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Items: 1 to 50 of 137

1.

Phosphorylation of Parkin at serine 65 is essential for its activation in vivo.

McWilliams TG, Barini E, Pohjolan-Pirhonen R, Brooks SP, Singh F, Burel S, Balk K, Kumar A, Montava-Garriga L, Prescott AR, Hassoun SM, Mouton-Liger F, Ball G, Hills R, Knebel A, Ulusoy A, Di Monte DA, Tamjar J, Antico O, Fears K, Smith L, Brambilla R, Palin E, Valori M, Eerola-Rautio J, Tienari P, Corti O, Dunnett SB, Ganley IG, Suomalainen A, Muqit MMK.

Open Biol. 2018 Nov 7;8(11). pii: 180108. doi: 10.1098/rsob.180108.

2.

Basal Mitophagy Occurs Independently of PINK1 in Mouse Tissues of High Metabolic Demand.

McWilliams TG, Prescott AR, Montava-Garriga L, Ball G, Singh F, Barini E, Muqit MMK, Brooks SP, Ganley IG.

Cell Metab. 2018 Feb 6;27(2):439-449.e5. doi: 10.1016/j.cmet.2017.12.008. Epub 2018 Jan 11.

3.

Mechanism of activation of SGK3 by growth factors via the Class 1 and Class 3 PI3Ks.

Malik N, Macartney T, Hornberger A, Anderson KE, Tovell H, Prescott AR, Alessi DR.

Biochem J. 2018 Jan 2;475(1):117-135. doi: 10.1042/BCJ20170650.

4.

Bifunctionality of a biofilm matrix protein controlled by redox state.

Arnaouteli S, Ferreira AS, Schor M, Morris RJ, Bromley KM, Jo J, Cortez KL, Sukhodub T, Prescott AR, Dietrich LEP, MacPhee CE, Stanley-Wall NR.

Proc Natl Acad Sci U S A. 2017 Jul 25;114(30):E6184-E6191. doi: 10.1073/pnas.1707687114. Epub 2017 Jul 11.

5.

Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification.

Fernandez-Alonso R, Davidson L, Hukelmann J, Zengerle M, Prescott AR, Lamond A, Ciulli A, Sapkota GP, Findlay GM.

EMBO Rep. 2017 Jul;18(7):1108-1122. doi: 10.15252/embr.201643534. Epub 2017 Jun 6.

6.

mito-QC illuminates mitophagy and mitochondrial architecture in vivo.

McWilliams TG, Prescott AR, Allen GF, Tamjar J, Munson MJ, Thomson C, Muqit MM, Ganley IG.

J Cell Biol. 2016 Aug 1;214(3):333-45. doi: 10.1083/jcb.201603039. Epub 2016 Jul 25.

7.

The E3 ubiquitin ligase ZNRF2 is a substrate of mTORC1 and regulates its activation by amino acids.

Hoxhaj G, Caddye E, Najafov A, Houde VP, Johnson C, Dissanayake K, Toth R, Campbell DG, Prescott AR, MacKintosh C.

Elife. 2016 Apr 22;5. pii: e12278. doi: 10.7554/eLife.12278.

8.

The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning.

Zaru R, Matthews SP, Edgar AJ, Prescott AR, Gomez-Nicola D, Hanauer A, Watts C.

J Immunol. 2015 Nov 1;195(9):4264-72. doi: 10.4049/jimmunol.1501520. Epub 2015 Sep 23.

9.

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation.

Kazlauskaite A, Martínez-Torres RJ, Wilkie S, Kumar A, Peltier J, Gonzalez A, Johnson C, Zhang J, Hope AG, Peggie M, Trost M, van Aalten DM, Alessi DR, Prescott AR, Knebel A, Walden H, Muqit MM.

EMBO Rep. 2015 Aug;16(8):939-54. doi: 10.15252/embr.201540352. Epub 2015 Jun 25.

10.

A key role for PTP1B in dendritic cell maturation, migration, and T cell activation.

Martin-Granados C, Prescott AR, Le Sommer S, Klaska IP, Yu T, Muckersie E, Giuraniuc CV, Grant L, Delibegovic M, Forrester JV.

J Mol Cell Biol. 2015 Dec;7(6):517-28. doi: 10.1093/jmcb/mjv032. Epub 2015 Jun 10.

PMID:
26063615
11.

High-resolution quantitative proteome analysis reveals substantial differences between phagosomes of RAW 264.7 and bone marrow derived macrophages.

Guo M, Härtlova A, Dill BD, Prescott AR, Gierliński M, Trost M.

Proteomics. 2015 Sep;15(18):3169-74. doi: 10.1002/pmic.201400431. Epub 2015 Feb 5.

12.
13.

Characterization of VPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class III phosphoinositide 3-kinase.

Bago R, Malik N, Munson MJ, Prescott AR, Davies P, Sommer E, Shpiro N, Ward R, Cross D, Ganley IG, Alessi DR.

Biochem J. 2014 Nov 1;463(3):413-27. doi: 10.1042/BJ20140889.

14.

Interplay between Polo kinase, LKB1-activated NUAK1 kinase, PP1βMYPT1 phosphatase complex and the SCFβTrCP E3 ubiquitin ligase.

Banerjee S, Zagórska A, Deak M, Campbell DG, Prescott AR, Alessi DR.

Biochem J. 2014 Jul 15;461(2):233-45. doi: 10.1042/BJ20140408.

15.

Biochemical analysis of TssK, a core component of the bacterial Type VI secretion system, reveals distinct oligomeric states of TssK and identifies a TssK-TssFG subcomplex.

English G, Byron O, Cianfanelli FR, Prescott AR, Coulthurst SJ.

Biochem J. 2014 Jul 15;461(2):291-304. doi: 10.1042/BJ20131426.

16.

Time-resolved quantitative proteomics implicates the core snRNP protein SmB together with SMN in neural trafficking.

Prescott AR, Bales A, James J, Trinkle-Mulcahy L, Sleeman JE.

J Cell Sci. 2014 Feb 15;127(Pt 4):812-27. doi: 10.1242/jcs.137703. Epub 2013 Dec 19.

17.
18.

Characterization of WZ4003 and HTH-01-015 as selective inhibitors of the LKB1-tumour-suppressor-activated NUAK kinases.

Banerjee S, Buhrlage SJ, Huang HT, Deng X, Zhou W, Wang J, Traynor R, Prescott AR, Alessi DR, Gray NS.

Biochem J. 2014 Jan 1;457(1):215-25. doi: 10.1042/BJ20131152.

19.

p53 and cell cycle independent dysregulation of autophagy in chronic lymphocytic leukaemia.

Groves MJ, Johnson CE, James J, Prescott AR, Cunningham J, Haydock S, Pepper C, Fegan C, Pirrie L, Westwood NJ, Coates PJ, Ganley IG, Tauro S.

Br J Cancer. 2013 Oct 29;109(9):2434-44. doi: 10.1038/bjc.2013.601. Epub 2013 Oct 3.

20.

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects.

Saunders SP, Goh CS, Brown SJ, Palmer CN, Porter RM, Cole C, Campbell LE, Gierlinski M, Barton GJ, Schneider G, Balmain A, Prescott AR, Weidinger S, Baurecht H, Kabesch M, Gieger C, Lee YA, Tavendale R, Mukhopadhyay S, Turner SW, Madhok VB, Sullivan FM, Relton C, Burn J, Meggitt S, Smith CH, Allen MA, Barker JN, Reynolds NJ, Cordell HJ, Irvine AD, McLean WH, Sandilands A, Fallon PG.

J Allergy Clin Immunol. 2013 Nov;132(5):1121-9. doi: 10.1016/j.jaci.2013.08.046. Epub 2013 Sep 29.

21.

A synthetic system for expression of components of a bacterial microcompartment.

Sargent F, Davidson FA, Kelly CL, Binny R, Christodoulides N, Gibson D, Johansson E, Kozyrska K, Lado LL, Maccallum J, Montague R, Ortmann B, Owen R, Coulthurst SJ, Dupuy L, Prescott AR, Palmer T.

Microbiology. 2013 Nov;159(Pt 11):2427-36. doi: 10.1099/mic.0.069922-0. Epub 2013 Sep 6.

22.

Protein phosphatase 4 is phosphorylated and inactivated by Cdk in response to spindle toxins and interacts with γ-tubulin.

Voss M, Campbell K, Saranzewa N, Campbell DG, Hastie CJ, Peggie MW, Martin-Granados C, Prescott AR, Cohen PT.

Cell Cycle. 2013 Sep 1;12(17):2876-87. doi: 10.4161/cc.25919. Epub 2013 Aug 2.

23.

BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm.

Hobley L, Ostrowski A, Rao FV, Bromley KM, Porter M, Prescott AR, MacPhee CE, van Aalten DM, Stanley-Wall NR.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13600-5. doi: 10.1073/pnas.1306390110. Epub 2013 Jul 31. Erratum in: Proc Natl Acad Sci U S A. 2015 Sep 22;112(38):E5371-5.

24.

The specificity of the interaction between αB-crystallin and desmin filaments and its impact on filament aggregation and cell viability.

Elliott JL, Der Perng M, Prescott AR, Jansen KA, Koenderink GH, Quinlan RA.

Philos Trans R Soc Lond B Biol Sci. 2013 Mar 25;368(1617):20120375. doi: 10.1098/rstb.2012.0375. Print 2013 May 5.

25.

Dysregulation of autophagy in chronic lymphocytic leukemia with the small-molecule Sirtuin inhibitor Tenovin-6.

MacCallum SF, Groves MJ, James J, Murray K, Appleyard V, Prescott AR, Drbal AA, Nicolaou A, Cunningham J, Haydock S, Ganley IG, Westwood NJ, Coates PJ, Lain S, Tauro S.

Sci Rep. 2013;3:1275. doi: 10.1038/srep01275.

26.

A role for PP1/NIPP1 in steering migration of human cancer cells.

Martin-Granados C, Prescott AR, Van Dessel N, Van Eynde A, Arocena M, Klaska IP, Görnemann J, Beullens M, Bollen M, Forrester JV, McCaig CD.

PLoS One. 2012;7(7):e40769. doi: 10.1371/journal.pone.0040769. Epub 2012 Jul 16.

27.

ZNRF2 is released from membranes by growth factors and, together with ZNRF1, regulates the Na+/K+ATPase.

Hoxhaj G, Najafov A, Toth R, Campbell DG, Prescott AR, MacKintosh C.

J Cell Sci. 2012 Oct 1;125(Pt 19):4662-75. doi: 10.1242/jcs.110296. Epub 2012 Jul 13.

28.

Cellular responses to the metal-binding properties of metformin.

Logie L, Harthill J, Patel K, Bacon S, Hamilton DL, Macrae K, McDougall G, Wang HH, Xue L, Jiang H, Sakamoto K, Prescott AR, Rena G.

Diabetes. 2012 Jun;61(6):1423-33. doi: 10.2337/db11-0961. Epub 2012 Apr 9.

29.

The anti-neurodegenerative agent clioquinol regulates the transcription factor FOXO1a.

Cameron AR, Wallace K, Logie L, Prescott AR, Unterman TG, Harthill J, Rena G.

Biochem J. 2012 Apr 1;443(1):57-64. doi: 10.1042/BJ20112124.

PMID:
22248233
30.

Evolution of the vertebrate beaded filament protein, Bfsp2; comparing the in vitro assembly properties of a "tailed" zebrafish Bfsp2 to its "tailless" human orthologue.

Qu B, Landsbury A, Schönthaler HB, Dahm R, Liu Y, Clark JI, Prescott AR, Quinlan RA.

Exp Eye Res. 2012 Jan;94(1):192-202. doi: 10.1016/j.exer.2011.12.001. Epub 2011 Dec 11.

31.

Homeostasis in the vertebrate lens: mechanisms of solute exchange.

Dahm R, van Marle J, Quinlan RA, Prescott AR, Vrensen GF.

Philos Trans R Soc Lond B Biol Sci. 2011 Apr 27;366(1568):1265-77. doi: 10.1098/rstb.2010.0299. Review.

32.

Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways.

Richardson C, Sakamoto K, de los Heros P, Deak M, Campbell DG, Prescott AR, Alessi DR.

J Cell Sci. 2011 Mar 1;124(Pt 5):789-800. doi: 10.1242/jcs.077230.

33.

ERK/p90(RSK)/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicúa.

Dissanayake K, Toth R, Blakey J, Olsson O, Campbell DG, Prescott AR, MacKintosh C.

Biochem J. 2011 Feb 1;433(3):515-25. doi: 10.1042/BJ20101562.

34.

Inhibition of LRRK2 kinase activity leads to dephosphorylation of Ser(910)/Ser(935), disruption of 14-3-3 binding and altered cytoplasmic localization.

Dzamko N, Deak M, Hentati F, Reith AD, Prescott AR, Alessi DR, Nichols RJ.

Biochem J. 2010 Sep 15;430(3):405-13. doi: 10.1042/BJ20100784.

35.

14-3-3 binding to LRRK2 is disrupted by multiple Parkinson's disease-associated mutations and regulates cytoplasmic localization.

Nichols RJ, Dzamko N, Morrice NA, Campbell DG, Deak M, Ordureau A, Macartney T, Tong Y, Shen J, Prescott AR, Alessi DR.

Biochem J. 2010 Sep 15;430(3):393-404. doi: 10.1042/BJ20100483.

36.

New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.

Zagórska A, Deak M, Campbell DG, Banerjee S, Hirano M, Aizawa S, Prescott AR, Alessi DR.

Sci Signal. 2010 Mar 30;3(115):ra25. doi: 10.1126/scisignal.2000616.

37.

Fate of glycosylphosphatidylinositol (GPI)-less procyclin and characterization of sialylated non-GPI-anchored surface coat molecules of procyclic-form Trypanosoma brucei.

Güther ML, Beattie K, Lamont DJ, James J, Prescott AR, Ferguson MA.

Eukaryot Cell. 2009 Sep;8(9):1407-17. doi: 10.1128/EC.00178-09. Epub 2009 Jul 24.

38.

Activated cAMP receptors switch encystation into sporulation.

Kawabe Y, Morio T, James JL, Prescott AR, Tanaka Y, Schaap P.

Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7089-94. doi: 10.1073/pnas.0901617106. Epub 2009 Apr 14.

39.

TLR ligand-induced podosome disassembly in dendritic cells is ADAM17 dependent.

West MA, Prescott AR, Chan KM, Zhou Z, Rose-John S, Scheller J, Watts C.

J Cell Biol. 2008 Sep 8;182(5):993-1005. doi: 10.1083/jcb.200801022. Epub 2008 Sep 1.

40.

Expression and localisation of apical junctional complex proteins in lens epithelial cells.

Sugiyama Y, Prescott AR, Tholozan FM, Ohno S, Quinlan RA.

Exp Eye Res. 2008 Jul;87(1):64-70. doi: 10.1016/j.exer.2008.03.017. Epub 2008 Apr 3.

PMID:
18508048
41.

Depletion of protein phosphatase 4 in human cells reveals essential roles in centrosome maturation, cell migration and the regulation of Rho GTPases.

Martin-Granados C, Philp A, Oxenham SK, Prescott AR, Cohen PT.

Int J Biochem Cell Biol. 2008;40(10):2315-32. doi: 10.1016/j.biocel.2008.03.021. Epub 2008 Apr 8.

PMID:
18487071
42.

The synthesis of UDP-N-acetylglucosamine is essential for bloodstream form trypanosoma brucei in vitro and in vivo and UDP-N-acetylglucosamine starvation reveals a hierarchy in parasite protein glycosylation.

Stokes MJ, Güther ML, Turnock DC, Prescott AR, Martin KL, Alphey MS, Ferguson MA.

J Biol Chem. 2008 Jun 6;283(23):16147-61. doi: 10.1074/jbc.M709581200. Epub 2008 Apr 1.

43.

A role for ARF6 in dendritic cell podosome formation and migration.

Svensson HG, West MA, Mollahan P, Prescott AR, Zaru R, Watts C.

Eur J Immunol. 2008 Mar;38(3):818-28. doi: 10.1002/eji.200737331.

44.

TPL2-mediated activation of ERK1 and ERK2 regulates the processing of pre-TNF alpha in LPS-stimulated macrophages.

Rousseau S, Papoutsopoulou M, Symons A, Cook D, Lucocq JM, Prescott AR, O'Garra A, Ley SC, Cohen P.

J Cell Sci. 2008 Jan 15;121(Pt 2):149-54. doi: 10.1242/jcs.018671.

45.

Endocytosis of DNA-Hsp65 alters the pH of the late endosome/lysosome and interferes with antigen presentation.

Trombone AP, Silva CL, Lima KM, Oliver C, Jamur MC, Prescott AR, Coelho-Castelo AA.

PLoS One. 2007 Sep 26;2(9):e923.

46.

Reorganization of centrosomal marker proteins coincides with epithelial cell differentiation in the vertebrate lens.

Dahm R, Procter JE, Ireland ME, Lo WK, Mogensen MM, Quinlan RA, Prescott AR.

Exp Eye Res. 2007 Nov;85(5):696-713. Epub 2007 Aug 15.

PMID:
17888905
47.

FGF-2 release from the lens capsule by MMP-2 maintains lens epithelial cell viability.

Tholozan FM, Gribbon C, Li Z, Goldberg MW, Prescott AR, McKie N, Quinlan RA.

Mol Biol Cell. 2007 Nov;18(11):4222-31. Epub 2007 Aug 15.

48.

Ninein is released from the centrosome and moves bi-directionally along microtubules.

Moss DK, Bellett G, Carter JM, Liovic M, Keynton J, Prescott AR, Lane EB, Mogensen MM.

J Cell Sci. 2007 Sep 1;120(Pt 17):3064-74. Epub 2007 Aug 14.

49.

Regulation of activity and localization of the WNK1 protein kinase by hyperosmotic stress.

Zagórska A, Pozo-Guisado E, Boudeau J, Vitari AC, Rafiqi FH, Thastrup J, Deak M, Campbell DG, Morrice NA, Prescott AR, Alessi DR.

J Cell Biol. 2007 Jan 1;176(1):89-100. Epub 2006 Dec 26.

50.

Burkholderia phymatum is a highly effective nitrogen-fixing symbiont of Mimosa spp. and fixes nitrogen ex planta.

Elliott GN, Chen WM, Chou JH, Wang HC, Sheu SY, Perin L, Reis VM, Moulin L, Simon MF, Bontemps C, Sutherland JM, Bessi R, de Faria SM, Trinick MJ, Prescott AR, Sprent JI, James EK.

New Phytol. 2007;173(1):168-80.

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