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Items: 14


Systemic Immunity Is Required for Effective Cancer Immunotherapy.

Spitzer MH, Carmi Y, Reticker-Flynn NE, Kwek SS, Madhireddy D, Martins MM, Gherardini PF, Prestwood TR, Chabon J, Bendall SC, Fong L, Nolan GP, Engleman EG.

Cell. 2017 Jan 26;168(3):487-502.e15. doi: 10.1016/j.cell.2016.12.022. Epub 2017 Jan 19.


Akt and SHP-1 are DC-intrinsic checkpoints for tumor immunity.

Carmi Y, Prestwood TR, Spitzer MH, Linde IL, Chabon J, Reticker-Flynn NE, Bhattacharya N, Zhang H, Zhang X, Basto PA, Burt BM, Alonso MN, Engleman EG.

JCI Insight. 2016 Nov 3;1(18):e89020. doi: 10.1172/jci.insight.89020.


Restoring Retinoic Acid Attenuates Intestinal Inflammation and Tumorigenesis in APCMin/+ Mice.

Penny HL, Prestwood TR, Bhattacharya N, Sun F, Kenkel JA, Davidson MG, Shen L, Zuniga LA, Seeley ES, Pai R, Choi O, Tolentino L, Wang J, Napoli JL, Engleman EG.

Cancer Immunol Res. 2016 Nov;4(11):917-926. Epub 2016 Sep 16.


Normalizing Microbiota-Induced Retinoic Acid Deficiency Stimulates Protective CD8(+) T Cell-Mediated Immunity in Colorectal Cancer.

Bhattacharya N, Yuan R, Prestwood TR, Penny HL, DiMaio MA, Reticker-Flynn NE, Krois CR, Kenkel JA, Pham TD, Carmi Y, Tolentino L, Choi O, Hulett R, Wang J, Winer DA, Napoli JL, Engleman EG.

Immunity. 2016 Sep 20;45(3):641-655. doi: 10.1016/j.immuni.2016.08.008. Epub 2016 Aug 30.


Design of Protease Activated Optical Contrast Agents That Exploit a Latent Lysosomotropic Effect for Use in Fluorescence-Guided Surgery.

Ofori LO, Withana NP, Prestwood TR, Verdoes M, Brady JJ, Winslow MM, Sorger J, Bogyo M.

ACS Chem Biol. 2015 Sep 18;10(9):1977-88. doi: 10.1021/acschembio.5b00205. Epub 2015 Jun 24.


Allogeneic IgG combined with dendritic cell stimuli induce antitumour T-cell immunity.

Carmi Y, Spitzer MH, Linde IL, Burt BM, Prestwood TR, Perlman N, Davidson MG, Kenkel JA, Segal E, Pusapati GV, Bhattacharya N, Engleman EG.

Nature. 2015 May 7;521(7550):99-104. doi: 10.1038/nature14424. Epub 2015 Apr 29.


Detection of intestinal cancer by local, topical application of a quenched fluorescence probe for cysteine cathepsins.

Segal E, Prestwood TR, van der Linden WA, Carmi Y, Bhattacharya N, Withana N, Verdoes M, Habtezion A, Engleman EG, Bogyo M.

Chem Biol. 2015 Jan 22;22(1):148-58. doi: 10.1016/j.chembiol.2014.11.008. Epub 2015 Jan 8.


Gamma interferon (IFN-γ) receptor restricts systemic dengue virus replication and prevents paralysis in IFN-α/β receptor-deficient mice.

Prestwood TR, Morar MM, Zellweger RM, Miller R, May MM, Yauch LE, Lada SM, Shresta S.

J Virol. 2012 Dec;86(23):12561-70. doi: 10.1128/JVI.06743-11. Epub 2012 Sep 12.


Trafficking and replication patterns reveal splenic macrophages as major targets of dengue virus in mice.

Prestwood TR, May MM, Plummer EM, Morar MM, Yauch LE, Shresta S.

J Virol. 2012 Nov;86(22):12138-47. doi: 10.1128/JVI.00375-12. Epub 2012 Aug 29.


CD4+ T cells are not required for the induction of dengue virus-specific CD8+ T cell or antibody responses but contribute to protection after vaccination.

Yauch LE, Prestwood TR, May MM, Morar MM, Zellweger RM, Peters B, Sette A, Shresta S.

J Immunol. 2010 Nov 1;185(9):5405-16. doi: 10.4049/jimmunol.1001709. Epub 2010 Sep 24.


Enhanced infection of liver sinusoidal endothelial cells in a mouse model of antibody-induced severe dengue disease.

Zellweger RM, Prestwood TR, Shresta S.

Cell Host Microbe. 2010 Feb 18;7(2):128-39. doi: 10.1016/j.chom.2010.01.004.


Cardif-mediated signaling controls the initial innate response to dengue virus in vivo.

Perry ST, Prestwood TR, Lada SM, Benedict CA, Shresta S.

J Virol. 2009 Aug;83(16):8276-81. doi: 10.1128/JVI.00365-09. Epub 2009 Jun 3.


A protective role for dengue virus-specific CD8+ T cells.

Yauch LE, Zellweger RM, Kotturi MF, Qutubuddin A, Sidney J, Peters B, Prestwood TR, Sette A, Shresta S.

J Immunol. 2009 Apr 15;182(8):4865-73. doi: 10.4049/jimmunol.0801974.


A mouse-passaged dengue virus strain with reduced affinity for heparan sulfate causes severe disease in mice by establishing increased systemic viral loads.

Prestwood TR, Prigozhin DM, Sharar KL, Zellweger RM, Shresta S.

J Virol. 2008 Sep;82(17):8411-21. doi: 10.1128/JVI.00611-08. Epub 2008 Jun 18.

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