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Items: 22

1.

In vivo efficacy of mutant IDH1 inhibitor HMS-101 and structural resolution of distinct binding site.

Chaturvedi A, Goparaju R, Gupta C, Weder J, Klünemann T, Araujo Cruz MM, Kloos A, Goerlich K, Schottmann R, Othman B, Struys EA, Bähre H, Grote-Koska D, Brand K, Ganser A, Preller M, Heuser M.

Leukemia. 2019 Oct 4. doi: 10.1038/s41375-019-0582-x. [Epub ahead of print]

PMID:
31586149
2.

Analysis of the dominant mutation N188T of human connexin46 (hCx46) using concatenation and molecular dynamics simulation.

Schadzek P, Stahl Y, Preller M, Ngezahayo A.

FEBS Open Bio. 2019 May;9(5):840-850. doi: 10.1002/2211-5463.12624. Epub 2019 Mar 23.

3.

Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.

Chinthalapudi K, Heissler SM, Preller M, Sellers JR, Manstein DJ.

Elife. 2017 Dec 19;6. pii: e32742. doi: 10.7554/eLife.32742.

4.

Development of a microarray-based assay for efficient testing of new HSP70/DnaK inhibitors.

Mohammadi-Ostad-Kalayeh S, Hrupins V, Helmsen S, Ahlbrecht C, Stahl F, Scheper T, Preller M, Surup F, Stadler M, Kirschning A, Zeilinger C.

Bioorg Med Chem. 2017 Dec 15;25(24):6345-6352. doi: 10.1016/j.bmc.2017.10.003. Epub 2017 Oct 7.

PMID:
29042222
5.

Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.

Beyer U, Brand F, Martens H, Weder J, Christians A, Elyan N, Hentschel B, Westphal M, Schackert G, Pietsch T, Hong B, Krauss JK, Samii A, Raab P, Das A, Dumitru CA, Sandalcioglu IE, Hakenberg OW, Erbersdobler A, Lehmann U, Reifenberger G, Weller M, Reijns MAM, Preller M, Wiese B, Hartmann C, Weber RG.

Acta Neuropathol. 2017 Dec;134(6):905-922. doi: 10.1007/s00401-017-1774-y. Epub 2017 Oct 13.

6.

Calcium Sensor for Photoacoustic Imaging.

Roberts S, Seeger M, Jiang Y, Mishra A, Sigmund F, Stelzl A, Lauri A, Symvoulidis P, Rolbieski H, Preller M, Deán-Ben XL, Razansky D, Orschmann T, Desbordes SC, Vetschera P, Bach T, Ntziachristos V, Westmeyer GG.

J Am Chem Soc. 2018 Feb 28;140(8):2718-2721. doi: 10.1021/jacs.7b03064. Epub 2017 Oct 16.

PMID:
28945084
7.

FIG4 variants in central European patients with amyotrophic lateral sclerosis: a whole-exome and targeted sequencing study.

Osmanovic A, Rangnau I, Kosfeld A, Abdulla S, Janssen C, Auber B, Raab P, Preller M, Petri S, Weber RG.

Eur J Hum Genet. 2017 Feb;25(3):324-331. doi: 10.1038/ejhg.2016.186. Epub 2017 Jan 4.

8.

Data of the molecular dynamics simulations of mutations in the human connexin46 docking interface.

Schadzek P, Schlingmann B, Schaarschmidt F, Lindner J, Koval M, Heisterkamp A, Ngezahayo A, Preller M.

Data Brief. 2016 Feb 13;7:93-9. doi: 10.1016/j.dib.2016.01.067. eCollection 2016 Jun.

9.

Context-Dependent Sensitivity to Mutations Disrupting the Structural Integrity of Individual EGF Repeats in the Mouse Notch Ligand DLL1.

Schuster-Gossler K, Cordes R, Müller J, Geffers I, Delany-Heiken P, Taft M, Preller M, Gossler A.

Genetics. 2016 Mar;202(3):1119-33. doi: 10.1534/genetics.115.184515. Epub 2016 Jan 22.

10.

The cataract related mutation N188T in human connexin46 (hCx46) revealed a critical role for residue N188 in the docking process of gap junction channels.

Schadzek P, Schlingmann B, Schaarschmidt F, Lindner J, Koval M, Heisterkamp A, Preller M, Ngezahayo A.

Biochim Biophys Acta. 2016 Jan;1858(1):57-66. doi: 10.1016/j.bbamem.2015.10.001. Epub 2015 Oct 9.

11.

Kinetic mechanism of Nicotiana tabacum myosin-11 defines a new type of a processive motor.

Diensthuber RP, Tominaga M, Preller M, Hartmann FK, Orii H, Chizhov I, Oiwa K, Tsiavaliaris G.

FASEB J. 2015 Jan;29(1):81-94. doi: 10.1096/fj.14-254763. Epub 2014 Oct 17.

PMID:
25326536
12.

Molecular mechanisms of disease-related human β-actin mutations p.R183W and p.E364K.

Hundt N, Preller M, Swolski O, Ang AM, Mannherz HG, Manstein DJ, Müller M.

FEBS J. 2014 Dec;281(23):5279-91. doi: 10.1111/febs.13068. Epub 2014 Oct 13.

13.

Small molecule-mediated refolding and activation of myosin motor function.

Radke MB, Taft MH, Stapel B, Hilfiker-Kleiner D, Preller M, Manstein DJ.

Elife. 2014 Feb 11;3:e01603. doi: 10.7554/eLife.01603.

14.

Myosin structure, allostery, and mechano-chemistry.

Preller M, Manstein DJ.

Structure. 2013 Nov 5;21(11):1911-22. doi: 10.1016/j.str.2013.09.015. Review.

15.

Mutant IDH1 promotes leukemogenesis in vivo and can be specifically targeted in human AML.

Chaturvedi A, Araujo Cruz MM, Jyotsana N, Sharma A, Yun H, Görlich K, Wichmann M, Schwarzer A, Preller M, Thol F, Meyer J, Haemmerle R, Struys EA, Jansen EE, Modlich U, Li Z, Sly LM, Geffers R, Lindner R, Manstein DJ, Lehmann U, Krauter J, Ganser A, Heuser M.

Blood. 2013 Oct 17;122(16):2877-87. doi: 10.1182/blood-2013-03-491571. Epub 2013 Aug 16.

PMID:
23954893
16.

Distinct functional interactions between actin isoforms and nonsarcomeric myosins.

Müller M, Diensthuber RP, Chizhov I, Claus P, Heissler SM, Preller M, Taft MH, Manstein DJ.

PLoS One. 2013 Jul 26;8(7):e70636. doi: 10.1371/journal.pone.0070636. Print 2013.

17.

The myosin start-of-power stroke state and how actin binding drives the power stroke.

Preller M, Holmes KC.

Cytoskeleton (Hoboken). 2013 Oct;70(10):651-60. doi: 10.1002/cm.21125. Epub 2013 Aug 13.

PMID:
23852739
18.

Structural basis for the allosteric interference of myosin function by reactive thiol region mutations G680A and G680V.

Preller M, Bauer S, Adamek N, Fujita-Becker S, Fedorov R, Geeves MA, Manstein DJ.

J Biol Chem. 2011 Oct 7;286(40):35051-60. doi: 10.1074/jbc.M111.265298. Epub 2011 Aug 13.

19.

Mechanism and specificity of pentachloropseudilin-mediated inhibition of myosin motor activity.

Chinthalapudi K, Taft MH, Martin R, Heissler SM, Preller M, Hartmann FK, Brandstaetter H, Kendrick-Jones J, Tsiavaliaris G, Gutzeit HO, Fedorov R, Buss F, Knölker HJ, Coluccio LM, Manstein DJ.

J Biol Chem. 2011 Aug 26;286(34):29700-8. doi: 10.1074/jbc.M111.239210. Epub 2011 Jun 16.

20.

Calculation of the structure, potential energy surface, vibrational dynamics, and electric dipole properties for the Xe:HI van der Waals complex.

Preller M, Grunenberg J, Bulychev VP, Bulanin MO.

J Chem Phys. 2011 May 7;134(17):174302. doi: 10.1063/1.3583817.

PMID:
21548682
21.

Inhibition of Myosin ATPase activity by halogenated pseudilins: a structure-activity study.

Preller M, Chinthalapudi K, Martin R, Knolker HJ, Manstein DJ.

J Med Chem. 2011 Jun 9;54(11):3675-85. doi: 10.1021/jm200259f. Epub 2011 May 13.

PMID:
21534527
22.

Epigallocatechin gallate supplementation alleviates diabetes in rodents.

Wolfram S, Raederstorff D, Preller M, Wang Y, Teixeira SR, Riegger C, Weber P.

J Nutr. 2006 Oct;136(10):2512-8.

PMID:
16988119

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