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Items: 48


A mutation-independent approach for muscular dystrophy via upregulation of a modifier gene.

Kemaladewi DU, Bassi PS, Erwood S, Al-Basha D, Gawlik KI, Lindsay K, Hyatt E, Kember R, Place KM, Marks RM, Durbeej M, Prescott SA, Ivakine EA, Cohn RD.

Nature. 2019 Aug;572(7767):125-130. doi: 10.1038/s41586-019-1430-x. Epub 2019 Jul 24.


Chloride Dysregulation through Downregulation of KCC2 Mediates Neuropathic Pain in Both Sexes.

Mapplebeck JCS, Lorenzo LE, Lee KY, Gauthier C, Muley MM, De Koninck Y, Prescott SA, Salter MW.

Cell Rep. 2019 Jul 16;28(3):590-596.e4. doi: 10.1016/j.celrep.2019.06.059.


Differentially synchronized spiking enables multiplexed neural coding.

Lankarany M, Al-Basha D, Ratté S, Prescott SA.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10097-10102. doi: 10.1073/pnas.1812171116. Epub 2019 Apr 26.


Electrophysiology equipment for reliable study of kHz electrical stimulation.

FallahRad M, Zannou AL, Khadka N, Prescott SA, Ratté S, Zhang T, Esteller R, Hershey B, Bikson M.

J Physiol. 2019 Apr;597(8):2131-2137. doi: 10.1113/JP277654. Epub 2019 Mar 18.


Microglial pannexin-1 channel activation is a spinal determinant of joint pain.

Mousseau M, Burma NE, Lee KY, Leduc-Pessah H, Kwok CHT, Reid AR, O'Brien M, Sagalajev B, Stratton JA, Patrick N, Stemkowski PL, Biernaskie J, Zamponi GW, Salo P, McDougall JJ, Prescott SA, Matyas JR, Trang T.

Sci Adv. 2018 Aug 8;4(8):eaas9846. doi: 10.1126/sciadv.aas9846. eCollection 2018 Aug.


Lionfish venom elicits pain predominantly through the activation of nonpeptidergic nociceptors.

Mouchbahani-Constance S, Lesperance LS, Petitjean H, Davidova A, Macpherson A, Prescott SA, Sharif-Naeini R.

Pain. 2018 Nov;159(11):2255-2266. doi: 10.1097/j.pain.0000000000001326.


Sensory Afferents Use Different Coding Strategies for Heat and Cold.

Wang F, Bélanger E, Côté SL, Desrosiers P, Prescott SA, Côté DC, De Koninck Y.

Cell Rep. 2018 May 15;23(7):2001-2013. doi: 10.1016/j.celrep.2018.04.065.


Using dynamic clamp to quantify pathological changes in the excitability of primary somatosensory neurons.

Takkala P, Prescott SA.

J Physiol. 2018 Jun;596(11):2209-2227. doi: 10.1113/JP275580. Epub 2018 May 10.


Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons.

Balachandar A, Prescott SA.

J Physiol. 2018 May 1;596(9):1681-1697. doi: 10.1113/JP275240. Epub 2018 Feb 21.


Nonlinear Relationship Between Spike-Dependent Calcium Influx and TRPC Channel Activation Enables Robust Persistent Spiking in Neurons of the Anterior Cingulate Cortex.

Ratté S, Karnup S, Prescott SA.

J Neurosci. 2018 Feb 14;38(7):1788-1801. doi: 10.1523/JNEUROSCI.0538-17.2018. Epub 2018 Jan 15.


Artifactual hyperpolarization during extracellular electrical stimulation: Proposed mechanism of high-rate neuromodulation disproved.

Lesperance LS, Lankarany M, Zhang TC, Esteller R, Ratté S, Prescott SA.

Brain Stimul. 2018 May - Jun;11(3):582-591. doi: 10.1016/j.brs.2017.12.004. Epub 2017 Dec 15.


Changes in White Matter Microstructure Impact Cognition by Disrupting the Ability of Neural Assemblies to Synchronize.

Bells S, Lefebvre J, Prescott SA, Dockstader C, Bouffet E, Skocic J, Laughlin S, Mabbott DJ.

J Neurosci. 2017 Aug 23;37(34):8227-8238. doi: 10.1523/JNEUROSCI.0560-17.2017. Epub 2017 Jul 25.


Combined Changes in Chloride Regulation and Neuronal Excitability Enable Primary Afferent Depolarization to Elicit Spiking without Compromising its Inhibitory Effects.

Takkala P, Zhu Y, Prescott SA.

PLoS Comput Biol. 2016 Nov 11;12(11):e1005215. doi: 10.1371/journal.pcbi.1005215. eCollection 2016 Nov.


Chloride Regulation: A Dynamic Equilibrium Crucial for Synaptic Inhibition.

Doyon N, Vinay L, Prescott SA, De Koninck Y.

Neuron. 2016 Mar 16;89(6):1157-1172. doi: 10.1016/j.neuron.2016.02.030. Review.


Mild KCC2 Hypofunction Causes Inconspicuous Chloride Dysregulation that Degrades Neural Coding.

Doyon N, Prescott SA, De Koninck Y.

Front Cell Neurosci. 2016 Jan 29;9:516. doi: 10.3389/fncel.2015.00516. eCollection 2015.


Physiological Dynamics in Demyelinating Diseases: Unraveling Complex Relationships through Computer Modeling.

Coggan JS, Bittner S, Stiefel KM, Meuth SG, Prescott SA.

Int J Mol Sci. 2015 Sep 7;16(9):21215-36. doi: 10.3390/ijms160921215. Review.


Afferent hyperexcitability in neuropathic pain and the inconvenient truth about its degeneracy.

Ratté S, Prescott SA.

Curr Opin Neurobiol. 2016 Feb;36:31-7. doi: 10.1016/j.conb.2015.08.007. Epub 2015 Sep 11. Review.


Regulation of Cortical Dynamic Range by Background Synaptic Noise and Feedforward Inhibition.

Khubieh A, Ratté S, Lankarany M, Prescott SA.

Cereb Cortex. 2016 Aug;26(8):3357-69. doi: 10.1093/cercor/bhv157. Epub 2015 Jul 24.


Cooperativity between remote sites of ectopic spiking allows afterdischarge to be initiated and maintained at different locations.

Coggan JS, Sejnowski TJ, Prescott SA.

J Comput Neurosci. 2015 Aug;39(1):17-28. doi: 10.1007/s10827-015-0562-8. Epub 2015 May 1.


Synaptic inhibition and disinhibition in the spinal dorsal horn.

Prescott SA.

Prog Mol Biol Transl Sci. 2015;131:359-83. doi: 10.1016/bs.pmbts.2014.11.008. Epub 2015 Jan 30. Review.


Inhibitory regulation of the pain gate and how its failure causes pathological pain.

Price TJ, Prescott SA.

Pain. 2015 May;156(5):789-92. doi: 10.1097/j.pain.0000000000000139. Review. No abstract available.


Subthreshold membrane currents confer distinct tuning properties that enable neurons to encode the integral or derivative of their input.

Ratté S, Lankarany M, Rho YA, Patterson A, Prescott SA.

Front Cell Neurosci. 2015 Jan 9;8:452. doi: 10.3389/fncel.2014.00452. eCollection 2014.


Novel method to assess axonal excitability using channelrhodopsin-based photoactivation.

Zhu Y, Feng B, Schwartz ES, Gebhart GF, Prescott SA.

J Neurophysiol. 2015 Apr 1;113(7):2242-9. doi: 10.1152/jn.00982.2014. Epub 2015 Jan 21.


Normal and abnormal coding of somatosensory stimuli causing pain.

Prescott SA, Ma Q, De Koninck Y.

Nat Neurosci. 2014 Feb;17(2):183-91. doi: 10.1038/nn.3629. Epub 2014 Jan 28. Review.


Impact of neuronal properties on network coding: roles of spike initiation dynamics and robust synchrony transfer.

Ratté S, Hong S, De Schutter E, Prescott SA.

Neuron. 2013 Jun 5;78(5):758-72. doi: 10.1016/j.neuron.2013.05.030.


Identification of molecular pathologies sufficient to cause neuropathic excitability in primary somatosensory afferents using dynamical systems theory.

Rho YA, Prescott SA.

PLoS Comput Biol. 2012;8(5):e1002524. doi: 10.1371/journal.pcbi.1002524. Epub 2012 May 24.


Pain processing by spinal microcircuits: afferent combinatorics.

Prescott SA, Ratté S.

Curr Opin Neurobiol. 2012 Aug;22(4):631-9. doi: 10.1016/j.conb.2012.02.010. Epub 2012 Mar 10.


Single neuron firing properties impact correlation-based population coding.

Hong S, Ratté S, Prescott SA, De Schutter E.

J Neurosci. 2012 Jan 25;32(4):1413-28. doi: 10.1523/JNEUROSCI.3735-11.2012.


Explaining pathological changes in axonal excitability through dynamical analysis of conductance-based models.

Coggan JS, Ocker GK, Sejnowski TJ, Prescott SA.

J Neural Eng. 2011 Dec;8(6):065002. doi: 10.1088/1741-2560/8/6/065002. Epub 2011 Nov 4.


ClC-2 channels regulate neuronal excitability, not intracellular chloride levels.

Ratté S, Prescott SA.

J Neurosci. 2011 Nov 2;31(44):15838-43. doi: 10.1523/JNEUROSCI.2748-11.2011.


Efficacy of synaptic inhibition depends on multiple, dynamically interacting mechanisms implicated in chloride homeostasis.

Doyon N, Prescott SA, Castonguay A, Godin AG, Kröger H, De Koninck Y.

PLoS Comput Biol. 2011 Sep;7(9):e1002149. doi: 10.1371/journal.pcbi.1002149. Epub 2011 Sep 8.


Imbalance of ionic conductances contributes to diverse symptoms of demyelination.

Coggan JS, Prescott SA, Bartol TM, Sejnowski TJ.

Proc Natl Acad Sci U S A. 2010 Nov 30;107(48):20602-9. doi: 10.1073/pnas.1013798107. Epub 2010 Oct 25.


Chloride regulation in the pain pathway.

Price TJ, Cervero F, Gold MS, Hammond DL, Prescott SA.

Brain Res Rev. 2009 Apr;60(1):149-70. doi: 10.1016/j.brainresrev.2008.12.015. Epub 2008 Dec 31. Review.


Spike-rate coding and spike-time coding are affected oppositely by different adaptation mechanisms.

Prescott SA, Sejnowski TJ.

J Neurosci. 2008 Dec 10;28(50):13649-61. doi: 10.1523/JNEUROSCI.1792-08.2008.


Biophysical basis for three distinct dynamical mechanisms of action potential initiation.

Prescott SA, De Koninck Y, Sejnowski TJ.

PLoS Comput Biol. 2008 Oct;4(10):e1000198. doi: 10.1371/journal.pcbi.1000198. Epub 2008 Oct 10.


Pyramidal neurons switch from integrators in vitro to resonators under in vivo-like conditions.

Prescott SA, Ratté S, De Koninck Y, Sejnowski TJ.

J Neurophysiol. 2008 Dec;100(6):3030-42. doi: 10.1152/jn.90634.2008. Epub 2008 Oct 1.


Hippocampal bursts caused by changes in NMDA receptor-dependent excitation in a mouse model of variant CJD.

Ratté S, Prescott SA, Collinge J, Jefferys JG.

Neurobiol Dis. 2008 Oct;32(1):96-104. doi: 10.1016/j.nbd.2008.06.007. Epub 2008 Jun 26.


Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain.

Coull JA, Boudreau D, Bachand K, Prescott SA, Nault F, Sík A, De Koninck P, De Koninck Y.

Nature. 2003 Aug 21;424(6951):938-42.


Gain control of firing rate by shunting inhibition: roles of synaptic noise and dendritic saturation.

Prescott SA, De Koninck Y.

Proc Natl Acad Sci U S A. 2003 Feb 18;100(4):2076-81. Epub 2003 Feb 4.


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