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Items: 1 to 50 of 75

1.

Effects of Stathmin 1 Gene Knockout on Behaviors and Dopaminergic Markers in Mice Exposed to Social Defeat Stress.

Nguyen TB, Prabhu VV, Piao YH, Oh YE, Zahra RF, Chung YC.

Brain Sci. 2019 Aug 26;9(9). pii: E215. doi: 10.3390/brainsci9090215.

2.

Imipridone ONC212 activates orphan G protein-coupled receptor GPR132 and integrated stress response in acute myeloid leukemia.

Nii T, Prabhu VV, Ruvolo V, Madhukar N, Zhao R, Mu H, Heese L, Nishida Y, Kojima K, Garnett MJ, McDermott U, Benes CH, Charter N, Deacon S, Elemento O, Allen JE, Oster W, Stogniew M, Ishizawa J, Andreeff M.

Leukemia. 2019 May 24. doi: 10.1038/s41375-019-0491-z. [Epub ahead of print]

PMID:
31127149
3.

Safety and enhanced immunostimulatory activity of the DRD2 antagonist ONC201 in advanced solid tumor patients with weekly oral administration.

Stein MN, Malhotra J, Tarapore RS, Malhotra U, Silk AW, Chan N, Rodriguez L, Aisner J, Aiken RD, Mayer T, Haffty BG, Newman JH, Aspromonte SM, Bommareddy PK, Estupinian R, Chesson CB, Sadimin ET, Li S, Medina DJ, Saunders T, Frankel M, Kareddula A, Damare S, Wesolowsky E, Gabel C, El-Deiry WS, Prabhu VV, Allen JE, Stogniew M, Oster W, Bertino JR, Libutti SK, Mehnert JM, Zloza A.

J Immunother Cancer. 2019 May 22;7(1):136. doi: 10.1186/s40425-019-0599-8.

4.

Metabolite signature associated with stress susceptibility in socially defeated mice.

Prabhu VV, Nguyen TB, Cui Y, Oh YE, Piao YH, Baek HM, Kim JY, Shin KH, Kim JH, Lee KH, Chung YC.

Brain Res. 2019 Apr 1;1708:171-180. doi: 10.1016/j.brainres.2018.12.020. Epub 2018 Dec 17.

PMID:
30571984
5.

Dopamine Receptor D5 is a Modulator of Tumor Response to Dopamine Receptor D2 Antagonism.

Prabhu VV, Madhukar NS, Gilvary C, Kline CLB, Oster S, El-Deiry WS, Elemento O, Doherty F, VanEngelenburg A, Durrant J, Tarapore RS, Deacon S, Charter N, Jung J, Park DM, Gilbert MR, Rusert J, Wechsler-Reya R, Arrillaga-Romany I, Batchelor TT, Wen PY, Oster W, Allen JE.

Clin Cancer Res. 2019 Apr 1;25(7):2305-2313. doi: 10.1158/1078-0432.CCR-18-2572. Epub 2018 Dec 17.

PMID:
30559168
6.

Effects of social defeat stress on dopamine D2 receptor isoforms and proteins involved in intracellular trafficking.

Prabhu VV, Nguyen TB, Cui Y, Oh YE, Lee KH, Bagalkot TR, Chung YC.

Behav Brain Funct. 2018 Oct 8;14(1):16. doi: 10.1186/s12993-018-0148-5.

7.

ONC201 demonstrates anti-tumorigenic and anti-metastatic activity in uterine serous carcinoma in vitro.

Fang Z, Wang J, Clark LH, Sun W, Yin Y, Kong W, Pierce SR, West L, Sullivan SA, Tran AQ, Prabhu VV, Zhou C, Bae-Jump V.

Am J Cancer Res. 2018 Aug 1;8(8):1551-1563. eCollection 2018.

8.

Metabolic Reprogramming by Dual AKT/ERK Inhibition through Imipridones Elicits Unique Vulnerabilities in Glioblastoma.

Ishida CT, Zhang Y, Bianchetti E, Shu C, Nguyen TTT, Kleiner G, Sanchez-Quintero MJ, Quinzii CM, Westhoff MA, Karpel-Massler G, Prabhu VV, Allen JE, Siegelin MD.

Clin Cancer Res. 2018 Nov 1;24(21):5392-5406. doi: 10.1158/1078-0432.CCR-18-1040. Epub 2018 Jul 23.

PMID:
30037819
9.

KAI1/CD82, Metastasis Suppressor Gene as a Therapeutic Target for Non-Small-Cell Lung Carcinoma.

Prabhu VV, Devaraj SN.

J Environ Pathol Toxicol Oncol. 2017;36(3):269-275. doi: 10.1615/JEnvironPatholToxicolOncol.2017024619. Review.

PMID:
29283339
10.

Epidermal Growth Factor Receptor Tyrosine Kinase: A Potential Target in Treatment of Non-Small-Cell Lung Carcinoma.

Prabhu VV, Devaraj N.

J Environ Pathol Toxicol Oncol. 2017;36(2):151-158. doi: 10.1615/JEnvironPatholToxicolOncol.2017018341. Review.

PMID:
29199595
11.

Copine 3 as a Novel Potential Drug Target for Non-Small-Cell Lung Carcinoma.

Sakthivel KM, Prabhu VV.

J Environ Pathol Toxicol Oncol. 2017;36(2):107-112. doi: 10.1615/JEnvironPatholToxicolOncol.2017019540. Review.

PMID:
29199591
12.

Regulating RNA Binding Motif 5 Gene Expression- A Novel Therapeutic Target for Lung Cancer.

Prabhu VV, Devaraj N.

J Environ Pathol Toxicol Oncol. 2017;36(2):99-105. doi: 10.1615/JEnvironPatholToxicolOncol.2017019366. Review.

PMID:
29199590
13.

Single agent and synergistic combinatorial efficacy of first-in-class small molecule imipridone ONC201 in hematological malignancies.

Prabhu VV, Talekar MK, Lulla AR, Kline CLB, Zhou L, Hall J, Van den Heuvel APJ, Dicker DT, Babar J, Grupp SA, Garnett MJ, McDermott U, Benes CH, Pu JJ, Claxton DF, Khan N, Oster W, Allen JE, El-Deiry WS.

Cell Cycle. 2018;17(4):468-478. doi: 10.1080/15384101.2017.1403689. Epub 2018 Feb 19.

14.

Anti-pancreatic cancer activity of ONC212 involves the unfolded protein response (UPR) and is reduced by IGF1-R and GRP78/BIP.

Lev A, Lulla AR, Wagner J, Ralff MD, Kiehl JB, Zhou Y, Benes CH, Prabhu VV, Oster W, Astsaturov I, Dicker DT, El-Deiry WS.

Oncotarget. 2017 Sep 12;8(47):81776-81793. doi: 10.18632/oncotarget.20819. eCollection 2017 Oct 10.

15.

Cancer stem cell-related gene expression as a potential biomarker of response for first-in-class imipridone ONC201 in solid tumors.

Prabhu VV, Lulla AR, Madhukar NS, Ralff MD, Zhao D, Kline CLB, Van den Heuvel APJ, Lev A, Garnett MJ, McDermott U, Benes CH, Batchelor TT, Chi AS, Elemento O, Allen JE, El-Deiry WS.

PLoS One. 2017 Aug 2;12(8):e0180541. doi: 10.1371/journal.pone.0180541. eCollection 2017.

16.

Preclinical evaluation of the imipridone family, analogs of clinical stage anti-cancer small molecule ONC201, reveals potent anti-cancer effects of ONC212.

Wagner J, Kline CL, Ralff MD, Lev A, Lulla A, Zhou L, Olson GL, Nallaganchu BR, Benes CH, Allen JE, Prabhu VV, Stogniew M, Oster W, El-Deiry WS.

Cell Cycle. 2017 Oct 2;16(19):1790-1799. doi: 10.1080/15384101.2017.1325046. Epub 2017 May 10.

17.

Longer Telomere Length of T lymphocytes in Patients with Early and Chronic Psychosis.

Cui Y, Prabhu VV, Nguyen TB, Devi SM, Chung YC.

Clin Psychopharmacol Neurosci. 2017 May 31;15(2):146-152. doi: 10.9758/cpn.2017.15.2.146.

18.

ONC201 Demonstrates Antitumor Effects in Both Triple-Negative and Non-Triple-Negative Breast Cancers through TRAIL-Dependent and TRAIL-Independent Mechanisms.

Ralff MD, Kline CLB, Küçükkase OC, Wagner J, Lim B, Dicker DT, Prabhu VV, Oster W, El-Deiry WS.

Mol Cancer Ther. 2017 Jul;16(7):1290-1298. doi: 10.1158/1535-7163.MCT-17-0121. Epub 2017 Apr 19.

19.

Discovery and clinical introduction of first-in-class imipridone ONC201.

Allen JE, Kline CL, Prabhu VV, Wagner J, Ishizawa J, Madhukar N, Lev A, Baumeister M, Zhou L, Lulla A, Stogniew M, Schalop L, Benes C, Kaufman HL, Pottorf RS, Nallaganchu BR, Olson GL, Al-Mulla F, Duvic M, Wu GS, Dicker DT, Talekar MK, Lim B, Elemento O, Oster W, Bertino J, Flaherty K, Wang ML, Borthakur G, Andreeff M, Stein M, El-Deiry WS.

Oncotarget. 2016 Nov 8;7(45):74380-74392. doi: 10.18632/oncotarget.11814. Review.

20.

Measuring agreement between healthcare survey instruments using mutual information.

Kang Y, Steis MR, Kolanowski AM, Fick D, Prabhu VV.

BMC Med Inform Decis Mak. 2016 Jul 26;16:99. doi: 10.1186/s12911-016-0335-y.

21.

ONC201 kills solid tumor cells by triggering an integrated stress response dependent on ATF4 activation by specific eIF2α kinases.

Kline CL, Van den Heuvel AP, Allen JE, Prabhu VV, Dicker DT, El-Deiry WS.

Sci Signal. 2016 Feb 16;9(415):ra18. doi: 10.1126/scisignal.aac4374.

22.

A case of losartan-induced severe hyponatremia.

Das S, Bandyopadhyay S, Ramasamy A, Prabhu VV, Pachiappan S.

J Pharmacol Pharmacother. 2015 Oct-Dec;6(4):219-21. doi: 10.4103/0976-500X.171880.

23.

Evaluation of protective effects of diosmin (a citrus flavonoid) in chemical-induced urolithiasis in experimental rats.

Prabhu VV, Sathyamurthy D, Ramasamy A, Das S, Anuradha M, Pachiappan S.

Pharm Biol. 2016 Sep;54(9):1513-21. doi: 10.3109/13880209.2015.1107105. Epub 2016 Jan 22.

PMID:
26799954
24.

Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation.

Prabhu VV, Hong B, Allen JE, Zhang S, Lulla AR, Dicker DT, El-Deiry WS.

Cancer Res. 2016 Apr 1;76(7):1989-99. doi: 10.1158/0008-5472.CAN-14-2430. Epub 2016 Jan 12.

25.

Modelling Adherence Behaviour for the Treatment of Obstructive Sleep Apnoea.

Kang Y, Sawyer AM, Griffin PM, Prabhu VV.

Eur J Oper Res. 2016 Mar 16;249(3):1005-1013.

26.

Chronic social defeat stress increases dopamine D2 receptor dimerization in the prefrontal cortex of adult mice.

Bagalkot TR, Jin HM, Prabhu VV, Muna SS, Cui Y, Yadav BK, Chae HJ, Chung YC.

Neuroscience. 2015 Dec 17;311:444-52. doi: 10.1016/j.neuroscience.2015.10.024. Epub 2015 Oct 17.

PMID:
26484605
27.

Small-Molecule NSC59984 Restores p53 Pathway Signaling and Antitumor Effects against Colorectal Cancer via p73 Activation and Degradation of Mutant p53.

Zhang S, Zhou L, Hong B, van den Heuvel AP, Prabhu VV, Warfel NA, Kline CL, Dicker DT, Kopelovich L, El-Deiry WS.

Cancer Res. 2015 Sep 15;75(18):3842-52. doi: 10.1158/0008-5472.CAN-13-1079. Epub 2015 Aug 20.

28.

Targeting TRAIL in the treatment of cancer: new developments.

Lim B, Allen JE, Prabhu VV, Talekar MK, Finnberg NK, El-Deiry WS.

Expert Opin Ther Targets. 2015;19(9):1171-85. doi: 10.1517/14728222.2015.1049838. Epub 2015 May 25. Review.

PMID:
26004811
29.

4th international conference on tumor progression and therapeutic resistance: meeting report.

Prabhu VV, El-Deiry WS.

Cancer Biol Ther. 2015;16(3):363-76. doi: 10.1080/15384047.2015.1004928.

30.

Small-Molecule ONC201/TIC10 Targets Chemotherapy-Resistant Colorectal Cancer Stem-like Cells in an Akt/Foxo3a/TRAIL-Dependent Manner.

Prabhu VV, Allen JE, Dicker DT, El-Deiry WS.

Cancer Res. 2015 Apr 1;75(7):1423-32. doi: 10.1158/0008-5472.CAN-13-3451. Epub 2015 Feb 20.

31.

Genetic and Pharmacological Screens Converge in Identifying FLIP, BCL2, and IAP Proteins as Key Regulators of Sensitivity to the TRAIL-Inducing Anticancer Agent ONC201/TIC10.

Allen JE, Prabhu VV, Talekar M, van den Heuvel AP, Lim B, Dicker DT, Fritz JL, Beck A, El-Deiry WS.

Cancer Res. 2015 Apr 15;75(8):1668-74. doi: 10.1158/0008-5472.CAN-14-2356. Epub 2015 Feb 13.

32.

Simulator-based assessment of haptic surgical skill: a comparative study.

Singapogu RB, Long LO, Smith DE, Burg TC, Pagano CC, Prabhu VV, Burg KJ.

Surg Innov. 2015 Apr;22(2):183-8. doi: 10.1177/1553350614537119. Epub 2014 Jul 22.

PMID:
25053621
33.

COX-2 drives metastatic breast cells from brain lesions into the cerebrospinal fluid and systemic circulation.

Allen JE, Patel AS, Prabhu VV, Dicker DT, Sheehan JM, Glantz MJ, El-Deiry WS.

Cancer Res. 2014 May 1;74(9):2385-90. doi: 10.1158/0008-5472.CAN-13-2660. Epub 2014 Mar 10.

34.

Targeting tumor suppressor p53 for cancer therapy: strategies, challenges and opportunities.

Hong B, van den Heuvel AP, Prabhu VV, Zhang S, El-Deiry WS.

Curr Drug Targets. 2014 Jan;15(1):80-9. Review.

PMID:
24387333
35.

Kisspeptins (KiSS-1): essential players in suppressing tumor metastasis.

Prabhu VV, Sakthivel KM, Guruvayoorappan C.

Asian Pac J Cancer Prev. 2013;14(11):6215-20. Review.

36.

Prodigiosin rescues deficient p53 signaling and antitumor effects via upregulating p73 and disrupting its interaction with mutant p53.

Hong B, Prabhu VV, Zhang S, van den Heuvel AP, Dicker DT, Kopelovich L, El-Deiry WS.

Cancer Res. 2014 Feb 15;74(4):1153-65. doi: 10.1158/0008-5472.CAN-13-0955. Epub 2013 Nov 18.

37.

1,2-Diazole prevents cisplatin-induced nephrotoxicity in experimental rats.

Prabhu VV, Kannan N, Guruvayoorappan C.

Pharmacol Rep. 2013;65(4):980-90.

38.

Inhibition of metastatic lung cancer in C57BL/6 mice by marine mangrove Rhizophora apiculata.

Prabhu VV, Guruvayoorappan C.

Asian Pac J Cancer Prev. 2013;14(3):1833-40.

39.

Effect of marine mangrove Avicennia marina (Forssk.) Vierh against acetic acid-induced ulcerative colitis in experimental mice.

Rise CL, Prabhu VV, Guruvayoorappan C.

J Environ Pathol Toxicol Oncol. 2012;31(2):179-92.

PMID:
23216642
40.

Targeting tumor metastasis by regulating Nm23 gene expression.

Prabhu VV, Siddikuzzaman, Grace VM, Guruvayoorappan C.

Asian Pac J Cancer Prev. 2012;13(8):3539-48. Review.

41.

Therapeutic targeting of the p53 pathway in cancer stem cells.

Prabhu VV, Allen JE, Hong B, Zhang S, Cheng H, El-Deiry WS.

Expert Opin Ther Targets. 2012 Dec;16(12):1161-74. doi: 10.1517/14728222.2012.726985. Epub 2012 Sep 24. Review.

42.

WAVEs: a novel and promising weapon in the cancer therapy tool box.

Sakthivel KM, Prabhu VV, Guruvayoorappan C.

Asian Pac J Cancer Prev. 2012;13(5):1719-22. Review.

43.

Anti-inflammatory and anti-tumor activity of the marine mangrove Rhizophora apiculata.

Prabhu VV, Guruvayoorappan C.

J Immunotoxicol. 2012 Oct-Dec;9(4):341-52. doi: 10.3109/1547691X.2012.660997. Epub 2012 Jul 16.

PMID:
22800297
44.

CTGF-mediated autophagy-senescence transition in tumor stroma promotes anabolic tumor growth and metastasis.

Prabhu VV, Warfel NA, El-Deiry WS.

Cell Cycle. 2012 Jul 15;11(14):2592-3. doi: 10.4161/cc.21240. Epub 2012 Jul 15. No abstract available.

45.

Evaluation and quantification of angiogenesis activity of terminalia bellirica roxb, by mice sponge implantation method.

Prabhu VV, Chidambaranathan N, Gopal V.

J Young Pharm. 2012 Jan;4(1):22-7. doi: 10.4103/0975-1483.93577.

46.

Assessing surgeon and novice force skill on a haptic stiffness simulator for laparoscopic surgery.

Singapogu RB, Smith DE, Altenhoff BM, Long LO, Prabhu VV, Pagano CC, Burg TC, Burg KJ.

Stud Health Technol Inform. 2012;173:469-74.

PMID:
22357038
47.

Combination therapy of low-fluence photodynamic therapy and intravitreal ranibizumab for choroidal neovascular membrane in choroidal osteoma.

Morris RJ, Prabhu VV, Shah PK, Narendran V.

Indian J Ophthalmol. 2011 Sep-Oct;59(5):394-6. doi: 10.4103/0301-4738.83622.

48.
49.

Role of haptic feedback in a basic laparoscopic task requiring hand-eye coordination.

Singapogu RB, Pagano CC, Burg TC, Burg KJ, Prabhu VV.

Stud Health Technol Inform. 2011;163:591-3.

PMID:
21335862
50.

Growth factor signals in neural cells: coherent patterns of interaction control multiple levels of molecular and phenotypic responses.

Martin B, Brenneman R, Golden E, Walent T, Becker KG, Prabhu VV, Wood W 3rd, Ladenheim B, Cadet JL, Maudsley S.

J Biol Chem. 2009 Jan 23;284(4):2493-511. doi: 10.1074/jbc.M804545200. Epub 2008 Nov 26.

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