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Items: 1 to 50 of 172

1.

How a four-year-old boy connects healthcare, biomedical research and undergraduate education.

Drost RH, Dictus WJAG, Prakken BJ, Bovenschen N.

Nat Biotechnol. 2019 Sep;37(9):1092-1095. doi: 10.1038/s41587-019-0245-5. No abstract available.

PMID:
31485047
2.

Critical Gaps in Understanding the Clinician-Scientist Workforce: Results of an International Expert Meeting.

Weggemans MM, Friesen F, Kluijtmans M, Prakken B, Ten Cate O, Woods NN, Rosenblum ND; International Expert Group on the Clinician–Scientist Workforce.

Acad Med. 2019 Oct;94(10):1448-1454. doi: 10.1097/ACM.0000000000002802.

PMID:
31135403
3.

Microbiome Analytics of the Gut Microbiota in Patients With Juvenile Idiopathic Arthritis: A Longitudinal Observational Cohort Study.

van Dijkhuizen EHP, Del Chierico F, Malattia C, Russo A, Pires Marafon D, Ter Haar NM, Magni-Manzoni S, Vastert SJ, Dallapiccola B, Prakken B, Martini A, De Benedetti F, Putignani L; Model Driven Paediatric European Digital Repository Consortium.

Arthritis Rheumatol. 2019 Jun;71(6):1000-1010. doi: 10.1002/art.40827. Epub 2019 Apr 29.

4.

Preventing Translational Scientists From Extinction: The Long-Term Impact of a Personalized Training Program in Translational Medicine on the Careers of Translational Scientists.

Weggemans MM, van der Schaaf M, Kluijtmans M, Hafler JP, Rosenblum ND, Prakken BJ.

Front Med (Lausanne). 2018 Nov 9;5:298. doi: 10.3389/fmed.2018.00298. eCollection 2018.

5.

Children and young people get rheumatic disease too.

Egert Y, Egert T, Costello W, Prakken BJ, Smith EMD, Wulffraat NM.

Lancet Child Adolesc Health. 2019 Jan;3(1):8-9. doi: 10.1016/S2352-4642(18)30374-2. Epub 2018 Nov 23. No abstract available.

PMID:
30473439
6.

PD-1+CD8+ T cells are clonally expanding effectors in human chronic inflammation.

Petrelli A, Mijnheer G, Hoytema van Konijnenburg DP, van der Wal MM, Giovannone B, Mocholi E, Vazirpanah N, Broen JC, Hijnen D, Oldenburg B, Coffer PJ, Vastert SJ, Prakken BJ, Spierings E, Pandit A, Mokry M, van Wijk F.

J Clin Invest. 2018 Oct 1;128(10):4669-4681. doi: 10.1172/JCI96107. Epub 2018 Aug 2.

7.

Update on research and clinical translation on specific clinical areas from biology to bedside: Unpacking the mysteries of juvenile idiopathic arthritis pathogenesis.

van Loosdregt J, van Wijk F, Prakken B, Vastert B.

Best Pract Res Clin Rheumatol. 2017 Aug;31(4):460-475. doi: 10.1016/j.berh.2018.02.003. Epub 2018 Apr 1. Review.

PMID:
29773267
8.

Monocyte gene expression in childhood obesity is associated with obesity and complexity of atherosclerosis in adults.

Keustermans GC, Kofink D, Eikendal A, de Jager W, Meerding J, Nuboer R, Waltenberger J, Kraaijeveld AO, Jukema JW, Sels JW, Garssen J, Prakken BJ, Asselbergs FW, Kalkhoven E, Hoefer IE, Pasterkamp G, Schipper HS.

Sci Rep. 2017 Dec 4;7(1):16826. doi: 10.1038/s41598-017-17195-3.

9.

Effect of anticoagulants on 162 circulating immune related proteins in healthy subjects.

Scholman RC, Giovannone B, Hiddingh S, Meerding JM, Malvar Fernandez B, van Dijk MEA, Tempelman MJ, Prakken BJ, de Jager W.

Cytokine. 2018 Jun;106:114-124. doi: 10.1016/j.cyto.2017.10.021. Epub 2017 Oct 28.

10.

Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children.

Keustermans G, van der Heijden LB, Boer B, Scholman R, Nuboer R, Pasterkamp G, Prakken B, de Jager W, Kalkhoven E, Janse AJ, Schipper HS.

PLoS One. 2017 Oct 26;12(10):e0187068. doi: 10.1371/journal.pone.0187068. eCollection 2017.

11.

Short term effectiveness and experiences of a peer guided web-based self-management intervention for young adults with juvenile idiopathic arthritis.

Ammerlaan J, van Os-Medendorp H, de Boer-Nijhof N, Scholtus L, Kruize AA, van Pelt P, Prakken B, Bijlsma H.

Pediatr Rheumatol Online J. 2017 Oct 13;15(1):75. doi: 10.1186/s12969-017-0201-1.

12.

Recommendations for collaborative paediatric research including biobanking in Europe: a Single Hub and Access point for paediatric Rheumatology in Europe (SHARE) initiative.

Kuemmerle-Deschner JB, Hansmann S, Wulffraat NM, Vastert SJ, Hens K, Anton J, Avcin T, Martini A, Koné-Paut I, Uziel Y, Ravelli A, Wouters C, Shaw D, Özen S, Eikelberg A, Prakken BJ, Ruperto N, Horneff G, Constantin T, Beresford MW, Sikken M, Foster HE, Haug I, Schuller S, Jägle C, Benseler SM.

Ann Rheum Dis. 2018 Mar;77(3):319-327. doi: 10.1136/annrheumdis-2017-211904. Epub 2017 Oct 11. Review.

PMID:
29021237
13.

The most important needs and preferences of patients for support from health care professionals: A reflective practice on (transitional) care for young adults with Juvenile Idiopathic Arthritis.

Ammerlaan JW, van Os-Medendorp H, de Boer-Nijhof NC, Prakken B, Bijlsma JWJ, Kruize AA.

Patient Educ Couns. 2017 Oct;100(10):1961-1964. doi: 10.1016/j.pec.2017.03.018. Epub 2017 Mar 12.

PMID:
28363359
14.

Embracing Complexity beyond Systems Medicine: A New Approach to Chronic Immune Disorders.

Te Velde AA, Bezema T, van Kampen AH, Kraneveld AD, 't Hart BA, van Middendorp H, Hack EC, van Montfrans JM, Belzer C, Jans-Beken L, Pieters RH, Knipping K, Huber M, Boots AM, Garssen J, Radstake TR, Evers AW, Prakken BJ, Joosten I.

Front Immunol. 2016 Dec 12;7:587. doi: 10.3389/fimmu.2016.00587. eCollection 2016.

15.

Developing translational medicine professionals: the Marie Skłodowska-Curie action model.

Petrelli A, Prakken BJ, Rosenblum ND; EUtrain fellows.

J Transl Med. 2016 Nov 29;14(1):329.

16.

Enhancing translational research in paediatric rheumatology through standardization.

Yeung RS, Albani S, Feldman BM, Mellins E, Prakken B, Wedderburn LR.

Nat Rev Rheumatol. 2016 Nov;12(11):684-690. doi: 10.1038/nrrheum.2016.156. Epub 2016 Sep 22. Review.

PMID:
27652504
17.

Lost in the citation valley.

Pasterkamp G, Hoefer I, Prakken B.

Nat Biotechnol. 2016 Oct 11;34(10):1016-1018. doi: 10.1038/nbt.3691. No abstract available.

PMID:
27727210
18.

Understanding inflammation in juvenile idiopathic arthritis: How immune biomarkers guide clinical strategies in the systemic onset subtype.

Swart JF, de Roock S, Prakken BJ.

Eur J Immunol. 2016 Sep;46(9):2068-77. doi: 10.1002/eji.201546092. Review.

19.

Autoimmune disease-associated gene expression is reduced by BET-inhibition.

Peeters JG, Vervoort SJ, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Mokry M, van Loosdregt J.

Genom Data. 2015 Nov 7;7:14-7. doi: 10.1016/j.gdata.2015.11.004. eCollection 2016 Mar.

20.

Neonatal thymectomy reveals differentiation and plasticity within human naive T cells.

van den Broek T, Delemarre EM, Janssen WJ, Nievelstein RA, Broen JC, Tesselaar K, Borghans JA, Nieuwenhuis EE, Prakken BJ, Mokry M, Jansen NJ, van Wijk F.

J Clin Invest. 2016 Mar 1;126(3):1126-36. doi: 10.1172/JCI84997. Epub 2016 Feb 22.

21.

Primary Hypertrophic Osteoarthropathy: An Update on Patient Features and Treatment.

Giancane G, Diggle CP, Legger EG, Tekstra J, Prakken B, Brenkman AB, Carr IM, Markham AF, Bonthron DT, Wulffraat N.

J Rheumatol. 2015 Nov;42(11):2211-4. doi: 10.3899/jrheum.150364. No abstract available.

22.

Autologous stem cell transplantation aids autoimmune patients by functional renewal and TCR diversification of regulatory T cells.

Delemarre EM, van den Broek T, Mijnheer G, Meerding J, Wehrens EJ, Olek S, Boes M, van Herwijnen MJ, Broere F, van Royen A, Wulffraat NM, Prakken BJ, Spierings E, van Wijk F.

Blood. 2016 Jan 7;127(1):91-101. doi: 10.1182/blood-2015-06-649145. Epub 2015 Oct 19.

PMID:
26480932
23.

Inhibition of Super-Enhancer Activity in Autoinflammatory Site-Derived T Cells Reduces Disease-Associated Gene Expression.

Peeters JG, Vervoort SJ, Tan SC, Mijnheer G, de Roock S, Vastert SJ, Nieuwenhuis EE, van Wijk F, Prakken BJ, Creyghton MP, Coffer PJ, Mokry M, van Loosdregt J.

Cell Rep. 2015 Sep 29;12(12):1986-96. doi: 10.1016/j.celrep.2015.08.046. Epub 2015 Sep 17.

24.

Self-Sustained Resistance to Suppression of CD8+ Teff Cells at the Site of Autoimmune Inflammation Can Be Reversed by Tumor Necrosis Factor and Interferon-γ Blockade.

Petrelli A, Wehrens EJ, Scholman RC, Prakken BJ, Vastert SJ, van Wijk F.

Arthritis Rheumatol. 2016 Jan;68(1):229-36. doi: 10.1002/art.39418.

25.

Feasibility of a Website and a Hospital-Based Online Portal for Young Adults With Juvenile Idiopathic Arthritis: Views and Experiences of Patients.

Ammerlaan JJ, Scholtus LW, Drossaert CH, van Os-Medendorp H, Prakken B, Kruize AA, Bijlsma JJ.

JMIR Res Protoc. 2015 Aug 14;4(3):e102. doi: 10.2196/resprot.3952.

26.

Methotrexate treatment affects effector but not regulatory T cells in juvenile idiopathic arthritis.

Bulatović Ćalasan M, Vastert SJ, Scholman RC, Verweij F, Klein M, Wulffraat NM, Prakken BJ, van Wijk F.

Rheumatology (Oxford). 2015 Sep;54(9):1724-34. doi: 10.1093/rheumatology/kev101. Epub 2015 Apr 14.

PMID:
25877908
27.

Paediatric rheumatology in 2014: Digging deeper for greater precision and more impact in JIA.

Prakken B, Martini A.

Nat Rev Rheumatol. 2015 Feb;11(2):70-2. doi: 10.1038/nrrheum.2014.224. Epub 2015 Jan 6.

PMID:
25561366
28.

Cytokine profiling at disease onset: support for classification of young antinuclear antibody-positive patients as a separate category of juvenile idiopathic arthritis.

van den Broek T, Hoppenreijs E, Meerding J, Scholman R, Otten HG, Swart JF, Martini A, Prakken B, de Jager W.

Ann Rheum Dis. 2015 Feb;74(2):470-2. doi: 10.1136/annrheumdis-2014-206424. Epub 2014 Nov 10. No abstract available.

PMID:
25384964
29.

Autologous stem cell transplantation leads to a change in proinflammatory plasma cytokine profile of patients with juvenile dermatomyositis correlating with disease activity.

Bellutti Enders F, Delemarre EM, Kuemmerle-Deschner J, van der Torre P, Wulffraat NM, Prakken BP, van Royen-Kerkhof A, van Wijk F.

Ann Rheum Dis. 2015 Jan;74(1):315-7. doi: 10.1136/annrheumdis-2014-206287. Epub 2014 Sep 30. No abstract available.

PMID:
25269830
30.

Paediatric rheumatic disease: Diagnosing macrophage activation syndrome in systemic JIA.

Vastert SJ, Prakken BJ.

Nat Rev Rheumatol. 2014 Nov;10(11):640-2. doi: 10.1038/nrrheum.2014.143. Epub 2014 Sep 9.

PMID:
25201384
31.

Redefining Strategies to Introduce Tolerance-Inducing Cellular Therapy in Human beings to Combat Autoimmunity and Transplantation Reactions.

Ten Brinke A, Joosten I, van Ham SM, van Kooten C, Prakken BJ.

Front Immunol. 2014 Aug 15;5:392. doi: 10.3389/fimmu.2014.00392. eCollection 2014. Review.

32.

Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood.

Vercoulen Y, Bellutti Enders F, Meerding J, Plantinga M, Elst EF, Varsani H, van Schieveen C, Bakker MH, Klein M, Scholman RC, Spliet W, Ricotti V, Koenen HJ, de Weger RA, Wedderburn LR, van Royen-Kerkhof A, Prakken BJ.

PLoS One. 2014 Aug 26;9(8):e105353. doi: 10.1371/journal.pone.0105353. eCollection 2014.

33.

A sensitive protocol for FOXP3 epigenetic analysis in scarce human samples.

Spreafico R, Rossetti M, van den Broek T, Jansen NJ, Zhang H, Moshref M, Prakken B, van Loosdregt J, van Wijk F, Albani S.

Eur J Immunol. 2014 Oct;44(10):3141-3. doi: 10.1002/eji.201444627. Epub 2014 Aug 25. No abstract available.

34.
35.

Effectiveness of first-line treatment with recombinant interleukin-1 receptor antagonist in steroid-naive patients with new-onset systemic juvenile idiopathic arthritis: results of a prospective cohort study.

Vastert SJ, de Jager W, Noordman BJ, Holzinger D, Kuis W, Prakken BJ, Wulffraat NM.

Arthritis Rheumatol. 2014 Apr;66(4):1034-43. doi: 10.1002/art.38296.

36.

Correlation of CXCL10, tumor necrosis factor receptor type II, and galectin 9 with disease activity in juvenile dermatomyositis.

Bellutti Enders F, van Wijk F, Scholman R, Hofer M, Prakken BJ, van Royen-Kerkhof A, de Jager W.

Arthritis Rheumatol. 2014 Aug;66(8):2281-9. doi: 10.1002/art.38676.

37.

Brief report: Autologous stem cell transplantation restores immune tolerance in experimental arthritis by renewal and modulation of the Teff cell compartment.

Delemarre EM, Roord ST, van den Broek T, Zonneveld-Huijssoon E, de Jager W, Rozemuller H, Martens AC, Broere F, Wulffraat NM, Glant TT, Prakken BJ, van Wijk F.

Arthritis Rheumatol. 2014 Feb;66(2):350-6. doi: 10.1002/art.38261.

38.

Allergen-specific Th2 responses in young children precede sensitization later in life.

Reubsaet LL, Meerding J, Scholman R, Arets B, Prakken BJ, van Wijk F, Knol EF.

Allergy. 2014 Mar;69(3):406-10. doi: 10.1111/all.12366. Epub 2014 Jan 28.

PMID:
24467266
39.

T cell recognition of naturally presented epitopes of self-heat shock protein 70.

de Jong H, Koffeman EC, Meerding JM, Scholman RC, Wieten L, de Jager W, Klein M, Otten H, van Wijk F, van der Zee R, Bijlsma JW, Broere F, van Eden W, Prakken BJ.

Cell Stress Chaperones. 2014 Jul;19(4):569-78. doi: 10.1007/s12192-013-0484-1. Epub 2014 Jan 15.

40.

Mesenchymal stem cell therapy in proteoglycan induced arthritis.

Swart JF, de Roock S, Hofhuis FM, Rozemuller H, van den Broek T, Moerer P, Broere F, van Wijk F, Kuis W, Prakken BJ, Martens AC, Wulffraat NM.

Ann Rheum Dis. 2015 Apr;74(4):769-77. doi: 10.1136/annrheumdis-2013-204147. Epub 2014 Jan 6.

PMID:
24395558
41.

Plasma IL-25 is elevated in a subgroup of patients with clinical reactivity to peanut.

Aalberse JA, van Thuijl AO, Meijer Y, de Jager W, van der Palen-Merkus T, Sprikkelman AB, Hoekstra MO, Prakken BJ, van Wijk F.

Clin Transl Allergy. 2013 Dec 2;3(1):40. doi: 10.1186/2045-7022-3-40.

42.

TH17 differentiation capacity develops within the first 3 months of life.

Dijkstra KK, Hoeks SB, Prakken BJ, de Roock S.

J Allergy Clin Immunol. 2014 Mar;133(3):891-4.e5. doi: 10.1016/j.jaci.2013.09.022. Epub 2013 Nov 1. No abstract available.

PMID:
24188977
43.

Differential homeostatic dynamics of human regulatory T-cell subsets following neonatal thymectomy.

Schadenberg AW, van den Broek T, Siemelink MA, Algra SO, de Jong PR, Jansen NJ, Prakken BJ, van Wijk F.

J Allergy Clin Immunol. 2014 Jan;133(1):277-80.e1-6. doi: 10.1016/j.jaci.2013.08.030. Epub 2013 Oct 18. No abstract available.

PMID:
24139831
44.

Plasma chemokines in early wheezers predict the development of allergic asthma.

Reubsaet LL, Meerding J, de Jager W, de Kleer IM, Hoekstra MO, Prakken BJ, van Wijk F, Arets HG.

Am J Respir Crit Care Med. 2013 Oct 15;188(8):1039-40. doi: 10.1164/rccm.201212-2330LE. No abstract available.

PMID:
24127809
45.

Anti-tumor necrosis factor α targets protein kinase B/c-Akt-induced resistance of effector cells to suppression in juvenile idiopathic arthritis.

Wehrens EJ, Vastert SJ, Mijnheer G, Meerding J, Klein M, Wulffraat NM, Prakken BJ, van Wijk F.

Arthritis Rheum. 2013 Dec;65(12):3279-84. doi: 10.1002/art.38132.

46.

Stabilization of the transcription factor Foxp3 by the deubiquitinase USP7 increases Treg-cell-suppressive capacity.

van Loosdregt J, Fleskens V, Fu J, Brenkman AB, Bekker CP, Pals CE, Meerding J, Berkers CR, Barbi J, Gröne A, Sijts AJ, Maurice MM, Kalkhoven E, Prakken BJ, Ovaa H, Pan F, Zaiss DM, Coffer PJ.

Immunity. 2013 Aug 22;39(2):259-71. doi: 10.1016/j.immuni.2013.05.018.

47.

Canonical Wnt signaling negatively modulates regulatory T cell function.

van Loosdregt J, Fleskens V, Tiemessen MM, Mokry M, van Boxtel R, Meerding J, Pals CE, Kurek D, Baert MR, Delemarre EM, Gröne A, Koerkamp MJ, Sijts AJ, Nieuwenhuis EE, Maurice MM, van Es JH, Ten Berge D, Holstege FC, Staal FJ, Zaiss DM, Prakken BJ, Coffer PJ.

Immunity. 2013 Aug 22;39(2):298-310. doi: 10.1016/j.immuni.2013.07.019. Epub 2013 Aug 15.

48.

Der p 1-induced CD4⁺FOXP3⁺GATA3⁺ T cells have suppressive properties and contribute to the polarization of the TH2-associated response.

Reubsaet L, Meerding J, Giezeman R, de Kleer I, Arets B, Prakken B, Beekman J, van Wijk F.

J Allergy Clin Immunol. 2013 Dec;132(6):1440-44. doi: 10.1016/j.jaci.2013.06.028. Epub 2013 Jul 27. No abstract available.

PMID:
23900057
49.

Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.

Reyman M, Verrijn Stuart AA, van Summeren M, Rakhshandehroo M, Nuboer R, de Boer FK, van den Ham HJ, Kalkhoven E, Prakken B, Schipper HS.

Int J Obes (Lond). 2014 Jan;38(1):46-52. doi: 10.1038/ijo.2013.75. Epub 2013 May 20.

PMID:
23736361
50.

Defective TH17 development in human neonatal T cells involves reduced RORC2 mRNA content.

de Roock S, Stoppelenburg AJ, Scholman R, Hoeks SBEA, Meerding J, Prakken BJ, Boes M.

J Allergy Clin Immunol. 2013 Sep;132(3):754-756.e3. doi: 10.1016/j.jaci.2013.04.014. Epub 2013 May 29. No abstract available.

PMID:
23726039

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