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Items: 1 to 50 of 74

1.

Ruthenium-Cyclopentadienyl Bipyridine-Biotin Based Compounds: Synthesis and Biological Effect.

Côrte-Real L, Karas B, Brás AR, Pilon A, Avecilla F, Marques F, Preto A, Buckley BT, Cooper KR, Doherty C, Garcia MH, Valente A.

Inorg Chem. 2019 Jul 15;58(14):9135-9149. doi: 10.1021/acs.inorgchem.9b00735. Epub 2019 Jun 26.

PMID:
31241925
2.

Structural Characterization of Membrane Protein Dimers.

Preto AJ, Matos-Filipe P, Koukos PI, Renault P, Sousa SF, Moreira IS.

Methods Mol Biol. 2019;1958:403-436. doi: 10.1007/978-1-4939-9161-7_21.

PMID:
30945231
3.

A Complete Assessment of Dopamine Receptor- Ligand Interactions through Computational Methods.

Bueschbell B, Barreto CAV, Preto AJ, Schiedel AC, Moreira IS.

Molecules. 2019 Mar 27;24(7). pii: E1196. doi: 10.3390/molecules24071196.

4.

Polymer "ruthenium-cyclopentadienyl" conjugates - New emerging anti-cancer drugs.

Moreira T, Francisco R, Comsa E, Duban-Deweer S, Labas V, Teixeira-Gomes AP, Combes-Soia L, Marques F, Matos A, Favrelle A, Rousseau C, Zinck P, Falson P, Garcia MH, Preto A, Valente A.

Eur J Med Chem. 2019 Apr 15;168:373-384. doi: 10.1016/j.ejmech.2019.02.061. Epub 2019 Feb 25.

PMID:
30826512
5.

MCT1, MCT4 and CD147 expression and 3-bromopyruvate toxicity in colorectal cancer cells are modulated by the extracellular conditions.

Pereira-Vieira J, Azevedo-Silva J, Preto A, Casal M, Queirós O.

Biol Chem. 2019 May 27;400(6):787-799. doi: 10.1515/hsz-2018-0411.

PMID:
30699066
6.

An overview of antiretroviral agents for treating HIV infection in paediatric population.

Melo R, Lemos A, Preto AJ, Bueschell B, Matos-Filipe P, Barreto C, Almeida JG, Silva RDM, Correia JDG, Moreira I.

Curr Med Chem. 2018 Sep 4. doi: 10.2174/0929867325666180904123549. [Epub ahead of print]

PMID:
30182840
7.

Ultrasound elastography: compression elastography and shear-wave elastography in the assessment of tendon injury.

Prado-Costa R, Rebelo J, Monteiro-Barroso J, Preto AS.

Insights Imaging. 2018 Oct;9(5):791-814. doi: 10.1007/s13244-018-0642-1. Epub 2018 Aug 17. Review.

8.

Computational Approaches in Antibody-drug Conjugate Optimization for Targeted Cancer Therapy.

Melo R, Lemos A, Preto AJ, Almeida JG, Correia JDG, Sensoy O, Moreira IS.

Curr Top Med Chem. 2018;18(13):1091-1109. doi: 10.2174/1568026618666180731165222. Review.

PMID:
30068276
9.

Colorectal Cancer Cells Increase the Production of Short Chain Fatty Acids by Propionibacterium freudenreichii Impacting on Cancer Cells Survival.

Casanova MR, Azevedo-Silva J, Rodrigues LR, Preto A.

Front Nutr. 2018 May 24;5:44. doi: 10.3389/fnut.2018.00044. eCollection 2018.

10.

The Role of Diet Related Short-Chain Fatty Acids in Colorectal Cancer Metabolism and Survival: Prevention and Therapeutic Implications.

Gomes SD, Oliveira CS, Azevedo-Silva J, Casanova M, Barreto J, Pereira H, Chaves S, Rodrigues L, Casal M, Corte-Real M, Baltazar F, Preto A.

Curr Med Chem. 2018 May 29. doi: 10.2174/0929867325666180530102050. [Epub ahead of print]

PMID:
29848266
11.

In Silico Studies Targeting G-protein Coupled Receptors for Drug Research Against Parkinson's Disease.

Lemos A, Melo R, Preto AJ, Almeida JG, Moreira IS, Dias Soeiro Cordeiro MN.

Curr Neuropharmacol. 2018;16(6):786-848. doi: 10.2174/1570159X16666180308161642.

12.

Small bowel intussusception in 2 adults caused by inflammatory polyps.

Carvalho A, Leitão P, Pinheiro J, Sá Fernandes M, Rodrigues M, Preto AS, Silva N.

Radiol Case Rep. 2017 Sep 13;12(4):710-714. doi: 10.1016/j.radcr.2017.08.010. eCollection 2017 Dec.

13.

The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis.

Cazzanelli G, Pereira F, Alves S, Francisco R, Azevedo L, Dias Carvalho P, Almeida A, Côrte-Real M, Oliveira MJ, Lucas C, Sousa MJ, Preto A.

Cells. 2018 Feb 19;7(2). pii: E14. doi: 10.3390/cells7020014. Review.

14.

Novel ruthenium methylcyclopentadienyl complex bearing a bipyridine perfluorinated ligand shows strong activity towards colorectal cancer cells.

Teixeira RG, Brás AR, Côrte-Real L, Tatikonda R, Sanches A, Robalo MP, Avecilla F, Moreira T, Garcia MH, Haukka M, Preto A, Valente A.

Eur J Med Chem. 2018 Jan 1;143:503-514. doi: 10.1016/j.ejmech.2017.11.059.

PMID:
29202411
15.

Fab antibody fragment-functionalized liposomes for specific targeting of antigen-positive cells.

Ohradanova-Repic A, Nogueira E, Hartl I, Gomes AC, Preto A, Steinhuber E, Mühlgrabner V, Repic M, Kuttke M, Zwirzitz A, Prouza M, Suchanek M, Wozniak-Knopp G, Horejsi V, Schabbauer G, Cavaco-Paulo A, Stockinger H.

Nanomedicine. 2018 Jan;14(1):123-130. doi: 10.1016/j.nano.2017.09.003. Epub 2017 Sep 19.

PMID:
28939491
16.

Characterization of acetate transport in colorectal cancer cells and potential therapeutic implications.

Ferro S, Azevedo-Silva J, Casal M, Côrte-Real M, Baltazar F, Preto A.

Oncotarget. 2016 Sep 21;7(43):70639-70653. doi: 10.18632/oncotarget.12156. eCollection 2016 Oct 25.

17.

SpotOn: High Accuracy Identification of Protein-Protein Interface Hot-Spots.

Moreira IS, Koukos PI, Melo R, Almeida JG, Preto AJ, Schaarschmidt J, Trellet M, Gümüş ZH, Costa J, Bonvin AMJJ.

Sci Rep. 2017 Aug 14;7(1):8007. doi: 10.1038/s41598-017-08321-2.

18.

Membrane proteins structures: A review on computational modeling tools.

Almeida JG, Preto AJ, Koukos PI, Bonvin AMJJ, Moreira IS.

Biochim Biophys Acta Biomembr. 2017 Oct;1859(10):2021-2039. doi: 10.1016/j.bbamem.2017.07.008. Epub 2017 Jul 15. Review.

19.

Neutral PEGylated liposomal formulation for efficient folate-mediated delivery of MCL1 siRNA to activated macrophages.

Nogueira E, Freitas J, Loureiro A, Nogueira P, Gomes AC, Preto A, Carmo AM, Moreira A, Cavaco-Paulo A.

Colloids Surf B Biointerfaces. 2017 Jul 1;155:459-465. doi: 10.1016/j.colsurfb.2017.04.023. Epub 2017 Apr 13.

PMID:
28472749
20.

Significance of glycolytic metabolism-related protein expression in colorectal cancer, lymph node and hepatic metastasis.

Martins SF, Amorim R, Viana-Pereira M, Pinheiro C, Costa RF, Silva P, Couto C, Alves S, Fernandes S, Vilaça S, Falcão J, Marques H, Pardal F, Rodrigues M, Preto A, Reis RM, Longatto-Filho A, Baltazar F.

BMC Cancer. 2016 Jul 26;16:535. doi: 10.1186/s12885-016-2566-9.

21.

The anticancer agent 3-bromopyruvate: a simple but powerful molecule taken from the lab to the bedside.

Azevedo-Silva J, Queirós O, Baltazar F, Ułaszewski S, Goffeau A, Ko YH, Pedersen PL, Preto A, Casal M.

J Bioenerg Biomembr. 2016 Aug;48(4):349-62. doi: 10.1007/s10863-016-9670-z. Epub 2016 Jul 25. Review.

PMID:
27457582
22.

Update on Therapeutic Approaches for Rheumatoid Arthritis.

Nogueira E, Gomes A, Preto A, Cavaco-Paulo A.

Curr Med Chem. 2016;23(21):2190-203. Review.

PMID:
27149868
23.

Folate-targeted nanoparticles for rheumatoid arthritis therapy.

Nogueira E, Gomes AC, Preto A, Cavaco-Paulo A.

Nanomedicine. 2016 May;12(4):1113-1126. doi: 10.1016/j.nano.2015.12.365. Epub 2015 Dec 28. Review.

PMID:
26733257
24.

Assessment of liposome disruption to quantify drug delivery in vitro.

Nogueira E, Cruz CF, Loureiro A, Nogueira P, Freitas J, Moreira A, Carmo AM, Gomes AC, Preto A, Cavaco-Paulo A.

Biochim Biophys Acta. 2016 Feb;1858(2):163-7. doi: 10.1016/j.bbamem.2015.11.008. Epub 2015 Nov 14.

25.

Enhancing Methotrexate Tolerance with Folate Tagged Liposomes in Arthritic Mice.

Nogueira E, Lager F, Le Roux D, Nogueira P, Freitas J, Charvet C, Renault G, Loureiro A, Almeida CR, Ohradanova-Repic A, Machacek C, Bernardes GJ, Moreira A, Stockinger H, Burnet M, Carmo AM, Gomes AC, Preto A, Bismuth G, Cavaco-Paulo A.

J Biomed Nanotechnol. 2015 Dec;11(12):2243-52.

PMID:
26510317
26.

Design of liposomal formulations for cell targeting.

Nogueira E, Gomes AC, Preto A, Cavaco-Paulo A.

Colloids Surf B Biointerfaces. 2015 Dec 1;136:514-26. doi: 10.1016/j.colsurfb.2015.09.034. Epub 2015 Sep 25. Review.

PMID:
26454541
27.

Colorectal cancer-related mutant KRAS alleles function as positive regulators of autophagy.

Alves S, Castro L, Fernandes MS, Francisco R, Castro P, Priault M, Chaves SR, Moyer MP, Oliveira C, Seruca R, Côrte-Real M, Sousa MJ, Preto A.

Oncotarget. 2015 Oct 13;6(31):30787-802. doi: 10.18632/oncotarget.5021.

28.

RAF-1 promotes survival of thyroid cancer cells harboring RET/PTC1 rearrangement independently of ERK activation.

Castro L, Alves S, Chaves SR, Costa JL, Soares P, Preto A.

Mol Cell Endocrinol. 2015 Nov 5;415:64-75. doi: 10.1016/j.mce.2015.08.006. Epub 2015 Aug 8.

PMID:
26265449
29.

Size controlled protein nanoemulsions for active targeting of folate receptor positive cells.

Loureiro A, Nogueira E, Azoia NG, Sárria MP, Abreu AS, Shimanovich U, Rollett A, Härmark J, Hebert H, Guebitz G, Bernardes GJ, Preto A, Gomes AC, Cavaco-Paulo A.

Colloids Surf B Biointerfaces. 2015 Nov 1;135:90-8. doi: 10.1016/j.colsurfb.2015.06.073. Epub 2015 Jul 17.

PMID:
26241920
30.

Peptide Anchor for Folate-Targeted Liposomal Delivery.

Nogueira E, Mangialavori IC, Loureiro A, Azoia NG, Sárria MP, Nogueira P, Freitas J, Härmark J, Shimanovich U, Rollett A, Lacroix G, Bernardes GJ, Guebitz G, Hebert H, Moreira A, Carmo AM, Rossi JP, Gomes AC, Preto A, Cavaco-Paulo A.

Biomacromolecules. 2015 Sep 14;16(9):2904-10. doi: 10.1021/acs.biomac.5b00823. Epub 2015 Aug 11.

PMID:
26241560
31.

Yeast as a tool to explore cathepsin D function.

Pereira H, Oliveira CS, Castro L, Preto A, Chaves SR, Côrte-Real M.

Microb Cell. 2015 Jul 11;2(7):225-234. doi: 10.15698/mic2015.07.212. Review.

32.

Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria.

Oliveira CS, Pereira H, Alves S, Castro L, Baltazar F, Chaves SR, Preto A, Côrte-Real M.

Cell Death Dis. 2015 Jun 18;6:e1788. doi: 10.1038/cddis.2015.157.

33.

Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells.

Amorim R, Pinheiro C, Miranda-Gonçalves V, Pereira H, Moyer MP, Preto A, Baltazar F.

Cancer Lett. 2015 Aug 28;365(1):68-78. doi: 10.1016/j.canlet.2015.05.015. Epub 2015 May 25.

PMID:
26021766
34.

Folic acid-tagged protein nanoemulsions loaded with CORM-2 enhance the survival of mice bearing subcutaneous A20 lymphoma tumors.

Loureiro A, Bernardes GJ, Shimanovich U, Sárria MP, Nogueira E, Preto A, Gomes AC, Cavaco-Paulo A.

Nanomedicine. 2015 Jul;11(5):1077-83. doi: 10.1016/j.nano.2015.02.022. Epub 2015 Mar 16.

PMID:
25791804
35.

The cytotoxicity of 3-bromopyruvate in breast cancer cells depends on extracellular pH.

Azevedo-Silva J, Queirós O, Ribeiro A, Baltazar F, Young KH, Pedersen PL, Preto A, Casal M.

Biochem J. 2015 Apr 15;467(2):247-58. doi: 10.1042/BJ20140921.

PMID:
25641640
36.

Monocarboxylate transporters as targets and mediators in cancer therapy response.

Baltazar F, Pinheiro C, Morais-Santos F, Azevedo-Silva J, Queirós O, Preto A, Casal M.

Histol Histopathol. 2014 Dec;29(12):1511-24. doi: 10.14670/HH-29.1511. Epub 2014 Jun 12. Review.

PMID:
24921258
37.

Frequency of TERT promoter mutations in human cancers.

Vinagre J, Almeida A, Pópulo H, Batista R, Lyra J, Pinto V, Coelho R, Celestino R, Prazeres H, Lima L, Melo M, da Rocha AG, Preto A, Castro P, Castro L, Pardal F, Lopes JM, Santos LL, Reis RM, Cameselle-Teijeiro J, Sobrinho-Simões M, Lima J, Máximo V, Soares P.

Nat Commun. 2013;4:2185. doi: 10.1038/ncomms3185.

PMID:
23887589
38.

In vitro induction of melanin synthesis and extrusion by tamoxifen.

Matamá T, Araújo R, Preto A, Cavaco-Paulo A, Gomes AC.

Int J Cosmet Sci. 2013 Aug;35(4):368-74. doi: 10.1111/ics.12052. Epub 2013 May 20.

PMID:
23574448
39.

Acetate-induced apoptosis in colorectal carcinoma cells involves lysosomal membrane permeabilization and cathepsin D release.

Marques C, Oliveira CS, Alves S, Chaves SR, Coutinho OP, Côrte-Real M, Preto A.

Cell Death Dis. 2013 Feb 21;4:e507. doi: 10.1038/cddis.2013.29.

40.

Liposome and protein based stealth nanoparticles.

Nogueira E, Loureiro A, Nogueira P, Freitas J, Almeida CR, Härmark J, Hebert H, Moreira A, Carmo AM, Preto A, Gomes AC, Cavaco-Pauloa A.

Faraday Discuss. 2013;166:417-29.

PMID:
24611291
41.

Genetic alterations in poorly differentiated and undifferentiated thyroid carcinomas.

Soares P, Lima J, Preto A, Castro P, Vinagre J, Celestino R, Couto JP, Prazeres H, Eloy C, Máximo V, Sobrinho-Simões M.

Curr Genomics. 2011 Dec;12(8):609-17. doi: 10.2174/138920211798120853.

42.

Butyrate activates the monocarboxylate transporter MCT4 expression in breast cancer cells and enhances the antitumor activity of 3-bromopyruvate.

Queirós O, Preto A, Pacheco A, Pinheiro C, Azevedo-Silva J, Moreira R, Pedro M, Ko YH, Pedersen PL, Baltazar F, Casal M.

J Bioenerg Biomembr. 2012 Feb;44(1):141-53. doi: 10.1007/s10863-012-9418-3. Epub 2012 Feb 17.

PMID:
22350013
43.

Vacuole-mitochondrial cross-talk during apoptosis in yeast: a model for understanding lysosome-mitochondria-mediated apoptosis in mammals.

Sousa MJ, Azevedo F, Pedras A, Marques C, Coutinho OP, Preto A, Gerós H, Chaves SR, Côrte-Real M.

Biochem Soc Trans. 2011 Oct;39(5):1533-7. doi: 10.1042/BST0391533. Review. Erratum in: Biochem Soc Trans. 2011 Dec;39(6):1901. Azevedo, Flávìa [corrected to Azevedo, Flávio]; Pedras, Ana [corrected to Pedras, Andreia].

PMID:
21936847
44.

[Transcatheter arterial chemoembolization with doxorubicin eluting beads in the treatment of hepatocellular carcinoma].

Sousa PF, Preto AS, Leão D, Madureira AM, Paquete J, Costa-Maia J, Vilares-Morgado P.

Acta Med Port. 2011 Jan-Feb;24(1):29-36. Epub 2011 Feb 28. Portuguese.

45.

Design, construction, and performance of a real-time holographic refractometry prototype for liquid analysis.

Barbosa EA, Silva DM, Preto AO, Verzini R.

Rev Sci Instrum. 2011 Jan;82(1):013103. doi: 10.1063/1.3523049.

PMID:
21280812
46.

Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations.

Preto A, Gonçalves J, Rebocho AP, Figueiredo J, Meireles AM, Rocha AS, Vasconcelos HM, Seca H, Seruca R, Soares P, Sobrinho-Simões M.

BMC Cancer. 2009 Oct 31;9:387. doi: 10.1186/1471-2407-9-387.

47.

BRAFV600E mutation in papillary thyroid carcinoma: a potential target for therapy?

Soares P, Preto A, Sobrinho-Simões M.

Expert Rev Endocrinol Metab. 2009 Sep;4(5):467-480. doi: 10.1586/eem.09.29.

PMID:
30736186
48.

Luteolin, quercetin and ursolic acid are potent inhibitors of proliferation and inducers of apoptosis in both KRAS and BRAF mutated human colorectal cancer cells.

Xavier CP, Lima CF, Preto A, Seruca R, Fernandes-Ferreira M, Pereira-Wilson C.

Cancer Lett. 2009 Aug 28;281(2):162-70. doi: 10.1016/j.canlet.2009.02.041. Epub 2009 Apr 2.

PMID:
19344998
49.

Intragenic mutations in thyroid cancer.

Sobrinho-Simões M, Máximo V, Rocha AS, Trovisco V, Castro P, Preto A, Lima J, Soares P.

Endocrinol Metab Clin North Am. 2008 Jun;37(2):333-62, viii. doi: 10.1016/j.ecl.2008.02.004. Review.

PMID:
18502330
50.

BRAF provides proliferation and survival signals in MSI colorectal carcinoma cells displaying BRAF(V600E) but not KRAS mutations.

Preto A, Figueiredo J, Velho S, Ribeiro AS, Soares P, Oliveira C, Seruca R.

J Pathol. 2008 Feb;214(3):320-7.

PMID:
18098337

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