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Ablation of conceptus PTGS2 expression does not alter early conceptus development and establishment of pregnancy in the pig†.

Pfeiffer CA, Meyer AE, Brooks KE, Chen PR, Milano-Foster J, Spate LD, Benne JA, Cecil R, Samuel MS, Ciernia LA, Spinka CM, Smith MF, Wells KD, Spencer TE, Prather RS, Geisert RD.

Biol Reprod. 2019 Oct 16. pii: ioz192. doi: 10.1093/biolre/ioz192. [Epub ahead of print]


Applications of omics and nanotechnology to improve pig embryo production in vitro.

Lucas CG, Chen PR, Seixas FK, Prather RS, Collares T.

Mol Reprod Dev. 2019 Sep 3. doi: 10.1002/mrd.23260. [Epub ahead of print] Review.


Pharmacologic treatment with CPI-613 and PS48 decreases mitochondrial membrane potential and increases quantity of autolysosomes in porcine fibroblasts.

Mordhorst BR, Kerns KC, Schauflinger M, Zigo M, Murphy SL, Ross RM, Wells KD, Green JA, Sutovsky P, Prather RS.

Sci Rep. 2019 Jul 1;9(1):9417. doi: 10.1038/s41598-019-45850-4.


In Vitro Maturation, Fertilization, and Culture of Pig Oocytes and Embryos.

Redel BK, Spate LD, Prather RS.

Methods Mol Biol. 2019;2006:93-103. doi: 10.1007/978-1-4939-9566-0_6.


New perspective on conceptus estrogens in maternal recognition and pregnancy establishment in the pig†.

Meyer AE, Pfeiffer CA, Brooks KE, Spate LD, Benne JA, Cecil R, Samuel MS, Murphy CN, Behura S, McLean MK, Ciernia LA, Smith MF, Whitworth KM, Wells KD, Spencer TE, Prather RS, Geisert RD.

Biol Reprod. 2019 Jul 1;101(1):148-161. doi: 10.1093/biolre/ioz058.


Improvement of in vitro and early in utero porcine clone development after somatic donor cells are cultured under hypoxia.

Mordhorst BR, Benne JA, Cecil RF, Whitworth KM, Samuel MS, Spate LD, Murphy CN, Wells KD, Green JA, Prather RS.

Mol Reprod Dev. 2019 May;86(5):558-565. doi: 10.1002/mrd.23132. Epub 2019 Feb 19.


Resistance to coronavirus infection in amino peptidase N-deficient pigs.

Whitworth KM, Rowland RRR, Petrovan V, Sheahan M, Cino-Ozuna AG, Fang Y, Hesse R, Mileham A, Samuel MS, Wells KD, Prather RS.

Transgenic Res. 2019 Feb;28(1):21-32. doi: 10.1007/s11248-018-0100-3. Epub 2018 Oct 12.


Anatomic Studies of the Miniature Swine Cornea.

Abhari S, Eisenback M, Kaplan HJ, Walters E, Prather RS, Scott PA.

Anat Rec (Hoboken). 2018 Nov;301(11):1955-1967. doi: 10.1002/ar.23890. Epub 2018 Oct 5.


Porcine Fetal-Derived Fibroblasts Alter Gene Expression and Mitochondria to Compensate for Hypoxic Stress During Culture.

Mordhorst BR, Murphy SL, Schauflinger M, Rojas Salazar S, Ji T, Behura SK, Wells KD, Green JA, Prather RS.

Cell Reprogram. 2018 Aug;20(4):225-235. doi: 10.1089/cell.2018.0008.


Glutamine supplementation enhances development of in vitro-produced porcine embryos and increases leucine consumption from the medium.

Chen PR, Redel BK, Spate LD, Ji T, Salazar SR, Prather RS.

Biol Reprod. 2018 Nov 1;99(5):938-948. doi: 10.1093/biolre/ioy129.


Single step production of Cas9 mRNA for zygote injection.

Redel BK, Beaton BP, Spate LD, Benne JA, Murphy SL, O'Gorman CW, Spate AM, Prather RS, Wells KD.

Biotechniques. 2018 Mar 1;64(3):118-124. doi: 10.2144/btn-2017-0116.


Zygote injection of RNA encoding Cre recombinase results in efficient removal of LoxP flanked neomycin cassettes in pigs.

Whitworth KM, Cecil R, Benne JA, Redel BK, Spate LD, Samuel MS, Prather RS, Wells KD.

Transgenic Res. 2018 Apr;27(2):167-178. doi: 10.1007/s11248-018-0064-3. Epub 2018 Mar 7.


Use of gene-editing technology to introduce targeted modifications in pigs.

Ryu J, Prather RS, Lee K.

J Anim Sci Biotechnol. 2018 Jan 29;9:5. doi: 10.1186/s40104-017-0228-7. eCollection 2018. Review.


Pharmacologic Reprogramming Designed to Induce a Warburg Effect in Porcine Fetal Fibroblasts Alters Gene Expression and Quantities of Metabolites from Conditioned Media Without Increased Cell Proliferation.

Mordhorst BR, Murphy SL, Ross RM, Samuel MS, Rojas Salazar S, Ji T, Behura SK, Wells KD, Green JA, Prather RS.

Cell Reprogram. 2018 Feb;20(1):38-48. doi: 10.1089/cell.2017.0040.


Pharmacologic treatment of donor cells induced to have a Warburg effect-like metabolism does not alter embryonic development in vitro or survival during early gestation when used in somatic cell nuclear transfer in pigs.

Mordhorst BR, Murphy SL, Ross RM, Benne JA, Samuel MS, Cecil RF, Redel BK, Spate LD, Murphy CN, Wells KD, Green JA, Prather RS.

Mol Reprod Dev. 2018 Apr;85(4):290-302. doi: 10.1002/mrd.22964. Epub 2018 Mar 5.


Inactivation of porcine interleukin-1β results in failure of rapid conceptus elongation.

Whyte JJ, Meyer AE, Spate LD, Benne JA, Cecil R, Samuel MS, Murphy CN, Prather RS, Geisert RD.

Proc Natl Acad Sci U S A. 2018 Jan 9;115(2):307-312. doi: 10.1073/pnas.1718004115. Epub 2017 Dec 26.


Porcine Neural Progenitor Cells Derived from Tissue at Different Gestational Ages Can Be Distinguished by Global Transcriptome.

Yang J, Menges S, Gu P, Tongbai R, Samuel M, Prather RS, Klassen H.

Cell Transplant. 2017 Sep;26(9):1582-1595. doi: 10.1177/0963689717723015.


Recombination activating gene-2null severe combined immunodeficient pigs and mice engraft human induced pluripotent stem cells differently.

Choi YJ, Kim E, Reza AMMT, Hong K, Song H, Park C, Cho SK, Lee K, Prather RS, Kim JH.

Oncotarget. 2017 Sep 2;8(41):69398-69407. doi: 10.18632/oncotarget.20626. eCollection 2017 Sep 19.


Knockout of maternal CD163 protects fetuses from infection with porcine reproductive and respiratory syndrome virus (PRRSV).

Prather RS, Wells KD, Whitworth KM, Kerrigan MA, Samuel MS, Mileham A, Popescu LN, Rowland RRR.

Sci Rep. 2017 Oct 17;7(1):13371. doi: 10.1038/s41598-017-13794-2.


Quadrupling efficiency in production of genetically modified pigs through improved oocyte maturation.

Yuan Y, Spate LD, Redel BK, Tian Y, Zhou J, Prather RS, Roberts RM.

Proc Natl Acad Sci U S A. 2017 Jul 18;114(29):E5796-E5804. doi: 10.1073/pnas.1703998114. Epub 2017 Jul 3.


Genome-editing technologies to improve research, reproduction, and production in pigs.

Wells KD, Prather RS.

Mol Reprod Dev. 2017 Sep;84(9):1012-1017. doi: 10.1002/mrd.22812. Epub 2017 Jun 8. Review.


Rapid conceptus elongation in the pig: An interleukin 1 beta 2 and estrogen-regulated phenomenon.

Geisert RD, Whyte JJ, Meyer AE, Mathew DJ, Juárez MR, Lucy MC, Prather RS, Spencer TE.

Mol Reprod Dev. 2017 Sep;84(9):760-774. doi: 10.1002/mrd.22813. Epub 2017 Jun 8. Review.


Gene editing as applied to prevention of reproductive porcine reproductive and respiratory syndrome.

Whitworth KM, Prather RS.

Mol Reprod Dev. 2017 Sep;84(9):926-933. doi: 10.1002/mrd.22811. Epub 2017 Jun 8. Review.


Swine models, genomic tools and services to enhance our understanding of human health and diseases.

Walters EM, Wells KD, Bryda EC, Schommer S, Prather RS.

Lab Anim (NY). 2017 Mar 22;46(4):167-172. doi: 10.1038/laban.1215.


Progression of Pro23His Retinopathy in a Miniature Swine Model of Retinitis Pigmentosa.

Scott PA, de Castro JP, DeMarco PJ, Ross JW, Njoka J, Walters E, Prather RS, McCall MA, Kaplan HJ.

Transl Vis Sci Technol. 2017 Mar 15;6(2):4. doi: 10.1167/tvst.6.2.4. eCollection 2017 Mar.


Genetic engineering alveolar macrophages for host resistance to PRRSV.

Prather RS, Whitworth KM, Schommer SK, Wells KD.

Vet Microbiol. 2017 Sep;209:124-129. doi: 10.1016/j.vetmic.2017.01.036. Epub 2017 Feb 10. Review.


Genetically edited pigs lacking CD163 show no resistance following infection with the African swine fever virus isolate, Georgia 2007/1.

Popescu L, Gaudreault NN, Whitworth KM, Murgia MV, Nietfeld JC, Mileham A, Samuel M, Wells KD, Prather RS, Rowland RRR.

Virology. 2017 Jan 15;501:102-106. doi: 10.1016/j.virol.2016.11.012. Epub 2016 Nov 26.


Replacement of Porcine CD163 Scavenger Receptor Cysteine-Rich Domain 5 with a CD163-Like Homolog Confers Resistance of Pigs to Genotype 1 but Not Genotype 2 Porcine Reproductive and Respiratory Syndrome Virus.

Wells KD, Bardot R, Whitworth KM, Trible BR, Fang Y, Mileham A, Kerrigan MA, Samuel MS, Prather RS, Rowland RRR.

J Virol. 2017 Jan 3;91(2). pii: e01521-16. doi: 10.1128/JVI.01521-16. Print 2017 Jan 15.


Zygote injection of CRISPR/Cas9 RNA successfully modifies the target gene without delaying blastocyst development or altering the sex ratio in pigs.

Whitworth KM, Benne JA, Spate LD, Murphy SL, Samuel MS, Murphy CN, Richt JA, Walters E, Prather RS, Wells KD.

Transgenic Res. 2017 Feb;26(1):97-107. doi: 10.1007/s11248-016-9989-6. Epub 2016 Oct 15.


Partial loss of interleukin 2 receptor gamma function in pigs provides mechanistic insights for the study of human immunodeficiency syndrome.

Choi YJ, Lee K, Park WJ, Kwon DN, Park C, Do JT, Song H, Cho SK, Park KW, Brown AN, Samuel MS, Murphy CN, Prather RS, Kim JH.

Oncotarget. 2016 Aug 9;7(32):50914-50926. doi: 10.18632/oncotarget.10812.


Glycine supplementation in vitro enhances porcine preimplantation embryo cell number and decreases apoptosis but does not lead to live births.

Redel BK, Spate LD, Lee K, Mao J, Whitworth KM, Prather RS.

Mol Reprod Dev. 2016 Mar;83(3):246-58. doi: 10.1002/mrd.22618. Epub 2016 Feb 8.


Transcriptome Analysis of Pig In Vivo, In Vitro-Fertilized, and Nuclear Transfer Blastocyst-Stage Embryos Treated with Histone Deacetylase Inhibitors Postfusion and Activation Reveals Changes in the Lysosomal Pathway.

Whitworth KM, Mao J, Lee K, Spollen WG, Samuel MS, Walters EM, Spate LD, Prather RS.

Cell Reprogram. 2015 Aug;17(4):243-58. doi: 10.1089/cell.2015.0022.


Gene-edited pigs are protected from porcine reproductive and respiratory syndrome virus.

Whitworth KM, Rowland RR, Ewen CL, Trible BR, Kerrigan MA, Cino-Ozuna AG, Samuel MS, Lightner JE, McLaren DG, Mileham AJ, Wells KD, Prather RS.

Nat Biotechnol. 2016 Jan;34(1):20-2. doi: 10.1038/nbt.3434. Epub 2015 Dec 7. No abstract available.


Meganucleases Revolutionize the Production of Genetically Engineered Pigs for the Study of Human Diseases.

Redel BK, Prather RS.

Toxicol Pathol. 2016 Apr;44(3):428-33. doi: 10.1177/0192623315613160. Epub 2015 Oct 28. Review.


Engineering protein processing of the mammary gland to produce abundant hemophilia B therapy in milk.

Zhao J, Xu W, Ross JW, Walters EM, Butler SP, Whyte JJ, Kelso L, Fatemi M, Vanderslice NC, Giroux K, Spate LD, Samuel MS, Murphy CN, Wells KD, Masiello NC, Prather RS, Velander WH.

Sci Rep. 2015 Sep 21;5:14176. doi: 10.1038/srep14176.


Inclusion of homologous DNA in nuclease-mediated gene targeting facilitates a higher incidence of bi-allelically modified cells.

Beaton BP, Kwon DN, Choi YJ, Kim JH, Samuel MS, Benne JA, Wells KD, Lee K, Kim JH, Prather RS.

Xenotransplantation. 2015 Sep-Oct;22(5):379-90. doi: 10.1111/xen.12194.


Cryopreservation of In Vitro-Produced Early-Stage Porcine Embryos in a Closed System.

Men H, Spate LD, Murphy CN, Prather RS.

Biores Open Access. 2015 May 1;4(1):258-65. doi: 10.1089/biores.2015.0012. eCollection 2015.


Pig oocyte activation using a Zn²⁺ chelator, TPEN.

Lee K, Davis A, Zhang L, Ryu J, Spate LD, Park KW, Samuel MS, Walters EM, Murphy CN, Machaty Z, Prather RS.

Theriogenology. 2015 Oct 1;84(6):1024-32. doi: 10.1016/j.theriogenology.2015.05.036. Epub 2015 Jun 12.


A Genetic Porcine Model of Cancer.

Schook LB, Collares TV, Hu W, Liang Y, Rodrigues FM, Rund LA, Schachtschneider KM, Seixas FK, Singh K, Wells KD, Walters EM, Prather RS, Counter CM.

PLoS One. 2015 Jul 1;10(7):e0128864. doi: 10.1371/journal.pone.0128864. eCollection 2015.


Disruption of Mitochondrion-To-Nucleus Interaction in Deceased Cloned Piglets.

Park J, Lai L, Samuel MS, Wax D, Prather RS, Tian X.

PLoS One. 2015 Jun 11;10(6):e0129378. doi: 10.1371/journal.pone.0129378. eCollection 2015.


PS48 can replace bovine serum albumin in pig embryo culture medium, and improve in vitro embryo development by phosphorylating AKT.

Spate LD, Brown A, Redel BK, Whitworth KM, Prather RS.

Mol Reprod Dev. 2015 Apr;82(4):315-20. doi: 10.1002/mrd.22474. Epub 2015 Mar 16.


Applying metabolomic analyses to the practice of embryology: physiology, development and assisted reproductive technology.

Krisher RL, Heuberger AL, Paczkowski M, Stevens J, Pospisil C, Prather RS, Sturmey RG, Herrick JR, Schoolcraft WB.

Reprod Fertil Dev. 2015 May;27(4):602-20. doi: 10.1071/RD14359.


Impairment of preimplantation porcine embryo development by histone demethylase KDM5B knockdown through disturbance of bivalent H3K4me3-H3K27me3 modifications.

Huang J, Zhang H, Wang X, Dobbs KB, Yao J, Qin G, Whitworth K, Walters EM, Prather RS, Zhao J.

Biol Reprod. 2015 Mar;92(3):72. doi: 10.1095/biolreprod.114.122762. Epub 2015 Jan 21.


Oxamflatin treatment enhances cloned porcine embryo development and nuclear reprogramming.

Mao J, Zhao MT, Whitworth KM, Spate LD, Walters EM, O'Gorman C, Lee K, Samuel MS, Murphy CN, Wells K, Rivera RM, Prather RS.

Cell Reprogram. 2015 Feb;17(1):28-40. doi: 10.1089/cell.2014.0075. Epub 2014 Dec 30.


Dysregulation of genome-wide gene expression and DNA methylation in abnormal cloned piglets.

Li G, Jia Q, Zhao J, Li X, Yu M, Samuel MS, Zhao S, Prather RS, Li C.

BMC Genomics. 2014 Sep 24;15:811. doi: 10.1186/1471-2164-15-811.


Use of the CRISPR/Cas9 system to produce genetically engineered pigs from in vitro-derived oocytes and embryos.

Whitworth KM, Lee K, Benne JA, Beaton BP, Spate LD, Murphy SL, Samuel MS, Mao J, O'Gorman C, Walters EM, Murphy CN, Driver J, Mileham A, McLaren D, Wells KD, Prather RS.

Biol Reprod. 2014 Sep;91(3):78. doi: 10.1095/biolreprod.114.121723. Epub 2014 Aug 6.


Genomic profiling to improve embryogenesis in the pig.

Prather RS, Redel BK, Whitworth KM, Zhao MT.

Anim Reprod Sci. 2014 Sep;149(1-2):39-45. doi: 10.1016/j.anireprosci.2014.04.017. Epub 2014 May 14. Review.


Engraftment of human iPS cells and allogeneic porcine cells into pigs with inactivated RAG2 and accompanying severe combined immunodeficiency.

Lee K, Kwon DN, Ezashi T, Choi YJ, Park C, Ericsson AC, Brown AN, Samuel MS, Park KW, Walters EM, Kim DY, Kim JH, Franklin CL, Murphy CN, Roberts RM, Prather RS, Kim JH.

Proc Natl Acad Sci U S A. 2014 May 20;111(20):7260-5. doi: 10.1073/pnas.1406376111. Epub 2014 May 5.


Methylated DNA immunoprecipitation and high-throughput sequencing (MeDIP-seq) using low amounts of genomic DNA.

Zhao MT, Whyte JJ, Hopkins GM, Kirk MD, Prather RS.

Cell Reprogram. 2014 Jun;16(3):175-84. doi: 10.1089/cell.2014.0002. Epub 2014 Apr 28.


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