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Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η.

Rechkoblit O, Johnson RE, Buku A, Prakash L, Prakash S, Aggarwal AK.

Sci Rep. 2019 Nov 8;9(1):16400. doi: 10.1038/s41598-019-52703-7.


Translesion synthesis DNA polymerases η, ι, and ν promote mutagenic replication through the anticancer nucleoside cytarabine.

Yoon JH, Roy Choudhury J, Prakash L, Prakash S.

J Biol Chem. 2019 Nov 4. pii: jbc.RA119.011381. doi: 10.1074/jbc.RA119.011381. [Epub ahead of print]


Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme.

Jain R, Rice WJ, Malik R, Johnson RE, Prakash L, Prakash S, Ubarretxena-Belandia I, Aggarwal AK.

Nat Struct Mol Biol. 2019 Oct;26(10):955-962. doi: 10.1038/s41594-019-0305-z. Epub 2019 Oct 3.


Pancreatic neuroendocrine tumors.

Perri G, Prakash LR, Katz MHG.

Curr Opin Gastroenterol. 2019 Sep;35(5):468-477. doi: 10.1097/MOG.0000000000000571.


Radiographic and Serologic Predictors of Pathologic Major Response to Preoperative Therapy for Pancreatic Cancer.

Perri G, Prakash L, Wang H, Bhosale P, Varadhachary GR, Wolff R, Fogelman D, Overman M, Pant S, Javle M, Koay E, Herman J, Kim M, Ikoma N, Tzeng CW, Lee JE, Katz MHG.

Ann Surg. 2019 Jul 3. doi: 10.1097/SLA.0000000000003442. [Epub ahead of print]


Benefit of Gemcitabine/Nab-Paclitaxel Rescue of Patients With Borderline Resectable or Locally Advanced Pancreatic Adenocarcinoma After Early Failure of FOLFIRINOX.

Vreeland TJ, McAllister F, Javadi S, Prakash LR, Fogelman DR, Ho L, Varadhachary G, Aloia TA, Vauthey JN, Lee JE, Kim MP, Katz MHG, Tzeng CD.

Pancreas. 2019 Jul;48(6):837-843. doi: 10.1097/MPA.0000000000001345.


Significance of Cancer Cells at the Vein Edge in Patients with Pancreatic Adenocarcinoma Following Pancreatectomy with Vein Resection.

Prakash LR, Wang H, Zhao J, Nogueras-Gonzalez GM, Cloyd JM, Tzeng CD, Kim MP, Lee JE, Katz MHG.

J Gastrointest Surg. 2019 Feb 28. doi: 10.1007/s11605-019-04126-y. [Epub ahead of print]


DNA polymerase θ accomplishes translesion synthesis opposite 1,N6-ethenodeoxyadenosine with a remarkably high fidelity in human cells.

Yoon JH, Johnson RE, Prakash L, Prakash S.

Genes Dev. 2019 Mar 1;33(5-6):282-287. doi: 10.1101/gad.320531.118. Epub 2019 Feb 26.


Error-Prone Replication through UV Lesions by DNA Polymerase θ Protects against Skin Cancers.

Yoon JH, McArthur MJ, Park J, Basu D, Wakamiya M, Prakash L, Prakash S.

Cell. 2019 Mar 7;176(6):1295-1309.e15. doi: 10.1016/j.cell.2019.01.023. Epub 2019 Feb 14.


Contemporary analysis of complications associated with biliary stents during neoadjuvant therapy for pancreatic adenocarcinoma.

Kim BJ, Prakash L, Narula N, Davis CH, Kim MP, Aloia TA, Vauthey JN, Lee JE, Katz MH, Tzeng CD.

HPB (Oxford). 2019 Jun;21(6):662-668. doi: 10.1016/j.hpb.2018.10.009. Epub 2018 Dec 3.


Perioperative blood transfusions for vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Identification of clinical targets for optimization.

Snyder RA, Prakash LR, Nogueras-Gonzalez GM, Kim MP, Aloia TA, Vauthey JN, Lee JE, Fleming JB, Katz MHG, Tzeng CD.

HPB (Oxford). 2019 Jul;21(7):841-848. doi: 10.1016/j.hpb.2018.10.018. Epub 2018 Nov 28.


Clinical Factors Associated With Practice Variation in Discharge Opioid Prescriptions After Pancreatectomy.

Newhook TE, Vreeland TJ, Dewhurst WL, Wang X, Prakash L, Feng C, Bruno ML, Kim MP, Aloia TA, Vauthey JN, Lee JE, Katz MHG, Tzeng CD.

Ann Surg. 2018 Nov 29. doi: 10.1097/SLA.0000000000003112. [Epub ahead of print]


First-Line Gemcitabine and Nab-Paclitaxel Chemotherapy for Localized Pancreatic Ductal Adenocarcinoma.

Gulhati P, Prakash L, Katz MHG, Wang X, Javle M, Shroff R, Fogelman D, Lee JE, Tzeng CD, Lee JH, Weston B, Tamm E, Bhosale P, Koay EJ, Maitra A, Wang H, Wolff RA, Varadhachary GR.

Ann Surg Oncol. 2019 Feb;26(2):619-627. doi: 10.1245/s10434-018-6807-9. Epub 2018 Oct 15.


The role of preoperative therapy prior to pancreatoduodenectomy for distal cholangiocarcinoma.

Cloyd JM, Prakash L, Vauthey JN, Aloia TA, Chun YS, Tzeng CW, Kim MP, Lee JE, Katz MHG.

Am J Surg. 2019 Jul;218(1):145-150. doi: 10.1016/j.amjsurg.2018.08.024. Epub 2018 Sep 6.


Structural basis for polymerase η-promoted resistance to the anticancer nucleoside analog cytarabine.

Rechkoblit O, Choudhury JR, Buku A, Prakash L, Prakash S, Aggarwal AK.

Sci Rep. 2018 Aug 23;8(1):12702. doi: 10.1038/s41598-018-30796-w.


Vein resection during pancreaticoduodenectomy for pancreatic adenocarcinoma: Patency rates and outcomes associated with thrombosis.

Snyder RA, Prakash LR, Nogueras-Gonzalez GM, Kim MP, Aloia TA, Vauthey JN, Lee JE, Fleming JB, Katz MHG, Tzeng CD.

J Surg Oncol. 2018 Jun;117(8):1648-1654. doi: 10.1002/jso.25067. Epub 2018 May 3.


Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer.

Wang YN, Lee HH, Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Zhu C, Ying H, Ye Y, Wang WJ, Lim SO, Xia W, Ko HW, Liu X, Liu CG, Wu X, Wang H, Li D, Prakash LR, Katz MH, Kang Y, Kim M, Fleming JB, Fogelman D, Javle M, Maitra A, Hung MC.

Cancer Cell. 2018 Apr 9;33(4):752-769.e8. doi: 10.1016/j.ccell.2018.02.012. Epub 2018 Mar 29.


Genetic control of predominantly error-free replication through an acrolein-derived minor-groove DNA adduct.

Yoon JH, Hodge RP, Hackfeld LC, Park J, Roy Choudhury J, Prakash S, Prakash L.

J Biol Chem. 2018 Feb 23;293(8):2949-2958. doi: 10.1074/jbc.RA117.000962. Epub 2018 Jan 12.


Anthropometric Changes in Patients with Pancreatic Cancer Undergoing Preoperative Therapy and Pancreatoduodenectomy.

Cloyd JM, Nogueras-González GM, Prakash LR, Petzel MQB, Parker NH, Ngo-Huang AT, Fogelman D, Denbo JW, Garg N, Kim MP, Lee JE, Tzeng CD, Fleming JB, Katz MHG.

J Gastrointest Surg. 2018 Apr;22(4):703-712. doi: 10.1007/s11605-017-3618-4. Epub 2017 Dec 11.


Translesion synthesis DNA polymerases promote error-free replication through the minor-groove DNA adduct 3-deaza-3-methyladenine.

Yoon JH, Roy Choudhury J, Park J, Prakash S, Prakash L.

J Biol Chem. 2017 Nov 10;292(45):18682-18688. doi: 10.1074/jbc.M117.808659. Epub 2017 Sep 22.


Identification of bioactive glucose-lowering compounds of methanolic extract of Hodgsonia heteroclita fruit pulp.

Usha T, Goyal AK, Narzary D, Prakash L, Wadhwa G, Babu D, Shanmugarajan D, Middha SK.

Front Biosci (Landmark Ed). 2018 Jan 1;23:875-888.


"Targeted" prophylaxis: Impact of rectal swab culture-directed prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy.

Singh P, Kumar A, Yadav S, Prakash L, Nayak B, Kumar R, Kapil A, Dogra PN.

Investig Clin Urol. 2017 Sep;58(5):365-370. doi: 10.4111/icu.2017.58.5.365. Epub 2017 Aug 8.


Multimodality management of borderline resectable pancreatic adenocarcinoma.

Prakash LR, Katz MHG.

Chin Clin Oncol. 2017 Jun;6(3):27. doi: 10.21037/cco.2017.06.17. Review.


Association of Clinical Factors With a Major Pathologic Response Following Preoperative Therapy for Pancreatic Ductal Adenocarcinoma.

Cloyd JM, Wang H, Egger ME, Tzeng CD, Prakash LR, Maitra A, Varadhachary GR, Shroff R, Javle M, Fogelman D, Wolff RA, Overman MJ, Koay EJ, Das P, Herman JM, Kim MP, Vauthey JN, Aloia TA, Fleming JB, Lee JE, Katz MHG.

JAMA Surg. 2017 Nov 1;152(11):1048-1056. doi: 10.1001/jamasurg.2017.2227.


Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-ι.

Jain R, Choudhury JR, Buku A, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Sci Rep. 2017 Mar 8;7:43904. doi: 10.1038/srep43904.


Influence of Preoperative Therapy on Short- and Long-Term Outcomes of Patients with Adenocarcinoma of the Ampulla of Vater.

Cloyd JM, Wang H, Overman M, Zhao J, Denbo J, Prakash L, Kim MP, Shroff R, Javle M, Varadhachary GR, Fogelman D, Wolff RA, Koay EJ, Das P, Maitra A, Aloia TA, Vauthey JN, Fleming JB, Lee JE, Katz MHG.

Ann Surg Oncol. 2017 Jul;24(7):2031-2039. doi: 10.1245/s10434-017-5777-7. Epub 2017 Jan 25.


Selective Perioperative Administration of Pasireotide is More Cost-Effective Than Routine Administration for Pancreatic Fistula Prophylaxis.

Denbo JW, Slack RS, Bruno M, Cloyd JM, Prakash L, Fleming JB, Kim MP, Aloia TA, Vauthey JN, Lee JE, Katz MH.

J Gastrointest Surg. 2017 Apr;21(4):636-646. doi: 10.1007/s11605-016-3340-7. Epub 2017 Jan 3.


Structure and mechanism of human PrimPol, a DNA polymerase with primase activity.

Rechkoblit O, Gupta YK, Malik R, Rajashankar KR, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Sci Adv. 2016 Oct 21;2(10):e1601317. eCollection 2016 Oct.


Preoperative Therapy and Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma: a 25-Year Single-Institution Experience.

Cloyd JM, Katz MH, Prakash L, Varadhachary GR, Wolff RA, Shroff RT, Javle M, Fogelman D, Overman M, Crane CH, Koay EJ, Das P, Krishnan S, Minsky BD, Lee JH, Bhutani MS, Weston B, Ross W, Bhosale P, Tamm EP, Wang H, Maitra A, Kim MP, Aloia TA, Vauthey JN, Fleming JB, Abbruzzese JL, Pisters PW, Evans DB, Lee JE.

J Gastrointest Surg. 2017 Jan;21(1):164-174. doi: 10.1007/s11605-016-3265-1. Epub 2016 Oct 24.


Preoperative Chemoradiation for Pancreatic Adenocarcinoma Does Not Increase 90-Day Postoperative Morbidity or Mortality.

Denbo JW, Bruno ML, Cloyd JM, Prakash L, Lee JE, Kim M, Crane CH, Koay EJ, Krishnan S, Das P, Minsky BD, Varadhachary G, Shroff R, Wolff R, Javle M, Overman MJ, Fogelman D, Aloia TA, Vauthey JN, Fleming JB, Katz MH.

J Gastrointest Surg. 2016 Dec;20(12):1975-1985. Epub 2016 Oct 11.


Role of Fluorouracil, Doxorubicin, and Streptozocin Therapy in the Preoperative Treatment of Localized Pancreatic Neuroendocrine Tumors.

Prakash L, Bhosale P, Cloyd J, Kim M, Parker N, Yao J, Dasari A, Halperin D, Aloia T, Lee JE, Vauthey JN, Fleming JB, Katz MH.

J Gastrointest Surg. 2017 Jan;21(1):155-163. doi: 10.1007/s11605-016-3270-4. Epub 2016 Sep 15.


Impact of hypofractionated and standard fractionated chemoradiation before pancreatoduodenectomy for pancreatic ductal adenocarcinoma.

Cloyd JM, Crane CH, Koay EJ, Das P, Krishnan S, Prakash L, Snyder RA, Varadhachary GR, Wolff RA, Javle M, Shroff RT, Fogelman D, Overman M, Wang H, Maitra A, Lee JE, Fleming JB, Katz MH.

Cancer. 2016 Sep 1;122(17):2671-9. doi: 10.1002/cncr.30117. Epub 2016 May 31.


Human DNA polymerase α in binary complex with a DNA:DNA template-primer.

Coloma J, Johnson RE, Prakash L, Prakash S, Aggarwal AK.

Sci Rep. 2016 Apr 1;6:23784. doi: 10.1038/srep23784.


Response to Burgers et al.

Johnson RE, Klassen R, Prakash L, Prakash S.

Mol Cell. 2016 Feb 18;61(4):494-495. doi: 10.1016/j.molcel.2016.01.018. No abstract available.


Cost-Effective Isolation of a Process Impurity of Pregabalin.

Prakash L, Himaja M, Ramakrishna Yadav B, Maheshwara Reddy A.

Sci Pharm. 2015 Mar 25;83(3):453-63. doi: 10.3797/scipharm.1501-16. Print 2015 Jul-Sep.


Micropropagation and validation of genetic and biochemical fidelity among regenerants of Nothapodytes nimmoniana (Graham) Mabb. employing ISSR markers and HPLC.

Prakash L, Middha SK, Mohanty SK, Swamy MK.

3 Biotech. 2016 Dec;6(2):171. doi: 10.1007/s13205-016-0490-y. Epub 2016 Aug 16.


Rev1 promotes replication through UV lesions in conjunction with DNA polymerases η, ι, and κ but not DNA polymerase ζ.

Yoon JH, Park J, Conde J, Wakamiya M, Prakash L, Prakash S.

Genes Dev. 2015 Dec 15;29(24):2588-602. doi: 10.1101/gad.272229.115.


After Pancreatectomy, the “90 Days from Surgery” Definition Is Superior to the “30 Days from Discharge” Definition for Capture of Clinically Relevant Readmissions.

Mise Y, Day RW, Vauthey JN, Brudvik KW, Schwarz L, Prakash L, Parker NH, Katz MH, Conrad C, Lee JE, Fleming JB, Aloia TA.

J Gastrointest Surg. 2016 Jan;20(1):77-84; discussion 84.


Genetic Control of Replication through N1-methyladenine in Human Cells.

Conde J, Yoon JH, Roy Choudhury J, Prakash L, Prakash S.

J Biol Chem. 2015 Dec 11;290(50):29794-800. doi: 10.1074/jbc.M115.693010. Epub 2015 Oct 21.


Role and Operative Technique of Portal Venous Tumor Thrombectomy in Patients with Pancreatic Neuroendocrine Tumors.

Prakash L, Lee JE, Yao J, Bhosale P, Balachandran A, Wang H, Fleming JB, Katz MH.

J Gastrointest Surg. 2015 Nov;19(11):2011-8. doi: 10.1007/s11605-015-2914-0. Epub 2015 Aug 18.


Superior Mesenteric Artery Margin of Posttherapy Pancreaticoduodenectomy and Prognosis in Patients With Pancreatic Ductal Adenocarcinoma.

Liu L, Katz MH, Lee SM, Fischer LK, Prakash L, Parker N, Wang H, Varadhachary GR, Wolff RA, Lee JE, Pisters PW, Maitra A, Fleming JB, Estrella J, Rashid A, Wang H.

Am J Surg Pathol. 2015 Oct;39(10):1395-403. doi: 10.1097/PAS.0000000000000491.


A Major Role of DNA Polymerase δ in Replication of Both the Leading and Lagging DNA Strands.

Johnson RE, Klassen R, Prakash L, Prakash S.

Mol Cell. 2015 Jul 16;59(2):163-175. doi: 10.1016/j.molcel.2015.05.038. Epub 2015 Jul 2.


Comparison of electrocautery incision with scalpel incision in midline abdominal surgery - A double blind randomized controlled trial.

Prakash LD, Balaji N, Kumar SS, Kate V.

Int J Surg. 2015 Jul;19:78-82. doi: 10.1016/j.ijsu.2015.04.085. Epub 2015 May 26.


Targeted next generation sequencing of RB1 gene for the molecular diagnosis of Retinoblastoma.

Devarajan B, Prakash L, Kannan TR, Abraham AA, Kim U, Muthukkaruppan V, Vanniarajan A.

BMC Cancer. 2015 Apr 28;15:320. doi: 10.1186/s12885-015-1340-8.


Active Surveillance for Adverse Events Within 90 Days: The Standard for Reporting Surgical Outcomes After Pancreatectomy.

Schwarz L, Bruno M, Parker NH, Prakash L, Mise Y, Lee JE, Vauthey JN, Aloia TA, Conrad C, Fleming JB, Katz MH.

Ann Surg Oncol. 2015 Oct;22(11):3522-9. doi: 10.1245/s10434-015-4437-z. Epub 2015 Feb 19.


Identification of two functional PCNA-binding domains in human DNA polymerase κ.

Yoon JH, Acharya N, Park J, Basu D, Prakash S, Prakash L.

Genes Cells. 2014 Jul;19(7):594-601. doi: 10.1111/gtc.12156. Epub 2014 May 22.


Preparative isolation and high-resolution mass identification of 10 stressed study degradants of nicorandil tablets.

Prakash L, Malipeddi H, Subbaiah BV.

J Chromatogr Sci. 2015 Jan;53(1):122-6. doi: 10.1093/chromsci/bmu028. Epub 2014 May 15.


Impurity profiling and a stability-indicating UPLC method development and validation for the estimation of related impurities of halobetasol propionate in halobetasol propionate 0.05% (w/w) cream.

Prakash L, Malipeddi H, Subbaiah BV, Lakka NS.

J Chromatogr Sci. 2015 Jan;53(1):112-21. doi: 10.1093/chromsci/bmu027. Epub 2014 May 2.


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