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Items: 1 to 50 of 416

1.

Early Hyperbilirubinemia in Neonates with Down Syndrome.

Bahr TM, Henry E, Hulse W, Baer VL, Prchal JT, Bhutani VK, Christensen RD.

J Pediatr. 2020 Jan 31. pii: S0022-3476(19)31718-4. doi: 10.1016/j.jpeds.2019.12.039. [Epub ahead of print]

PMID:
32014279
2.

Clonal hematopoiesis in hematological disorders: Three different scenarios.

Swierczek S, Prchal JT.

Exp Hematol. 2020 Jan 30. pii: S0301-472X(20)30034-5. doi: 10.1016/j.exphem.2020.01.013. [Epub ahead of print]

PMID:
32007480
3.

JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera.

Patel AB, Franzini A, Leroy E, Kim SJ, Pomicter AD, Genet L, Xiao M, Yan D, Ahmann JM, Agarwal AM, Clair P, Addada J, Lambert J, Salmon M, Gleich GJ, Cross NCP, Constantinescu SN, O'Hare T, Prchal JT, Deininger MW.

Blood. 2019 Dec 26;134(26):2388-2398. doi: 10.1182/blood.2019001385.

PMID:
31697804
4.

Response to interferon treatment in essential thrombocythemia with inv(3)(q21q26).

Gangaraju R, Carroll AJ, Prchal JT.

Ann Hematol. 2019 Nov 1. doi: 10.1007/s00277-019-03805-9. [Epub ahead of print] No abstract available.

PMID:
31676985
5.

Experimental Modeling of Myeloproliferative Neoplasms.

Lanikova L, Babosova O, Prchal JT.

Genes (Basel). 2019 Oct 15;10(10). pii: E813. doi: 10.3390/genes10100813. Review.

6.

Iron chelation and 2-oxoglutarate-dependent dioxygenase inhibition suppress mantle cell lymphoma's cyclin D1.

Babosova O, Kapralova K, Raskova Kafkova L, Korinek V, Divoky V, Prchal JT, Lanikova L.

J Cell Mol Med. 2019 Nov;23(11):7785-7795. doi: 10.1111/jcmm.14655. Epub 2019 Sep 13.

7.

Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea.

Yacoub A, Mascarenhas J, Kosiorek H, Prchal JT, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Papaemmanuil E, Salama M, Singer-Weinberg R, Rampal R, Goldberg JD, Barbui T, Mesa R, Dueck AC, Hoffman R.

Blood. 2019 Oct 31;134(18):1498-1509. doi: 10.1182/blood.2019000428.

8.

A prospective evaluation of pegylated interferon alfa-2a therapy in patients with polycythemia vera and essential thrombocythemia with a prior splanchnic vein thrombosis.

Mascarenhas J, Kosiorek H, Prchal J, Yacoub A, Berenzon D, Baer MR, Ritchie E, Silver RT, Kessler C, Winton E, Finazzi MC, Rambaldi A, Vannucchi AM, Leibowitz D, Rondelli D, Arcasoy MO, Catchatourian R, Vadakara J, Rosti V, Hexner E, Kremyanskaya M, Sandy L, Tripodi J, Najfeld V, Farnoud N, Salama ME, Weinberg RS, Rampal R, Goldberg JD, Mesa R, Dueck AC, Hoffman R.

Leukemia. 2019 Dec;33(12):2974-2978. doi: 10.1038/s41375-019-0524-7. Epub 2019 Jul 30. No abstract available.

9.

Thrombotic risk in congenital erythrocytosis due to up-regulated hypoxia sensing is not associated with elevated hematocrit.

Gordeuk VR, Miasnikova GY, Sergueeva AI, Lorenzo FR, Zhang X, Song J, Stockton DW, Prchal JT.

Haematologica. 2019 Jul 9. pii: haematol.2019.216267. doi: 10.3324/haematol.2019.216267. [Epub ahead of print]

10.
11.

Development of a symptom assessment in patients with myelofibrosis: qualitative study findings.

Mesa RA, Su Y, Woolfson A, Prchal JT, Turnbull K, Jabbour E, Scherber R, Shields AL, Krohe M, Ojo F, Pompilus F, Cappelleri JC, Harrison C.

Health Qual Life Outcomes. 2019 Apr 11;17(1):61. doi: 10.1186/s12955-019-1121-1.

12.

Re-evaluation of hematocrit as a determinant of thrombotic risk in erythrocytosis.

Gordeuk VR, Key NS, Prchal JT.

Haematologica. 2019 Apr;104(4):653-658. doi: 10.3324/haematol.2018.210732. Epub 2019 Mar 14. Review.

13.

Diagnosing or ruling out polycythemia vera in patients with erythrocytosis.

Prchal JT.

Clin Adv Hematol Oncol. 2019 Jan;17(1):24-27. No abstract available.

PMID:
30843892
14.

Nuclear-Cytoplasmic Transport Is a Therapeutic Target in Myelofibrosis.

Yan D, Pomicter AD, Tantravahi S, Mason CC, Senina AV, Ahmann JM, Wang Q, Than H, Patel AB, Heaton WL, Eiring AM, Clair PM, Gantz KC, Redwine HM, Swierczek SI, Halverson BJ, Baloglu E, Shacham S, Khorashad JS, Kelley TW, Salama ME, Miles RR, Boucher KM, Prchal JT, O'Hare T, Deininger MW.

Clin Cancer Res. 2019 Apr 1;25(7):2323-2335. doi: 10.1158/1078-0432.CCR-18-0959. Epub 2018 Dec 18.

15.

De novo mutations in the GTP/GDP-binding region of RALA, a RAS-like small GTPase, cause intellectual disability and developmental delay.

Hiatt SM, Neu MB, Ramaker RC, Hardigan AA, Prokop JW, Hancarova M, Prchalova D, Havlovicova M, Prchal J, Stranecky V, Yim DKC, Powis Z, Keren B, Nava C, Mignot C, Rio M, Revah-Politi A, Hemati P, Stong N, Iglesias AD, Suchy SF, Willaert R, Wentzensen IM, Wheeler PG, Brick L, Kozenko M, Hurst ACE, Wheless JW, Lacassie Y, Myers RM, Barsh GS, Sedlacek Z, Cooper GM.

PLoS Genet. 2018 Nov 30;14(11):e1007671. doi: 10.1371/journal.pgen.1007671. eCollection 2018 Nov.

16.

Hypoxia and thrombosis.

Prchal JT.

Blood. 2018 Jul 26;132(4):348-349. doi: 10.1182/blood-2018-06-854976. No abstract available.

PMID:
30049732
17.

Autocrine Tnf signaling favors malignant cells in myelofibrosis in a Tnfr2-dependent fashion.

Heaton WL, Senina AV, Pomicter AD, Salama ME, Clair PM, Yan D, Bell RN, Gililland JM, Prchal JT, O'Hare T, Deininger MW.

Leukemia. 2018 Nov;32(11):2399-2411. doi: 10.1038/s41375-018-0131-z. Epub 2018 Apr 18.

18.

Pegylated interferon Alfa-2a and hydroxyurea in polycythemia vera and essential thrombocythemia: differential cellular and molecular responses.

Tashi T, Swierczek S, Kim SJ, Salama ME, Song J, Heikal N, King KY, Hickman K, Litton S, Prchal JT.

Leukemia. 2018 Aug;32(8):1830-1833. doi: 10.1038/s41375-018-0080-6. Epub 2018 Feb 28. No abstract available.

19.

Erythropoietin Signaling Increases Choroidal Macrophages and Cytokine Expression, and Exacerbates Choroidal Neovascularization.

Bretz CA, Divoky V, Prchal J, Kunz E, Simmons AB, Wang H, Hartnett ME.

Sci Rep. 2018 Feb 1;8(1):2161. doi: 10.1038/s41598-018-20520-z.

20.

Evaluation of Erythrocyte Changes After Normoxic Return from Hypoxia.

Song J, Prchal JT.

Methods Mol Biol. 2018;1742:185-194. doi: 10.1007/978-1-4939-7665-2_16.

PMID:
29330800
21.

Natural Selection on Genes Related to Cardiovascular Health in High-Altitude Adapted Andeans.

Crawford JE, Amaru R, Song J, Julian CG, Racimo F, Cheng JY, Guo X, Yao J, Ambale-Venkatesh B, Lima JA, Rotter JI, Stehlik J, Moore LG, Prchal JT, Nielsen R.

Am J Hum Genet. 2017 Nov 2;101(5):752-767. doi: 10.1016/j.ajhg.2017.09.023.

22.

Ruxolitinib-induced defects in DNA repair cause sensitivity to PARP inhibitors in myeloproliferative neoplasms.

Nieborowska-Skorska M, Maifrede S, Dasgupta Y, Sullivan K, Flis S, Le BV, Solecka M, Belyaeva EA, Kubovcakova L, Nawrocki M, Kirschner M, Zhao H, Prchal JT, Piwocka K, Moliterno AR, Wasik M, Koschmieder S, Green TR, Skoda RC, Skorski T.

Blood. 2017 Dec 28;130(26):2848-2859. doi: 10.1182/blood-2017-05-784942. Epub 2017 Oct 17.

23.

Familial MPN Predisposition.

Tashi T, Swierczek S, Prchal JT.

Curr Hematol Malig Rep. 2017 Oct;12(5):442-447. doi: 10.1007/s11899-017-0414-x. Review.

PMID:
29027642
24.

A phase 1 study of the Janus kinase 2 (JAK2)V617F inhibitor, gandotinib (LY2784544), in patients with primary myelofibrosis, polycythemia vera, and essential thrombocythemia.

Verstovsek S, Mesa RA, Salama ME, Li L, Pitou C, Nunes FP, Price GL, Giles JL, D'Souza DN, Walgren RA, Prchal JT.

Leuk Res. 2017 Oct;61:89-95. doi: 10.1016/j.leukres.2017.08.010. Epub 2017 Aug 31.

PMID:
28934680
25.

Ironing out the role of hepcidin in infection.

Prchal JT.

Blood. 2017 Jul 20;130(3):233-234. doi: 10.1182/blood-2017-05-783688. No abstract available.

PMID:
28729331
26.

Thrombotic Thrombocytopenic Purpura Associated With Pegylated Interferon Alfa-2a Use in a Patient With Polycythemia Vera.

Gangaraju R, Kim SJ, Dong JF, Swierczek S, Prchal JT.

J Natl Compr Canc Netw. 2017 Jun;15(6):757-760. doi: 10.6004/jnccn.2017.0108.

PMID:
28596255
27.

Regulation of erythropoiesis after normoxic return from chronic sustained and intermittent hypoxia.

Song J, Sundar K, Gangaraju R, Prchal JT.

J Appl Physiol (1985). 2017 Dec 1;123(6):1671-1675. doi: 10.1152/japplphysiol.00119.2017. Epub 2017 May 18. Review.

28.

Evolutionary history of Tibetans inferred from whole-genome sequencing.

Hu H, Petousi N, Glusman G, Yu Y, Bohlender R, Tashi T, Downie JM, Roach JC, Cole AM, Lorenzo FR, Rogers AR, Brunkow ME, Cavalleri G, Hood L, Alpatty SM, Prchal JT, Jorde LB, Robbins PA, Simonson TS, Huff CD.

PLoS Genet. 2017 Apr 27;13(4):e1006675. doi: 10.1371/journal.pgen.1006675. eCollection 2017 Apr.

29.

The Cornerstone of the Aberrant Pathophysiology of Obstructive Sleep Apnea: Tissue Responses to Chronic Sustained Versus Intermittent Hypoxia.

Sundar KM, Prchal JT.

Am J Respir Cell Mol Biol. 2017 Apr;56(4):419-420. doi: 10.1165/rcmb.2017-0028ED. No abstract available.

PMID:
28362150
30.

Gain-of-function EGLN1 prolyl hydroxylase (PHD2 D4E:C127S) in combination with EPAS1 (HIF-2α) polymorphism lowers hemoglobin concentration in Tibetan highlanders.

Tashi T, Scott Reading N, Wuren T, Zhang X, Moore LG, Hu H, Tang F, Shestakova A, Lorenzo F, Burjanivova T, Koul P, Guchhait P, Wittwer CT, Julian CG, Shah B, Huff CD, Gordeuk VR, Prchal JT, Ge R.

J Mol Med (Berl). 2017 Jun;95(6):665-670. doi: 10.1007/s00109-017-1519-3. Epub 2017 Feb 23.

PMID:
28233034
31.

A patient with both methemoglobinemia and G6PD deficiency: A therapeutic conundrum.

Reading NS, Ruiz-Bonilla JA, Christensen RD, Cáceres-Perkins W, Prchal JT.

Am J Hematol. 2017 May;92(5):474-477. doi: 10.1002/ajh.24683. Epub 2017 Mar 24. No abstract available.

32.

A genetic variation associated with plasma erythropoietin and a non-coding transcript of PRKAR1A in sickle cell disease.

Zhang X, Shah BN, Zhang W, Saraf SL, Miasnikova G, Sergueeva A, Ammosova T, Niu X, Nouraie M, Nekhai S, Castro O, Gladwin MT, Prchal JT, Garcia JG, Machado RF, Gordeuk VR.

Hum Mol Genet. 2016 Oct 15;25(20):4601-4609. doi: 10.1093/hmg/ddw299.

33.

Prospective study of thrombosis and thrombospondin-1 expression in Chuvash polycythemia.

Sergueeva A, Miasnikova G, Shah BN, Song J, Lisina E, Okhotin DJ, Nouraie M, Nekhai S, Ammosova T, Niu XM, Prchal JT, Zhang X, Gordeuk VR.

Haematologica. 2017 May;102(5):e166-e169. doi: 10.3324/haematol.2016.158170. Epub 2017 Jan 19. No abstract available.

34.

Three Novel Spectrin Variants in Jaundiced Neonates.

Christensen RD, Agarwal AM, Yaish HM, Reading NS, O'Brien EA, Prchal JT.

Clin Pediatr (Phila). 2018 Jan;57(1):19-26. doi: 10.1177/0009922816687326. Epub 2017 Jan 15.

PMID:
28090778
35.

Possible association of 3' UTR +357 A>G, IVS11-nt 93 T>C, c.1311 C>T polymorphism with G6PD deficiency.

Sirdah MM, Shubair ME, Al-Kahlout MS, Al-Tayeb JM, Prchal JT, Reading NS.

Hematology. 2017 Jul;22(6):370-374. doi: 10.1080/10245332.2016.1276117. Epub 2017 Jan 6.

PMID:
28059001
36.

Evolutionary selected Tibetan variants of HIF pathway and risk of lung cancer.

Lanikova L, Reading NS, Hu H, Tashi T, Burjanivova T, Shestakova A, Siwakoti B, Thakur BK, Pun CB, Sapkota A, Abdelaziz S, Feng BJ, Huff CD, Hashibe M, Prchal JT.

Oncotarget. 2017 Feb 14;8(7):11739-11747. doi: 10.18632/oncotarget.14340.

37.

Adjuvant Endocrine Therapy in Breast Cancer: A Novel e-Health Approach in Optimizing Treatment for Seniors (OPTIMUM): A Two-Group Controlled Comparison Pilot Study.

Meguerditchian A, Tamblyn R, Meterissian S, Law S, Prchal J, Winslade N, Stern D.

JMIR Res Protoc. 2016 Nov 7;5(4):e199.

38.

Involvement of an Arginine Triplet in M1 Matrix Protein Interaction with Membranes and in M1 Recruitment into Virus-Like Particles of the Influenza A(H1N1)pdm09 Virus.

Kerviel A, Dash S, Moncorgé O, Panthu B, Prchal J, Décimo D, Ohlmann T, Lina B, Favard C, Decroly E, Ottmann M, Roingeard P, Muriaux D.

PLoS One. 2016 Nov 4;11(11):e0165421. doi: 10.1371/journal.pone.0165421. eCollection 2016.

39.

Coexistence of gain-of-function JAK2 germ line mutations with JAK2V617F in polycythemia vera.

Lanikova L, Babosova O, Swierczek S, Wang L, Wheeler DA, Divoky V, Korinek V, Prchal JT.

Blood. 2016 Nov 3;128(18):2266-2270. Epub 2016 Sep 19. No abstract available.

40.

Novel insights into the polycythemia-paraganglioma-somatostatinoma syndrome.

Därr R, Nambuba J, Del Rivero J, Janssen I, Merino M, Todorovic M, Balint B, Jochmanova I, Prchal JT, Lechan RM, Tischler AS, Popovic V, Miljic D, Adams KT, Prall FR, Ling A, Golomb MR, Ferguson M, Nilubol N, Chen CC, Chew E, Taïeb D, Stratakis CA, Fojo T, Yang C, Kebebew E, Zhuang Z, Pacak K.

Endocr Relat Cancer. 2016 Dec;23(12):899-908. Epub 2016 Sep 27.

41.

Membrane Interactions of the Mason-Pfizer Monkey Virus Matrix Protein and Its Budding Deficient Mutants.

Kroupa T, Langerová H, Doležal M, Prchal J, Spiwok V, Hunter E, Rumlová M, Hrabal R, Ruml T.

J Mol Biol. 2016 Nov 20;428(23):4708-4722. doi: 10.1016/j.jmb.2016.10.010. Epub 2016 Oct 8.

PMID:
27725181
42.

Molecular aspects of the interaction between Mason-Pfizer monkey virus matrix protein and artificial phospholipid membrane.

Junková P, Prchal J, Spiwok V, Pleskot R, Kadlec J, Krásný L, Hynek R, Hrabal R, Ruml T.

Proteins. 2016 Nov;84(11):1717-1727. doi: 10.1002/prot.25156. Epub 2016 Sep 15.

PMID:
27578150
43.

Changes in peripheral blood lymphocytes in polycythemia vera and essential thrombocythemia patients treated with pegylated-interferon alpha and correlation with JAK2V617F allelic burden.

Kovacsovics-Bankowski M, Kelley TW, Efimova O, Kim SJ, Wilson A, Swierczek S, Prchal J.

Exp Hematol Oncol. 2016 Sep 27;5:28. eCollection 2015.

44.

Laboratory Investigation of Myeloproliferative Neoplasms (MPNs):  Recommendations of the Canadian Mpn Group.

Busque L, Porwit A, Day R, Olney HJ, Leber B, Éthier V, Sirhan S, Foltz L, Prchal J, Kamel-Reid S, Karsan A, Gupta V.

Am J Clin Pathol. 2016 Oct;146(4):408-22. doi: 10.1093/ajcp/aqw131. Review.

PMID:
27686169
45.

Favism, the commonest form of severe hemolytic anemia in Palestinian children, varies in severity with three different variants of G6PD deficiency within the same community.

Reading NS, Sirdah MM, Shubair ME, Nelson BE, Al-Kahlout MS, Al-Tayeb JM, Aboud LN, Shaban MA, Luzzatto L, Prchal JT.

Blood Cells Mol Dis. 2016 Sep;60:58-64. doi: 10.1016/j.bcmd.2016.07.001. Epub 2016 Jul 6.

PMID:
27519946
46.

Loss of Major DNase I Hypersensitive Sites in Duplicated β-globin Gene Cluster Incompletely Silences HBB Gene Expression.

Reading NS, Shooter C, Song J, Miller R, Agarwal A, Lanikova L, Clark B, Thein SL, Divoky V, Prchal JT.

Hum Mutat. 2016 Nov;37(11):1153-1156. doi: 10.1002/humu.23061. Epub 2016 Aug 25.

PMID:
27492747
47.

A Genome-Wide Search for Greek and Jewish Admixture in the Kashmiri Population.

Downie JM, Tashi T, Lorenzo FR, Feusier JE, Mir H, Prchal JT, Jorde LB, Koul PA.

PLoS One. 2016 Aug 4;11(8):e0160614. doi: 10.1371/journal.pone.0160614. eCollection 2016.

48.

Clinical utility of next-generation sequencing in the diagnosis of hereditary haemolytic anaemias.

Agarwal AM, Nussenzveig RH, Reading NS, Patel JL, Sangle N, Salama ME, Prchal JT, Perkins SL, Yaish HM, Christensen RD.

Br J Haematol. 2016 Sep;174(5):806-14. doi: 10.1111/bjh.14131. Epub 2016 Jun 12.

PMID:
27292444
49.

Delayed hemoglobin switching and perinatal neocytolysis in mice with gain-of-function erythropoietin receptor.

Divoky V, Song J, Horvathova M, Kralova B, Votavova H, Prchal JT, Yoon D.

J Mol Med (Berl). 2016 May;94(5):597-608. doi: 10.1007/s00109-015-1375-y. Epub 2015 Dec 26.

50.

Acquired uniparental disomy of chromosome 9p in hematologic malignancies.

Wang L, Wheeler DA, Prchal JT.

Exp Hematol. 2016 Aug;44(8):644-52. doi: 10.1016/j.exphem.2015.11.005. Epub 2015 Dec 2. Review.

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