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Letter by Reynolds et al Regarding Article, "Hemoglobin β93 Cysteine Is Not Required for Export of Nitric Oxide Bioactivity From the Red Blood Cell".

Reynolds JD, Premont RT, Stamler JS.

Circulation. 2019 Nov 5;140(19):e758-e759. doi: 10.1161/CIRCULATIONAHA.119.041389. Epub 2019 Nov 4. No abstract available.


Single cell RNA sequencing identifies YAP1-dependent hepatic mesothelial progenitors in fibrolamellar carcinoma.

Jewell ML, Gibson JR, Guy CD, Hyun J, Du K, Oh SH, Premont RT, Hsu DS, Ribar T, Gregory SG, Diehl AM.

Am J Pathol. 2019 Oct 24. pii: S0002-9440(19)30770-9. doi: 10.1016/j.ajpath.2019.09.018. [Epub ahead of print]


AKR1A1 is a novel mammalian S-nitroso-glutathione reductase.

Stomberski CT, Anand P, Venetos NM, Hausladen A, Zhou HL, Premont RT, Stamler JS.

J Biol Chem. 2019 Oct 23. pii: jbc.RA119.011067. doi: 10.1074/jbc.RA119.011067. [Epub ahead of print]


Role of Nitric Oxide Carried by Hemoglobin in Cardiovascular Physiology: Developments on a Three-Gas Respiratory Cycle.

Premont RT, Reynolds JD, Zhang R, Stamler JS.

Circ Res. 2019 Oct 8. doi: 10.1161/CIRCRESAHA.119.315626. [Epub ahead of print]


Dysregulated activation of fetal liver programme in acute liver failure.

Hyun J, Oh SH, Premont RT, Guy CD, Berg CL, Diehl AM.

Gut. 2019 Jun;68(6):1076-1087. doi: 10.1136/gutjnl-2018-317603. Epub 2019 Jan 22.


Niclosamide-induced Wnt signaling inhibition in colorectal cancer is mediated by autophagy.

Wang J, Ren XR, Piao H, Zhao S, Osada T, Premont RT, Mook RA Jr, Morse MA, Lyerly HK, Chen W.

Biochem J. 2019 Feb 8;476(3):535-546. doi: 10.1042/BCJ20180385.


GRK5 - A Functional Bridge Between Cardiovascular and Neurodegenerative Disorders.

Hendrickx JO, van Gastel J, Leysen H, Santos-Otte P, Premont RT, Martin B, Maudsley S.

Front Pharmacol. 2018 Dec 17;9:1484. doi: 10.3389/fphar.2018.01484. eCollection 2018. Review.


Microbial nitrogen limitation in the mammalian large intestine.

Reese AT, Pereira FC, Schintlmeister A, Berry D, Wagner M, Hale LP, Wu A, Jiang S, Durand HK, Zhou X, Premont RT, Diehl AM, O'Connell TM, Alberts SC, Kartzinel TR, Pringle RM, Dunn RR, Wright JP, David LA.

Nat Microbiol. 2018 Dec;3(12):1441-1450. doi: 10.1038/s41564-018-0267-7. Epub 2018 Oct 29.


RNA Binding Proteins Control Transdifferentiation of Hepatic Stellate Cells into Myofibroblasts.

Wang S, Jung Y, Hyun J, Friedersdorf M, Oh SH, Kim J, Premont RT, Keene JD, Diehl AM.

Cell Physiol Biochem. 2018;48(3):1215-1229. doi: 10.1159/000491987. Epub 2018 Jul 25.


Liver regeneration requires Yap1-TGFβ-dependent epithelial-mesenchymal transition in hepatocytes.

Oh SH, Swiderska-Syn M, Jewell ML, Premont RT, Diehl AM.

J Hepatol. 2018 Aug;69(2):359-367. doi: 10.1016/j.jhep.2018.05.008. Epub 2018 May 23.


GIT1 regulates synaptic structural plasticity underlying learning.

Martyn AC, Toth K, Schmalzigaug R, Hedrick NG, Rodriguiz RM, Yasuda R, Wetsel WC, Premont RT.

PLoS One. 2018 Mar 19;13(3):e0194350. doi: 10.1371/journal.pone.0194350. eCollection 2018.


GIT2-A keystone in ageing and age-related disease.

van Gastel J, Boddaert J, Jushaj A, Premont RT, Luttrell LM, Janssens J, Martin B, Maudsley S.

Ageing Res Rev. 2018 May;43:46-63. doi: 10.1016/j.arr.2018.02.002. Epub 2018 Feb 13. Review.


Hedgehog-YAP Signaling Pathway Regulates Glutaminolysis to Control Activation of Hepatic Stellate Cells.

Du K, Hyun J, Premont RT, Choi SS, Michelotti GA, Swiderska-Syn M, Dalton GD, Thelen E, Rizi BS, Jung Y, Diehl AM.

Gastroenterology. 2018 Apr;154(5):1465-1479.e13. doi: 10.1053/j.gastro.2017.12.022. Epub 2018 Jan 3.


β-Arrestin2 mediates progression of murine primary myelofibrosis.

Rein LA, Wisler JW, Kim J, Theriot B, Huang L, Price T, Yang H, Chen M, Chen W, Sipkins D, Fedoriw Y, Walker JK, Premont RT, Lefkowitz RJ.

JCI Insight. 2017 Dec 21;2(24). pii: 98094. doi: 10.1172/jci.insight.98094.


Niclosamide-conjugated polypeptide nanoparticles inhibit Wnt signaling and colon cancer growth.

Bhattacharyya J, Ren XR, Mook RA, Wang J, Spasojevic I, Premont RT, Li X, Chilkoti A, Chen W.

Nanoscale. 2017 Aug 31;9(34):12709-12717. doi: 10.1039/c7nr01973d.


Correction for Lu et al., "Nuclear GIT2 Is an ATM Substrate and Promotes DNA Repair".

Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S.

Mol Cell Biol. 2017 Aug 11;37(17). pii: e00310-17. doi: 10.1128/MCB.00310-17. Print 2017 Sep 1. No abstract available.


Loss of pericyte smoothened activity in mice with genetic deficiency of leptin.

Xie G, Swiderska-Syn M, Jewell ML, Machado MV, Michelotti GA, Premont RT, Diehl AM.

BMC Cell Biol. 2017 Apr 20;18(1):20. doi: 10.1186/s12860-017-0135-y.


Niclosamide: Beyond an antihelminthic drug.

Chen W, Mook RA Jr, Premont RT, Wang J.

Cell Signal. 2018 Jan;41:89-96. doi: 10.1016/j.cellsig.2017.04.001. Epub 2017 Apr 4. Review.


Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption.

Siddiqui S, Lustig A, Carter A, Sankar M, Daimon CM, Premont RT, Etienne H, van Gastel J, Azmi A, Janssens J, Becker KG, Zhang Y, Wood W, Lehrmann E, Martin JG, Martin B, Taub DD, Maudsley S.

Aging (Albany NY). 2017 Mar 4;9(3):706-740. doi: 10.18632/aging.101185.


Caveolin 1 and G-Protein-Coupled Receptor Kinase-2 Coregulate Endothelial Nitric Oxide Synthase Activity in Sinusoidal Endothelial Cells.

Liu S, Premont RT, Singh S, Rockey DC.

Am J Pathol. 2017 Apr;187(4):896-907. doi: 10.1016/j.ajpath.2016.11.017. Epub 2017 Feb 3.


Functional analysis of rare variants found in schizophrenia implicates a critical role for GIT1-PAK3 signaling in neuroplasticity.

Kim MJ, Biag J, Fass DM, Lewis MC, Zhang Q, Fleishman M, Gangwar SP, Machius M, Fromer M, Purcell SM, McCarroll SA, Rudenko G, Premont RT, Scolnick EM, Haggarty SJ.

Mol Psychiatry. 2017 Mar;22(3):417-429. doi: 10.1038/mp.2016.98. Epub 2016 Jul 26.


GRK5 Deficiency Leads to Selective Basal Forebrain Cholinergic Neuronal Vulnerability.

He M, Singh P, Cheng S, Zhang Q, Peng W, Ding X, Li L, Liu J, Premont RT, Morgan D, Burns JM, Swerdlow RH, Suo WZ.

Sci Rep. 2016 May 19;6:26116. doi: 10.1038/srep26116.


Expanding functions of GIT Arf GTPase-activating proteins, PIX Rho guanine nucleotide exchange factors and GIT-PIX complexes.

Zhou W, Li X, Premont RT.

J Cell Sci. 2016 May 15;129(10):1963-74. doi: 10.1242/jcs.179465. Review.


Hedgehog regulates yes-associated protein 1 in regenerating mouse liver.

Swiderska-Syn M, Xie G, Michelotti GA, Jewell ML, Premont RT, Syn WK, Diehl AM.

Hepatology. 2016 Jul;64(1):232-44. doi: 10.1002/hep.28542. Epub 2016 Apr 21.


Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease.

Machado MV, Michelotti GA, Jewell ML, Pereira TA, Xie G, Premont RT, Diehl AM.

Cell Death Dis. 2016 Feb 18;7:e2096. doi: 10.1038/cddis.2016.19.


GIT2 Acts as a Systems-Level Coordinator of Neurometabolic Activity and Pathophysiological Aging.

Martin B, Chadwick W, Janssens J, Premont RT, Schmalzigaug R, Becker KG, Lehrmann E, Wood WH, Zhang Y, Siddiqui S, Park SS, Cong WN, Daimon CM, Maudsley S.

Front Endocrinol (Lausanne). 2016 Jan 18;6:191. doi: 10.3389/fendo.2015.00191. eCollection 2015.


Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins.

Black JB, Premont RT, Daaka Y.

Semin Cell Dev Biol. 2016 Feb;50:95-104. doi: 10.1016/j.semcdb.2015.12.015. Epub 2016 Jan 7. Review.


Presynaptic Deletion of GIT Proteins Results in Increased Synaptic Strength at a Mammalian Central Synapse.

Montesinos MS, Dong W, Goff K, Das B, Guerrero-Given D, Schmalzigaug R, Premont RT, Satterfield R, Kamasawa N, Young SM Jr.

Neuron. 2015 Dec 2;88(5):918-925. doi: 10.1016/j.neuron.2015.10.042.


Structure-activity relationship studies of QS11, a small molecule Wnt synergistic agonist.

Singh MK, Gao H, Sun W, Song Z, Schmalzigaug R, Premont RT, Zhang Q.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4838-4842. doi: 10.1016/j.bmcl.2015.06.062. Epub 2015 Jun 23.


G protein-coupled receptor kinases: from molecules to diseases.

Gurevich EV, Premont RT, Gainetdinov RR.

FASEB J. 2015 Feb;29(2):361-4. doi: 10.1096/fj.14-263657ufm. No abstract available.


Nuclear GIT2 is an ATM substrate and promotes DNA repair.

Lu D, Cai H, Park SS, Siddiqui S, Premont RT, Schmalzigaug R, Paramasivam M, Seidman M, Bodogai I, Biragyn A, Daimon CM, Martin B, Maudsley S.

Mol Cell Biol. 2015 Apr;35(7):1081-96. doi: 10.1128/MCB.01432-14. Epub 2015 Jan 20. Erratum in: Mol Cell Biol. 2017 Aug 11;37(17 ):.


Pleiotrophin regulates the ductular reaction by controlling the migration of cells in liver progenitor niches.

Michelotti GA, Tucker A, Swiderska-Syn M, Machado MV, Choi SS, Kruger L, Soderblom E, Thompson JW, Mayer-Salman M, Himburg HA, Moylan CA, Guy CD, Garman KS, Premont RT, Chute JP, Diehl AM.

Gut. 2016 Apr;65(4):683-92. doi: 10.1136/gutjnl-2014-308176. Epub 2015 Jan 16.


Genetic Deletion of β-Arrestin-2 and the Mitigation of Established Airway Hyperresponsiveness in a Murine Asthma Model.

Chen M, Hegde A, Choi YH, Theriot BS, Premont RT, Chen W, Walker JK.

Am J Respir Cell Mol Biol. 2015 Sep;53(3):346-54. doi: 10.1165/rcmb.2014-0231OC.


Endothelial nitric-oxide synthase (eNOS) is activated through G-protein-coupled receptor kinase-interacting protein 1 (GIT1) tyrosine phosphorylation and Src protein.

Liu S, Premont RT, Rockey DC.

J Biol Chem. 2014 Jun 27;289(26):18163-74. doi: 10.1074/jbc.M113.521203. Epub 2014 Apr 24.


αPIX RhoGEF supports positive selection by restraining migration and promoting arrest of thymocytes.

Korthals M, Schilling K, Reichardt P, Mamula D, Schlüter T, Steiner M, Langnäse K, Thomas U, Gundelfinger E, Premont RT, Tedford K, Fischer KD.

J Immunol. 2014 Apr 1;192(7):3228-38. doi: 10.4049/jimmunol.1302585. Epub 2014 Mar 3.


Myofibroblastic cells function as progenitors to regenerate murine livers after partial hepatectomy.

Swiderska-Syn M, Syn WK, Xie G, Krüger L, Machado MV, Karaca G, Michelotti GA, Choi SS, Premont RT, Diehl AM.

Gut. 2014 Aug;63(8):1333-44. doi: 10.1136/gutjnl-2013-305962. Epub 2013 Oct 30.


Grk5l controls heart development by limiting mTOR signaling during symmetry breaking.

Burkhalter MD, Fralish GB, Premont RT, Caron MG, Philipp M.

Cell Rep. 2013 Aug 29;4(4):625-32. doi: 10.1016/j.celrep.2013.07.036. Epub 2013 Aug 22.


Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice.

Xie G, Karaca G, Swiderska-Syn M, Michelotti GA, Krüger L, Chen Y, Premont RT, Choi SS, Diehl AM.

Hepatology. 2013 Nov;58(5):1801-13. doi: 10.1002/hep.26511. Epub 2013 Sep 30.


Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication.

Gold JI, Gao E, Shang X, Premont RT, Koch WJ.

Circ Res. 2012 Sep 28;111(8):1048-53. Epub 2012 Aug 2.


The cytoskeletal regulatory scaffold protein GIT2 modulates mesenchymal stem cell differentiation and osteoblastogenesis.

Wang X, Liao S, Nelson ER, Schmalzigaug R, Spurney RF, Guilak F, Premont RT, Gesty-Palmer D.

Biochem Biophys Res Commun. 2012 Aug 24;425(2):407-12. doi: 10.1016/j.bbrc.2012.07.111. Epub 2012 Jul 27.


The role of GRK6 in animal models of Parkinson's disease and L-DOPA treatment.

Managò F, Espinoza S, Salahpour A, Sotnikova TD, Caron MG, Premont RT, Gainetdinov RR.

Sci Rep. 2012;2:301. doi: 10.1038/srep00301. Epub 2012 Mar 5.


G-protein-coupled receptor kinase interactor-1 (GIT1) is a new endothelial nitric-oxide synthase (eNOS) interactor with functional effects on vascular homeostasis.

Liu S, Premont RT, Rockey DC.

J Biol Chem. 2012 Apr 6;287(15):12309-20. doi: 10.1074/jbc.M111.320465. Epub 2012 Jan 31.


GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity.

Cheng S, Li L, He S, Liu J, Sun Y, He M, Grasing K, Premont RT, Suo WZ.

J Biol Chem. 2010 Dec 31;285(53):41541-8. doi: 10.1074/jbc.M110.170894. Epub 2010 Nov 1.


Metastasis: wherefore arf thou?

Premont RT, Schmalzigaug R.

Curr Biol. 2009 Dec 1;19(22):R1036-8. doi: 10.1016/j.cub.2009.10.032.


G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

Chen M, Philipp M, Wang J, Premont RT, Garrison TR, Caron MG, Lefkowitz RJ, Chen W.

J Biol Chem. 2009 Dec 11;284(50):35040-8. doi: 10.1074/jbc.M109.047456. Epub 2009 Oct 2.


Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6.

Raehal KM, Schmid CL, Medvedev IO, Gainetdinov RR, Premont RT, Bohn LM.

Drug Alcohol Depend. 2009 Oct 1;104(3):187-96. doi: 10.1016/j.drugalcdep.2009.04.011. Epub 2009 Jun 3.


GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization.

Liu J, Rasul I, Sun Y, Wu G, Li L, Premont RT, Suo WZ.

J Biol Chem. 2009 Jul 17;284(29):19564-71. doi: 10.1074/jbc.M109.005959. Epub 2009 May 28.


Impaired fear response in mice lacking GIT1.

Schmalzigaug R, Rodriguiz RM, Bonner PE, Davidson CE, Wetsel WC, Premont RT.

Neurosci Lett. 2009 Jul 17;458(2):79-83. doi: 10.1016/j.neulet.2009.04.037. Epub 2009 Apr 19.


Anxiety-like behaviors in mice lacking GIT2.

Schmalzigaug R, Rodriguiz RM, Phillips LE, Davidson CE, Wetsel WC, Premont RT.

Neurosci Lett. 2009 Feb 20;451(2):156-61. doi: 10.1016/j.neulet.2008.12.034. Epub 2008 Dec 24.


Reciprocal regulation of the platelet-derived growth factor receptor-beta and G protein-coupled receptor kinase 5 by cross-phosphorylation: effects on catalysis.

Cai X, Wu JH, Exum ST, Oppermann M, Premont RT, Shenoy SK, Freedman NJ.

Mol Pharmacol. 2009 Mar;75(3):626-36. doi: 10.1124/mol.108.050278. Epub 2008 Dec 17.

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