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Items: 33


Vaccination reduces fentanyl distribution to the brain and fentanyl-induced toxicity in mice and rats: a potential role for a prophylactic vaccine against fentanyl-induced overdose.

Raleigh MD, Baruffaldi F, Peterson SJ, Le Naour M, Harmon TM, Vigliaturo JR, Pentel PR, Pravetoni M.

J Pharmacol Exp Ther. 2018 Nov 8. pii: jpet.118.253674. doi: 10.1124/jpet.118.253674. [Epub ahead of print]


Vaccines to treat opioid use disorders and to reduce opioid overdoses.

Baehr C, Pravetoni M.

Neuropsychopharmacology. 2018 Sep 12. doi: 10.1038/s41386-018-0197-3. [Epub ahead of print] No abstract available.


Preclinical Efficacy and Characterization of Candidate Vaccines for Treatment of Opioid Use Disorders Using Clinically Viable Carrier Proteins.

Baruffaldi F, Kelcher AH, Laudenbach M, Gradinati V, Limkar A, Roslawski M, Birnbaum A, Lees A, Hassler C, Runyon S, Pravetoni M.

Mol Pharm. 2018 Nov 5;15(11):4947-4962. doi: 10.1021/acs.molpharmaceut.8b00592. Epub 2018 Oct 10.


Blocking interleukin-4 enhances efficacy of vaccines for treatment of opioid abuse and prevention of opioid overdose.

Laudenbach M, Baruffaldi F, Robinson C, Carter P, Seelig D, Baehr C, Pravetoni M.

Sci Rep. 2018 Apr 3;8(1):5508. doi: 10.1038/s41598-018-23777-6.


Opioid Dose- and Route-Dependent Efficacy of Oxycodone and Heroin Vaccines in Rats.

Raleigh MD, Laudenbach M, Baruffaldi F, Peterson SJ, Roslawski MJ, Birnbaum AK, Carroll FI, Runyon SP, Winston S, Pentel PR, Pravetoni M.

J Pharmacol Exp Ther. 2018 May;365(2):346-353. doi: 10.1124/jpet.117.247049. Epub 2018 Mar 13.


Safety and efficacy of an oxycodone vaccine: Addressing some of the unique considerations posed by opioid abuse.

Raleigh MD, Peterson SJ, Laudenbach M, Baruffaldi F, Carroll FI, Comer SD, Navarro HA, Langston TL, Runyon SP, Winston S, Pravetoni M, Pentel PR.

PLoS One. 2017 Dec 1;12(12):e0184876. doi: 10.1371/journal.pone.0184876. eCollection 2017.


Oxycodone self-administration in male and female rats.

Mavrikaki M, Pravetoni M, Page S, Potter D, Chartoff E.

Psychopharmacology (Berl). 2017 Mar;234(6):977-987. doi: 10.1007/s00213-017-4536-6. Epub 2017 Jan 27.


Biologics to treat substance use disorders: Current status and new directions.

Pravetoni M.

Hum Vaccin Immunother. 2016 Dec;12(12):3005-3019. doi: 10.1080/21645515.2016.1212785. Epub 2016 Jul 21. Review.


The frequency of early-activated hapten-specific B cell subsets predicts the efficacy of vaccines for nicotine dependence.

Laudenbach M, Tucker AM, Runyon SP, Carroll FI, Pravetoni M.

Vaccine. 2015 Nov 17;33(46):6332-9. doi: 10.1016/j.vaccine.2015.09.015. Epub 2015 Sep 26.


The frequency of naive and early-activated hapten-specific B cell subsets dictates the efficacy of a therapeutic vaccine against prescription opioid abuse.

Laudenbach M, Baruffaldi F, Vervacke JS, Distefano MD, Titcombe PJ, Mueller DL, Tubo NJ, Griffith TS, Pravetoni M.

J Immunol. 2015 Jun 15;194(12):5926-36. doi: 10.4049/jimmunol.1500385. Epub 2015 May 13.


GIRK Channels Modulate Opioid-Induced Motor Activity in a Cell Type- and Subunit-Dependent Manner.

Kotecki L, Hearing M, McCall NM, Marron Fernandez de Velasco E, Pravetoni M, Arora D, Victoria NC, Munoz MB, Xia Z, Slesinger PA, Weaver CD, Wickman K.

J Neurosci. 2015 May 6;35(18):7131-42. doi: 10.1523/JNEUROSCI.5051-14.2015.


Effects of an oxycodone conjugate vaccine on oxycodone self-administration and oxycodone-induced brain gene expression in rats.

Pravetoni M, Pentel PR, Potter DN, Chartoff EH, Tally L, LeSage MG.

PLoS One. 2014 Jul 15;9(7):e101807. doi: 10.1371/journal.pone.0101807. eCollection 2014.


Effect of currently approved carriers and adjuvants on the pre-clinical efficacy of a conjugate vaccine against oxycodone in mice and rats.

Pravetoni M, Vervacke JS, Distefano MD, Tucker AM, Laudenbach M, Pentel PR.

PLoS One. 2014 May 5;9(5):e96547. doi: 10.1371/journal.pone.0096547. eCollection 2014.


Hapten-specific naïve B cells are biomarkers of vaccine efficacy against drugs of abuse.

Taylor JJ, Laudenbach M, Tucker AM, Jenkins MK, Pravetoni M.

J Immunol Methods. 2014 Mar;405:74-86. doi: 10.1016/j.jim.2014.01.010. Epub 2014 Jan 23.


Immunogenicity of individual vaccine components in a bivalent nicotine vaccine differ according to vaccine formulation and administration conditions.

Cornish KE, de Villiers SH, Pravetoni M, Pentel PR.

PLoS One. 2013 Dec 2;8(12):e82557. doi: 10.1371/journal.pone.0082557. eCollection 2013.


Increased efficacy of a trivalent nicotine vaccine compared to a dose-matched monovalent vaccine when formulated with alum.

de Villiers SH, Cornish KE, Troska AJ, Pravetoni M, Pentel PR.

Vaccine. 2013 Dec 16;31(52):6185-93. doi: 10.1016/j.vaccine.2013.10.051. Epub 2013 Oct 29.


Reduced antinociception of opioids in rats and mice by vaccination with immunogens containing oxycodone and hydrocodone haptens.

Pravetoni M, Le Naour M, Tucker AM, Harmon TM, Hawley TM, Portoghese PS, Pentel PR.

J Med Chem. 2013 Feb 14;56(3):915-23. doi: 10.1021/jm3013745. Epub 2013 Jan 15.


Selective effects of a morphine conjugate vaccine on heroin and metabolite distribution and heroin-induced behaviors in rats.

Raleigh MD, Pravetoni M, Harris AC, Birnbaum AK, Pentel PR.

J Pharmacol Exp Ther. 2013 Feb;344(2):397-406. doi: 10.1124/jpet.112.201194. Epub 2012 Dec 7.


High immunogenicity of nicotine vaccines obtained by intradermal delivery with safe adjuvants.

Chen X, Pravetoni M, Bhayana B, Pentel PR, Wu MX.

Vaccine. 2012 Dec 17;31(1):159-64. doi: 10.1016/j.vaccine.2012.10.069. Epub 2012 Oct 30.


Co-administration of morphine and oxycodone vaccines reduces the distribution of 6-monoacetylmorphine and oxycodone to brain in rats.

Pravetoni M, Raleigh MD, Le Naour M, Tucker AM, Harmon TM, Jones JM, Birnbaum AK, Portoghese PS, Pentel PR.

Vaccine. 2012 Jun 29;30(31):4617-24. doi: 10.1016/j.vaccine.2012.04.101. Epub 2012 May 11.


Enhanced attenuation of nicotine discrimination in rats by combining nicotine-specific antibodies with a nicotinic receptor antagonist.

LeSage MG, Shelley D, Pravetoni M, Pentel PR.

Pharmacol Biochem Behav. 2012 Jul;102(1):157-62. doi: 10.1016/j.pbb.2012.03.026. Epub 2012 Apr 4.


An oxycodone conjugate vaccine elicits drug-specific antibodies that reduce oxycodone distribution to brain and hot-plate analgesia.

Pravetoni M, Le Naour M, Harmon TM, Tucker AM, Portoghese PS, Pentel PR.

J Pharmacol Exp Ther. 2012 Apr;341(1):225-32. doi: 10.1124/jpet.111.189506. Epub 2012 Jan 18.


Structurally distinct nicotine immunogens elicit antibodies with non-overlapping specificities.

Pravetoni M, Keyler DE, Pidaparthi RR, Carroll FI, Runyon SP, Murtaugh MP, Earley CA, Pentel PR.

Biochem Pharmacol. 2012 Feb 15;83(4):543-50. doi: 10.1016/j.bcp.2011.11.004. Epub 2011 Nov 15.


Vaccination against nicotine alters the distribution of nicotine delivered via cigarette smoke inhalation to rats.

Pravetoni M, Keyler DE, Raleigh MD, Harris AC, Lesage MG, Mattson CK, Pettersson S, Pentel PR.

Biochem Pharmacol. 2011 May 1;81(9):1164-70. doi: 10.1016/j.bcp.2011.02.004. Epub 2011 Feb 17.


Altered neurotransmission in the mesolimbic reward system of Girk mice.

Arora D, Haluk DM, Kourrich S, Pravetoni M, Fernández-Alacid L, Nicolau JC, Luján R, Wickman K.

J Neurochem. 2010 Sep 1;114(5):1487-97. doi: 10.1111/j.1471-4159.2010.06864.x. Epub 2010 Jun 16.


R7BP complexes with RGS9-2 and RGS7 in the striatum differentially control motor learning and locomotor responses to cocaine.

Anderson GR, Cao Y, Davidson S, Truong HV, Pravetoni M, Thomas MJ, Wickman K, Giesler GJ Jr, Martemyanov KA.

Neuropsychopharmacology. 2010 Mar;35(4):1040-50. doi: 10.1038/npp.2009.212. Epub 2009 Dec 30.


Predisposition to late-onset obesity in GIRK4 knockout mice.

Perry CA, Pravetoni M, Teske JA, Aguado C, Erickson DJ, Medrano JF, Luján R, Kotz CM, Wickman K.

Proc Natl Acad Sci U S A. 2008 Jun 10;105(23):8148-53. doi: 10.1073/pnas.0803261105. Epub 2008 Jun 3.


Absence and rescue of morphine withdrawal in GIRK/Kir3 knock-out mice.

Cruz HG, Berton F, Sollini M, Blanchet C, Pravetoni M, Wickman K, Lüscher C.

J Neurosci. 2008 Apr 9;28(15):4069-77. doi: 10.1523/JNEUROSCI.0267-08.2008.


Behavioral characterization of mice lacking GIRK/Kir3 channel subunits.

Pravetoni M, Wickman K.

Genes Brain Behav. 2008 Jul;7(5):523-31. doi: 10.1111/j.1601-183X.2008.00388.x.


Expression and localization of RGS9-2/G 5/R7BP complex in vivo is set by dynamic control of its constitutive degradation by cellular cysteine proteases.

Anderson GR, Lujan R, Semenov A, Pravetoni M, Posokhova EN, Song JH, Uversky V, Chen CK, Wickman K, Martemyanov KA.

J Neurosci. 2007 Dec 19;27(51):14117-27.


Inhibition of nitric oxide synthase enhances cocaine's developmental toxicity: vascular and CNS effects.

Mendoza-Baumgart MI, Pravetoni M, Sparber SB.

Neuropsychopharmacology. 2007 Apr;32(4):940-5. Epub 2006 Jul 26.


Vasoconstriction caused by cocaine is enhanced by sodium salicylate: is inducible nitric oxide synthase mRNA related?

Mendoza-Baumgart MI, Pravetoni M, Sparber SB.

Neuropsychopharmacology. 2004 Jul;29(7):1294-300.


Quantification of housekeeping transcript levels during the development of bovine preimplantation embryos.

Robert C, McGraw S, Massicotte L, Pravetoni M, Gandolfi F, Sirard MA.

Biol Reprod. 2002 Nov;67(5):1465-72.


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