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Items: 1 to 50 of 322

1.

Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit.

Gordeuk VR, Miasnikova GY, Sergueeva AI, Lorenzo FR, Zhang X, Song J, Stockton DW, Prchal JT.

Haematologica. 2019 Jul 9. pii: haematol.2019.216267. doi: 10.3324/haematol.2019.216267. [Epub ahead of print]

2.
3.

Development of a symptom assessment in patients with myelofibrosis: qualitative study findings.

Mesa RA, Su Y, Woolfson A, Prchal JT, Turnbull K, Jabbour E, Scherber R, Shields AL, Krohe M, Ojo F, Pompilus F, Cappelleri JC, Harrison C.

Health Qual Life Outcomes. 2019 Apr 11;17(1):61. doi: 10.1186/s12955-019-1121-1.

4.

Re-evaluation of hematocrit as a determinant of thrombotic risk in erythrocytosis.

Gordeuk VR, Key NS, Prchal JT.

Haematologica. 2019 Apr;104(4):653-658. doi: 10.3324/haematol.2018.210732. Epub 2019 Mar 14. Review.

5.

Diagnosing or ruling out polycythemia vera in patients with erythrocytosis.

Prchal JT.

Clin Adv Hematol Oncol. 2019 Jan;17(1):24-27. No abstract available.

PMID:
30843892
6.

Nuclear-Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis.

Yan D, Pomicter AD, Tantravahi S, Mason CC, Senina AV, Ahmann JM, Wang Q, Than H, Patel AB, Heaton WL, Eiring AM, Clair PM, Gantz KC, Redwine HM, Swierczek SI, Halverson BJ, Baloglu E, Shacham S, Khorashad JS, Kelley TW, Salama ME, Miles RR, Boucher KM, Prchal JT, O'Hare T, Deininger MW.

Clin Cancer Res. 2019 Apr 1;25(7):2323-2335. doi: 10.1158/1078-0432.CCR-18-0959. Epub 2018 Dec 18.

PMID:
30563936
7.

Hypoxia and thrombosis.

Prchal JT.

Blood. 2018 Jul 26;132(4):348-349. doi: 10.1182/blood-2018-06-854976. No abstract available.

8.

Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion.

Heaton WL, Senina AV, Pomicter AD, Salama ME, Clair PM, Yan D, Bell RN, Gililland JM, Prchal JT, O'Hare T, Deininger MW.

Leukemia. 2018 Nov;32(11):2399-2411. doi: 10.1038/s41375-018-0131-z. Epub 2018 Apr 18.

9.

Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses.

Tashi T, Swierczek S, Kim SJ, Salama ME, Song J, Heikal N, King KY, Hickman K, Litton S, Prchal JT.

Leukemia. 2018 Aug;32(8):1830-1833. doi: 10.1038/s41375-018-0080-6. Epub 2018 Feb 28. No abstract available.

10.

Evaluation of Erythrocyte Changes After Normoxic Return from Hypoxia.

Song J, Prchal JT.

Methods Mol Biol. 2018;1742:185-194. doi: 10.1007/978-1-4939-7665-2_16.

PMID:
29330800
11.

Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.

Crawford JE, Amaru R, Song J, Julian CG, Racimo F, Cheng JY, Guo X, Yao J, Ambale-Venkatesh B, Lima JA, Rotter JI, Stehlik J, Moore LG, Prchal JT, Nielsen R.

Am J Hum Genet. 2017 Nov 2;101(5):752-767. doi: 10.1016/j.ajhg.2017.09.023.

12.

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.

Nieborowska-Skorska M, Maifrede S, Dasgupta Y, Sullivan K, Flis S, Le BV, Solecka M, Belyaeva EA, Kubovcakova L, Nawrocki M, Kirschner M, Zhao H, Prchal JT, Piwocka K, Moliterno AR, Wasik M, Koschmieder S, Green TR, Skoda RC, Skorski T.

Blood. 2017 Dec 28;130(26):2848-2859. doi: 10.1182/blood-2017-05-784942. Epub 2017 Oct 17.

13.

Familial MPN Predisposition.

Tashi T, Swierczek S, Prchal JT.

Curr Hematol Malig Rep. 2017 Oct;12(5):442-447. doi: 10.1007/s11899-017-0414-x. Review.

PMID:
29027642
14.

A phase 1 study of the Janus kinase 2 (JAK2)V617F inhibitor, gandotinib (LY2784544), in patients with primary myelofibrosis, polycythemia vera, and essential thrombocythemia.

Verstovsek S, Mesa RA, Salama ME, Li L, Pitou C, Nunes FP, Price GL, Giles JL, D'Souza DN, Walgren RA, Prchal JT.

Leuk Res. 2017 Oct;61:89-95. doi: 10.1016/j.leukres.2017.08.010. Epub 2017 Aug 31.

PMID:
28934680
15.

Ironing out the role of hepcidin in infection.

Prchal JT.

Blood. 2017 Jul 20;130(3):233-234. doi: 10.1182/blood-2017-05-783688. No abstract available.

16.

Thrombotic Thrombocytopenic Purpura Associated With Pegylated Interferon Alfa-2a Use in a Patient With Polycythemia Vera.

Gangaraju R, Kim SJ, Dong JF, Swierczek S, Prchal JT.

J Natl Compr Canc Netw. 2017 Jun;15(6):757-760. doi: 10.6004/jnccn.2017.0108.

PMID:
28596255
17.

Regulation of erythropoiesis after normoxic return from chronic sustained and intermittent hypoxia.

Song J, Sundar K, Gangaraju R, Prchal JT.

J Appl Physiol (1985). 2017 Dec 1;123(6):1671-1675. doi: 10.1152/japplphysiol.00119.2017. Epub 2017 May 18. Review.

18.

Evolutionary history of Tibetans inferred from whole-genome sequencing.

Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD.

PLoS Genet. 2017 Apr 27;13(4):e1006675. doi: 10.1371/journal.pgen.1006675. eCollection 2017 Apr.

19.

The Cornerstone of the Aberrant Pathophysiology of Obstructive Sleep Apnea: Tissue Responses to Chronic Sustained Versus Intermittent Hypoxia.

Sundar KM, Prchal JT.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):419-420. doi: 10.1165/rcmb.2017-0028ED. No abstract available.

PMID:
28362150
20.

Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders.

Tashi T, Scott Reading N, Wuren T, Zhang X, Moore LG, Hu H, Tang F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer CT, Julian CG, Shah B, Huff CD, Gordeuk VR, Prchal JT, Ge R.

J Mol Med (Berl). 2017 Jun;95(6):665-670. doi: 10.1007/s00109-017-1519-3. Epub 2017 Feb 23.

PMID:
28233034
21.

A patient with both methemoglobinemia and G6PD deficiency: A therapeutic conundrum.

Reading NS, Ruiz-Bonilla JA, Christensen RD, Cáceres-Perkins W, Prchal JT.

Am J Hematol. 2017 May;92(5):474-477. doi: 10.1002/ajh.24683. Epub 2017 Mar 24. No abstract available.

22.

A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.

Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR.

Hum Mol Genet. 2016 Oct 15;25(20):4601-4609. doi: 10.1093/hmg/ddw299.

23.

Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia.

Sergueeva A, Miasnikova G, Shah BN, Song J, Lisina E, Okhotin DJ, Nouraie M, Nekhai S, Ammosova T, Niu XM, Prchal JT, Zhang X, Gordeuk VR.

Haematologica. 2017 May;102(5):e166-e169. doi: 10.3324/haematol.2016.158170. Epub 2017 Jan 19. No abstract available.

24.

Three Novel Spectrin Variants in Jaundiced Neonates.

Christensen RD, Agarwal AM, Yaish HM, Reading NS, O'Brien EA, Prchal JT.

Clin Pediatr (Phila). 2018 Jan;57(1):19-26. doi: 10.1177/0009922816687326. Epub 2017 Jan 15.

PMID:
28090778
25.

Possible association of 3' UTR +357 A>G, IVS11-nt 93 T>C, c.1311 C>T polymorphism with G6PD deficiency.

Sirdah MM, Shubair ME, Al-Kahlout MS, Al-Tayeb JM, Prchal JT, Reading NS.

Hematology. 2017 Jul;22(6):370-374. doi: 10.1080/10245332.2016.1276117. Epub 2017 Jan 6.

PMID:
28059001
26.

Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer.

Lanikova L, Reading NS, Hu H, Tashi T, Burjanivova T, Shestakova A, Siwakoti B, Thakur BK, Pun CB, Sapkota A, Abdelaziz S, Feng BJ, Huff CD, Hashibe M, Prchal JT.

Oncotarget. 2017 Feb 14;8(7):11739-11747. doi: 10.18632/oncotarget.14340.

27.

Coexistence of gain-of-function JAK2 germ line mutations with JAK2V617F in polycythemia vera.

Lanikova L, Babosova O, Swierczek S, Wang L, Wheeler DA, Divoky V, Korinek V, Prchal JT.

Blood. 2016 Nov 3;128(18):2266-2270. Epub 2016 Sep 19. No abstract available.

28.

Novel insights into the polycythemia-paraganglioma-somatostatinoma syndrome.

Därr R, Nambuba J, Del Rivero J, Janssen I, Merino M, Todorovic M, Balint B, Jochmanova I, Prchal JT, Lechan RM, Tischler AS, Popovic V, Miljic D, Adams KT, Prall FR, Ling A, Golomb MR, Ferguson M, Nilubol N, Chen CC, Chew E, Taïeb D, Stratakis CA, Fojo T, Yang C, Kebebew E, Zhuang Z, Pacak K.

Endocr Relat Cancer. 2016 Dec;23(12):899-908. Epub 2016 Sep 27.

29.

Favism, the commonest form of severe hemolytic anemia in Palestinian children, varies in severity with three different variants of G6PD deficiency within the same community.

Reading NS, Sirdah MM, Shubair ME, Nelson BE, Al-Kahlout MS, Al-Tayeb JM, Aboud LN, Shaban MA, Luzzatto L, Prchal JT.

Blood Cells Mol Dis. 2016 Sep;60:58-64. doi: 10.1016/j.bcmd.2016.07.001. Epub 2016 Jul 6.

PMID:
27519946
30.

Loss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression.

Reading NS, Shooter C, Song J, Miller R, Agarwal A, Lanikova L, Clark B, Thein SL, Divoky V, Prchal JT.

Hum Mutat. 2016 Nov;37(11):1153-1156. doi: 10.1002/humu.23061. Epub 2016 Aug 25.

PMID:
27492747
31.

A Genome-Wide Search for Greek and Jewish Admixture in the Kashmiri Population.

Downie JM, Tashi T, Lorenzo FR, Feusier JE, Mir H, Prchal JT, Jorde LB, Koul PA.

PLoS One. 2016 Aug 4;11(8):e0160614. doi: 10.1371/journal.pone.0160614. eCollection 2016.

32.

Clinical utility of next-generation sequencing in the diagnosis of hereditary haemolytic anaemias.

Agarwal AM, Nussenzveig RH, Reading NS, Patel JL, Sangle N, Salama ME, Prchal JT, Perkins SL, Yaish HM, Christensen RD.

Br J Haematol. 2016 Sep;174(5):806-14. doi: 10.1111/bjh.14131. Epub 2016 Jun 12.

PMID:
27292444
33.

Delayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor.

Divoky V, Song J, Horvathova M, Kralova B, Votavova H, Prchal JT, Yoon D.

J Mol Med (Berl). 2016 May;94(5):597-608. doi: 10.1007/s00109-015-1375-y. Epub 2015 Dec 26.

34.

Acquired uniparental disomy of chromosome 9p in hematologic malignancies.

Wang L, Wheeler DA, Prchal JT.

Exp Hematol. 2016 Aug;44(8):644-52. doi: 10.1016/j.exphem.2015.11.005. Epub 2015 Dec 2. Review.

35.

Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.

Simonson TS, Huff CD, Witherspoon DJ, Prchal JT, Jorde LB.

Exp Physiol. 2015 Nov;100(11):1263-8. doi: 10.1113/EP085035. Review.

36.

Increased frequency of co-existing JAK2 exon-12 or MPL exon-10 mutations in patients with low JAK2(V617F) allelic burden.

Nussenzveig RH, Pham HT, Perkins SL, Prchal JT, Agarwal AM, Salama ME.

Leuk Lymphoma. 2016;57(6):1429-35. doi: 10.3109/10428194.2015.1091932. Epub 2015 Dec 23.

PMID:
26419289
37.

Measuring End-Tidal Carbon Monoxide of Jaundiced Neonates in the Birth Hospital to Identify Those with Hemolysis.

Christensen RD, Malleske DT, Lambert DK, Baer VL, Prchal JT, Denson LE, Gerday E, Weaver Lewis KA, Shepherd JG.

Neonatology. 2016;109(1):1-5. doi: 10.1159/000438482. Epub 2015 Sep 23.

PMID:
26394287
38.

Presence of polyclonal hematopoiesis in females with Ph-negative myeloproliferative neoplasms.

Swierczek S, Lima LT, Tashi T, Kim SJ, Gregg XT, Prchal JT.

Leukemia. 2015 Dec;29(12):2432-4. doi: 10.1038/leu.2015.249. Epub 2015 Sep 15. No abstract available.

39.

Genetic selection by high altitude: Beware of experiments at ambient conditions.

Prchal JT.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10080-1. doi: 10.1073/pnas.1512899112. Epub 2015 Aug 10. No abstract available.

40.

Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells.

King KY, Matatall KA, Shen CC, Goodell MA, Swierczek SI, Prchal JT.

Exp Hematol. 2015 Oct;43(10):912-918.e2. doi: 10.1016/j.exphem.2015.05.013. Epub 2015 Jun 11.

41.

Metabolic aspects of high-altitude adaptation in Tibetans.

Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA.

Exp Physiol. 2015 Nov;100(11):1247-55. doi: 10.1113/EP085292. Epub 2015 Jul 14. Review.

42.

HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis.

Song J, Yoon D, Christensen RD, Horvathova M, Thiagarajan P, Prchal JT.

J Mol Med (Berl). 2015 Aug;93(8):857-66. doi: 10.1007/s00109-015-1294-y. Epub 2015 May 28.

PMID:
26017143
43.

Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm.

Pomicter AD, Eiring AM, Senina AV, Zabriskie MS, Marvin JE, Prchal JT, O'Hare T, Deininger MW.

Exp Hematol. 2015 Jul;43(7):537-45.e1-11. doi: 10.1016/j.exphem.2015.03.006. Epub 2015 Apr 24.

44.

End-tidal carbon monoxide as an indicator of the hemolytic rate.

Christensen RD, Lambert DK, Henry E, Yaish HM, Prchal JT.

Blood Cells Mol Dis. 2015 Mar;54(3):292-6. doi: 10.1016/j.bcmd.2014.11.018. Epub 2014 Nov 26.

PMID:
25624169
45.

Complications in children and adolescents with Chuvash polycythemia.

Sergueeva AI, Miasnikova GY, Polyakova LA, Nouraie M, Prchal JT, Gordeuk VR.

Blood. 2015 Jan 8;125(2):414-5. doi: 10.1182/blood-2014-10-604660. No abstract available.

46.

Somatic mosaicism of EPAS1 mutations in the syndrome of paraganglioma and somatostatinoma associated with polycythemia.

Yang C, Hong CS, Prchal JT, Balint MT, Pacak K, Zhuang Z.

Hum Genome Var. 2015 Dec 10;2:15053. doi: 10.1038/hgv.2015.53. eCollection 2015.

47.

Novel α-spectrin mutation in trans with α-spectrin causing severe neonatal jaundice from hereditary spherocytosis.

Nussenzveig RH, Christensen RD, Prchal JT, Yaish HM, Agarwal AM.

Neonatology. 2014;106(4):355-7. doi: 10.1159/000365586. Epub 2014 Oct 1.

PMID:
25277063
48.

Calreticulin mutated prefibrotic-stage myelofibrosis and PMF represent an independent clone from coexisting CLL.

Salama ME, Swierczek SI, Tashi T, Warby CA, Reading NS, Prchal JT.

Blood. 2014 Sep 4;124(10):1691-2. doi: 10.1182/blood-2014-04-568410. No abstract available.

49.

A genetic mechanism for Tibetan high-altitude adaptation.

Lorenzo FR, Huff C, Myllymäki M, Olenchock B, Swierczek S, Tashi T, Gordeuk V, Wuren T, Ri-Li G, McClain DA, Khan TM, Koul PA, Guchhait P, Salama ME, Xing J, Semenza GL, Liberzon E, Wilson A, Simonson TS, Jorde LB, Kaelin WG Jr, Koivunen P, Prchal JT.

Nat Genet. 2014 Sep;46(9):951-6. doi: 10.1038/ng.3067. Epub 2014 Aug 17.

50.

MPD-RC 101 prospective study of reduced-intensity allogeneic hematopoietic stem cell transplantation in patients with myelofibrosis.

Rondelli D, Goldberg JD, Isola L, Price LS, Shore TB, Boyer M, Bacigalupo A, Rambaldi A, Scarano M, Klisovic RB, Gupta V, Andreasson B, Mascarenhas J, Wetzler M, Vannucchi AM, Prchal JT, Najfeld V, Orazi A, Weinberg RS, Miller C, Barosi G, Silverman LR, Prosperini G, Marchioli R, Hoffman R.

Blood. 2014 Aug 14;124(7):1183-91. doi: 10.1182/blood-2014-04-572545. Epub 2014 Jun 24.

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