Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 230


Enhanced Immune Responses Conferring Cross-Protection by Skin Vaccination With a Tri-Component Influenza Vaccine Using a Microneedle Patch.

Zhu W, Li S, Wang C, Yu G, Prausnitz MR, Wang BZ.

Front Immunol. 2018 Jul 30;9:1705. doi: 10.3389/fimmu.2018.01705. eCollection 2018.


Heterosubtypic influenza protection elicited by double-layered polypeptide nanoparticles in mice.

Deng L, Chang TZ, Wang Y, Li S, Wang S, Matsuyama S, Yu G, Compans RW, Li JD, Prausnitz MR, Champion JA, Wang BZ.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):E7758-E7767. doi: 10.1073/pnas.1805713115. Epub 2018 Jul 31.


Intradermal immunization by Ebola virus GP subunit vaccines using microneedle patches protects mice against lethal EBOV challenge.

Liu Y, Ye L, Lin F, Gomaa Y, Flyer D, Carrion R Jr, Patterson JL, Prausnitz MR, Smith G, Glenn G, Wu H, Compans RW, Yang C.

Sci Rep. 2018 Jul 25;8(1):11193. doi: 10.1038/s41598-018-29135-w.


Intradermal Vaccination With Adjuvanted Ebola Virus Soluble Glycoprotein Subunit Vaccine by Microneedle Patches Protects Mice Against Lethal Ebola Virus Challenge.

Liu Y, Ye L, Lin F, Gomaa Y, Flyer D, Carrion R Jr, Patterson JL, Prausnitz MR, Smith G, Glenn G, Wu H, Compans RW, Yang C.

J Infect Dis. 2018 Jun 8. doi: 10.1093/infdis/jiy267. [Epub ahead of print]


Effect of laser fluence, nanoparticle concentration and total energy input per cell on photoporation of cells.

Holguin SY, Thadhani NN, Prausnitz MR.

Nanomedicine. 2018 Jul;14(5):1667-1677. doi: 10.1016/j.nano.2018.04.015. Epub 2018 Apr 30.


Drug delivery using microneedle patches: not just for skin.

Lee JW, Prausnitz MR.

Expert Opin Drug Deliv. 2018 Jun;15(6):541-543. doi: 10.1080/17425247.2018.1471059. Epub 2018 May 7. No abstract available.


A Microneedle Patch for Measles and Rubella Vaccination Is Immunogenic and Protective in Infant Rhesus Macaques.

Joyce JC, Carroll TD, Collins ML, Chen MH, Fritts L, Dutra JC, Rourke TL, Goodson JL, McChesney MB, Prausnitz MR, Rota PA.

J Infect Dis. 2018 Jun 5;218(1):124-132. doi: 10.1093/infdis/jiy139.


Targeted Drug Delivery in the Suprachoroidal Space by Swollen Hydrogel Pushing.

Jung JH, Desit P, Prausnitz MR.

Invest Ophthalmol Vis Sci. 2018 Apr 1;59(5):2069-2079. doi: 10.1167/iovs.17-23758.


Mechanisms of sampling interstitial fluid from skin using a microneedle patch.

Samant PP, Prausnitz MR.

Proc Natl Acad Sci U S A. 2018 May 1;115(18):4583-4588. doi: 10.1073/pnas.1716772115. Epub 2018 Apr 16.


The suprachoroidal space as a route of administration to the posterior segment of the eye.

Chiang B, Jung JH, Prausnitz MR.

Adv Drug Deliv Rev. 2018 Feb 15;126:58-66. doi: 10.1016/j.addr.2018.03.001. Epub 2018 Mar 12. Review.


Ocular drug delivery targeted by iontophoresis in the suprachoroidal space using a microneedle.

Jung JH, Chiang B, Grossniklaus HE, Prausnitz MR.

J Control Release. 2018 May 10;277:14-22. doi: 10.1016/j.jconrel.2018.03.001. Epub 2018 Mar 2.


Stable incorporation of GM-CSF into dissolvable microneedle patch improves skin vaccination against influenza.

Littauer EQ, Mills LK, Brock N, Esser ES, Romanyuk A, Pulit-Penaloza JA, Vassilieva EV, Beaver JT, Antao O, Krammer F, Compans RW, Prausnitz MR, Skountzou I.

J Control Release. 2018 Apr 28;276:1-16. doi: 10.1016/j.jconrel.2018.02.033. Epub 2018 Feb 26.


Human Suction Blister Fluid Composition Determined Using High-Resolution Metabolomics.

Niedzwiecki MM, Samant P, Walker DI, Tran V, Jones DP, Prausnitz MR, Miller GW.

Anal Chem. 2018 Mar 20;90(6):3786-3792. doi: 10.1021/acs.analchem.7b04073. Epub 2018 Feb 27.


Skin immunization by microneedle patch overcomes statin-induced suppression of immune responses to influenza vaccine.

Vassilieva EV, Wang S, Li S, Prausnitz MR, Compans RW.

Sci Rep. 2017 Dec 19;7(1):17855. doi: 10.1038/s41598-017-18140-0.


Photoporation Using Carbon Nanotubes for Intracellular Delivery of Molecules and Its Relationship to Photoacoustic Pressure.

Holguin SY, Gray MD, Joseph P, Thadhani NN, Prausnitz MR.

Adv Healthc Mater. 2018 Mar;7(5). doi: 10.1002/adhm.201701007. Epub 2017 Dec 4.


Dihydroergotamine mesylate-loaded dissolving microneedle patch made of polyvinylpyrrolidone for management of acute migraine therapy.

Tas C, Joyce JC, Nguyen HX, Eangoor P, Knaack JS, Banga AK, Prausnitz MR.

J Control Release. 2017 Dec 28;268:159-165. doi: 10.1016/j.jconrel.2017.10.021. Epub 2017 Oct 16.


Microneedle patch delivery of influenza vaccine during pregnancy enhances maternal immune responses promoting survival and long-lasting passive immunity to offspring.

Esser ES, Pulit-Penaloza JA, Kalluri H, McAllister D, Vassilieva EV, Littauer EQ, Lelutiu N, Prausnitz MR, Compans RW, Skountzou I.

Sci Rep. 2017 Jul 18;7(1):5705. doi: 10.1038/s41598-017-05940-7.


The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial.

Rouphael NG, Paine M, Mosley R, Henry S, McAllister DV, Kalluri H, Pewin W, Frew PM, Yu T, Thornburg NJ, Kabbani S, Lai L, Vassilieva EV, Skountzou I, Compans RW, Mulligan MJ, Prausnitz MR; TIV-MNP 2015 Study Group.

Lancet. 2017 Aug 12;390(10095):649-658. doi: 10.1016/S0140-6736(17)30575-5. Epub 2017 Jun 27.


A boosting skin vaccination with dissolving microneedle patch encapsulating M2e vaccine broadens the protective efficacy of conventional influenza vaccines.

Zhu W, Pewin W, Wang C, Luo Y, Gonzalez GX, Mohan T, Prausnitz MR, Wang BZ.

J Control Release. 2017 Sep 10;261:1-9. doi: 10.1016/j.jconrel.2017.06.017. Epub 2017 Jun 19.


Role of cytoskeletal mechanics and cell membrane fluidity in the intracellular delivery of molecules mediated by laser-activated carbon nanoparticles.

Holguin SY, Anderson CF, Thadhani NN, Prausnitz MR.

Biotechnol Bioeng. 2017 Oct;114(10):2390-2399. doi: 10.1002/bit.26355. Epub 2017 Jul 11.


Engineering Microneedle Patches for Vaccination and Drug Delivery to Skin.

Prausnitz MR.

Annu Rev Chem Biomol Eng. 2017 Jun 7;8:177-200. doi: 10.1146/annurev-chembioeng-060816-101514. Epub 2017 Mar 24. Review.


Energy Transfer Mechanisms during Molecular Delivery to Cells by Laser-Activated Carbon Nanoparticles.

Sengupta A, Gray MD, Kelly SC, Holguin SY, Thadhani NN, Prausnitz MR.

Biophys J. 2017 Mar 28;112(6):1258-1269. doi: 10.1016/j.bpj.2017.02.007.


Tolerability, usability and acceptability of dissolving microneedle patch administration in human subjects.

Arya J, Henry S, Kalluri H, McAllister DV, Pewin WP, Prausnitz MR.

Biomaterials. 2017 Jun;128:1-7. doi: 10.1016/j.biomaterials.2017.02.040. Epub 2017 Mar 2.


Challenges and Future Prospects for the Delivery of Biologics: Oral Mucosal, Pulmonary, and Transdermal Routes.

Morales JO, Fathe KR, Brunaugh A, Ferrati S, Li S, Montenegro-Nicolini M, Mousavikhamene Z, McConville JT, Prausnitz MR, Smyth HDC.

AAPS J. 2017 May;19(3):652-668. doi: 10.1208/s12248-017-0054-z. Epub 2017 Feb 13.


Thickness and Closure Kinetics of the Suprachoroidal Space Following Microneedle Injection of Liquid Formulations.

Chiang B, Venugopal N, Grossniklaus HE, Jung JH, Edelhauser HF, Prausnitz MR.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):555-564. doi: 10.1167/iovs.16-20377.


Clearance Kinetics and Clearance Routes of Molecules From the Suprachoroidal Space After Microneedle Injection.

Chiang B, Wang K, Ethier CR, Prausnitz MR.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):545-554. doi: 10.1167/iovs.16-20679.


Ebola Vaccination Using a DNA Vaccine Coated on PLGA-PLL/╬│PGA Nanoparticles Administered Using a Microneedle Patch.

Yang HW, Ye L, Guo XD, Yang C, Compans RW, Prausnitz MR.

Adv Healthc Mater. 2017 Jan;6(1). doi: 10.1002/adhm.201600750. Epub 2016 Nov 7.


Targeted Drug Delivery Within the Eye Through the Suprachoroidal Space.

Patel SR, Prausnitz MR.

J Ocul Pharmacol Ther. 2016 Dec;32(10):640-641. Epub 2016 Nov 16. No abstract available.


Distribution of particles, small molecules and polymeric formulation excipients in the suprachoroidal space after microneedle injection.

Chiang B, Venugopal N, Edelhauser HF, Prausnitz MR.

Exp Eye Res. 2016 Dec;153:101-109. doi: 10.1016/j.exer.2016.10.011. Epub 2016 Oct 11.


Rabies vaccination in dogs using a dissolving microneedle patch.

Arya JM, Dewitt K, Scott-Garrard M, Chiang YW, Prausnitz MR.

J Control Release. 2016 Oct 10;239:19-26. doi: 10.1016/j.jconrel.2016.08.012. Epub 2016 Aug 11.


Tetanus vaccination with a dissolving microneedle patch confers protective immune responses in pregnancy.

Esser ES, Romanyuk A, Vassilieva EV, Jacob J, Prausnitz MR, Compans RW, Skountzou I.

J Control Release. 2016 Aug 28;236:47-56. doi: 10.1016/j.jconrel.2016.06.026. Epub 2016 Jun 18.


DNA uptake, intracellular trafficking and gene transfection after ultrasound exposure.

Liu Y, Yan J, Santangelo PJ, Prausnitz MR.

J Control Release. 2016 Jul 28;234:1-9. doi: 10.1016/j.jconrel.2016.05.013. Epub 2016 May 7.


Circumferential flow of particles in the suprachoroidal space is impeded by the posterior ciliary arteries.

Chiang B, Kim YC, Edelhauser HF, Prausnitz MR.

Exp Eye Res. 2016 Apr;145:424-431. doi: 10.1016/j.exer.2016.03.008. Epub 2016 Mar 11.


Sustained reduction of intraocular pressure by supraciliary delivery of brimonidine-loaded poly(lactic acid) microspheres for the treatment of glaucoma.

Chiang B, Kim YC, Doty AC, Grossniklaus HE, Schwendeman SP, Prausnitz MR.

J Control Release. 2016 Apr 28;228:48-57. doi: 10.1016/j.jconrel.2016.02.041. Epub 2016 Feb 28.


Long-term stability of influenza vaccine in a dissolving microneedle patch.

Mistilis MJ, Joyce JC, Esser ES, Skountzou I, Compans RW, Bommarius AS, Prausnitz MR.

Drug Deliv Transl Res. 2017 Apr;7(2):195-205. doi: 10.1007/s13346-016-0282-2.


Parameters affecting intracellular delivery of molecules using laser-activated carbon nanoparticles.

Chakravarty P, Lane CD, Orlando TM, Prausnitz MR.

Nanomedicine. 2016 May;12(4):1003-1011. doi: 10.1016/j.nano.2015.12.380. Epub 2016 Jan 7.


Enhanced Stability of Inactivated Influenza Vaccine Encapsulated in Dissolving Microneedle Patches.

Chu LY, Ye L, Dong K, Compans RW, Yang C, Prausnitz MR.

Pharm Res. 2016 Apr;33(4):868-78. doi: 10.1007/s11095-015-1833-9. Epub 2015 Dec 1.


Microneedle patches for vaccination in developing countries.

Arya J, Prausnitz MR.

J Control Release. 2016 Oct 28;240:135-141. doi: 10.1016/j.jconrel.2015.11.019. Epub 2015 Nov 18. Review.


Effect of Osmotic Pressure on the Stability of Whole Inactivated Influenza Vaccine for Coating on Microneedles.

Choi HJ, Song JM, Bondy BJ, Compans RW, Kang SM, Prausnitz MR.

PLoS One. 2015 Jul 31;10(7):e0134431. doi: 10.1371/journal.pone.0134431. eCollection 2015.


Delivery of siRNA to ovarian cancer cells using laser-activated carbon nanoparticles.

Sengupta A, Mezencev R, McDonald JF, Prausnitz MR.

Nanomedicine (Lond). 2015;10(11):1775-84. doi: 10.2217/nnm.15.27.


Formulation to target delivery to the ciliary body and choroid via the suprachoroidal space of the eye using microneedles.

Kim YC, Oh KH, Edelhauser HF, Prausnitz MR.

Eur J Pharm Biopharm. 2015 Sep;95(Pt B):398-406. doi: 10.1016/j.ejpb.2015.05.020. Epub 2015 May 31.


Microneedle patch delivery to the skin of virus-like particles containing heterologous M2e extracellular domains of influenza virus induces broad heterosubtypic cross-protection.

Kim MC, Lee JW, Choi HJ, Lee YN, Hwang HS, Lee J, Kim C, Lee JS, Montemagno C, Prausnitz MR, Kang SM.

J Control Release. 2015 Jul 28;210:208-16. doi: 10.1016/j.jconrel.2015.05.278. Epub 2015 May 21.


Drug delivery: Puncturing cells en masse.

Prausnitz MR.

Nat Mater. 2015 May;14(5):470-1. doi: 10.1038/nmat4274. No abstract available.


Improved immunogenicity of individual influenza vaccine components delivered with a novel dissolving microneedle patch stable at room temperature.

Vassilieva EV, Kalluri H, McAllister D, Taherbhai MT, Esser ES, Pewin WP, Pulit-Penaloza JA, Prausnitz MR, Compans RW, Skountzou I.

Drug Deliv Transl Res. 2015 Aug;5(4):360-71. doi: 10.1007/s13346-015-0228-0.


Reliability and accuracy of intradermal injection by Mantoux technique, hypodermic needle adapter, and hollow microneedle in pigs.

Norman JJ, Gupta J, Patel SR, Park S, Jarrahian C, Zehrung D, Prausnitz MR.

Drug Deliv Transl Res. 2014 Apr;4(2):126-30. doi: 10.1007/s13346-013-0184-5.


Vaccination with human papillomavirus pseudovirus-encapsidated plasmids targeted to skin using microneedles.

Kines RC, Zarnitsyn V, Johnson TR, Pang YY, Corbett KS, Nicewonger JD, Gangopadhyay A, Chen M, Liu J, Prausnitz MR, Schiller JT, Graham BS.

PLoS One. 2015 Mar 18;10(3):e0120797. doi: 10.1371/journal.pone.0120797. eCollection 2015.


An economic model assessing the value of microneedle patch delivery of the seasonal influenza vaccine.

Lee BY, Bartsch SM, Mvundura M, Jarrahian C, Zapf KM, Marinan K, Wateska AR, Snyder B, Swaminathan S, Jacoby E, Norman JJ, Prausnitz MR, Zehrung D.

Vaccine. 2015 Sep 8;33(37):4727-36. doi: 10.1016/j.vaccine.2015.02.076. Epub 2015 Mar 13.


A microneedle patch containing measles vaccine is immunogenic in non-human primates.

Edens C, Collins ML, Goodson JL, Rota PA, Prausnitz MR.

Vaccine. 2015 Sep 8;33(37):4712-8. doi: 10.1016/j.vaccine.2015.02.074. Epub 2015 Mar 12.


Inactivated polio vaccination using a microneedle patch is immunogenic in the rhesus macaque.

Edens C, Dybdahl-Sissoko NC, Weldon WC, Oberste MS, Prausnitz MR.

Vaccine. 2015 Sep 8;33(37):4683-90. doi: 10.1016/j.vaccine.2015.01.089. Epub 2015 Mar 3.


Enhanced immune responses by skin vaccination with influenza subunit vaccine in young hosts.

Koutsonanos DG, Esser ES, McMaster SR, Kalluri P, Lee JW, Prausnitz MR, Skountzou I, Denning TL, Kohlmeier JE, Compans RW.

Vaccine. 2015 Sep 8;33(37):4675-82. doi: 10.1016/j.vaccine.2015.01.086. Epub 2015 Mar 3.

Supplemental Content

Loading ...
Support Center