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Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion.

Heaton WL, Senina AV, Pomicter AD, Salama ME, Clair PM, Yan D, Bell RN, Gililland JM, Prchal JT, O'Hare T, Deininger MW.

Leukemia. 2018 Apr 18. doi: 10.1038/s41375-018-0131-z. [Epub ahead of print]


Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses.

Tashi T, Swierczek S, Kim SJ, Salama ME, Song J, Heikal N, King KY, Hickman K, Litton S, Prchal JT.

Leukemia. 2018 Feb 28. doi: 10.1038/s41375-018-0080-6. [Epub ahead of print] No abstract available.


Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization.

Bretz CA, Divoky V, Prchal J, Kunz E, Simmons AB, Wang H, Hartnett ME.

Sci Rep. 2018 Feb 1;8(1):2161. doi: 10.1038/s41598-018-20520-z.


Evaluation of Erythrocyte Changes After Normoxic Return from Hypoxia.

Song J, Prchal JT.

Methods Mol Biol. 2018;1742:185-194. doi: 10.1007/978-1-4939-7665-2_16.


Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.

Crawford JE, Amaru R, Song J, Julian CG, Racimo F, Cheng JY, Guo X, Yao J, Ambale-Venkatesh B, Lima JA, Rotter JI, Stehlik J, Moore LG, Prchal JT, Nielsen R.

Am J Hum Genet. 2017 Nov 2;101(5):752-767. doi: 10.1016/j.ajhg.2017.09.023.


Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.

Nieborowska-Skorska M, Maifrede S, Dasgupta Y, Sullivan K, Flis S, Le BV, Solecka M, Belyaeva EA, Kubovcakova L, Nawrocki M, Kirschner M, Zhao H, Prchal JT, Piwocka K, Moliterno AR, Wasik M, Koschmieder S, Green TR, Skoda RC, Skorski T.

Blood. 2017 Dec 28;130(26):2848-2859. doi: 10.1182/blood-2017-05-784942. Epub 2017 Oct 17.


Familial MPN Predisposition.

Tashi T, Swierczek S, Prchal JT.

Curr Hematol Malig Rep. 2017 Oct;12(5):442-447. doi: 10.1007/s11899-017-0414-x. Review.


A phase 1 study of the Janus kinase 2 (JAK2)V617F inhibitor, gandotinib (LY2784544), in patients with primary myelofibrosis, polycythemia vera, and essential thrombocythemia.

Verstovsek S, Mesa RA, Salama ME, Li L, Pitou C, Nunes FP, Price GL, Giles JL, D'Souza DN, Walgren RA, Prchal JT.

Leuk Res. 2017 Oct;61:89-95. doi: 10.1016/j.leukres.2017.08.010. Epub 2017 Aug 31.


Ironing out the role of hepcidin in infection.

Prchal JT.

Blood. 2017 Jul 20;130(3):233-234. doi: 10.1182/blood-2017-05-783688. No abstract available.


Thrombotic Thrombocytopenic Purpura Associated With Pegylated Interferon Alfa-2a Use in a Patient With Polycythemia Vera.

Gangaraju R, Kim SJ, Dong JF, Swierczek S, Prchal JT.

J Natl Compr Canc Netw. 2017 Jun;15(6):757-760. doi: 10.6004/jnccn.2017.0108.


Regulation of erythropoiesis after normoxic return from chronic sustained and intermittent hypoxia.

Song J, Sundar K, Gangaraju R, Prchal JT.

J Appl Physiol (1985). 2017 Dec 1;123(6):1671-1675. doi: 10.1152/japplphysiol.00119.2017. Epub 2017 May 18.


Evolutionary history of Tibetans inferred from whole-genome sequencing.

Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD.

PLoS Genet. 2017 Apr 27;13(4):e1006675. doi: 10.1371/journal.pgen.1006675. eCollection 2017 Apr.


The Cornerstone of the Aberrant Pathophysiology of Obstructive Sleep Apnea: Tissue Responses to Chronic Sustained Versus Intermittent Hypoxia.

Sundar KM, Prchal JT.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):419-420. doi: 10.1165/rcmb.2017-0028ED. No abstract available.


Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders.

Tashi T, Scott Reading N, Wuren T, Zhang X, Moore LG, Hu H, Tang F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer CT, Julian CG, Shah B, Huff CD, Gordeuk VR, Prchal JT, Ge R.

J Mol Med (Berl). 2017 Jun;95(6):665-670. doi: 10.1007/s00109-017-1519-3. Epub 2017 Feb 23.


A patient with both methemoglobinemia and G6PD deficiency: A therapeutic conundrum.

Reading NS, Ruiz-Bonilla JA, Christensen RD, Cáceres-Perkins W, Prchal JT.

Am J Hematol. 2017 May;92(5):474-477. doi: 10.1002/ajh.24683. Epub 2017 Mar 24. No abstract available.


A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.

Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR.

Hum Mol Genet. 2016 Oct 15;25(20):4601-4609. doi: 10.1093/hmg/ddw299.


Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia.

Sergueeva A, Miasnikova G, Shah BN, Song J, Lisina E, Okhotin DJ, Nouraie M, Nekhai S, Ammosova T, Niu XM, Prchal JT, Zhang X, Gordeuk VR.

Haematologica. 2017 May;102(5):e166-e169. doi: 10.3324/haematol.2016.158170. Epub 2017 Jan 19. No abstract available.


Three Novel Spectrin Variants in Jaundiced Neonates.

Christensen RD, Agarwal AM, Yaish HM, Reading NS, O'Brien EA, Prchal JT.

Clin Pediatr (Phila). 2018 Jan;57(1):19-26. doi: 10.1177/0009922816687326. Epub 2017 Jan 15.


Possible association of 3' UTR +357 A>G, IVS11-nt 93 T>C, c.1311 C>T polymorphism with G6PD deficiency.

Sirdah MM, Shubair ME, Al-Kahlout MS, Al-Tayeb JM, Prchal JT, Reading NS.

Hematology. 2017 Jul;22(6):370-374. doi: 10.1080/10245332.2016.1276117. Epub 2017 Jan 6.


Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer.

Lanikova L, Reading NS, Hu H, Tashi T, Burjanivova T, Shestakova A, Siwakoti B, Thakur BK, Pun CB, Sapkota A, Abdelaziz S, Feng BJ, Huff CD, Hashibe M, Prchal JT.

Oncotarget. 2017 Feb 14;8(7):11739-11747. doi: 10.18632/oncotarget.14340.


Adjuvant Endocrine Therapy in Breast Cancer: A Novel e-Health Approach in Optimizing Treatment for Seniors (OPTIMUM): A Two-Group Controlled Comparison Pilot Study.

Meguerditchian A, Tamblyn R, Meterissian S, Law S, Prchal J, Winslade N, Stern D.

JMIR Res Protoc. 2016 Nov 7;5(4):e199.


Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus.

Kerviel A, Dash S, Moncorgé O, Panthu B, Prchal J, Décimo D, Ohlmann T, Lina B, Favard C, Decroly E, Ottmann M, Roingeard P, Muriaux D.

PLoS One. 2016 Nov 4;11(11):e0165421. doi: 10.1371/journal.pone.0165421. eCollection 2016.


Coexistence of gain-of-function JAK2 germ line mutations with JAK2V617F in polycythemia vera.

Lanikova L, Babosova O, Swierczek S, Wang L, Wheeler DA, Divoky V, Korinek V, Prchal JT.

Blood. 2016 Nov 3;128(18):2266-2270. Epub 2016 Sep 19. No abstract available.


Novel insights into the polycythemia-paraganglioma-somatostatinoma syndrome.

Därr R, Nambuba J, Del Rivero J, Janssen I, Merino M, Todorovic M, Balint B, Jochmanova I, Prchal JT, Lechan RM, Tischler AS, Popovic V, Miljic D, Adams KT, Prall FR, Ling A, Golomb MR, Ferguson M, Nilubol N, Chen CC, Chew E, Taïeb D, Stratakis CA, Fojo T, Yang C, Kebebew E, Zhuang Z, Pacak K.

Endocr Relat Cancer. 2016 Dec;23(12):899-908. Epub 2016 Sep 27.


Membrane Interactions of the Mason-Pfizer Monkey Virus Matrix Protein and Its Budding Deficient Mutants.

Kroupa T, Langerová H, Doležal M, Prchal J, Spiwok V, Hunter E, Rumlová M, Hrabal R, Ruml T.

J Mol Biol. 2016 Nov 20;428(23):4708-4722. doi: 10.1016/j.jmb.2016.10.010. Epub 2016 Oct 8.


Molecular aspects of the interaction between Mason-Pfizer monkey virus matrix protein and artificial phospholipid membrane.

Junková P, Prchal J, Spiwok V, Pleskot R, Kadlec J, Krásný L, Hynek R, Hrabal R, Ruml T.

Proteins. 2016 Nov;84(11):1717-1727. doi: 10.1002/prot.25156. Epub 2016 Sep 15.


Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2V617F allelic burden.

Kovacsovics-Bankowski M, Kelley TW, Efimova O, Kim SJ, Wilson A, Swierczek S, Prchal J.

Exp Hematol Oncol. 2016 Sep 27;5:28. eCollection 2015.


Laboratory Investigation of Myeloproliferative Neoplasms (MPNs):  Recommendations of the Canadian Mpn Group.

Busque L, Porwit A, Day R, Olney HJ, Leber B, Éthier V, Sirhan S, Foltz L, Prchal J, Kamel-Reid S, Karsan A, Gupta V.

Am J Clin Pathol. 2016 Oct;146(4):408-22. doi: 10.1093/ajcp/aqw131. Review.


Favism, the commonest form of severe hemolytic anemia in Palestinian children, varies in severity with three different variants of G6PD deficiency within the same community.

Reading NS, Sirdah MM, Shubair ME, Nelson BE, Al-Kahlout MS, Al-Tayeb JM, Aboud LN, Shaban MA, Luzzatto L, Prchal JT.

Blood Cells Mol Dis. 2016 Sep;60:58-64. doi: 10.1016/j.bcmd.2016.07.001. Epub 2016 Jul 6.


Loss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression.

Reading NS, Shooter C, Song J, Miller R, Agarwal A, Lanikova L, Clark B, Thein SL, Divoky V, Prchal JT.

Hum Mutat. 2016 Nov;37(11):1153-1156. doi: 10.1002/humu.23061. Epub 2016 Aug 25.


A Genome-Wide Search for Greek and Jewish Admixture in the Kashmiri Population.

Downie JM, Tashi T, Lorenzo FR, Feusier JE, Mir H, Prchal JT, Jorde LB, Koul PA.

PLoS One. 2016 Aug 4;11(8):e0160614. doi: 10.1371/journal.pone.0160614. eCollection 2016.


Clinical utility of next-generation sequencing in the diagnosis of hereditary haemolytic anaemias.

Agarwal AM, Nussenzveig RH, Reading NS, Patel JL, Sangle N, Salama ME, Prchal JT, Perkins SL, Yaish HM, Christensen RD.

Br J Haematol. 2016 Sep;174(5):806-14. doi: 10.1111/bjh.14131. Epub 2016 Jun 12.


Delayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor.

Divoky V, Song J, Horvathova M, Kralova B, Votavova H, Prchal JT, Yoon D.

J Mol Med (Berl). 2016 May;94(5):597-608. doi: 10.1007/s00109-015-1375-y. Epub 2015 Dec 26.


Acquired uniparental disomy of chromosome 9p in hematologic malignancies.

Wang L, Wheeler DA, Prchal JT.

Exp Hematol. 2016 Aug;44(8):644-52. doi: 10.1016/j.exphem.2015.11.005. Epub 2015 Dec 2. Review.


Adaptive genetic changes related to haemoglobin concentration in native high-altitude Tibetans.

Simonson TS, Huff CD, Witherspoon DJ, Prchal JT, Jorde LB.

Exp Physiol. 2015 Nov;100(11):1263-8. doi: 10.1113/EP085035. Review.


Evolving Therapeutic Options for Polycythemia Vera: Perspectives of the Canadian Myeloproliferative Neoplasms Group.

Sirhan S, Busque L, Foltz L, Grewal K, Hamm C, Laferriere N, Laneuville P, Leber B, Liew E, Olney HJ, Prchal J, Porwit A, Gupta V.

Clin Lymphoma Myeloma Leuk. 2015 Dec;15(12):715-27. doi: 10.1016/j.clml.2015.07.650. Epub 2015 Aug 7.


Increased frequency of co-existing JAK2 exon-12 or MPL exon-10 mutations in patients with low JAK2(V617F) allelic burden.

Nussenzveig RH, Pham HT, Perkins SL, Prchal JT, Agarwal AM, Salama ME.

Leuk Lymphoma. 2016;57(6):1429-35. doi: 10.3109/10428194.2015.1091932. Epub 2015 Dec 23.


Measuring End-Tidal Carbon Monoxide of Jaundiced Neonates in the Birth Hospital to Identify Those with Hemolysis.

Christensen RD, Malleske DT, Lambert DK, Baer VL, Prchal JT, Denson LE, Gerday E, Weaver Lewis KA, Shepherd JG.

Neonatology. 2016;109(1):1-5. doi: 10.1159/000438482. Epub 2015 Sep 23.


Presence of polyclonal hematopoiesis in females with Ph-negative myeloproliferative neoplasms.

Swierczek S, Lima LT, Tashi T, Kim SJ, Gregg XT, Prchal JT.

Leukemia. 2015 Dec;29(12):2432-4. doi: 10.1038/leu.2015.249. Epub 2015 Sep 15. No abstract available.


Genetic selection by high altitude: Beware of experiments at ambient conditions.

Prchal JT.

Proc Natl Acad Sci U S A. 2015 Aug 18;112(33):10080-1. doi: 10.1073/pnas.1512899112. Epub 2015 Aug 10. No abstract available.


In Support of a Patient-Driven Initiative and Petition to Lower the High Price of Cancer Drugs.

Tefferi A, Kantarjian H, Rajkumar SV, Baker LH, Abkowitz JL, Adamson JW, Advani RH, Allison J, Antman KH, Bast RC Jr, Bennett JM, Benz EJ Jr, Berliner N, Bertino J, Bhatia R, Bhatia S, Bhojwani D, Blanke CD, Bloomfield CD, Bosserman L, Broxmeyer HE, Byrd JC, Cabanillas F, Canellos GP, Chabner BA, Chanan-Khan A, Cheson B, Clarkson B, Cohn SL, Colon-Otero G, Cortes J, Coutre S, Cristofanilli M, Curran WJ Jr, Daley GQ, DeAngelo DJ, Deeg HJ, Einhorn LH, Erba HP, Esteva FJ, Estey E, Fidler IJ, Foran J, Forman S, Freireich E, Fuchs C, George JN, Gertz MA, Giralt S, Golomb H, Greenberg P, Gutterman J, Handin RI, Hellman S, Hoff PM, Hoffman R, Hong WK, Horowitz M, Hortobagyi GN, Hudis C, Issa JP, Johnson BE, Kantoff PW, Kaushansky K, Khayat D, Khuri FR, Kipps TJ, Kripke M, Kyle RA, Larson RA, Lawrence TS, Levine R, Link MP, Lippman SM, Lonial S, Lyman GH, Markman M, Mendelsohn J, Meropol NJ, Messinger Y, Mulvey TM, O'Brien S, Perez-Soler R, Pollock R, Prchal J, Press O, Radich J, Rai K, Rosenberg SA, Rowe JM, Rugo H, Runowicz CD, Sandmaier BM, Saven A, Schafer AI, Schiffer C, Sekeres MA, Silver RT, Siu LL, Steensma DP, Stewart FM, Stock W, Stone R, Storb R, Strong LC, Tallman MS, Thompson M, Ueno NT, Van Etten RA, Vose JM, Wiernik PH, Winer EP, Younes A, Zelenetz AD, LeMaistre CA.

Mayo Clin Proc. 2015 Aug;90(8):996-1000. doi: 10.1016/j.mayocp.2015.06.001. Epub 2015 Jul 23. No abstract available.


Comparative long-term effects of interferon α and hydroxyurea on human hematopoietic progenitor cells.

King KY, Matatall KA, Shen CC, Goodell MA, Swierczek SI, Prchal JT.

Exp Hematol. 2015 Oct;43(10):912-918.e2. doi: 10.1016/j.exphem.2015.05.013. Epub 2015 Jun 11.


Metabolic aspects of high-altitude adaptation in Tibetans.

Ge RL, Simonson TS, Gordeuk V, Prchal JT, McClain DA.

Exp Physiol. 2015 Nov;100(11):1247-55. doi: 10.1113/EP085292. Epub 2015 Jul 14. Review.


HIF-mediated increased ROS from reduced mitophagy and decreased catalase causes neocytolysis.

Song J, Yoon D, Christensen RD, Horvathova M, Thiagarajan P, Prchal JT.

J Mol Med (Berl). 2015 Aug;93(8):857-66. doi: 10.1007/s00109-015-1294-y. Epub 2015 May 28.


Limited efficacy of BMS-911543 in a murine model of Janus kinase 2 V617F myeloproliferative neoplasm.

Pomicter AD, Eiring AM, Senina AV, Zabriskie MS, Marvin JE, Prchal JT, O'Hare T, Deininger MW.

Exp Hematol. 2015 Jul;43(7):537-45.e1-11. doi: 10.1016/j.exphem.2015.03.006. Epub 2015 Apr 24.


Historical views, conventional approaches, and evolving management strategies for myeloproliferative neoplasms.

Stein BL, Gotlib J, Arcasoy M, Nguyen MH, Shah N, Moliterno A, Jamieson C, Pollyea DA, Scott B, Wadleigh M, Levine R, Komrokji R, Klisovic R, Gundabolu K, Kropf P, Wetzler M, Oh ST, Ribeiro R, Paschal R, Mohan S, Podoltsev N, Prchal J, Talpaz M, Snyder D, Verstovsek S, Mesa RA.

J Natl Compr Canc Netw. 2015 Apr;13(4):424-34. Review.


Tuning the pressure-induced superconductivity in Pd-substituted CeRhIn5.

Kratochvilova M, Uhlirova K, Prchal J, Prokleska J, Misek M, Sechovsky V.

J Phys Condens Matter. 2015 Mar 11;27(9):095602. doi: 10.1088/0953-8984/27/9/095602. Epub 2015 Feb 13.


Allo-SCT for myelofibrosis: reversing the chronic phase in the JAK inhibitor era?

Tamari R, Mughal TI, Rondelli D, Hasserjian R, Gupta V, Odenike O, Fauble V, Finazzi G, Pane F, Mascarenhas J, Prchal J, Giralt S, Hoffman R.

Bone Marrow Transplant. 2015 May;50(5):628-36. doi: 10.1038/bmt.2014.323. Epub 2015 Feb 9. Review.


End-tidal carbon monoxide as an indicator of the hemolytic rate.

Christensen RD, Lambert DK, Henry E, Yaish HM, Prchal JT.

Blood Cells Mol Dis. 2015 Mar;54(3):292-6. doi: 10.1016/j.bcmd.2014.11.018. Epub 2014 Nov 26.


Complications in children and adolescents with Chuvash polycythemia.

Sergueeva AI, Miasnikova GY, Polyakova LA, Nouraie M, Prchal JT, Gordeuk VR.

Blood. 2015 Jan 8;125(2):414-5. doi: 10.1182/blood-2014-10-604660. No abstract available.

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