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Items: 1 to 50 of 147

1.

Metabolic Reprogramming by MYCN Confers Dependence on the Serine-Glycine-One-Carbon Biosynthetic Pathway.

Xia Y, Ye B, Ding J, Yu Y, Alptekin A, Thangaraju M, Prasad PD, Ding ZC, Park EJ, Choi JH, Gao B, Fiehn O, Yan C, Dong Z, Zha Y, Ding HF.

Cancer Res. 2019 Aug 1;79(15):3837-3850. doi: 10.1158/0008-5472.CAN-18-3541. Epub 2019 May 14.

PMID:
31088832
2.

Canonical Wnt Signaling in CD11c+ APCs Regulates Microbiota-Induced Inflammation and Immune Cell Homeostasis in the Colon.

Swafford D, Shanmugam A, Ranganathan P, Hussein MS, Koni PA, Prasad PD, Thangaraju M, Manicassamy S.

J Immunol. 2018 May 1;200(9):3259-3268. doi: 10.4049/jimmunol.1701086. Epub 2018 Mar 30.

3.

GPR81, a Cell-Surface Receptor for Lactate, Regulates Intestinal Homeostasis and Protects Mice from Experimental Colitis.

Ranganathan P, Shanmugam A, Swafford D, Suryawanshi A, Bhattacharjee P, Hussein MS, Koni PA, Prasad PD, Kurago ZB, Thangaraju M, Ganapathy V, Manicassamy S.

J Immunol. 2018 Mar 1;200(5):1781-1789. doi: 10.4049/jimmunol.1700604. Epub 2018 Jan 31.

4.

NREM Sleep and Antiepileptic Medications Modulate Epileptiform Activity by Altering Cortical Synchrony.

Nayak CS, Mariyappa N, Majumdar KK, Ravi GS, Prasad PD, Nagappa M, Kandavel T, Taly AB, Sinha S.

Clin EEG Neurosci. 2018 Nov;49(6):417-424. doi: 10.1177/1550059417747436. Epub 2018 Jan 8.

PMID:
29308656
5.

Heightened Background Cortical Synchrony in Patients With Epilepsy: EEG Phase Synchrony Analysis During Awake and Sleep Stages Using Novel Ensemble Measure.

Nayak CS, Mariyappa N, Majumdar KK, Prasad PD, Ravi GS, Nagappa M, Kandavel T, Taly AB, Sinha S.

Clin EEG Neurosci. 2018 May;49(3):177-186. doi: 10.1177/1550059417696559. Epub 2017 Mar 1.

PMID:
29161907
6.

Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer.

Coothankandaswamy V, Cao S, Xu Y, Prasad PD, Singh PK, Reynolds CP, Yang S, Ogura J, Ganapathy V, Bhutia YD.

Br J Pharmacol. 2016 Dec;173(23):3292-3306. doi: 10.1111/bph.13616. Epub 2016 Oct 18.

7.

Phase Synchronization Analysis of Natural Wake and Sleep States in Healthy Individuals Using a Novel Ensemble Phase Synchronization Measure.

Nayak CS, Bhowmik A, Prasad PD, Pati S, Choudhury KK, Majumdar KK.

J Clin Neurophysiol. 2017 Jan;34(1):77-83. doi: 10.1097/WNP.0000000000000325.

PMID:
27490322
8.

Combined Inhibition of DNMT and HDAC Blocks the Tumorigenicity of Cancer Stem-like Cells and Attenuates Mammary Tumor Growth.

Pathania R, Ramachandran S, Mariappan G, Thakur P, Shi H, Choi JH, Manicassamy S, Kolhe R, Prasad PD, Sharma S, Lokeshwar BL, Ganapathy V, Thangaraju M.

Cancer Res. 2016 Jun 1;76(11):3224-35. doi: 10.1158/0008-5472.CAN-15-2249. Epub 2016 Apr 5.

9.

Benefits of short-chain fatty acids and their receptors in inflammation and carcinogenesis.

Sivaprakasam S, Prasad PD, Singh N.

Pharmacol Ther. 2016 Aug;164:144-51. doi: 10.1016/j.pharmthera.2016.04.007. Epub 2016 Apr 23. Review.

10.

Increased Retinal Expression of the Pro-Angiogenic Receptor GPR91 via BMP6 in a Mouse Model of Juvenile Hemochromatosis.

Arjunan P, Gnanaprakasam JP, Ananth S, Romej MA, Rajalakshmi VK, Prasad PD, Martin PM, Gurusamy M, Thangaraju M, Bhutia YD, Ganapathy V.

Invest Ophthalmol Vis Sci. 2016 Apr;57(4):1612-9. doi: 10.1167/iovs.15-17437.

11.

Deletion of the amino acid transporter Slc6a14 suppresses tumour growth in spontaneous mouse models of breast cancer.

Babu E, Bhutia YD, Ramachandran S, Gnanaprakasam JP, Prasad PD, Thangaraju M, Ganapathy V.

Biochem J. 2015 Jul 1;469(1):17-23. doi: 10.1042/BJ20150437. Epub 2015 May 13.

PMID:
26173258
12.

DNMT1 is essential for mammary and cancer stem cell maintenance and tumorigenesis.

Pathania R, Ramachandran S, Elangovan S, Padia R, Yang P, Cinghu S, Veeranan-Karmegam R, Arjunan P, Gnana-Prakasam JP, Sadanand F, Pei L, Chang CS, Choi JH, Shi H, Manicassamy S, Prasad PD, Sharma S, Ganapathy V, Jothi R, Thangaraju M.

Nat Commun. 2015 Apr 24;6:6910. doi: 10.1038/ncomms7910.

13.

Species-specific influence of lithium on the activity of SLC13A5 (NaCT): lithium-induced activation is specific for the transporter in primates.

Gopal E, Babu E, Ramachandran S, Bhutia YD, Prasad PD, Ganapathy V.

J Pharmacol Exp Ther. 2015 Apr;353(1):17-26. doi: 10.1124/jpet.114.221523. Epub 2015 Jan 23.

PMID:
25617245
14.

Single-trial EEG classification using logistic regression based on ensemble synchronization.

Prasad PD, Halahalli HN, John JP, Majumdar KK.

IEEE J Biomed Health Inform. 2014 May;18(3):1074-80. doi: 10.1109/JBHI.2013.2289741.

PMID:
24808232
15.

Activation of Gpr109a, receptor for niacin and the commensal metabolite butyrate, suppresses colonic inflammation and carcinogenesis.

Singh N, Gurav A, Sivaprakasam S, Brady E, Padia R, Shi H, Thangaraju M, Prasad PD, Manicassamy S, Munn DH, Lee JR, Offermanns S, Ganapathy V.

Immunity. 2014 Jan 16;40(1):128-39. doi: 10.1016/j.immuni.2013.12.007. Epub 2014 Jan 9.

16.

Comparative analysis of sodium coupled vitamin C transporter 2 in human osteoarthritis grade 1 and grade 3 tissues.

Blackburn AR 2nd, Hamrick MW, Chutkan N, Sangani R, Waller JL, Corpe R, Prasad PD, Isales CM, Ganapathy V, Fulzele S.

BMC Musculoskelet Disord. 2014 Jan 8;15:9. doi: 10.1186/1471-2474-15-9.

17.

The niacin/butyrate receptor GPR109A suppresses mammary tumorigenesis by inhibiting cell survival.

Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Lan L, Singh N, Martin PM, Hawthorn L, Prasad PD, Ganapathy V, Thangaraju M.

Cancer Res. 2014 Feb 15;74(4):1166-78. doi: 10.1158/0008-5472.CAN-13-1451. Epub 2013 Dec 26.

18.

Transporters and receptors for short-chain fatty acids as the molecular link between colonic bacteria and the host.

Ganapathy V, Thangaraju M, Prasad PD, Martin PM, Singh N.

Curr Opin Pharmacol. 2013 Dec;13(6):869-74. doi: 10.1016/j.coph.2013.08.006. Epub 2013 Aug 23. Review.

PMID:
23978504
19.

Molecular mechanism of SLC5A8 inactivation in breast cancer.

Elangovan S, Pathania R, Ramachandran S, Ananth S, Padia RN, Srinivas SR, Babu E, Hawthorn L, Schoenlein PV, Boettger T, Smith SB, Prasad PD, Ganapathy V, Thangaraju M.

Mol Cell Biol. 2013 Oct;33(19):3920-35. doi: 10.1128/MCB.01702-12. Epub 2013 Aug 5.

20.

Primary extragastrointestinal stromal tumors: a clinicopathological and immunohistochemical study - a tertiary care center experience.

Patnayak R, Jena A, Parthasarathy S, Prasad PD, Reddy MK, Chowhan AK, Rukamangadha N, Phaneendra BV.

Indian J Cancer. 2013 Jan-Mar;50(1):41-5. doi: 10.4103/0019-509X.112298.

21.

Hyperhomocysteinemia is detrimental to pregnancy in mice and is associated with preterm birth.

Sonne SR, Bhalla VK, Barman SA, White RE, Zhu S, Newman TM, Prasad PD, Smith SB, Offermanns S, Ganapathy V.

Biochim Biophys Acta. 2013 Aug;1832(8):1149-58. doi: 10.1016/j.bbadis.2013.04.006. Epub 2013 Apr 8.

22.

Synchronization implies seizure or seizure implies synchronization?

Majumdar K, Prasad PD, Verma S.

Brain Topogr. 2014 Jan;27(1):112-22. doi: 10.1007/s10548-013-0284-z. Epub 2013 Apr 6.

PMID:
23563905
23.

Enhanced phase and amplitude synchronization toward focal seizure offset.

Prasad PD, Datta SV, Majumdar K.

Clin EEG Neurosci. 2013 Jan;44(1):16-24. doi: 10.1177/1550059412456093.

PMID:
23467797
24.

Sodium-coupled vitamin C transporter (SVCT2): expression, function, and regulation in intervertebral disc cells.

Chothe PP, Chutkan N, Sangani R, Wenger KH, Prasad PD, Thangaraju M, Hamrick MW, Isales CM, Ganapathy V, Fulzele S.

Spine J. 2013 May;13(5):549-57. doi: 10.1016/j.spinee.2013.01.022. Epub 2013 Feb 13.

PMID:
23415019
25.

The plasma membrane transporter SLC5A8 suppresses tumour progression through depletion of survivin without involving its transport function.

Coothankandaswamy V, Elangovan S, Singh N, Prasad PD, Thangaraju M, Ganapathy V.

Biochem J. 2013 Feb 15;450(1):169-78. doi: 10.1042/BJ20121248.

26.

Sodium-dependent vitamin C transporter SVCT2: expression and function in bone marrow stromal cells and in osteogenesis.

Fulzele S, Chothe P, Sangani R, Chutkan N, Hamrick M, Bhattacharyya M, Prasad PD, Zakhary I, Bowser M, Isales C, Ganapathy V.

Stem Cell Res. 2013 Jan;10(1):36-47. doi: 10.1016/j.scr.2012.08.004. Epub 2012 Aug 23.

27.

Regulation of proton-coupled folate transporter in retinal Müller cells by the antipsoriatic drug monomethylfumarate.

Bozard BR, Chothe PP, Tawfik A, Williams C, Fulzele S, Prasad PD, Martin PM, Ganapathy V, Smith SB.

Glia. 2012 Mar;60(3):333-42. doi: 10.1002/glia.22266. Epub 2011 Nov 9.

28.

SIRT1 is essential for oncogenic signaling by estrogen/estrogen receptor α in breast cancer.

Elangovan S, Ramachandran S, Venkatesan N, Ananth S, Gnana-Prakasam JP, Martin PM, Browning DD, Schoenlein PV, Prasad PD, Ganapathy V, Thangaraju M.

Cancer Res. 2011 Nov 1;71(21):6654-64. doi: 10.1158/0008-5472.CAN-11-1446. Epub 2011 Sep 15.

29.

SLC6A14 (ATB0,+) protein, a highly concentrative and broad specific amino acid transporter, is a novel and effective drug target for treatment of estrogen receptor-positive breast cancer.

Karunakaran S, Ramachandran S, Coothankandaswamy V, Elangovan S, Babu E, Periyasamy-Thandavan S, Gurav A, Gnanaprakasam JP, Singh N, Schoenlein PV, Prasad PD, Thangaraju M, Ganapathy V.

J Biol Chem. 2011 Sep 9;286(36):31830-8. doi: 10.1074/jbc.M111.229518. Epub 2011 Jul 19.

30.

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate.

Babu E, Ramachandran S, CoothanKandaswamy V, Elangovan S, Prasad PD, Ganapathy V, Thangaraju M.

Oncogene. 2011 Sep 22;30(38):4026-37. doi: 10.1038/onc.2011.113. Epub 2011 Apr 18.

31.

Expression and iron-dependent regulation of succinate receptor GPR91 in retinal pigment epithelium.

Gnana-Prakasam JP, Ananth S, Prasad PD, Zhang M, Atherton SS, Martin PM, Smith SB, Ganapathy V.

Invest Ophthalmol Vis Sci. 2011 Jun 1;52(6):3751-8. doi: 10.1167/iovs.10-6722.

32.

Maternal protein restriction in the rat inhibits placental insulin, mTOR, and STAT3 signaling and down-regulates placental amino acid transporters.

Rosario FJ, Jansson N, Kanai Y, Prasad PD, Powell TL, Jansson T.

Endocrinology. 2011 Mar;152(3):1119-29. doi: 10.1210/en.2010-1153. Epub 2011 Feb 1.

33.

Blockade of dendritic cell development by bacterial fermentation products butyrate and propionate through a transporter (Slc5a8)-dependent inhibition of histone deacetylases.

Singh N, Thangaraju M, Prasad PD, Martin PM, Lambert NA, Boettger T, Offermanns S, Ganapathy V.

J Biol Chem. 2010 Sep 3;285(36):27601-8. doi: 10.1074/jbc.M110.102947. Epub 2010 Jul 2.

34.

Molecular origin of plasma membrane citrate transporter in human prostate epithelial cells.

Mazurek MP, Prasad PD, Gopal E, Fraser SP, Bolt L, Rizaner N, Palmer CP, Foster CS, Palmieri F, Ganapathy V, Stühmer W, Djamgoz MB, Mycielska ME.

EMBO Rep. 2010 Jun;11(6):431-7. doi: 10.1038/embor.2010.51. Epub 2010 May 7.

35.

Sodium-coupled electrogenic transport of pyroglutamate (5-oxoproline) via SLC5A8, a monocarboxylate transporter.

Miyauchi S, Gopal E, Babu E, Srinivas SR, Kubo Y, Umapathy NS, Thakkar SV, Ganapathy V, Prasad PD.

Biochim Biophys Acta. 2010 Jun;1798(6):1164-71. doi: 10.1016/j.bbamem.2010.03.002. Epub 2010 Mar 6.

36.

Expression of the actin-associated protein transgelin (SM22) is decreased in prostate cancer.

Prasad PD, Stanton JA, Assinder SJ.

Cell Tissue Res. 2010 Feb;339(2):337-47. doi: 10.1007/s00441-009-0902-y. Epub 2009 Dec 11.

PMID:
20012321
37.

Transport by SLC5A8 with subsequent inhibition of histone deacetylase 1 (HDAC1) and HDAC3 underlies the antitumor activity of 3-bromopyruvate.

Thangaraju M, Karunakaran SK, Itagaki S, Gopal E, Elangovan S, Prasad PD, Ganapathy V.

Cancer. 2009 Oct 15;115(20):4655-66. doi: 10.1002/cncr.24532.

38.

Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse.

Ganapathy PS, Moister B, Roon P, Mysona BA, Duplantier J, Dun Y, Moister TK, Farley MJ, Prasad PD, Liu K, Smith SB.

Invest Ophthalmol Vis Sci. 2009 Sep;50(9):4460-70. doi: 10.1167/iovs.09-3402. Epub 2009 Apr 8.

39.

GPR109A is a G-protein-coupled receptor for the bacterial fermentation product butyrate and functions as a tumor suppressor in colon.

Thangaraju M, Cresci GA, Liu K, Ananth S, Gnanaprakasam JP, Browning DD, Mellinger JD, Smith SB, Digby GJ, Lambert NA, Prasad PD, Ganapathy V.

Cancer Res. 2009 Apr 1;69(7):2826-32. doi: 10.1158/0008-5472.CAN-08-4466. Epub 2009 Mar 10.

40.

Nutrient transporters in cancer: relevance to Warburg hypothesis and beyond.

Ganapathy V, Thangaraju M, Prasad PD.

Pharmacol Ther. 2009 Jan;121(1):29-40. doi: 10.1016/j.pharmthera.2008.09.005. Epub 2008 Nov 1. Review.

PMID:
18992769
41.

Regulation of placental amino acid transporter activity by mammalian target of rapamycin.

Roos S, Kanai Y, Prasad PD, Powell TL, Jansson T.

Am J Physiol Cell Physiol. 2009 Jan;296(1):C142-50. doi: 10.1152/ajpcell.00330.2008. Epub 2008 Nov 5.

42.

High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice.

Jones HN, Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T.

FASEB J. 2009 Jan;23(1):271-8. doi: 10.1096/fj.08-116889. Epub 2008 Sep 30.

43.

Colon cancer cells maintain low levels of pyruvate to avoid cell death caused by inhibition of HDAC1/HDAC3.

Thangaraju M, Carswell KN, Prasad PD, Ganapathy V.

Biochem J. 2009 Jan 1;417(1):379-89. doi: 10.1042/BJ20081132.

PMID:
18789002
44.

Functional identification of a novel transport system for endogenous and synthetic opioid peptides in the rabbit conjunctival epithelial cell line CJVE.

Ananth S, Karunakaran S, Martin PM, Nagineni CN, Hooks JJ, Smith SB, Prasad PD, Ganapathy V.

Pharm Res. 2009 May;26(5):1226-35. doi: 10.1007/s11095-008-9709-x. Epub 2008 Sep 10.

45.
46.

An RPE cell line as a useful in vitro model for studying retinoic acid receptor beta: expression and affinity.

Pavan B, Dalpiaz A, Biondi C, Nieddu M, De Luca A, Prasad PD, Paganetto G, Favaloro B.

Biosci Rep. 2008 Dec;28(6):327-34. doi: 10.1042/BSR20080103.

PMID:
18673301
47.

Sodium-coupled transport of the short chain fatty acid butyrate by SLC5A8 and its relevance to colon cancer.

Thangaraju M, Cresci G, Itagaki S, Mellinger J, Browning DD, Berger FG, Prasad PD, Ganapathy V.

J Gastrointest Surg. 2008 Oct;12(10):1773-81; discussion 1781-2. doi: 10.1007/s11605-008-0573-0. Epub 2008 Jul 26.

PMID:
18661192
48.

Interaction of tryptophan derivatives with SLC6A14 (ATB0,+) reveals the potential of the transporter as a drug target for cancer chemotherapy.

Karunakaran S, Umapathy NS, Thangaraju M, Hatanaka T, Itagaki S, Munn DH, Prasad PD, Ganapathy V.

Biochem J. 2008 Sep 15;414(3):343-55. doi: 10.1042/BJ20080622.

PMID:
18522536
49.

Sodium-coupled monocarboxylate transporters in normal tissues and in cancer.

Ganapathy V, Thangaraju M, Gopal E, Martin PM, Itagaki S, Miyauchi S, Prasad PD.

AAPS J. 2008;10(1):193-9. doi: 10.1208/s12248-008-9022-y. Epub 2008 Apr 2. Review.

50.

Functional characterization, localization, and molecular identification of rabbit intestinal N-amino acid transporter.

Talukder JR, Kekuda R, Saha P, Prasad PD, Ganapathy V, Sundaram U.

Am J Physiol Gastrointest Liver Physiol. 2008 Jun;294(6):G1301-10. doi: 10.1152/ajpgi.00578.2007. Epub 2008 Apr 3.

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