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Mucinous adenocarcinoma of the colon and rectum: A genomic analysis.

Reynolds IS, O'Connell E, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Furney SJ, Burke JP.

J Surg Oncol. 2019 Nov 14. doi: 10.1002/jso.25764. [Epub ahead of print]


System-based approaches as prognostic tools for glioblastoma.

Salvucci M, Zakaria Z, Carberry S, Tivnan A, Seifert V, Kögel D, Murphy BM, Prehn JHM.

BMC Cancer. 2019 Nov 12;19(1):1092. doi: 10.1186/s12885-019-6280-2. Review.


Proteins and microRNAs are differentially expressed in tear fluid from patients with Alzheimer's disease.

Kenny A, Jiménez-Mateos EM, Zea-Sevilla MA, Rábano A, Gili-Manzanaro P, Prehn JHM, Henshall DC, Ávila J, Engel T, Hernández F.

Sci Rep. 2019 Oct 28;9(1):15437. doi: 10.1038/s41598-019-51837-y.


Mucin Pools Following Neoadjuvant Chemoradiotherapy For Rectal Cancer: A Marker of Response or Epiphenomenon?

Reynolds IS, O'Connell E, Fichtner M, Kay EW, McNamara DA, Prehn JHM, Burke JP.

Am J Surg Pathol. 2019 Sep 17. doi: 10.1097/PAS.0000000000001373. [Epub ahead of print]


Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform.

Matveeva A, Fichtner M, McAllister K, McCann C, Sturrock M, Longley DB, Prehn JHM.

PLoS Comput Biol. 2019 Sep 25;15(9):e1007374. doi: 10.1371/journal.pcbi.1007374. eCollection 2019 Sep.


The Anti-inflammatory Compound Candesartan Cilexetil Improves Neurological Outcomes in a Mouse Model of Neonatal Hypoxia.

Quinlan S, Merino-Serrais P, Di Grande A, Dussmann H, Prehn JHM, Ní Chonghaile T, Henshall DC, Jimenez-Mateos EM.

Front Immunol. 2019 Jul 24;10:1752. doi: 10.3389/fimmu.2019.01752. eCollection 2019.


Vascular regression precedes motor neuron loss in the FUS (1-359) ALS mouse model.

Crivello M, Hogg MC, Jirström E, Halang L, Woods I, Rayner M, Coughlan KS, Lewandowski SA, Prehn JHM.

Dis Model Mech. 2019 Aug 13;12(8). pii: dmm040238. doi: 10.1242/dmm.040238.


Electrical stimulation of the ventral hippocampal commissure delays experimental epilepsy and is associated with altered microRNA expression.

Costard LS, Neubert V, Venø MT, Su J, Kjems J, Connolly NMC, Prehn JHM, Schratt G, Henshall DC, Rosenow F, Bauer S.

Brain Stimul. 2019 Nov - Dec;12(6):1390-1401. doi: 10.1016/j.brs.2019.06.009. Epub 2019 Jun 7.


Context-Specific Switch from Anti- to Pro-epileptogenic Function of the P2Y1 Receptor in Experimental Epilepsy.

Alves M, De Diego Garcia L, Conte G, Jimenez-Mateos EM, D'Orsi B, Sanz-Rodriguez A, Prehn JHM, Henshall DC, Engel T.

J Neurosci. 2019 Jul 3;39(27):5377-5392. doi: 10.1523/JNEUROSCI.0089-19.2019. Epub 2019 May 2.


Elevation in plasma tRNA fragments precede seizures in human epilepsy.

Hogg MC, Raoof R, El Naggar H, Monsefi N, Delanty N, O'Brien DF, Bauer S, Rosenow F, Henshall DC, Prehn JH.

J Clin Invest. 2019 Apr 30;129(7):2946-2951. doi: 10.1172/JCI126346.


A Machine Learning Platform to Optimize the Translation of Personalized Network Models to the Clinic.

Salvucci M, Rahman A, Resler AJ, Udupi GM, McNamara DA, Kay EW, Laurent-Puig P, Longley DB, Johnston PG, Lawler M, Wilson R, Salto-Tellez M, Van Schaeybroeck S, Rafferty M, Gallagher WM, Rehm M, Prehn JHM.

JCO Clin Cancer Inform. 2019 Apr;3:1-17. doi: 10.1200/CCI.18.00056.


Meta-analysis of the molecular associations of mucinous colorectal cancer.

Reynolds IS, Furney SJ, Kay EW, McNamara DA, Prehn JHM, Burke JP.

Br J Surg. 2019 May;106(6):682-691. doi: 10.1002/bjs.11142. Epub 2019 Apr 4.


Systems biology identifies preserved integrity but impaired metabolism of mitochondria due to a glycolytic defect in Alzheimer's disease neurons.

Theurey P, Connolly NMC, Fortunati I, Basso E, Lauwen S, Ferrante C, Moreira Pinho C, Joselin A, Gioran A, Bano D, Park DS, Ankarcrona M, Pizzo P, Prehn JHM.

Aging Cell. 2019 Jun;18(3):e12924. doi: 10.1111/acel.12924. Epub 2019 Feb 21.


Implementing Reverse Phase Protein Array Profiling as a Sensitive Method for the Early Pre-Clinical Detection of Off-Target Toxicities Associated with Sunitinib Malate.

O'Farrell AC, Miller IS, Evans R, Alamanou M, Cary M, Mallya Udupi G, Lafferty A, Monsefi N, Cremona M, Prehn JHM, Verheul HM, Gallagher WM, Gehrmann M, Byrne AT.

Proteomics Clin Appl. 2019 Jul;13(4):e1800159. doi: 10.1002/prca.201800159. Epub 2019 Mar 19.


Profiling of Argonaute-2-loaded microRNAs in a mouse model of frontotemporal dementia with parkinsonism-17.

Kenny A, Hernández F, Avila J, Lucas JJ, Henshall DC, Prehn JH, Jiménez-Mateos EM, Engel T.

Int J Physiol Pathophysiol Pharmacol. 2018 Dec 25;10(6):172-183. eCollection 2018.


Mucin glycoproteins block apoptosis; promote invasion, proliferation, and migration; and cause chemoresistance through diverse pathways in epithelial cancers.

Reynolds IS, Fichtner M, McNamara DA, Kay EW, Prehn JHM, Burke JP.

Cancer Metastasis Rev. 2019 Jun;38(1-2):237-257. doi: 10.1007/s10555-019-09781-w. Review.


Dual-center, dual-platform microRNA profiling identifies potential plasma biomarkers of adult temporal lobe epilepsy.

Raoof R, Bauer S, El Naggar H, Connolly NMC, Brennan GP, Brindley E, Hill T, McArdle H, Spain E, Forster RJ, Prehn JHM, Hamer H, Delanty N, Rosenow F, Mooney C, Henshall DC.

EBioMedicine. 2018 Dec;38:127-141. doi: 10.1016/j.ebiom.2018.10.068. Epub 2018 Nov 2.


Copy number load predicts outcome of metastatic colorectal cancer patients receiving bevacizumab combination therapy.

Smeets D, Miller IS, O'Connor DP, Das S, Moran B, Boeckx B, Gaiser T, Betge J, Barat A, Klinger R, van Grieken NCT, Cremolini C, Prenen H, Mazzone M, Depreeuw J, Bacon O, Fender B, Brady J, Hennessy BT, McNamara DA, Kay E, Verheul HM, Maarten N, Gallagher WM, Murphy V, Prehn JHM, Koopman M, Punt CJA, Loupakis F, Ebert MPA, Ylstra B, Lambrechts D, Byrne AT.

Nat Commun. 2018 Oct 5;9(1):4112. doi: 10.1038/s41467-018-06567-6.


ER stress signaling has an activating transcription factor 6α (ATF6)-dependent "off-switch".

Walter F, O'Brien A, Concannon CG, Düssmann H, Prehn JHM.

J Biol Chem. 2018 Nov 23;293(47):18270-18284. doi: 10.1074/jbc.RA118.002121. Epub 2018 Oct 4.


Author Correction: Anti-angiogenic drug scheduling optimisation with application to colorectal cancer.

Sturrock M, Miller IS, Kang G, Arba'ie NH, O'Farrell AC, Barat A, Marston G, Coletta PL, Byrne AT, Prehn JH.

Sci Rep. 2018 Sep 27;8(1):14705. doi: 10.1038/s41598-018-31456-9.


Metabolic Targeting of Breast Cancer Cells With the 2-Deoxy-D-Glucose and the Mitochondrial Bioenergetics Inhibitor MDIVI-1.

Lucantoni F, Dussmann H, Prehn JHM.

Front Cell Dev Biol. 2018 Sep 11;6:113. doi: 10.3389/fcell.2018.00113. eCollection 2018.


Low cleaved caspase-7 levels indicate unfavourable outcome across all breast cancers.

Lindner AU, Lucantoni F, Varešlija D, Resler A, Murphy BM, Gallagher WM, Hill ADK, Young LS, Prehn JHM.

J Mol Med (Berl). 2018 Oct;96(10):1025-1037. doi: 10.1007/s00109-018-1675-0. Epub 2018 Aug 1.


Anti-angiogenic drug scheduling optimisation with application to colorectal cancer.

Sturrock M, Miller IS, Kang G, Hannis Arba'ie N, O'Farrell AC, Barat A, Marston G, Coletta PL, Byrne AT, Prehn JH.

Sci Rep. 2018 Jul 25;8(1):11182. doi: 10.1038/s41598-018-29318-5. Erratum in: Sci Rep. 2018 Sep 27;8(1):14705.


BCL2 and BCL(X)L selective inhibitors decrease mitochondrial ATP production in breast cancer cells and are synthetically lethal when combined with 2-deoxy-D-glucose.

Lucantoni F, Düssmann H, Llorente-Folch I, Prehn JHM.

Oncotarget. 2018 May 25;9(40):26046-26063. doi: 10.18632/oncotarget.25433. eCollection 2018 May 25.


Loss of Chromosome 18q11.2-q12.1 Is Predictive for Survival in Patients With Metastatic Colorectal Cancer Treated With Bevacizumab.

van Dijk E, Biesma HD, Cordes M, Smeets D, Neerincx M, Das S, Eijk PP, Murphy V, Barat A, Bacon O, Prehn JHM, Betge J, Gaiser T, Fender B, Meijer GA, McNamara DA, Klinger R, Koopman M, Ebert MPA, Kay EW, Hennessey BT, Verheul HMW, Gallagher WM, O'Connor DP, Punt CJA, Loupakis F, Lambrechts D, Byrne AT, van Grieken NCT, Ylstra B.

J Clin Oncol. 2018 Jul 10;36(20):2052-2060. doi: 10.1200/JCO.2017.77.1782. Epub 2018 May 24.


Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation.

Kinsella S, Fichtner M, Watters O, König HG, Prehn JHM.

J Neuroinflammation. 2018 May 2;15(1):130. doi: 10.1186/s12974-018-1143-3.


Apoptosis-Inducing Factor (AIF) in Physiology and Disease: The Tale of a Repented Natural Born Killer.

Bano D, Prehn JHM.

EBioMedicine. 2018 Apr;30:29-37. doi: 10.1016/j.ebiom.2018.03.016. Epub 2018 Mar 23. Review.


Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711.

Crawford N, Salvucci M, Hellwig CT, Lincoln FA, Mooney RE, O'Connor CL, Prehn JH, Longley DB, Rehm M.

Cell Death Differ. 2018 Nov;25(11):1952-1966. doi: 10.1038/s41418-018-0082-y. Epub 2018 Mar 2.


Pleiotropic activity of systemically delivered angiogenin in the SOD1G93A mouse model.

Crivello M, O'Riordan SL, Woods I, Cannon S, Halang L, Coughlan KS, Hogg MC, Lewandowski SA, Prehn JHM.

Neuropharmacology. 2018 May 1;133:503-511. doi: 10.1016/j.neuropharm.2018.02.022. Epub 2018 Feb 25.


The BAX/BAK-like protein BOK is a prognostic marker in colorectal cancer.

Carberry S, D'Orsi B, Monsefi N, Salvucci M, Bacon O, Fay J, Rehm M, McNamara D, Kay EW, Prehn JHM.

Cell Death Dis. 2018 Jan 26;9(2):125. doi: 10.1038/s41419-017-0140-2.


Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Galluzzi L, Vitale I, Aaronson SA, Abrams JM, Adam D, Agostinis P, Alnemri ES, Altucci L, Amelio I, Andrews DW, Annicchiarico-Petruzzelli M, Antonov AV, Arama E, Baehrecke EH, Barlev NA, Bazan NG, Bernassola F, Bertrand MJM, Bianchi K, Blagosklonny MV, Blomgren K, Borner C, Boya P, Brenner C, Campanella M, Candi E, Carmona-Gutierrez D, Cecconi F, Chan FK, Chandel NS, Cheng EH, Chipuk JE, Cidlowski JA, Ciechanover A, Cohen GM, Conrad M, Cubillos-Ruiz JR, Czabotar PE, D'Angiolella V, Dawson TM, Dawson VL, De Laurenzi V, De Maria R, Debatin KM, DeBerardinis RJ, Deshmukh M, Di Daniele N, Di Virgilio F, Dixit VM, Dixon SJ, Duckett CS, Dynlacht BD, El-Deiry WS, Elrod JW, Fimia GM, Fulda S, García-Sáez AJ, Garg AD, Garrido C, Gavathiotis E, Golstein P, Gottlieb E, Green DR, Greene LA, Gronemeyer H, Gross A, Hajnoczky G, Hardwick JM, Harris IS, Hengartner MO, Hetz C, Ichijo H, Jäättelä M, Joseph B, Jost PJ, Juin PP, Kaiser WJ, Karin M, Kaufmann T, Kepp O, Kimchi A, Kitsis RN, Klionsky DJ, Knight RA, Kumar S, Lee SW, Lemasters JJ, Levine B, Linkermann A, Lipton SA, Lockshin RA, López-Otín C, Lowe SW, Luedde T, Lugli E, MacFarlane M, Madeo F, Malewicz M, Malorni W, Manic G, Marine JC, Martin SJ, Martinou JC, Medema JP, Mehlen P, Meier P, Melino S, Miao EA, Molkentin JD, Moll UM, Muñoz-Pinedo C, Nagata S, Nuñez G, Oberst A, Oren M, Overholtzer M, Pagano M, Panaretakis T, Pasparakis M, Penninger JM, Pereira DM, Pervaiz S, Peter ME, Piacentini M, Pinton P, Prehn JHM, Puthalakath H, Rabinovich GA, Rehm M, Rizzuto R, Rodrigues CMP, Rubinsztein DC, Rudel T, Ryan KM, Sayan E, Scorrano L, Shao F, Shi Y, Silke J, Simon HU, Sistigu A, Stockwell BR, Strasser A, Szabadkai G, Tait SWG, Tang D, Tavernarakis N, Thorburn A, Tsujimoto Y, Turk B, Vanden Berghe T, Vandenabeele P, Vander Heiden MG, Villunger A, Virgin HW, Vousden KH, Vucic D, Wagner EF, Walczak H, Wallach D, Wang Y, Wells JA, Wood W, Yuan J, Zakeri Z, Zhivotovsky B, Zitvogel L, Melino G, Kroemer G.

Cell Death Differ. 2018 Mar;25(3):486-541. doi: 10.1038/s41418-017-0012-4. Epub 2018 Jan 23. Review.


Systems modeling accurately predicts responses to genotoxic agents and their synergism with BCL-2 inhibitors in triple negative breast cancer cells.

Lucantoni F, Lindner AU, O'Donovan N, Düssmann H, Prehn JHM.

Cell Death Dis. 2018 Jan 19;9(2):42. doi: 10.1038/s41419-017-0039-y.


Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases.

Connolly NMC, Theurey P, Adam-Vizi V, Bazan NG, Bernardi P, Bolaños JP, Culmsee C, Dawson VL, Deshmukh M, Duchen MR, Düssmann H, Fiskum G, Galindo MF, Hardingham GE, Hardwick JM, Jekabsons MB, Jonas EA, Jordán J, Lipton SA, Manfredi G, Mattson MP, McLaughlin B, Methner A, Murphy AN, Murphy MP, Nicholls DG, Polster BM, Pozzan T, Rizzuto R, Satrústegui J, Slack RS, Swanson RA, Swerdlow RH, Will Y, Ying Z, Joselin A, Gioran A, Moreira Pinho C, Watters O, Salvucci M, Llorente-Folch I, Park DS, Bano D, Ankarcrona M, Pizzo P, Prehn JHM.

Cell Death Differ. 2018 Mar;25(3):542-572. doi: 10.1038/s41418-017-0020-4. Epub 2017 Dec 11. Review.


Riluzole does not improve lifespan or motor function in three ALS mouse models.

Hogg MC, Halang L, Woods I, Coughlan KS, Prehn JHM.

Amyotroph Lateral Scler Frontotemporal Degener. 2018 Aug;19(5-6):438-445. doi: 10.1080/21678421.2017.1407796. Epub 2017 Dec 8.


Defining external factors that determine neuronal survival, apoptosis and necrosis during excitotoxic injury using a high content screening imaging platform.

Anilkumar U, Weisova P, Schmid J, Bernas T, Huber HJ, Düssmann H, Connolly NMC, Prehn JHM.

PLoS One. 2017 Nov 16;12(11):e0188343. doi: 10.1371/journal.pone.0188343. eCollection 2017.


Orexin-A/hypocretin-1 Immunoreactivity in the Lateral Hypothalamus is Reduced in Genetically Obese but not in Diet-induced Obese Mice.

González JA, Prehn JHM.

Neuroscience. 2018 Jan 15;369:183-191. doi: 10.1016/j.neuroscience.2017.11.009. Epub 2017 Nov 10.


A constitutively-active IKK-complex at the axon initial segment.

König HG, Watters O, Kinsella S, Ameen M, Fenner BJ, Prehn JHM.

Brain Res. 2018 Jan 1;1678:356-366. doi: 10.1016/j.brainres.2017.10.020. Epub 2017 Oct 24.


Assessment of concordance between fresh-frozen and formalin-fixed paraffin embedded tumor DNA methylation using a targeted sequencing approach.

Moran B, Das S, Smeets D, Peutman G, Klinger R, Fender B, Connor K, Ebert M, Gaiser T, Prehn JH, Bacon O, Kay E, Hennessy B, Murphy V, Ylstra B, Lambrechts D, Byrne AT, Gallagher WM, O'Connor DP.

Oncotarget. 2017 Jul 18;8(29):48126-48137. doi: 10.18632/oncotarget.18296.


Cerebrospinal fluid microRNAs are potential biomarkers of temporal lobe epilepsy and status epilepticus.

Raoof R, Jimenez-Mateos EM, Bauer S, Tackenberg B, Rosenow F, Lang J, Onugoren MD, Hamer H, Huchtemann T, Körtvélyessy P, Connolly NMC, Pfeiffer S, Prehn JHM, Farrell MA, O'Brien DF, Henshall DC, Mooney C.

Sci Rep. 2017 Jun 12;7(1):3328. doi: 10.1038/s41598-017-02969-6.


Single-cell time-lapse imaging of intracellular O2 in response to metabolic inhibition and mitochondrial cytochrome-c release.

Düssmann H, Perez-Alvarez S, Anilkumar U, Papkovsky DB, Prehn JH.

Cell Death Dis. 2017 Jun 1;8(6):e2853. doi: 10.1038/cddis.2017.247.


Apelin: A putative novel predictive biomarker for bevacizumab response in colorectal cancer.

Zuurbier L, Rahman A, Cordes M, Scheick J, Wong TJ, Rustenburg F, Joseph JC, Dynoodt P, Casey R, Drillenburg P, Gerhards M, Barat A, Klinger R, Fender B, O'Connor DP, Betge J, Ebert MP, Gaiser T, Prehn JHM, Griffioen AW, van Grieken NCT, Ylstra B, Byrne AT, van der Flier LG, Gallagher WM, Postel R.

Oncotarget. 2017 Jun 27;8(26):42949-42961. doi: 10.18632/oncotarget.17306.


Control of mitochondrial physiology and cell death by the Bcl-2 family proteins Bax and Bok.

D'Orsi B, Mateyka J, Prehn JHM.

Neurochem Int. 2017 Oct;109:162-170. doi: 10.1016/j.neuint.2017.03.010. Epub 2017 Mar 15. Review.


Time-lapse imaging of p65 and IκBα translocation kinetics following Ca2+-induced neuronal injury reveals biphasic translocation kinetics in surviving neurons.

Schwamborn R, Düssmann H, König HG, Prehn JHM.

Mol Cell Neurosci. 2017 Apr;80:148-158. doi: 10.1016/j.mcn.2017.02.007. Epub 2017 Feb 24.


NF-κB regulates neuronal ankyrin-G via a negative feedback loop.

König HG, Schwamborn R, Andresen S, Kinsella S, Watters O, Fenner B, Prehn JH.

Sci Rep. 2017 Feb 9;7:42006. doi: 10.1038/srep42006.


Anti-GD2-ch14.18/CHO coated nanoparticles mediate glioblastoma (GBM)-specific delivery of the aromatase inhibitor, Letrozole, reducing proliferation, migration and chemoresistance in patient-derived GBM tumor cells.

Tivnan A, Heilinger T, Ramsey JM, O'Connor G, Pokorny JL, Sarkaria JN, Stringer BW, Day BW, Boyd AW, Kim EL, Lode HN, Cryan SA, Prehn JH.

Oncotarget. 2017 Mar 7;8(10):16605-16620. doi: 10.18632/oncotarget.15073.


Deletion of the BH3-only protein Noxa alters electrographic seizures but does not protect against hippocampal damage after status epilepticus in mice.

Ichikawa N, Alves M, Pfeiffer S, Langa E, Hernández-Santana YE, Suzuki H, Prehn JH, Engel T, Henshall DC.

Cell Death Dis. 2017 Jan 12;8(1):e2556. doi: 10.1038/cddis.2016.301.


MicroRNAs in epilepsy: pathophysiology and clinical utility.

Henshall DC, Hamer HM, Pasterkamp RJ, Goldstein DB, Kjems J, Prehn JHM, Schorge S, Lamottke K, Rosenow F.

Lancet Neurol. 2016 Dec;15(13):1368-1376. doi: 10.1016/S1474-4422(16)30246-0. Review.


miRNAmeConverter: an R/bioconductor package for translating mature miRNA names to different miRBase versions.

Haunsberger SJ, Connolly NM, Prehn JH.

Bioinformatics. 2017 Feb 15;33(4):592-593. doi: 10.1093/bioinformatics/btw660.


In the Middle of a Chain Interaction.

Kinsella S, Prehn JH.

Mol Cell. 2016 Oct 20;64(2):217-218. doi: 10.1016/j.molcel.2016.09.036.


Outcome of Colorectal Cancer Patients Treated with Combination Bevacizumab Therapy: A Pooled Retrospective Analysis of Three European Cohorts from the Angiopredict Initiative.

Betge J, Barat A, Murphy V, Hielscher T, Van Grieken NC, Belle S, Zhan T, Härtel N, Kripp M, Bacon O, Cordes M, Kay EW, Verheul HM, Neerincx M, Hennessy B, Hofheinz RD, Gaiser T, Ylstra B, Prehn JH, Lambrechts D, Byrne AT, Ebert MP, Schulte N.

Digestion. 2016;94(3):129-137. doi: 10.1159/000449412. Epub 2016 Oct 19.


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