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Items: 1 to 50 of 69

1.

In vivo expansion of the endogenous B-cell compartment stimulated by radiation and serial bone marrow transplantation induces B-cell leukaemia in mice.

Holyoake TL, Freshney MG, Samuel K, Ansell J, Watson GE, Wright EG, Graham GJ, Pragnell IB.

Br J Haematol. 2001 Jul;114(1):49-56.

PMID:
11472344
2.

Preserved long-term repopulation and differentiation properties of hematopoietic grafts subjected to ex vivo expansion with stem cell factor and interleukin 11.

Albella B, Segovia JC, Guenechea G, Pragnell IB, Bueren JA.

Transplantation. 1999 May 27;67(10):1348-57.

PMID:
10360589
3.

CD34 positive PBPC expanded ex vivo may not provide durable engraftment following myeloablative chemoradiotherapy regimens.

Holyoake TL, Alcorn MJ, Richmond L, Farrell E, Pearson C, Green R, Dunlop DJ, Fitzsimons E, Pragnell IB, Franklin IM.

Bone Marrow Transplant. 1997 Jun;19(11):1095-101.

5.

Macrophage Inflammatory Protein-1 Alpha: A Paradox?

Parker AN, Pragnell IB.

Hematology. 1997;2(4):323-8. doi: 10.1080/10245332.1997.11746352.

PMID:
27405236
6.

Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP-1alpha by mutagenesis of the proteoglycan binding site.

Graham GJ, Wilkinson PC, Nibbs RJ, Lowe S, Kolset SO, Parker A, Freshney MG, Tsang ML, Pragnell IB.

EMBO J. 1996 Dec 2;15(23):6506-15.

7.

CD34-positive cells isolated from cryopreserved peripheral-blood progenitor cells can be expanded ex vivo and used for transplantation with little or no toxicity.

Alcorn MJ, Holyoake TL, Richmond L, Pearson C, Farrell E, Kyle B, Dunlop DJ, Fitzsimons E, Steward WP, Pragnell IB, Franklin IM.

J Clin Oncol. 1996 Jun;14(6):1839-47.

PMID:
8656252
8.

Ex vivo expansion with stem cell factor and interleukin-11 augments both short-term recovery posttransplant and the ability to serially transplant marrow.

Holyoake TL, Freshney MG, McNair L, Parker AN, McKay PJ, Steward WP, Fitzsimons E, Graham GJ, Pragnell IB.

Blood. 1996 Jun 1;87(11):4589-95.

PMID:
8639827
9.

Specificity and reciprocity in the interactions between TGF-beta and macrophage inflammatory protein-1 alpha.

Maltman J, Pragnell IB, Graham GJ.

J Immunol. 1996 Feb 15;156(4):1566-71.

PMID:
8568261
10.

Inhibitors of haemopoiesis and their potential clinical relevance.

Parker AN, Pragnell IB.

Blood Rev. 1995 Dec;9(4):226-33. Review.

PMID:
8839398
11.

Requirement of MIP-1 alpha for an inflammatory response to viral infection.

Cook DN, Beck MA, Coffman TM, Kirby SL, Sheridan JF, Pragnell IB, Smithies O.

Science. 1995 Sep 15;269(5230):1583-5.

PMID:
7667639
12.

Perturbations of multiple hemopoietic lineages in retrovirus-induced murine malignant histiocytosis.

Eckmann L, Pragnell IB, Löhler J.

Leukemia. 1995 Apr;9(4):700-10.

PMID:
7723406
13.

Aggregation of the chemokine MIP-1 alpha is a dynamic and reversible phenomenon. Biochemical and biological analyses.

Graham GJ, MacKenzie J, Lowe S, Tsang ML, Weatherbee JA, Issacson A, Medicherla J, Fang F, Wilkinson PC, Pragnell IB.

J Biol Chem. 1994 Feb 18;269(7):4974-8.

14.

Efficient isolation of human CD34 positive hemopoietic progenitor cells by immune panninga.

Holyoake TL, Alcorn MJ, Richmond LJ, Freshney MG, Pearson C, Fitzsimons E, Steward WP, Dunlop DJ, Pragnell IB.

Stem Cells. 1994 Jan;12(1):114-24. Erratum in: Stem Cells (Dayt) 1994 Mar;12(2):233.

PMID:
7511456
15.

Contrasting effects of rh-MIP-1 alpha and TGF-beta 1 on chronic myeloid leukemia progenitors in vitro.

Holyoake TL, Freshney MG, Sproul AM, Richmond LJ, Alcorn MJ, Steward WP, Fitzsimons E, Dunlop DJ, Franklin IM, Pragnell IB.

Stem Cells. 1993 Oct;11 Suppl 3:122-8.

PMID:
8298472
16.
17.

Hemopoietic stem cell inhibitor (SCI/MIP-1 alpha) also inhibits clonogenic epidermal keratinocyte proliferation.

Parkinson EK, Graham GJ, Daubersies P, Burns JE, Heufler C, Plumb M, Schuler G, Pragnell IB.

J Invest Dermatol. 1993 Aug;101(2):113-7.

18.

Use of 5-fluorouracil to analyze the effect of macrophage inflammatory protein-1 alpha on long-term reconstituting stem cells in vivo.

Quesniaux VF, Graham GJ, Pragnell I, Donaldson D, Wolpe SD, Iscove NN, Fagg B.

Blood. 1993 Mar 15;81(6):1497-504.

PMID:
8453096
19.

Characterization of a receptor for macrophage inflammatory protein 1 alpha and related proteins on human and murine cells.

Graham GJ, Zhou L, Weatherbee JA, Tsang ML, Napolitano M, Leonard WJ, Pragnell IB.

Cell Growth Differ. 1993 Mar;4(3):137-46.

20.

Mixed colony formation in vitro by the heterogeneous compartment of multipotential progenitors in human bone marrow.

Holyoake TL, Freshney MG, Konwalinka G, Haun M, Petzer A, Fitzsimons E, Lucie NP, Wright EG, Pragnell IB.

Leukemia. 1993 Feb;7(2):207-13.

PMID:
7678879
21.

The haemopoietic stem cell: properties and control mechanisms.

Graham GJ, Pragnell IB.

Semin Cell Biol. 1992 Dec;3(6):423-34. Review.

PMID:
1489974
22.

Expression of stem cell inhibitor (SCI) gene in patients with bone marrow failure.

Maciejewski JP, Liu JM, Green SW, Walsh CE, Plumb M, Pragnell IB, Young NS.

Exp Hematol. 1992 Oct;20(9):1112-7.

PMID:
1468544
23.

Stem cell proliferation inhibitors.

Wright EG, Pragnell IB.

Baillieres Clin Haematol. 1992 Jul;5(3):723-39. Review. No abstract available.

PMID:
1457966
24.

SCI/MIP-1 alpha: a potent stem cell inhibitor with potential roles in development.

Graham GJ, Pragnell IB.

Dev Biol. 1992 Jun;151(2):377-81. Review.

PMID:
1601173
25.

Demonstration of stem cell inhibition and myeloprotective effects of SCI/rhMIP1 alpha in vivo.

Dunlop DJ, Wright EG, Lorimore S, Graham GJ, Holyoake T, Kerr DJ, Wolpe SD, Pragnell IB.

Blood. 1992 May 1;79(9):2221-5.

PMID:
1571537
26.

Mutational activation of the N-ras oncogene assessed in primary clonogenic culture of acute myeloid leukemia (AML): implications for the role of N-ras mutation in AML pathogenesis.

Bashey A, Gill R, Levi S, Farr CJ, Clutterbuck R, Millar JL, Pragnell IB, Marshall CJ.

Blood. 1992 Feb 15;79(4):981-9.

PMID:
1737106
27.

The stem cell compartment: assays and negative regulators.

Wright EG, Pragnell IB.

Curr Top Microbiol Immunol. 1992;177:137-49. Review. No abstract available.

PMID:
1638868
28.

Purification and biochemical characterisation of human and murine stem cell inhibitors (SCI).

Graham GJ, Freshney MG, Donaldson D, Pragnell IB.

Growth Factors. 1992;7(2):151-60.

PMID:
1419072
29.

Molecular aspects of a negative regulator of haemopoiesis.

Plumb M, Graham GJ, Grove M, Reid A, Pragnell IB.

Br J Cancer. 1991 Dec;64(6):990-2. Review. No abstract available.

30.

Inhibitory effect of 2-chlorodeoxyadenosine on granulocytic, erythroid, and T-lymphocytic colony growth.

Petzer AL, Bilgeri R, Zilian U, Haun M, Geisen FH, Pragnell I, Braunsteiner H, Konwalinka G.

Blood. 1991 Nov 15;78(10):2583-7.

PMID:
1688098
31.

Treating cancer: the potential role of stem cell inhibitors.

Graham GJ, Pragnell IB.

Eur J Cancer. 1991;27(8):952-3. No abstract available.

PMID:
1832902
32.

Sequence of the murine haemopoietic stem cell inhibitor/macrophage inflammatory protein 1 alpha gene.

Grove M, Lowe S, Graham G, Pragnell I, Plumb M.

Nucleic Acids Res. 1990 Sep 25;18(18):5561. No abstract available.

33.

Retrovirus mediated transfer and expression of GM-CSF in haematopoietic cells.

Keith WN, Brown R, Pragnell IB.

Br J Cancer. 1990 Sep;62(3):388-94.

34.

Identification and characterization of an inhibitor of haemopoietic stem cell proliferation.

Graham GJ, Wright EG, Hewick R, Wolpe SD, Wilkie NM, Donaldson D, Lorimore S, Pragnell IB.

Nature. 1990 Mar 29;344(6265):442-4.

PMID:
2320111
35.

Synergistic interactions allow colony formation in vitro by murine haemopoietic stem cells.

Lorimore SA, Pragnell IB, Eckmann L, Wright EG.

Leuk Res. 1990;14(5):481-9.

PMID:
2189047
37.

Negative regulators of haemopoiesis--current advances.

Graham GJ, Pragnell IB.

Prog Growth Factor Res. 1990;2(3):181-92. Review.

PMID:
2132955
38.

The cytostatic effects of alpha-interferon may be mediated by transforming growth factor-beta.

Kerr DJ, Pragnell IB, Sproul A, Cowan S, Murray T, George D, Leake R.

J Mol Endocrinol. 1989 Mar;2(2):131-6.

PMID:
2505792
39.

A novel in vitro assay for murine haematopoietic stem cells.

Eckmann L, Freshney M, Wright EG, Sproul A, Wilkie N, Pragnell IB.

Br J Cancer Suppl. 1988 Dec;9:36-40.

40.

The effect of stem cell proliferation regulators demonstrated with an in vitro assay.

Pragnell IB, Wright EG, Lorimore SA, Adam J, Rosendaal M, DeLamarter JF, Freshney M, Eckmann L, Sproul A, Wilkie N.

Blood. 1988 Jul;72(1):196-201.

PMID:
3291981
41.

Murine retrovirus-induced malignant histiocytosis, an experimental model for the disease in humans.

Löhler J, Franz T, Fusco A, Pragnell I, Ostertag W.

Leukemia. 1987 Jan;1(1):58-68.

PMID:
2823012
42.

Consequences of altered oncogene expression in rodent cells.

Pragnell IB, Spandidos DA, Wilkie NM.

Proc R Soc Lond B Biol Sci. 1985 Oct 22;226(1242):107-19.

PMID:
2866518
43.

Transformation of mononuclear phagocytes in vivo and malignant histiocytosis caused by a novel murine spleen focus-forming virus.

Franz T, Löhler J, Fusco A, Pragnell I, Nobis P, Padua R, Ostertag W.

Nature. 1985 May 9-15;315(6015):149-51.

PMID:
3873013
44.
46.

Retroviruses induce granulocyte-macrophage colony stimulating activity in fibroblasts.

Koury MJ, Pragnell IB.

Nature. 1982 Oct 14;299(5884):638-40. No abstract available.

PMID:
6289128
47.

A study of added GM-CSF independent granulocyte and macrophage precursors in mouse spleen infected with myeloproliferative sarcoma virus (MPSV).

Klein B, Le Bousse-Kerdiles C, Smadja-Joffe F, Pragnell I, Ostertag W, Jasmin C.

Exp Hematol. 1982 Apr;10(4):373-82.

PMID:
6284533
48.
49.

The relationship between genomic RNAs of polycythaemic forms of spleen focus-forming Friend virus and its helper virus.

Mol JN, Vonk WP, Pragnell IB, Stoof TJ.

J Gen Virol. 1981 Jun;54(Pt 2):367-77.

PMID:
6270255
50.

Analysis of the myeloproliferative sarcoma virus genome: limited changes in the prototype lead to altered target cell specificity.

Pragnell IB, Fusco A, Arbuthnott C, Smadja-Joffe F, Klein B, Jasmin C, Ostertag W.

J Virol. 1981 Jun;38(3):952-7.

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