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Phosphorylation of Par-3 by Atypical Protein Kinase C and Competition between Its Substrates.

Holly RW, Prehoda KE.

Dev Cell. 2019 Jun 3;49(5):678-679. doi: 10.1016/j.devcel.2019.05.002. No abstract available.


Asymmetric recruitment and actin-dependent cortical flows drive the neuroblast polarity cycle.

Oon CH, Prehoda KE.

Elife. 2019 May 8;8. pii: e45815. doi: 10.7554/eLife.45815.


Activation of Discs large by aPKC aligns the mitotic spindle to the polarity axis during asymmetric cell division.

Golub O, Wee B, Newman RA, Paterson NM, Prehoda KE.

Elife. 2017 Nov 29;6. pii: e32137. doi: 10.7554/eLife.32137.


Evolution of a Protein Interaction Domain Family by Tuning Conformational Flexibility.

Whitney DS, Volkman BF, Prehoda KE.

J Am Chem Soc. 2016 Nov 23;138(46):15150-15156. Epub 2016 Aug 25.


Correction to Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42.

Whitney DS, Peterson FC, Kittell AW, Egner JM, Prehoda KE, Volkman BF.

Biochemistry. 2016 Apr 5;55(13):2063. doi: 10.1021/acs.biochem.6b00254. Epub 2016 Mar 25. No abstract available.


Molecular Control of Atypical Protein Kinase C: Tipping the Balance between Self-Renewal and Differentiation.

Drummond ML, Prehoda KE.

J Mol Biol. 2016 Apr 10;428(7):1455-64. doi: 10.1016/j.jmb.2016.03.003. Epub 2016 Mar 16. Review.


Binding of Crumbs to the Par-6 CRIB-PDZ Module Is Regulated by Cdc42.

Whitney DS, Peterson FC, Kittell AW, Egner JM, Prehoda KE, Volkman BF.

Biochemistry. 2016 Mar 15;55(10):1455-61. doi: 10.1021/acs.biochem.5b01342. Epub 2016 Mar 3. Erratum in: Biochemistry. 2016 Apr 5;55(13):2063.


Correction: Evolution of an ancient protein function involved in organized multicellularity in animals.

Anderson DP, Whitney DS, Hanson-Smith V, Woznica A, Campodonico-Burnett W, Volkman BF, King N, Thornton JW, Prehoda KE.

Elife. 2016 Jan 21;5:e14311. doi: 10.7554/eLife.14311. No abstract available.


Evolution of an ancient protein function involved in organized multicellularity in animals.

Anderson DP, Whitney DS, Hanson-Smith V, Woznica A, Campodonico-Burnett W, Volkman BF, King N, Thornton JW, Prehoda KE.

Elife. 2016 Jan 7;5:e10147. doi: 10.7554/eLife.10147. Erratum in: Elife. 2016;5:e14311.


Establishment of Par-Polarized Cortical Domains via Phosphoregulated Membrane Motifs.

Bailey MJ, Prehoda KE.

Dev Cell. 2015 Oct 26;35(2):199-210. doi: 10.1016/j.devcel.2015.09.016. Epub 2015 Oct 17.


Ordered multisite phosphorylation of lethal giant larvae by atypical protein kinase C.

Graybill C, Prehoda KE.

Biochemistry. 2014 Aug 5;53(30):4931-7. doi: 10.1021/bi500748w. Epub 2014 Jul 16.


A NudE/14-3-3 pathway coordinates dynein and the kinesin Khc73 to position the mitotic spindle.

Lu MS, Prehoda KE.

Dev Cell. 2013 Aug 26;26(4):369-80. doi: 10.1016/j.devcel.2013.07.021.


Formin-mediated actin polymerization cooperates with Mushroom body defect (Mud)-Dynein during Frizzled-Dishevelled spindle orientation.

Johnston CA, Manning L, Lu MS, Golub O, Doe CQ, Prehoda KE.

J Cell Sci. 2013 Oct 1;126(Pt 19):4436-44. doi: 10.1242/jcs.129544. Epub 2013 Jul 18.


Microtubules in distress release arrest.

Prehoda KE.

Dev Cell. 2012 Aug 14;23(2):233-4. doi: 10.1016/j.devcel.2012.07.005.


Ultrasensitive synthetic protein regulatory networks using mixed decoys.

Lu MS, Mauser JF, Prehoda KE.

ACS Synth Biol. 2012 Feb 17;1(2):65-72.


Structure of an enzyme-derived phosphoprotein recognition domain.

Johnston CA, Doe CQ, Prehoda KE.

PLoS One. 2012;7(4):e36014. doi: 10.1371/journal.pone.0036014. Epub 2012 Apr 24.


Partitioning-defective protein 6 (Par-6) activates atypical protein kinase C (aPKC) by pseudosubstrate displacement.

Graybill C, Wee B, Atwood SX, Prehoda KE.

J Biol Chem. 2012 Jun 15;287(25):21003-11. doi: 10.1074/jbc.M112.360495. Epub 2012 Apr 27.


Inscuteable regulates the Pins-Mud spindle orientation pathway.

Mauser JF, Prehoda KE.

PLoS One. 2012;7(1):e29611. doi: 10.1371/journal.pone.0029611. Epub 2012 Jan 10.


Canoe binds RanGTP to promote Pins(TPR)/Mud-mediated spindle orientation.

Wee B, Johnston CA, Prehoda KE, Doe CQ.

J Cell Biol. 2011 Oct 31;195(3):369-76. doi: 10.1083/jcb.201102130. Epub 2011 Oct 24.


Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing.

Johnston CA, Whitney DS, Volkman BF, Doe CQ, Prehoda KE.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):E973-8. doi: 10.1073/pnas.1104365108. Epub 2011 Oct 11.


Asymmetric cortical extension shifts cleavage furrow position in Drosophila neuroblasts.

Connell M, Cabernard C, Ricketson D, Doe CQ, Prehoda KE.

Mol Biol Cell. 2011 Nov;22(22):4220-6. doi: 10.1091/mbc.E11-02-0173. Epub 2011 Sep 21.


Robust spindle alignment in Drosophila neuroblasts by ultrasensitive activation of pins.

Smith NR, Prehoda KE.

Mol Cell. 2011 Aug 19;43(4):540-9. doi: 10.1016/j.molcel.2011.06.030.


Multiple tail domain interactions stabilize nonmuscle myosin II bipolar filaments.

Ricketson D, Johnston CA, Prehoda KE.

Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20964-9. doi: 10.1073/pnas.1007025107. Epub 2010 Nov 15.


The Fz-Dsh planar cell polarity pathway induces oriented cell division via Mud/NuMA in Drosophila and zebrafish.

Ségalen M, Johnston CA, Martin CA, Dumortier JG, Prehoda KE, David NB, Doe CQ, Bellaïche Y.

Dev Cell. 2010 Nov 16;19(5):740-52. doi: 10.1016/j.devcel.2010.10.004.


A spindle-independent cleavage furrow positioning pathway.

Cabernard C, Prehoda KE, Doe CQ.

Nature. 2010 Sep 2;467(7311):91-4. doi: 10.1038/nature09334.


Cell polarity: keeping worms LeGaL.

Prehoda KE, Bowerman B.

Curr Biol. 2010 Aug 10;20(15):R646-8. doi: 10.1016/j.cub.2010.06.011.


Polarization of Drosophila neuroblasts during asymmetric division.

Prehoda KE.

Cold Spring Harb Perspect Biol. 2009 Aug;1(2):a001388. doi: 10.1101/cshperspect.a001388. Review.


Allosteric control of regulated scaffolding in membrane-associated guanylate kinases.

Marcette J, Hood IV, Johnston CA, Doe CQ, Prehoda KE.

Biochemistry. 2009 Oct 27;48(42):10014-9. doi: 10.1021/bi901160f.


Identification of an Aurora-A/PinsLINKER/Dlg spindle orientation pathway using induced cell polarity in S2 cells.

Johnston CA, Hirono K, Prehoda KE, Doe CQ.

Cell. 2009 Sep 18;138(6):1150-63. doi: 10.1016/j.cell.2009.07.041.


aPKC phosphorylates Miranda to polarize fate determinants during neuroblast asymmetric cell division.

Atwood SX, Prehoda KE.

Curr Biol. 2009 May 12;19(9):723-9. doi: 10.1016/j.cub.2009.03.056. Epub 2009 Apr 16.


Intramolecular interactions between the SRC homology 3 and guanylate kinase domains of discs large regulate its function in asymmetric cell division.

Newman RA, Prehoda KE.

J Biol Chem. 2009 May 8;284(19):12924-32. doi: 10.1074/jbc.M809304200. Epub 2009 Mar 4.


Filament-dependent and -independent localization modes of Drosophila non-muscle myosin II.

Liu SL, Fewkes N, Ricketson D, Penkert RR, Prehoda KE.

J Biol Chem. 2008 Jan 4;283(1):380-7. Epub 2007 Nov 6.


Galphai generates multiple Pins activation states to link cortical polarity and spindle orientation in Drosophila neuroblasts.

Nipper RW, Siller KH, Smith NR, Doe CQ, Prehoda KE.

Proc Natl Acad Sci U S A. 2007 Sep 4;104(36):14306-11. Epub 2007 Aug 28.


Cdc42 acts downstream of Bazooka to regulate neuroblast polarity through Par-6 aPKC.

Atwood SX, Chabu C, Penkert RR, Doe CQ, Prehoda KE.

J Cell Sci. 2007 Sep 15;120(Pt 18):3200-6. Epub 2007 Aug 28.


Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP.

Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim WA, Way M, Volkman BF.

J Biol Chem. 2007 Mar 16;282(11):8446-53. Epub 2007 Jan 16.


A polybasic motif allows N-WASP to act as a sensor of PIP(2) density.

Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA.

Mol Cell. 2005 Jan 21;17(2):181-91.


Internal recognition through PDZ domain plasticity in the Par-6-Pals1 complex.

Penkert RR, DiVittorio HM, Prehoda KE.

Nat Struct Mol Biol. 2004 Nov;11(11):1122-7. Epub 2004 Oct 10.


Calcium channel function regulated by the SH3-GK module in beta subunits.

McGee AW, Nunziato DA, Maltez JM, Prehoda KE, Pitt GS, Bredt DS.

Neuron. 2004 Apr 8;42(1):89-99.


Cdc42 regulates the Par-6 PDZ domain through an allosteric CRIB-PDZ transition.

Peterson FC, Penkert RR, Volkman BF, Prehoda KE.

Mol Cell. 2004 Mar 12;13(5):665-76.


Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome.

Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA.

Cell. 2002 Nov 15;111(4):565-76.


How signaling proteins integrate multiple inputs: a comparison of N-WASP and Cdk2.

Prehoda KE, Lim WA.

Curr Opin Cell Biol. 2002 Apr;14(2):149-54. Review.


Structure of the SH3-guanylate kinase module from PSD-95 suggests a mechanism for regulated assembly of MAGUK scaffolding proteins.

McGee AW, Dakoji SR, Olsen O, Bredt DS, Lim WA, Prehoda KE.

Mol Cell. 2001 Dec;8(6):1291-301.


The double life of PX domains.

Prehoda KE, Lim WA.

Nat Struct Biol. 2001 Jul;8(7):570-2. No abstract available.


Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex.

Prehoda KE, Scott JA, Mullins RD, Lim WA.

Science. 2000 Oct 27;290(5492):801-6.


Unexpected modes of PDZ domain scaffolding revealed by structure of nNOS-syntrophin complex.

Hillier BJ, Christopherson KS, Prehoda KE, Bredt DS, Lim WA.

Science. 1999 Apr 30;284(5415):812-5.


Pressure denaturation of proteins: evaluation of compressibility effects.

Prehoda KE, Mooberry ES, Markley JL.

Biochemistry. 1998 Apr 28;37(17):5785-90.


Microscopic pKa values of Escherichia coli thioredoxin.

Chivers PT, Prehoda KE, Volkman BF, Kim BM, Markley JL, Raines RT.

Biochemistry. 1997 Dec 2;36(48):14985-91.


The CXXC motif: a rheostat in the active site.

Chivers PT, Prehoda KE, Raines RT.

Biochemistry. 1997 Apr 8;36(14):4061-6.


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