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Items: 22


Gβγ directly modulates vesicle fusion by competing with synaptotagmin for binding to neuronal SNARE proteins embedded in membranes.

Zurawski Z, Page B, Chicka MC, Brindley RL, Wells CA, Preininger AM, Hyde K, Gilbert JA, Cruz-Rodriguez O, Currie KPM, Chapman ER, Alford S, Hamm HE.

J Biol Chem. 2017 Jul 21;292(29):12165-12177. doi: 10.1074/jbc.M116.773523. Epub 2017 May 17.


A transient interaction between the phosphate binding loop and switch I contributes to the allosteric network between receptor and nucleotide in Gαi1.

Thaker TM, Sarwar M, Preininger AM, Hamm HE, Iverson TM.

J Biol Chem. 2014 Apr 18;289(16):11331-41. doi: 10.1074/jbc.M113.539064. Epub 2014 Mar 4.


Energetic analysis of the rhodopsin-G-protein complex links the α5 helix to GDP release.

Alexander NS, Preininger AM, Kaya AI, Stein RA, Hamm HE, Meiler J.

Nat Struct Mol Biol. 2014 Jan;21(1):56-63. doi: 10.1038/nsmb.2705. Epub 2013 Dec 1.


Conformational flexibility and structural dynamics in GPCR-mediated G protein activation: a perspective.

Preininger AM, Meiler J, Hamm HE.

J Mol Biol. 2013 Jul 10;425(13):2288-98. doi: 10.1016/j.jmb.2013.04.011. Epub 2013 Apr 16. Review.


Linking receptor activation to changes in Sw I and II of Gα proteins.

Hamm HE, Kaya AI, Gilbert JA 3rd, Preininger AM.

J Struct Biol. 2013 Oct;184(1):63-74. doi: 10.1016/j.jsb.2013.02.016. Epub 2013 Mar 4.


Crystal structures of acetate kinases from the eukaryotic pathogens Entamoeba histolytica and Cryptococcus neoformans.

Thaker TM, Tanabe M, Fowler ML, Preininger AM, Ingram-Smith C, Smith KS, Iverson TM.

J Struct Biol. 2013 Feb;181(2):185-9. doi: 10.1016/j.jsb.2012.11.001. Epub 2012 Nov 16.


Myristoylation exerts direct and allosteric effects on Gα conformation and dynamics in solution.

Preininger AM, Kaya AI, Gilbert JA 3rd, Busenlehner LS, Armstrong RN, Hamm HE.

Biochemistry. 2012 Mar 6;51(9):1911-24. doi: 10.1021/bi201472c. Epub 2012 Feb 22.


Allosteric mechanisms of G protein-Coupled Receptor signaling: a structural perspective.

Thaker TM, Kaya AI, Preininger AM, Hamm HE, Iverson TM.

Methods Mol Biol. 2012;796:133-74. doi: 10.1007/978-1-61779-334-9_8.


Interaction of a G protein with an activated receptor opens the interdomain interface in the alpha subunit.

Van Eps N, Preininger AM, Alexander N, Kaya AI, Meier S, Meiler J, Hamm HE, Hubbell WL.

Proc Natl Acad Sci U S A. 2011 Jun 7;108(23):9420-4. doi: 10.1073/pnas.1105810108. Epub 2011 May 23.


Coupling efficiency of rhodopsin and transducin in bicelles.

Kaya AI, Thaker TM, Preininger AM, Iverson TM, Hamm HE.

Biochemistry. 2011 Apr 19;50(15):3193-203. doi: 10.1021/bi200037j. Epub 2011 Mar 25.


Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins.

Hamm HE, Meier SM, Liao G, Preininger AM.

Protein Sci. 2009 Nov;18(11):2326-35. doi: 10.1002/pro.243.


Irreversible platelet activation requires protease-activated receptor 1-mediated signaling to phosphatidylinositol phosphates.

Holinstat M, Preininger AM, Milne SB, Hudson WJ, Brown HA, Hamm HE.

Mol Pharmacol. 2009 Aug;76(2):301-13. doi: 10.1124/mol.109.056622. Epub 2009 May 29.


Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.

Preininger AM, Funk MA, Oldham WM, Meier SM, Johnston CA, Adhikary S, Kimple AJ, Siderovski DP, Hamm HE, Iverson TM.

Biochemistry. 2009 Mar 31;48(12):2630-42. doi: 10.1021/bi801853a. Erratum in: Biochemistry. 2010 Nov 23;49(46):10037.


Receptor-mediated changes at the myristoylated amino terminus of Galpha(il) proteins.

Preininger AM, Parello J, Meier SM, Liao G, Hamm HE.

Biochemistry. 2008 Sep 30;47(39):10281-93. doi: 10.1021/bi800741r. Epub 2008 Sep 5.


Biochemical analysis of phospholipase D.

Brown HA, Henage LG, Preininger AM, Xiang Y, Exton JH.

Methods Enzymol. 2007;434:49-87.


Mapping allosteric connections from the receptor to the nucleotide-binding pocket of heterotrimeric G proteins.

Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE.

Proc Natl Acad Sci U S A. 2007 May 8;104(19):7927-32. Epub 2007 Apr 26.


Mechanism of the receptor-catalyzed activation of heterotrimeric G proteins.

Oldham WM, Van Eps N, Preininger AM, Hubbell WL, Hamm HE.

Nat Struct Mol Biol. 2006 Sep;13(9):772-7. Epub 2006 Aug 6.


Direct modulation of phospholipase D activity by Gbetagamma.

Preininger AM, Henage LG, Oldham WM, Yoon EJ, Hamm HE, Brown HA.

Mol Pharmacol. 2006 Jul;70(1):311-8. Epub 2006 Apr 25.


G protein betagamma directly regulates SNARE protein fusion machinery for secretory granule exocytosis.

Blackmer T, Larsen EC, Bartleson C, Kowalchyk JA, Yoon EJ, Preininger AM, Alford S, Hamm HE, Martin TF.

Nat Neurosci. 2005 Apr;8(4):421-5. Epub 2005 Mar 20.


G protein signaling: insights from new structures.

Preininger AM, Hamm HE.

Sci STKE. 2004 Jan 27;2004(218):re3. Review.


The myristoylated amino terminus of Galpha(i)(1) plays a critical role in the structure and function of Galpha(i)(1) subunits in solution.

Preininger AM, Van Eps N, Yu NJ, Medkova M, Hubbell WL, Hamm HE.

Biochemistry. 2003 Jul 8;42(26):7931-41.


Conformational changes in the amino-terminal helix of the G protein alpha(i1) following dissociation from Gbetagamma subunit and activation.

Medkova M, Preininger AM, Yu NJ, Hubbell WL, Hamm HE.

Biochemistry. 2002 Aug 6;41(31):9962-72.


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