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Items: 28


Pharmacological Inhibition of Hippo Pathway using XMU-MP-1 Protects The Heart Against Adverse Effects during Pressure Overload.

Triastuti E, Nugroho AB, Zi M, Prehar S, Kohar YS, Bui TA, Stafford N, Cartwright EJ, Abraham S, Oceandy D.

Br J Pharmacol. 2019 Jul 22. doi: 10.1111/bph.14795. [Epub ahead of print]


TNAP limits TGF-β-dependent cardiac and skeletal muscle fibrosis by inactivating the SMAD2/3 transcription factors.

Arnò B, Galli F, Roostalu U, Aldeiri BM, Miyake T, Albertini A, Bragg L, Prehar S, McDermott JC, Cartwright EJ, Cossu G.

J Cell Sci. 2019 Aug 8;132(15). pii: jcs234948. doi: 10.1242/jcs.234948.


Acute inhibition of PMCA4, but not global ablation, reduces blood pressure and arterial contractility via a nNOS-dependent mechanism.

Lewis S, Little R, Baudoin F, Prehar S, Neyses L, Cartwright EJ, Austin C.

J Cell Mol Med. 2018 Feb;22(2):861-872. doi: 10.1111/jcmm.13371. Epub 2017 Nov 30.


Reduced expression of PMCA1 is associated with increased blood pressure with age which is preceded by remodelling of resistance arteries.

Little R, Zi M, Hammad SK, Nguyen L, Njegic A, Kurusamy S, Prehar S, Armesilla AL, Neyses L, Austin C, Cartwright EJ.

Aging Cell. 2017 Oct;16(5):1104-1113. doi: 10.1111/acel.12637. Epub 2017 Aug 9.


An erythroid-specific ATP2B4 enhancer mediates red blood cell hydration and malaria susceptibility.

Lessard S, Gatof ES, Beaudoin M, Schupp PG, Sher F, Ali A, Prehar S, Kurita R, Nakamura Y, Baena E, Ledoux J, Oceandy D, Bauer DE, Lettre G.

J Clin Invest. 2017 Aug 1;127(8):3065-3074. doi: 10.1172/JCI94378. Epub 2017 Jul 17.


Stress-Activated Kinase Mitogen-Activated Kinase Kinase-7 Governs Epigenetics of Cardiac Repolarization for Arrhythmia Prevention.

Chowdhury SK, Liu W, Zi M, Li Y, Wang S, Tsui H, Prehar S, Castro S, Zhang H, Ji Y, Zhang X, Xiao R, Zhang R, Lei M, Cyganek L, Guan K, Millar CB, Liao X, Jain MK, Boyett MR, Cartwright EJ, Shiels HA, Wang X.

Circulation. 2017 Feb 14;135(7):683-699. doi: 10.1161/CIRCULATIONAHA.116.022941. Epub 2016 Nov 29.


The oxoglutarate receptor 1 (OXGR1) modulates pressure overload-induced cardiac hypertrophy in mice.

Omede A, Zi M, Prehar S, Maqsood A, Stafford N, Mamas M, Cartwright E, Oceandy D.

Biochem Biophys Res Commun. 2016 Oct 28;479(4):708-714. doi: 10.1016/j.bbrc.2016.09.147. Epub 2016 Sep 29.


Calcium Extrusion Pump PMCA4: A New Player in Renal Calcium Handling?

van Loon EP, Little R, Prehar S, Bindels RJ, Cartwright EJ, Hoenderop JG.

PLoS One. 2016 Apr 21;11(4):e0153483. doi: 10.1371/journal.pone.0153483. eCollection 2016.


The plasma membrane calcium ATPase 4 signalling in cardiac fibroblasts mediates cardiomyocyte hypertrophy.

Mohamed TMA, Abou-Leisa R, Stafford N, Maqsood A, Zi M, Prehar S, Baudoin-Stanley F, Wang X, Neyses L, Cartwright EJ, Oceandy D.

Nat Commun. 2016 Mar 29;7:11074. doi: 10.1038/ncomms11074.


Smad3 Couples Pak1 With the Antihypertrophic Pathway Through the E3 Ubiquitin Ligase, Fbxo32.

Tsui H, Zi M, Wang S, Chowdhury SK, Prehar S, Liang Q, Cartwright EJ, Lei M, Liu W, Wang X.

Hypertension. 2015 Dec;66(6):1176-83. doi: 10.1161/HYPERTENSIONAHA.115.06068. Epub 2015 Oct 19.


The mammalian Ste20-like kinase 2 (Mst2) modulates stress-induced cardiac hypertrophy.

Zi M, Maqsood A, Prehar S, Mohamed TM, Abou-Leisa R, Robertson A, Cartwright EJ, Ray SG, Oh S, Lim DS, Neyses L, Oceandy D.

J Biol Chem. 2014 Aug 29;289(35):24275-88. doi: 10.1074/jbc.M114.562405. Epub 2014 Jul 17.


Exercise training reduces resting heart rate via downregulation of the funny channel HCN4.

D'Souza A, Bucchi A, Johnsen AB, Logantha SJ, Monfredi O, Yanni J, Prehar S, Hart G, Cartwright E, Wisloff U, Dobryznski H, DiFrancesco D, Morris GM, Boyett MR.

Nat Commun. 2014 May 13;5:3775. doi: 10.1038/ncomms4775.


The tumour suppressor Ras-association domain family protein 1A (RASSF1A) regulates TNF-α signalling in cardiomyocytes.

Mohamed TM, Zi M, Prehar S, Maqsood A, Abou-Leisa R, Nguyen L, Pfeifer GP, Cartwright EJ, Neyses L, Oceandy D.

Cardiovasc Res. 2014 Jul 1;103(1):47-59. doi: 10.1093/cvr/cvu111. Epub 2014 Apr 28.


Targeted deletion of ERK2 in cardiomyocytes attenuates hypertrophic response but provokes pathological stress induced cardiac dysfunction.

Ulm S, Liu W, Zi M, Tsui H, Chowdhury SK, Endo S, Satoh Y, Prehar S, Wang R, Cartwright EJ, Wang X.

J Mol Cell Cardiol. 2014 Jul;72:104-16. doi: 10.1016/j.yjmcc.2014.03.002. Epub 2014 Mar 12.


A novel immunomodulator, FTY-720 reverses existing cardiac hypertrophy and fibrosis from pressure overload by targeting NFAT (nuclear factor of activated T-cells) signaling and periostin.

Liu W, Zi M, Tsui H, Chowdhury SK, Zeef L, Meng QJ, Travis M, Prehar S, Berry A, Hanley NA, Neyses L, Xiao RP, Oceandy D, Ke Y, Solaro RJ, Cartwright EJ, Lei M, Wang X.

Circ Heart Fail. 2013 Jul;6(4):833-44. doi: 10.1161/CIRCHEARTFAILURE.112.000123. Epub 2013 Jun 10.


Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart.

Liu W, Zi M, Naumann R, Ulm S, Jin J, Taglieri DM, Prehar S, Gui J, Tsui H, Xiao RP, Neyses L, Solaro RJ, Ke Y, Cartwright EJ, Lei M, Wang X.

Circulation. 2011 Dec 13;124(24):2702-15. doi: 10.1161/CIRCULATIONAHA.111.048785. Epub 2011 Nov 14.


Plasma membrane calcium pump (PMCA4)-neuronal nitric-oxide synthase complex regulates cardiac contractility through modulation of a compartmentalized cyclic nucleotide microdomain.

Mohamed TM, Oceandy D, Zi M, Prehar S, Alatwi N, Wang Y, Shaheen MA, Abou-Leisa R, Schelcher C, Hegab Z, Baudoin F, Emerson M, Mamas M, Di Benedetto G, Zaccolo M, Lei M, Cartwright EJ, Neyses L.

J Biol Chem. 2011 Dec 2;286(48):41520-9. doi: 10.1074/jbc.M111.290411. Epub 2011 Sep 29.


Mitogen-activated protein kinase kinase 4 deficiency in cardiomyocytes causes connexin 43 reduction and couples hypertrophic signals to ventricular arrhythmogenesis.

Zi M, Kimura TE, Liu W, Jin J, Higham J, Kharche S, Hao G, Shi Y, Shen W, Prehar S, Mironov A, Neyses L, Bierhuizen MF, Boyett MR, Zhang H, Lei M, Cartwright EJ, Wang X.

J Biol Chem. 2011 May 20;286(20):17821-30. doi: 10.1074/jbc.M111.228791. Epub 2011 Mar 28. No abstract available.


Deprivation of MKK7 in cardiomyocytes provokes heart failure in mice when exposed to pressure overload.

Liu W, Zi M, Chi H, Jin J, Prehar S, Neyses L, Cartwright EJ, Flavell RA, Davis RJ, Wang X.

J Mol Cell Cardiol. 2011 Apr;50(4):702-11. doi: 10.1016/j.yjmcc.2011.01.013. Epub 2011 Jan 31.


Targeted deletion of the extracellular signal-regulated protein kinase 5 attenuates hypertrophic response and promotes pressure overload-induced apoptosis in the heart.

Kimura TE, Jin J, Zi M, Prehar S, Liu W, Oceandy D, Abe J, Neyses L, Weston AH, Cartwright EJ, Wang X.

Circ Res. 2010 Mar 19;106(5):961-70. doi: 10.1161/CIRCRESAHA.109.209320. Epub 2010 Jan 14.


Tumor suppressor Ras-association domain family 1 isoform A is a novel regulator of cardiac hypertrophy.

Oceandy D, Pickard A, Prehar S, Zi M, Mohamed TM, Stanley PJ, Baudoin-Stanley F, Nadif R, Tommasi S, Pfeifer GP, Armesilla AL, Cartwright EJ, Neyses L.

Circulation. 2009 Aug 18;120(7):607-16. doi: 10.1161/CIRCULATIONAHA.109.868554. Epub 2009 Aug 3.


Specific role of neuronal nitric-oxide synthase when tethered to the plasma membrane calcium pump in regulating the beta-adrenergic signal in the myocardium.

Mohamed TM, Oceandy D, Prehar S, Alatwi N, Hegab Z, Baudoin FM, Pickard A, Zaki AO, Nadif R, Cartwright EJ, Neyses L.

J Biol Chem. 2009 May 1;284(18):12091-8. doi: 10.1074/jbc.M809112200. Epub 2009 Mar 10.


The cardiovascular phenotype of a mouse model of acromegaly.

Izzard AS, Emerson M, Prehar S, Neyses L, Trainer P, List EO, Kopchick JJ, Heagerty AM.

Growth Horm IGF Res. 2009 Oct;19(5):413-9. doi: 10.1016/j.ghir.2008.12.006. Epub 2009 Mar 9.


Cardiac-specific deletion of mkk4 reveals its role in pathological hypertrophic remodeling but not in physiological cardiac growth.

Liu W, Zi M, Jin J, Prehar S, Oceandy D, Kimura TE, Lei M, Neyses L, Weston AH, Cartwright EJ, Wang X.

Circ Res. 2009 Apr 10;104(7):905-14. doi: 10.1161/CIRCRESAHA.108.188292. Epub 2009 Mar 5.


Neuronal nitric oxide synthase signaling in the heart is regulated by the sarcolemmal calcium pump 4b.

Oceandy D, Cartwright EJ, Emerson M, Prehar S, Baudoin FM, Zi M, Alatwi N, Venetucci L, Schuh K, Williams JC, Armesilla AL, Neyses L.

Circulation. 2007 Jan 30;115(4):483-92. Epub 2007 Jan 22.


Interleukin-6 is an afferent signal to the hypothalamo-pituitary-adrenal axis during local inflammation in mice.

Turnbull AV, Prehar S, Kennedy AR, Little RA, Hopkins SJ.

Endocrinology. 2003 May;144(5):1894-906.


Identification of [(125)I]endothelin binding sites in human coronary tissue.

Dashwood MR, Sykes RM, Collins MJ, Prehar S, Theodoropoulos S, Yacoub MH.

Neurochem Int. 1991;18(4):439-44.


Autoradiographic localization of [125I]endothelin binding sites in human blood vessels and coronary tissue: functional correlates.

Dashwood MR, Sykes RM, Muddle JR, Collins MJ, Prehar S, Theodoropoulos S, Yacoub MH.

J Cardiovasc Pharmacol. 1991;17 Suppl 7:S458-62.


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