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Long-acting reversible contraception by effervescent microneedle patch.

Li W, Tang J, Terry RN, Li S, Brunie A, Callahan RL, Noel RK, Rodríguez CA, Schwendeman SP, Prausnitz MR.

Sci Adv. 2019 Nov 6;5(11):eaaw8145. doi: 10.1126/sciadv.aaw8145. eCollection 2019 Nov.


Sustained scleral stiffening in rats after a single genipin treatment.

Hannon BG, Schwaner SA, Boazak EM, Gerberich BG, Winger EJ, Prausnitz MR, Ethier CR.

J R Soc Interface. 2019 Oct 31;16(159):20190427. doi: 10.1098/rsif.2019.0427. Epub 2019 Oct 16.


Microneedle patch drug delivery in the gut.

Prausnitz MR, Gomaa Y, Li W.

Nat Med. 2019 Oct;25(10):1471-1472. doi: 10.1038/s41591-019-0606-0. No abstract available.


Collagenase injection into the suprachoroidal space of the eye to expand drug delivery coverage and increase posterior drug targeting.

Jung JH, Park S, Chae JJ, Prausnitz MR.

Exp Eye Res. 2019 Oct 1;189:107824. doi: 10.1016/j.exer.2019.107824. [Epub ahead of print]


Feasibility of Hepatitis B Vaccination by Microneedle Patch: Cellular and Humoral Immunity Studies in Rhesus Macaques.

Choi YH, Perez-Cuevas MB, Kodani M, Zhang X, Prausnitz MR, Kamili S, O'Connor SM.

J Infect Dis. 2019 Nov 6;220(12):1926-1934. doi: 10.1093/infdis/jiz399.


Extended delivery of vaccines to the skin improves immune responses.

Joyce JC, Sella HE, Jost H, Mistilis MJ, Esser ES, Pradhan P, Toy R, Collins ML, Rota PA, Roy K, Skountzou I, Compans RW, Oberste MS, Weldon WC, Norman JJ, Prausnitz MR.

J Control Release. 2019 Jun 28;304:135-145. doi: 10.1016/j.jconrel.2019.05.006. Epub 2019 May 6. French.


Plasmonic Paper Microneedle Patch for On-Patch Detection of Molecules in Dermal Interstitial Fluid.

Kolluru C, Gupta R, Jiang Q, Williams M, Gholami Derami H, Cao S, Noel RK, Singamaneni S, Prausnitz MR.

ACS Sens. 2019 Jun 28;4(6):1569-1576. doi: 10.1021/acssensors.9b00258. Epub 2019 May 22.


Co-Delivery of M2e Virus-Like Particles with Influenza Split Vaccine to the Skin Using Microneedles Enhances the Efficacy of Cross Protection.

Kim MC, Kim KH, Lee JW, Lee YN, Choi HJ, Jung YJ, Kim YJ, Compans RW, Prausnitz MR, Kang SM.

Pharmaceutics. 2019 Apr 18;11(4). pii: E188. doi: 10.3390/pharmaceutics11040188.


Targeting drug delivery within the suprachoroidal space.

Jung JH, Chae JJ, Prausnitz MR.

Drug Discov Today. 2019 Aug;24(8):1654-1659. doi: 10.1016/j.drudis.2019.03.027. Epub 2019 Apr 3. Review.


Rapidly separable microneedle patch for the sustained release of a contraceptive.

Li W, Terry RN, Tang J, Feng MR, Schwendeman SP, Prausnitz MR.

Nat Biomed Eng. 2019 Mar;3(3):220-229. doi: 10.1038/s41551-018-0337-4. Epub 2019 Jan 14.


Pharmaceutical jewelry: Earring patch for transdermal delivery of contraceptive hormone.

Mofidfar M, O'Farrell L, Prausnitz MR.

J Control Release. 2019 May 10;301:140-145. doi: 10.1016/j.jconrel.2019.03.011. Epub 2019 Mar 12.


Electrospun Transdermal Patch for Contraceptive Hormone Delivery.

Mofidfar M, Prausnitz MR.

Curr Drug Deliv. 2019;16(6):577-583. doi: 10.2174/1567201816666190308112010.


Monitoring drug pharmacokinetics and immunologic biomarkers in dermal interstitial fluid using a microneedle patch.

Kolluru C, Williams M, Yeh JS, Noel RK, Knaack J, Prausnitz MR.

Biomed Microdevices. 2019 Feb 6;21(1):14. doi: 10.1007/s10544-019-0363-3.


Self-healing encapsulation and controlled release of vaccine antigens from PLGA microparticles delivered by microneedle patches.

Mazzara JM, Ochyl LJ, Hong JKY, Moon JJ, Prausnitz MR, Schwendeman SP.

Bioeng Transl Med. 2018 Oct 30;4(1):116-128. doi: 10.1002/btm2.10103. eCollection 2019 Jan.


Recruitment and Collection of Dermal Interstitial Fluid Using a Microneedle Patch.

Kolluru C, Williams M, Chae J, Prausnitz MR.

Adv Healthc Mater. 2019 Feb;8(3):e1801262. doi: 10.1002/adhm.201801262. Epub 2019 Jan 4.


Development of a thermostable microneedle patch for polio vaccination.

Kolluru C, Gomaa Y, Prausnitz MR.

Drug Deliv Transl Res. 2019 Feb;9(1):192-203. doi: 10.1007/s13346-018-00608-9.


Hepatitis B vaccination using a dissolvable microneedle patch is immunogenic in mice and rhesus macaques.

Perez Cuevas MB, Kodani M, Choi Y, Joyce J, O'Connor SM, Kamili S, Prausnitz MR.

Bioeng Transl Med. 2018 Aug 27;3(3):186-196. doi: 10.1002/btm2.10098. eCollection 2018 Sep.


Vaccination by microneedle patch with inactivated respiratory syncytial virus and monophosphoryl lipid A enhances the protective efficacy and diminishes inflammatory disease after challenge.

Park S, Lee Y, Kwon YM, Lee YT, Kim KH, Ko EJ, Jung JH, Song M, Graham B, Prausnitz MR, Kang SM.

PLoS One. 2018 Oct 26;13(10):e0205071. doi: 10.1371/journal.pone.0205071. eCollection 2018.


Enhanced Immune Responses Conferring Cross-Protection by Skin Vaccination With a Tri-Component Influenza Vaccine Using a Microneedle Patch.

Zhu W, Li S, Wang C, Yu G, Prausnitz MR, Wang BZ.

Front Immunol. 2018 Jul 30;9:1705. doi: 10.3389/fimmu.2018.01705. eCollection 2018.


Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice.

Deng L, Chang TZ, Wang Y, Li S, Wang S, Matsuyama S, Yu G, Compans RW, Li JD, Prausnitz MR, Champion JA, Wang BZ.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7758-E7767. doi: 10.1073/pnas.1805713115. Epub 2018 Jul 31.


Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge.

Liu Y, Ye L, Lin F, Gomaa Y, Flyer D, Carrion R Jr, Patterson JL, Prausnitz MR, Smith G, Glenn G, Wu H, Compans RW, Yang C.

Sci Rep. 2018 Jul 25;8(1):11193. doi: 10.1038/s41598-018-29135-w.


Intradermal Vaccination With Adjuvanted Ebola Virus Soluble Glycoprotein Subunit Vaccine by Microneedle Patches Protects Mice Against Lethal Ebola Virus Challenge.

Liu Y, Ye L, Lin F, Gomaa Y, Flyer D, Carrion R Jr, Patterson JL, Prausnitz MR, Smith G, Glenn G, Wu H, Compans RW, Yang C.

J Infect Dis. 2018 Nov 22;218(suppl_5):S545-S552. doi: 10.1093/infdis/jiy267.


Effect of laser fluence, nanoparticle concentration and total energy input per cell on photoporation of cells.

Holguin SY, Thadhani NN, Prausnitz MR.

Nanomedicine. 2018 Jul;14(5):1667-1677. doi: 10.1016/j.nano.2018.04.015. Epub 2018 Apr 30.


Drug delivery using microneedle patches: not just for skin.

Lee JW, Prausnitz MR.

Expert Opin Drug Deliv. 2018 Jun;15(6):541-543. doi: 10.1080/17425247.2018.1471059. Epub 2018 May 7. No abstract available.


A Microneedle Patch for Measles and Rubella Vaccination Is Immunogenic and Protective in Infant Rhesus Macaques.

Joyce JC, Carroll TD, Collins ML, Chen MH, Fritts L, Dutra JC, Rourke TL, Goodson JL, McChesney MB, Prausnitz MR, Rota PA.

J Infect Dis. 2018 Jun 5;218(1):124-132. doi: 10.1093/infdis/jiy139.


Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing.

Jung JH, Desit P, Prausnitz MR.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2069-2079. doi: 10.1167/iovs.17-23758.


Mechanisms of sampling interstitial fluid from skin using a microneedle patch.

Samant PP, Prausnitz MR.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4583-4588. doi: 10.1073/pnas.1716772115. Epub 2018 Apr 16.


The suprachoroidal space as a route of administration to the posterior segment of the eye.

Chiang B, Jung JH, Prausnitz MR.

Adv Drug Deliv Rev. 2018 Feb 15;126:58-66. doi: 10.1016/j.addr.2018.03.001. Epub 2018 Mar 12. Review.


Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle.

Jung JH, Chiang B, Grossniklaus HE, Prausnitz MR.

J Control Release. 2018 May 10;277:14-22. doi: 10.1016/j.jconrel.2018.03.001. Epub 2018 Mar 2.


Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza.

Littauer EQ, Mills LK, Brock N, Esser ES, Romanyuk A, Pulit-Penaloza JA, Vassilieva EV, Beaver JT, Antao O, Krammer F, Compans RW, Prausnitz MR, Skountzou I.

J Control Release. 2018 Apr 28;276:1-16. doi: 10.1016/j.jconrel.2018.02.033. Epub 2018 Feb 26.


Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics.

Niedzwiecki MM, Samant P, Walker DI, Tran V, Jones DP, Prausnitz MR, Miller GW.

Anal Chem. 2018 Mar 20;90(6):3786-3792. doi: 10.1021/acs.analchem.7b04073. Epub 2018 Feb 27.


Skin immunization by microneedle patch overcomes statin-induced suppression of immune responses to influenza vaccine.

Vassilieva EV, Wang S, Li S, Prausnitz MR, Compans RW.

Sci Rep. 2017 Dec 19;7(1):17855. doi: 10.1038/s41598-017-18140-0.


Photoporation Using Carbon Nanotubes for Intracellular Delivery of Molecules and Its Relationship to Photoacoustic Pressure.

Holguin SY, Gray MD, Joseph P, Thadhani NN, Prausnitz MR.

Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201701007. Epub 2017 Dec 4.


Dihydroergotamine mesylate-loaded dissolving microneedle patch made of polyvinylpyrrolidone for management of acute migraine therapy.

Tas C, Joyce JC, Nguyen HX, Eangoor P, Knaack JS, Banga AK, Prausnitz MR.

J Control Release. 2017 Dec 28;268:159-165. doi: 10.1016/j.jconrel.2017.10.021. Epub 2017 Oct 16.


Microneedle patch delivery of influenza vaccine during pregnancy enhances maternal immune responses promoting survival and long-lasting passive immunity to offspring.

Esser ES, Pulit-Penaloza JA, Kalluri H, McAllister D, Vassilieva EV, Littauer EQ, Lelutiu N, Prausnitz MR, Compans RW, Skountzou I.

Sci Rep. 2017 Jul 18;7(1):5705. doi: 10.1038/s41598-017-05940-7.


The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial.

Rouphael NG, Paine M, Mosley R, Henry S, McAllister DV, Kalluri H, Pewin W, Frew PM, Yu T, Thornburg NJ, Kabbani S, Lai L, Vassilieva EV, Skountzou I, Compans RW, Mulligan MJ, Prausnitz MR; TIV-MNP 2015 Study Group.

Lancet. 2017 Aug 12;390(10095):649-658. doi: 10.1016/S0140-6736(17)30575-5. Epub 2017 Jun 27.


A boosting skin vaccination with dissolving microneedle patch encapsulating M2e vaccine broadens the protective efficacy of conventional influenza vaccines.

Zhu W, Pewin W, Wang C, Luo Y, Gonzalez GX, Mohan T, Prausnitz MR, Wang BZ.

J Control Release. 2017 Sep 10;261:1-9. doi: 10.1016/j.jconrel.2017.06.017. Epub 2017 Jun 19.


Role of cytoskeletal mechanics and cell membrane fluidity in the intracellular delivery of molecules mediated by laser-activated carbon nanoparticles.

Holguin SY, Anderson CF, Thadhani NN, Prausnitz MR.

Biotechnol Bioeng. 2017 Oct;114(10):2390-2399. doi: 10.1002/bit.26355. Epub 2017 Jul 11.


Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin.

Prausnitz MR.

Annu Rev Chem Biomol Eng. 2017 Jun 7;8:177-200. doi: 10.1146/annurev-chembioeng-060816-101514. Epub 2017 Mar 24. Review.


Energy Transfer Mechanisms during Molecular Delivery to Cells by Laser-Activated Carbon Nanoparticles.

Sengupta A, Gray MD, Kelly SC, Holguin SY, Thadhani NN, Prausnitz MR.

Biophys J. 2017 Mar 28;112(6):1258-1269. doi: 10.1016/j.bpj.2017.02.007.


Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects.

Arya J, Henry S, Kalluri H, McAllister DV, Pewin WP, Prausnitz MR.

Biomaterials. 2017 Jun;128:1-7. doi: 10.1016/j.biomaterials.2017.02.040. Epub 2017 Mar 2.


Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes.

Morales JO, Fathe KR, Brunaugh A, Ferrati S, Li S, Montenegro-Nicolini M, Mousavikhamene Z, McConville JT, Prausnitz MR, Smyth HDC.

AAPS J. 2017 May;19(3):652-668. doi: 10.1208/s12248-017-0054-z. Epub 2017 Feb 13.


Thickness and Closure Kinetics of the Suprachoroidal Space Following Microneedle Injection of Liquid Formulations.

Chiang B, Venugopal N, Grossniklaus HE, Jung JH, Edelhauser HF, Prausnitz MR.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):555-564. doi: 10.1167/iovs.16-20377.


Clearance Kinetics and Clearance Routes of Molecules From the Suprachoroidal Space After Microneedle Injection.

Chiang B, Wang K, Ethier CR, Prausnitz MR.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):545-554. doi: 10.1167/iovs.16-20679.


Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/γPGA Nanoparticles Administered Using a Microneedle Patch.

Yang HW, Ye L, Guo XD, Yang C, Compans RW, Prausnitz MR.

Adv Healthc Mater. 2017 Jan;6(1). doi: 10.1002/adhm.201600750. Epub 2016 Nov 7.


Targeted Drug Delivery Within the Eye Through the Suprachoroidal Space.

Patel SR, Prausnitz MR.

J Ocul Pharmacol Ther. 2016 Dec;32(10):640-641. Epub 2016 Nov 16. No abstract available.


Distribution of particles, small molecules and polymeric formulation excipients in the suprachoroidal space after microneedle injection.

Chiang B, Venugopal N, Edelhauser HF, Prausnitz MR.

Exp Eye Res. 2016 Dec;153:101-109. doi: 10.1016/j.exer.2016.10.011. Epub 2016 Oct 11.


Rabies vaccination in dogs using a dissolving microneedle patch.

Arya JM, Dewitt K, Scott-Garrard M, Chiang YW, Prausnitz MR.

J Control Release. 2016 Oct 10;239:19-26. doi: 10.1016/j.jconrel.2016.08.012. Epub 2016 Aug 11.


Tetanus vaccination with a dissolving microneedle patch confers protective immune responses in pregnancy.

Esser ES, Romanyuk A, Vassilieva EV, Jacob J, Prausnitz MR, Compans RW, Skountzou I.

J Control Release. 2016 Aug 28;236:47-56. doi: 10.1016/j.jconrel.2016.06.026. Epub 2016 Jun 18.


DNA uptake, intracellular trafficking and gene transfection after ultrasound exposure.

Liu Y, Yan J, Santangelo PJ, Prausnitz MR.

J Control Release. 2016 Jul 28;234:1-9. doi: 10.1016/j.jconrel.2016.05.013. Epub 2016 May 7.


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