2017 Mar 6.


Phenotyping of adipose, liver, and skeletal muscle insulin resistance and response to pioglitazone in spontaneously obese rhesus monkeys.

Shang J, Previs SF, Conarello S, Chng K, Zhu Y, Souza SC, Staup M, Chen Y, Xie D, Zycband E, Schlessinger K, Johnson VP, Arreaza G, Liu F, Levitan D, Wang L, van Heek M, Erion M, Wang Y, Kelley DE.

Am J Physiol Endocrinol Metab. 2017 Apr 1;312(4):E235-E243. doi: 10.1152/ajpendo.00398.2016. Epub 2017 Jan 31.


Dose-dependent effects of siRNA-mediated inhibition of SCAP on PCSK9, LDLR, and plasma lipids in mouse and rhesus monkey.

Jensen KK, Tadin-Strapps M, Wang SP, Hubert J, Kan Y, Ma Y, McLaren DG, Previs SF, Herath KB, Mahsut A, Liaw A, Wang S, Stout SJ, Keohan C, Forrest G, Coelho D, Yendluri S, Williams S, Koser M, Bartz S, Akinsanya KO, Pinto S.

J Lipid Res. 2016 Dec;57(12):2150-2162. Epub 2016 Oct 5.


Analysis of Mammalian Cell Proliferation and Macromolecule Synthesis Using Deuterated Water and Gas Chromatography-Mass Spectrometry.

Foletta VC, Palmieri M, Kloehn J, Mason S, Previs SF, McConville MJ, Sieber OM, Bruce CR, Kowalski GM.

Metabolites. 2016 Oct 13;6(4). pii: E34.


Quantifying rates of glucose production in vivo following an intraperitoneal tracer bolus.

Wang SP, Zhou D, Yao Z, Satapati S, Chen Y, Daurio NA, Petrov A, Shen X, Metzger D, Yin W, Nawrocki AR, Eiermann GJ, Hwa J, Fancourt C, Miller C, Herath K, Roddy TP, Slipetz D, Erion MD, Previs SF, Kelley DE.

Am J Physiol Endocrinol Metab. 2016 Dec 1;311(6):E911-E921. doi: 10.1152/ajpendo.00182.2016. Epub 2016 Sep 20.


Proteome Dynamics Reveals Pro-Inflammatory Remodeling of Plasma Proteome in a Mouse Model of NAFLD.

Li L, Bebek G, Previs SF, Smith JD, Sadygov RG, McCullough AJ, Willard B, Kasumov T.

J Proteome Res. 2016 Sep 2;15(9):3388-404. doi: 10.1021/acs.jproteome.6b00601. Epub 2016 Aug 5.


Gaussian Process Modeling of Protein Turnover.

Rahman M, Previs SF, Kasumov T, Sadygov RG.

J Proteome Res. 2016 Jul 1;15(7):2115-22. doi: 10.1021/acs.jproteome.5b00990. Epub 2016 Jun 9.


A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis.

Li L, Zhang GF, Lee K, Lopez R, Previs SF, Willard B, McCullough A, Kasumov T.

Free Radic Biol Med. 2016 Jul;96:13-21. doi: 10.1016/j.freeradbiomed.2016.03.032. Epub 2016 Mar 30.


Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.

McLaren DG, Previs SF, Phair RD, Stout SJ, Xie D, Chen Y, Salituro GM, Xu SS, Castro-Perez JM, Opiteck GJ, Akinsanya KO, Cleary MA, Dansky HM, Johns DG, Roddy TP.

J Lipid Res. 2016 Mar;57(3):398-409. doi: 10.1194/jlr.M063842. Epub 2015 Dec 9.


Discovery and Pharmacology of a Novel Class of Diacylglycerol Acyltransferase 2 Inhibitors.

Imbriglio JE, Shen DM, Liang R, Marby K, You M, Youm HW, Feng Z, London C, Xiong Y, Tata J, Verras A, Garcia-Calvo M, Song X, Addona GH, McLaren DG, He T, Murphy B, Metzger DE, Salituro G, Deckman D, Chen Q, Jin X, Stout SJ, Wang SP, Wilsie L, Palyha O, Han S, Hubbard BK, Previs SF, Pinto S, Taggart A.

J Med Chem. 2015 Dec 10;58(23):9345-53. doi: 10.1021/acs.jmedchem.5b01345. Epub 2015 Nov 20.


Quantitative profiling of oxylipins in plasma and atherosclerotic plaques of hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Harms AC, Hankemeier T, Dane A, Wang SP, Rosa R, Previs SF, Johns DG, Castro-Perez JM.

Anal Bioanal Chem. 2016 Jan;408(1):97-105. doi: 10.1007/s00216-015-9105-4. Epub 2015 Oct 28.


Effect of Error Propagation in Stable Isotope Tracer Studies: An Approach for Estimating Impact on Apparent Biochemical Flux.

Previs SF, Herath K, Castro-Perez J, Mahsut A, Zhou H, McLaren DG, Shah V, Rohm RJ, Stout SJ, Zhong W, Wang SP, Johns DG, Hubbard BK, Cleary MA, Roddy TP.

Methods Enzymol. 2015;561:331-58. doi: 10.1016/bs.mie.2015.06.021. Epub 2015 Aug 19. Review.


Tracer-based assessments of hepatic anaplerotic and TCA cycle flux: practicality, stoichiometry, and hidden assumptions.

Previs SF, Kelley DE.

Am J Physiol Endocrinol Metab. 2015 Oct 15;309(8):E727-35. doi: 10.1152/ajpendo.00216.2015. Epub 2015 Sep 1.


Inhibition of cholesteryl ester transfer protein increases cholesteryl ester content of large HDL independently of HDL-to-HDL homotypic transfer: in vitro vs in vivo comparison using anacetrapib and dalcetrapib.

Johns DG, Chen Y, Wang SP, Castro-Perez J, Previs SF, Roddy TP.

Eur J Pharmacol. 2015 Sep 5;762:256-62. doi: 10.1016/j.ejphar.2015.05.061. Epub 2015 Jun 3.


Tracer-based estimates of protein flux in cases of incomplete product renewal: evidence and implications of heterogeneity in collagen turnover.

Zhou H, Wang SP, Herath K, Kasumov T, Sadygov RG, Previs SF, Kelley DE.

Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E115-21. doi: 10.1152/ajpendo.00435.2014. Epub 2015 May 26.


Lipidome of atherosclerotic plaques from hypercholesterolemic rabbits.

Bojic LA, McLaren DG, Shah V, Previs SF, Johns DG, Castro-Perez JM.

Int J Mol Sci. 2014 Dec 15;15(12):23283-93. doi: 10.3390/ijms151223283.


The hepatitis C virus core protein inhibits adipose triglyceride lipase (ATGL)-mediated lipid mobilization and enhances the ATGL interaction with comparative gene identification 58 (CGI-58) and lipid droplets.

Camus G, Schweiger M, Herker E, Harris C, Kondratowicz AS, Tsou CL, Farese RV Jr, Herath K, Previs SF, Roddy TP, Pinto S, Zechner R, Ott M.

J Biol Chem. 2014 Dec 26;289(52):35770-80. doi: 10.1074/jbc.M114.587816. Epub 2014 Nov 7.


Effects of anacetrapib on plasma lipids, apolipoproteins and PCSK9 in healthy, lean rhesus macaques.

Roddy TP, McLaren DG, Chen Y, Xie D, Dunn K, Kulick A, Szeto D, Forrest G, Albanese K, Donnelly M, Gai C, Gewain A, Lederman H, Jensen KK, Ai X, Vachal P, Akinsanya KO, Cleary MA, Previs SF, Dansky HM, Johns DG.

Eur J Pharmacol. 2014 Oct 5;740:410-6. doi: 10.1016/j.ejphar.2014.04.015. Epub 2014 Apr 21.


Static and turnover kinetic measurement of protein biomarkers involved in triglyceride metabolism including apoB48 and apoA5 by LC/MS/MS.

Pan Y, Zhou H, Mahsut A, Rohm RJ, Berejnaia O, Price O, Chen Y, Castro-Perez J, Lassman ME, McLaren D, Conway J, Jensen KK, Thomas T, Reyes-Soffer G, Ginsberg HN, Gutstein DE, Cleary M, Previs SF, Roddy TP.

J Lipid Res. 2014 Jun;55(6):1179-87. doi: 10.1194/jlr.D047829. Epub 2014 Apr 2.


Determination of low levels of 2H-labeling using high-resolution mass spectrometry: application in studies of lipid flux and beyond.

Herath KB, Zhong W, Yang J, Mahsut A, Rohm RJ, Shah V, Castro-Perez J, Zhou H, Attygalle AB, Kang L, Singh S, Johns DG, Cleary MA, Hubbard BK, Previs SF, Roddy TP.

Rapid Commun Mass Spectrom. 2014 Feb 15;28(3):239-44. doi: 10.1002/rcm.6776.


Enhanced data-independent analysis of lipids using ion mobility-TOFMSE to unravel quantitative and qualitative information in human plasma.

Shah V, Castro-Perez JM, McLaren DG, Herath KB, Previs SF, Roddy TP.

Rapid Commun Mass Spectrom. 2013 Oct 15;27(19):2195-200. doi: 10.1002/rcm.6675.


In vivo effects of anacetrapib on preβ HDL: improvement in HDL remodeling without effects on cholesterol absorption.

Wang SP, Daniels E, Chen Y, Castro-Perez J, Zhou H, Akinsanya KO, Previs SF, Roddy TP, Johns DG.

J Lipid Res. 2013 Oct;54(10):2858-65. doi: 10.1194/jlr.M041541. Epub 2013 Jul 29.


Effects of small interfering RNA-mediated hepatic glucagon receptor inhibition on lipid metabolism in db/db mice.

Han S, Akiyama TE, Previs SF, Herath K, Roddy TP, Jensen KK, Guan HP, Murphy BA, McNamara LA, Shen X, Strapps W, Hubbard BK, Pinto S, Li C, Li J.

J Lipid Res. 2013 Oct;54(10):2615-22. doi: 10.1194/jlr.M035592. Epub 2013 Jul 4.


New methodologies for studying lipid synthesis and turnover: looking backwards to enable moving forwards.

Previs SF, McLaren DG, Wang SP, Stout SJ, Zhou H, Herath K, Shah V, Miller PL, Wilsie L, Castro-Perez J, Johns DG, Cleary MA, Roddy TP.

Biochim Biophys Acta. 2014 Mar;1842(3):402-13. doi: 10.1016/j.bbadis.2013.05.019. Epub 2013 May 22. Review.


Measurement of apo(a) kinetics in human subjects using a microfluidic device with tandem mass spectrometry.

Zhou H, Castro-Perez J, Lassman ME, Thomas T, Li W, McLaughlin T, Dan X, Jumes P, Wagner JA, Gutstein DE, Hubbard BK, Rader DJ, Millar JS, Ginsberg HN, Reyes-Soffer G, Cleary M, Previs SF, Roddy TP.

Rapid Commun Mass Spectrom. 2013 Jun 30;27(12):1294-302. doi: 10.1002/rcm.6572.


Use of [13C18] oleic acid and mass isotopomer distribution analysis to study synthesis of plasma triglycerides in vivo: analytical and experimental considerations.

McLaren DG, Cardasis HL, Stout SJ, Wang SP, Mendoza V, Castro-Perez JM, Miller PL, Murphy BA, Cumiskey AM, Cleary MA, Johns DG, Previs SF, Roddy TP.

Anal Chem. 2013 Jul 2;85(13):6287-94. doi: 10.1021/ac400363k. Epub 2013 Jun 10.


Assessment of cardiac proteome dynamics with heavy water: slower protein synthesis rates in interfibrillar than subsarcolemmal mitochondria.

Kasumov T, Dabkowski ER, Shekar KC, Li L, Ribeiro RF Jr, Walsh K, Previs SF, Sadygov RG, Willard B, Stanley WC.

Am J Physiol Heart Circ Physiol. 2013 May;304(9):H1201-14. doi: 10.1152/ajpheart.00933.2012. Epub 2013 Mar 1.


An improved measurement of isotopic ratios by high resolution mass spectrometry.

Ilchenko S, Previs SF, Rachdaoui N, Willard B, McCullough AJ, Kasumov T.

J Am Soc Mass Spectrom. 2013 Feb;24(2):309-12. doi: 10.1007/s13361-012-0536-2. Epub 2013 Jan 3.


Tracking fatty acid kinetics in distinct lipoprotein fractions in vivo: a novel high-throughput approach for studying dyslipidemia in rodent models.

McLaren DG, Wang SP, Stout SJ, Xie D, Miller PL, Mendoza V, Rosa R, Castro-Perez J, Previs SF, Johns DG, Roddy TP.

J Lipid Res. 2013 Jan;54(1):276-81. doi: 10.1194/jlr.D030791. Epub 2012 Oct 5.


Quantifying apoprotein synthesis in rodents: coupling LC-MS/MS analyses with the administration of labeled water.

Zhou H, Li W, Wang SP, Mendoza V, Rosa R, Hubert J, Herath K, McLaughlin T, Rohm RJ, Lassman ME, Wong KK, Johns DG, Previs SF, Hubbard BK, Roddy TP.

J Lipid Res. 2012 Jun;53(6):1223-31. doi: 10.1194/jlr.D021295. Epub 2012 Mar 3.


Measuring H(2)(18)O tracer incorporation on a QQQ-MS platform provides a rapid, transferable screening tool for relative protein synthesis.

Conway JP, Johns DG, Wang SP, Walker ND, McAvoy TA, Zhou H, Zhao X, Previs SF, Roddy TP, Hubbard BK, Yates NA, Hendrickson RC.

J Proteome Res. 2012 Mar 2;11(3):1591-7. doi: 10.1021/pr2007494. Epub 2012 Feb 10.


Demonstration of diet-induced decoupling of fatty acid and cholesterol synthesis by combining gene expression array and 2H2O quantification.

Jensen KK, Previs SF, Zhu L, Herath K, Wang SP, Bhat G, Hu G, Miller PL, McLaren DG, Shin MK, Vogt TF, Wang L, Wong KK, Roddy TP, Johns DG, Hubbard BK.

Am J Physiol Endocrinol Metab. 2012 Jan 15;302(2):E209-17. doi: 10.1152/ajpendo.00436.2011. Epub 2011 Nov 1.


Acute resistance exercise augments integrative myofibrillar protein synthesis.

Gasier HG, Fluckey JD, Previs SF, Wiggs MP, Riechman SE.

Metabolism. 2012 Feb;61(2):153-6. doi: 10.1016/j.metabol.2011.07.001. Epub 2011 Aug 23.


Attenuation of Slc27a5 gene expression followed by LC-MS measurement of bile acid reconjugation using metabolomics and a stable isotope tracer strategy.

Castro-Perez JM, Roddy TP, Shah V, Wang SP, Ouyang X, Ogawa A, McLaren DG, Tadin-Strapps M, Robinson MJ, Bartz SR, Ason B, Chen Y, Previs SF, Wong KK, Vreeken RJ, Johns DG, Hubbard BK, Hankemeier T, Mitnaul L.

J Proteome Res. 2011 Oct 7;10(10):4683-91. doi: 10.1021/pr200475g. Epub 2011 Aug 26.


Identifying static and kinetic lipid phenotypes by high resolution UPLC-MS: unraveling diet-induced changes in lipid homeostasis by coupling metabolomics and fluxomics.

Castro-Perez JM, Roddy TP, Shah V, McLaren DG, Wang SP, Jensen K, Vreeken RJ, Hankemeier T, Johns DG, Previs SF, Hubbard BK.

J Proteome Res. 2011 Sep 2;10(9):4281-90. doi: 10.1021/pr200480g. Epub 2011 Aug 4.


Equilibration of (2)H labeling between body water and free amino acids: enabling studies of proteome synthesis.

Herath K, Bhat G, Miller PL, Wang SP, Kulick A, Andrews-Kelly G, Johnson C, Rohm RJ, Lassman ME, Previs SF, Johns DG, Hubbard BK, Roddy TP.

Anal Biochem. 2011 Aug 15;415(2):197-9. doi: 10.1016/j.ab.2011.04.031. Epub 2011 Apr 27.


Quantifying cholesterol synthesis in vivo using (2)H(2)O: enabling back-to-back studies in the same subject.

Previs SF, Mahsut A, Kulick A, Dunn K, Andrews-Kelly G, Johnson C, Bhat G, Herath K, Miller PL, Wang SP, Azer K, Xu J, Johns DG, Hubbard BK, Roddy TP.

J Lipid Res. 2011 Jul;52(7):1420-8. doi: 10.1194/jlr.D014993. Epub 2011 Apr 17.

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