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Natural product drug delivery: A special challenge?

Press NJ, Joly E, Ertl P.

Prog Med Chem. 2019;58:157-187. doi: 10.1016/bs.pmch.2019.01.001. Epub 2019 Mar 1.


Mortality among people living with HIV/AIDS with non-small-cell lung cancer in the modern HAART Era.

Smith DM, Salters KA, Eyawo O, Franco-Villalobos C, Jabbari S, Wiseman SM, Press N, Montaner JSG, Man SFP, Hull M, Hogg RS.

AIDS Care. 2018 Jul;30(7):936-942. doi: 10.1080/09540121.2018.1434120. Epub 2018 Feb 7.


Once-Daily Treatments for Methicillin-Susceptible Staphylococcus aureus Bacteremia: Are They Good Enough?

Lother SA, Press N.

Curr Infect Dis Rep. 2017 Sep 23;19(11):43. doi: 10.1007/s11908-017-0599-0. Review.


α-Halo carbonyls enable meta selective primary, secondary and tertiary C-H alkylations by ruthenium catalysis.

Paterson AJ, Heron CJ, McMullin CL, Mahon MF, Press NJ, Frost CG.

Org Biomol Chem. 2017 Jul 19;15(28):5993-6000. doi: 10.1039/c7ob01192j.


Identification of a Novel Allosteric Inhibitory Site on Tryptophan Hydroxylase 1 Enabling Unprecedented Selectivity Over all Related Hydroxylases.

Petrassi M, Barber R, Be C, Beach S, Cox B, D'Souza AM, Duggan N, Hussey M, Fox R, Hunt P, Jarai G, Kosaka T, Oakley P, Patel V, Press N, Rowlands D, Scheufler C, Schmidt O, Srinivas H, Turner M, Turner R, Westwick J, Wolfreys A, Pathan N, Watson S, Thomas M.

Front Pharmacol. 2017 May 5;8:240. doi: 10.3389/fphar.2017.00240. eCollection 2017.


A synthetic, catalytic and theoretical investigation of an unsymmetrical SCN pincer palladacycle.

Roffe GW, Boonseng S, Baltus CB, Coles SJ, Day IJ, Jones RN, Press NJ, Ruiz M, Tizzard GJ, Cox H, Spencer J.

R Soc Open Sci. 2016 Apr 6;3(4):150656. doi: 10.1098/rsos.150656. eCollection 2016 Apr.


Discovery and Optimization of 4-(8-(3-Fluorophenyl)-1,7-naphthyridin-6-yl)transcyclohexanecarboxylic Acid, an Improved PDE4 Inhibitor for the Treatment of Chronic Obstructive Pulmonary Disease (COPD).

Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Trifilieff A.

J Med Chem. 2015 Sep 10;58(17):6747-52. doi: 10.1021/acs.jmedchem.5b00902. Epub 2015 Aug 28.


Catalytic meta-selective C-H functionalization to construct quaternary carbon centres.

Paterson AJ, St John-Campbell S, Mahon MF, Press NJ, Frost CG.

Chem Commun (Camb). 2015 Aug 18;51(64):12807-10. doi: 10.1039/c5cc03951g.


A cluster of Bacillus cereus bacteremia cases among injection drug users.

Benusic MA, Press NM, Hoang LM, Romney MG.

Can J Infect Dis Med Microbiol. 2015 Mar-Apr;26(2):103-4.


Melioidosis in Trinidad and Tobago.

Hogan C, Wilmer A, Badawi M, Hoang L, Chapman M, Press N, Antonation K, Corbett C, Romney M, Murray M.

Emerg Infect Dis. 2015 May;21(5):902-4. doi: 10.3201/eid2105.141610. Review. No abstract available.


HAART slows progression to anal cancer in HIV-infected MSM.

Duncan KC, Chan KJ, Chiu CG, Montaner JS, Coldman AJ, Cescon A, Au-Yeung CG, Wiseman SM, Hogg RS, Press NM.

AIDS. 2015 Jan 28;29(3):305-11. doi: 10.1097/QAD.0000000000000537.


Decision making among Veterans with incidental pulmonary nodules: a qualitative analysis.

Slatore CG, Au DH, Press N, Wiener RS, Golden SE, Ganzini L.

Respir Med. 2015 Apr;109(4):532-9. doi: 10.1016/j.rmed.2015.01.007. Epub 2015 Jan 27.


Efficient and facile synthesis of acrylamide libraries for protein-guided tethering.

Allen CE, Curran PR, Brearley AS, Boissel V, Sviridenko L, Press NJ, Stonehouse JP, Armstrong A.

Org Lett. 2015 Feb 6;17(3):458-60. doi: 10.1021/ol503486t. Epub 2015 Jan 12.


The identification of 7-[(R)-2-((1S,2S)-2-benzyloxycyclopentylamino)-1-hydroxyethyl]-4-hydroxybenzothiazolone as an inhaled long-acting β2-adrenoceptor agonist.

Arnold N, Beattie D, Bradley M, Brearley A, Brown L, Charlton SJ, Fairhurst RA, Farr D, Fozard J, Fullerton J, Gosling M, Hatto J, Janus D, Jones D, Jordan L, Lewis C, Maas J, McCarthy C, Mercer M, Oakman H, Press N, Profit R, Schuerch F, Sykes D, Taylor RJ, Trifilieff A, Tuffnell A.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4341-7. doi: 10.1016/j.bmcl.2014.06.014. Epub 2014 Jun 26.


The discovery of potent, orally bioavailable pyrimidine-5-carbonitrile-6-alkyl CXCR2 receptor antagonists.

Porter DW, Bradley M, Brown Z, Charlton SJ, Cox B, Hunt P, Janus D, Lewis S, Oakley P, O'Connor D, Reilly J, Smith N, Press NJ.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3285-90. doi: 10.1016/j.bmcl.2014.06.011. Epub 2014 Jun 14.


The translational potential of research on the ethical, legal, and social implications of genomics.

Burke W, Appelbaum P, Dame L, Marshall P, Press N, Pyeritz R, Sharp R, Juengst E.

Genet Med. 2015 Jan;17(1):12-20. doi: 10.1038/gim.2014.74. Epub 2014 Jun 19. Review.


Colorectal and anal cancer in HIV/AIDS patients: a comprehensive review.

Kan M, Wong PH, Press N, Wiseman SM.

Expert Rev Anticancer Ther. 2014 Apr;14(4):395-405. doi: 10.1586/14737140.2013.877843. Epub 2014 Feb 9. Review.


Breastfeeding infants with phenylketonuria in the United States and Canada.

Banta-Wright SA, Press N, Knafl KA, Steiner RD, Houck GM.

Breastfeed Med. 2014 Apr;9(3):142-8. doi: 10.1089/bfm.2013.0092. Epub 2013 Dec 18.


The discovery of potent, orally bioavailable pyrazolo and triazolopyrimidine CXCR2 receptor antagonists.

Porter DW, Bradley M, Brown Z, Canova R, Charlton S, Cox B, Hunt P, Kolarik D, Lewis S, O'Connor D, Reilly J, Spanka C, Tedaldi L, Watson SJ, Wermuth R, Press NJ.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):72-6. doi: 10.1016/j.bmcl.2013.11.074. Epub 2013 Dec 4.


Essential elements of personalized medicine.

Burke W, Brown Trinidad S, Press NA.

Urol Oncol. 2014 Feb;32(2):193-7. doi: 10.1016/j.urolonc.2013.09.002. Epub 2013 Dec 8.


An inhibitor of NADPH oxidase-4 attenuates established pulmonary fibrosis in a rodent disease model.

Jarman ER, Khambata VS, Cope C, Jones P, Roger J, Ye LY, Duggan N, Head D, Pearce A, Press NJ, Bellenie B, Sohal B, Jarai G.

Am J Respir Cell Mol Biol. 2014 Jan;50(1):158-69. doi: 10.1165/rcmb.2013-0174OC.


What the heck is a "nodule"? A qualitative study of veterans with pulmonary nodules.

Slatore CG, Press N, Au DH, Curtis JR, Wiener RS, Ganzini L.

Ann Am Thorac Soc. 2013 Aug;10(4):330-5. doi: 10.1513/AnnalsATS.201304-080OC.


Recommendations for returning genomic incidental findings? We need to talk!

Burke W, Antommaria AH, Bennett R, Botkin J, Clayton EW, Henderson GE, Holm IA, Jarvik GP, Khoury MJ, Knoppers BM, Press NA, Ross LF, Rothstein MA, Saal H, Uhlmann WR, Wilfond B, Wolf SM, Zimmern R.

Genet Med. 2013 Nov;15(11):854-9. doi: 10.1038/gim.2013.113. Epub 2013 Aug 1. Review.


Trust is the basis for effective suicide risk screening and assessment in veterans.

Ganzini L, Denneson LM, Press N, Bair MJ, Helmer DA, Poat J, Dobscha SK.

J Gen Intern Med. 2013 Sep;28(9):1215-21. doi: 10.1007/s11606-013-2412-6.


Acute retinal necrosis secondary to cytomegalovirus following successful treatment of cytomegalovirus anterior uveitis in an immunocompetent adult.

Or C, Press N, Forooghian F.

Can J Ophthalmol. 2013 Apr;48(2):e18-20. doi: 10.1016/j.jcjo.2012.09.016. Epub 2013 Feb 27. No abstract available.


Patient experiences with full electronic access to health records and clinical notes through the My HealtheVet Personal Health Record Pilot: qualitative study.

Woods SS, Schwartz E, Tuepker A, Press NA, Nazi KM, Turvey CL, Nichol WP.

J Med Internet Res. 2013 Mar 27;15(3):e65. doi: 10.2196/jmir.2356.


Targeting the serotonin pathway for the treatment of pulmonary arterial hypertension.

Thomas M, Ciuclan L, Hussey MJ, Press NJ.

Pharmacol Ther. 2013 Jun;138(3):409-17. doi: 10.1016/j.pharmthera.2013.02.002. Epub 2013 Feb 14. Review.


Communication by nurses in the intensive care unit: qualitative analysis of domains of patient-centered care.

Slatore CG, Hansen L, Ganzini L, Press N, Osborne ML, Chesnutt MS, Mularski RA.

Am J Crit Care. 2012 Nov;21(6):410-8. doi: 10.4037/ajcc2012124.


Intramolecular nitrone dipolar cycloadditions: control of regioselectivity and synthesis of naturally-occurring spirocyclic alkaloids.

Hodges AJ, Adams JP, Bond AD, Holmes AB, Press NJ, Roughley SD, Ryan JH, Saubern S, Smith CJ, Turnbull MD, Newton AF.

Org Biomol Chem. 2012 Dec 7;10(45):8963-74. doi: 10.1039/c2ob26333e. Epub 2012 Oct 11.


Solubility-driven optimization of phosphodiesterase-4 inhibitors leading to a clinical candidate.

Press NJ, Taylor RJ, Fullerton JD, Tranter P, McCarthy C, Keller TH, Arnold N, Beer D, Brown L, Cheung R, Christie J, Denholm A, Haberthuer S, Hatto JD, Keenan M, Mercer MK, Oakman H, Sahri H, Tuffnell AR, Tweed M, Tyler JW, Wagner T, Fozard JR, Trifilieff A.

J Med Chem. 2012 Sep 13;55(17):7472-9. doi: 10.1021/jm300459a. Epub 2012 Aug 30.


Development of isoform selective PI3-kinase inhibitors as pharmacological tools for elucidating the PI3K pathway.

Bruce I, Akhlaq M, Bloomfield GC, Budd E, Cox B, Cuenoud B, Finan P, Gedeck P, Hatto J, Hayler JF, Head D, Keller T, Kirman L, Leblanc C, Le Grand D, McCarthy C, O'Connor D, Owen C, Oza MS, Pilgrim G, Press NE, Sviridenko L, Whitehead L.

Bioorg Med Chem Lett. 2012 Sep 1;22(17):5445-50. doi: 10.1016/j.bmcl.2012.07.042. Epub 2012 Jul 17.


Life-sustaining treatment decisions in the ICU for patients with ESLD: a prospective investigation.

Hansen L, Press N, Rosenkranz SJ, Baggs JG, Kendall J, Kerber A, Williamson A, Chesnutt MS.

Res Nurs Health. 2012 Oct;35(5):518-32. doi: 10.1002/nur.21488. Epub 2012 May 11.


Risk of anal cancer in HIV-infected and HIV-uninfected individuals in North America.

Silverberg MJ, Lau B, Justice AC, Engels E, Gill MJ, Goedert JJ, Kirk GD, D'Souza G, Bosch RJ, Brooks JT, Napravnik S, Hessol NA, Jacobson LP, Kitahata MM, Klein MB, Moore RD, Rodriguez B, Rourke SB, Saag MS, Sterling TR, Gebo KA, Press N, Martin JN, Dubrow R; North American AIDS Cohort Collaboration on Research and Design (NA-ACCORD) of IeDEA.

Clin Infect Dis. 2012 Apr;54(7):1026-34. doi: 10.1093/cid/cir1012. Epub 2012 Jan 30.


IRB perspectives on the return of individual results from genomic research.

Dressler LG, Smolek S, Ponsaran R, Markey JM, Starks H, Gerson N, Lewis S, Press N, Juengst E, Wiesner GL; GRRIP Consortium.

Genet Med. 2012 Feb;14(2):215-22. doi: 10.1038/gim.2011.10. Epub 2012 Jan 5.


Who is attending? End-of-life decision making in the intensive care unit.

Baggs JG, Schmitt MH, Prendergast TJ, Norton SA, Sellers CR, Quinn JR, Press N.

J Palliat Med. 2012 Jan;15(1):56-62. doi: 10.1089/jpm.2011.0307. Epub 2012 Jan 10.


Predictors of recruited melanoma families into a behavioral intervention project.

Bowen DJ, Hay JL, Mayer J, Kuniyuki A, Meischke H, Harris J, Asgari M, Shoveller J, Press N, Burke W.

Contemp Clin Trials. 2012 Jan;33(1):85-92. doi: 10.1016/j.cct.2011.09.016. Epub 2011 Oct 8.


Feasibility of incorporating self-collected rectal swabs into a community venue-based survey to measure the prevalence of HPV infection in men who have sex with men.

Gilbert M, Kwag M, Mei W, Rank C, Kropp R, Severini A, van Niekerk D, Zhou C, Press N, Ogilvie G, Wong T; ManCount Study Team.

Sex Transm Dis. 2011 Oct;38(10):964-9. doi: 10.1097/OLQ.0b013e318222899d.


Genetic screening.

Burke W, Tarini B, Press NA, Evans JP.

Epidemiol Rev. 2011;33:148-64. doi: 10.1093/epirev/mxr008. Epub 2011 Jun 27. Review.


Microwave-mediated synthesis of an arylboronate library.

Spencer J, Baltus CB, Patel H, Press NJ, Callear SK, Male L, Coles SJ.

ACS Comb Sci. 2011 Jan 10;13(1):24-31. doi: 10.1021/co100011g. Epub 2010 Nov 10.


Personal attributions for melanoma risk in melanoma-affected patients and family members.

Hay J, DiBonaventura M, Baser R, Press N, Shoveller J, Bowen D.

J Behav Med. 2011 Feb;34(1):53-63. doi: 10.1007/s10865-010-9286-4. Epub 2010 Sep 1.


Progress towards novel adenosine receptor therapeutics gleaned from the recent patent literature.

Press NJ, Fozard JR.

Expert Opin Ther Pat. 2010 Aug;20(8):987-1005. doi: 10.1517/13543776.2010.495388. Review.


Debating clinical utility.

Burke W, Laberge AM, Press N.

Public Health Genomics. 2010;13(4):215-23. doi: 10.1159/000279623. Epub 2010 Apr 15.


A common intracellular allosteric binding site for antagonists of the CXCR2 receptor.

Salchow K, Bond ME, Evans SC, Press NJ, Charlton SJ, Hunt PA, Bradley ME.

Br J Pharmacol. 2010 Apr;159(7):1429-39. doi: 10.1111/j.1476-5381.2009.00623.x. Epub 2010 Mar 3.


Using a family systems approach to investigate cancer risk communication within melanoma families.

Harris JN, Hay J, Kuniyuki A, Asgari MM, Press N, Bowen DJ.

Psychooncology. 2010 Oct;19(10):1102-11. doi: 10.1002/pon.1667.


Breast cancer risk communication: assessment of primary care physicians by standardized patients.

Culver JO, Bowen DJ, Reynolds SE, Pinsky LE, Press N, Burke W.

Genet Med. 2009 Oct;11(10):735-41. doi: 10.1097/GIM.0b013e3181b2e5eb.


Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease.

Banner KH, Press NJ.

Br J Pharmacol. 2009 Jul;157(6):892-906. doi: 10.1111/j.1476-5381.2009.00170.x. Epub 2009 Jun 5. Review.


PDE4 inhibitors - a review of the current field.

Press NJ, Banner KH.

Prog Med Chem. 2009;47:37-74. doi: 10.1016/S0079-6468(08)00202-6. Review. No abstract available.


Genetic assessment of breast cancer risk in primary care practice.

Burke W, Culver J, Pinsky L, Hall S, Reynolds SE, Yasui Y, Press N.

Am J Med Genet A. 2009 Mar;149A(3):349-56. doi: 10.1002/ajmg.a.32643.


Translational genomics: seeking a shared vision of benefit.

Burke W, Kuszler P, Starks H, Holland S, Press N.

Am J Bioeth. 2008 Mar;8(3):54-6; discussion W1-3. doi: 10.1080/15265160802109488. No abstract available.


Performance of the U.S. Office of Management and Budget's Revised Race and Ethnicity Categories in Asian Populations*

Holup JL, Press N, Vollmer WM, Harris EL, Vogt TM, Chen C.

Int J Intercult Relat. 2007 Sep;31(5):561-573.

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