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Sanguinarine Induces Apoptosis in Papillary Thyroid Cancer Cells via Generation of Reactive Oxygen Species.

Khan AQ, Mohamed EAN, Hakeem I, Nazeer A, Kuttikrishnan S, Prabhu KS, Siveen KS, Nawaz Z, Ahmad A, Zayed H, Uddin S.

Molecules. 2020 Mar 9;25(5). pii: E1229. doi: 10.3390/molecules25051229.


Role of non-coding RNA networks in leukemia progression, metastasis and drug resistance.

Bhat AA, Younes SN, Raza SS, Zarif L, Nisar S, Ahmed I, Mir R, Kumar S, Sharawat SK, Hashem S, Elfaki I, Kulinski M, Kuttikrishnan S, Prabhu KS, Khan AQ, Yadav SK, El-Rifai W, Zargar MA, Zayed H, Haris M, Uddin S.

Mol Cancer. 2020 Mar 12;19(1):57. doi: 10.1186/s12943-020-01175-9. Review.


Non-Coding RNAs as Regulators and Markers for Targeting of Breast Cancer and Cancer Stem Cells.

Prabhu KS, Raza A, Karedath T, Raza SS, Fathima H, Ahmed EI, Kuttikrishnan S, Therachiyil L, Kulinski M, Dermime S, Junejo K, Steinhoff M, Uddin S.

Cancers (Basel). 2020 Feb 4;12(2). pii: E351. doi: 10.3390/cancers12020351. Review.


Selenium and selenoproteins in prostanoid metabolism and immunity.

Qian F, Misra S, Prabhu KS.

Crit Rev Biochem Mol Biol. 2019 Dec;54(6):484-516. doi: 10.1080/10409238.2020.1717430. Epub 2020 Jan 30. Review.


Curcumin-Mediated Apoptotic Cell Death in Papillary Thyroid Cancer and Cancer Stem-Like Cells through Targeting of the JAK/STAT3 Signaling Pathway.

Khan AQ, Ahmed EI, Elareer N, Fathima H, Prabhu KS, Siveen KS, Kulinski M, Azizi F, Dermime S, Ahmad A, Steinhoff M, Uddin S.

Int J Mol Sci. 2020 Jan 9;21(2). pii: E438. doi: 10.3390/ijms21020438.


Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium.

Diwakar BT, Yoast R, Nettleford S, Qian F, Lee TJ, Berry S, Huffnagle I, Rossi RM, Trebak M, Paulson RF, Prabhu KS.

FASEB J. 2019 Nov;33(11):12838-12852. doi: 10.1096/fj.201802608R. Epub 2019 Sep 13.


Special Issue of "Optimal Selenium Status and Selenoproteins in Health".

Cheng WH, Prabhu KS.

Biol Trace Elem Res. 2019 Nov;192(1):1-2. doi: 10.1007/s12011-019-01898-x. No abstract available.


Inflammation induces stress erythropoiesis through heme-dependent activation of SPI-C.

Bennett LF, Liao C, Quickel MD, Yeoh BS, Vijay-Kumar M, Hankey-Giblin P, Prabhu KS, Paulson RF.

Sci Signal. 2019 Sep 10;12(598). pii: eaap7336. doi: 10.1126/scisignal.aap7336.


p38 MAP-kinase inhibitor protects against platelet-activating factor-induced death in mice.

Abhilasha KV, Sumanth MS, Chaithra VH, Jacob SP, Thyagarajan A, Sahu RP, Rajaiah R, Prabhu KS, Kemparaju K, Travers JB, Chen CH, Marathe GK.

Free Radic Biol Med. 2019 Nov 1;143:275-287. doi: 10.1016/j.freeradbiomed.2019.08.019. Epub 2019 Aug 20.


Curcumin Induces Apoptotic Cell Death via Inhibition of PI3-Kinase/AKT Pathway in B-Precursor Acute Lymphoblastic Leukemia.

Kuttikrishnan S, Siveen KS, Prabhu KS, Khan AQ, Ahmed EI, Akhtar S, Ali TA, Merhi M, Dermime S, Steinhoff M, Uddin S.

Front Oncol. 2019 Jun 19;9:484. doi: 10.3389/fonc.2019.00484. eCollection 2019.


Acute phase protein, α - 1- acid glycoprotein (AGP-1), has differential effects on TLR-2 and TLR-4 mediated responses.

Sumanth MS, Abhilasha KV, Jacob SP, Chaithra VH, Basrur V, Willard B, McIntyre TM, Prabhu KS, Marathe GK.

Immunobiology. 2019 Sep;224(5):672-680. doi: 10.1016/j.imbio.2019.06.003. Epub 2019 Jun 20.


The Role of Extracellular Vesicles as Modulators of the Tumor Microenvironment, Metastasis and Drug Resistance in Colorectal Cancer.

Siveen KS, Raza A, Ahmed EI, Khan AQ, Prabhu KS, Kuttikrishnan S, Mateo JM, Zayed H, Rasul K, Azizi F, Dermime S, Steinhoff M, Uddin S.

Cancers (Basel). 2019 May 29;11(6). pii: E746. doi: 10.3390/cancers11060746. Review.


Selenium-rich maize modulates the expression of prostaglandin genes in lipopolysaccharide-stimulated RAW264.7 macrophages.

Dhanjal NI, Sharma S, Skalny AV, Skalnaya MG, Ajsuvakova OP, Tinkov AA, Zhang F, Guo X, Prabhu KS, Tejo Prakash N.

Food Funct. 2019 May 22;10(5):2839-2846. doi: 10.1039/c9fo00186g.


Sanguinarine Induces Apoptosis Pathway in Multiple Myeloma Cell Lines via Inhibition of the JaK2/STAT3 Signaling.

Akhtar S, Achkar IW, Siveen KS, Kuttikrishnan S, Prabhu KS, Khan AQ, Ahmed EI, Sahir F, Jerobin J, Raza A, Merhi M, Elsabah HM, Taha R, Omri HE, Zayed H, Dermime S, Steinhoff M, Uddin S.

Front Oncol. 2019 Apr 17;9:285. doi: 10.3389/fonc.2019.00285. eCollection 2019.


Downregulation of CD73 associates with T cell exhaustion in AML patients.

Kong Y, Jia B, Zhao C, Claxton DF, Sharma A, Annageldiyev C, Fotos JS, Zeng H, Paulson RF, Prabhu KS, Zheng H.

J Hematol Oncol. 2019 Apr 24;12(1):40. doi: 10.1186/s13045-019-0728-3.


Selenoproteome Identification in Inflamed Murine Primary Bone Marrow-Derived Macrophages by Nano-LC Orbitrap Fusion Tribrid Mass Spectrometry.

Korwar AM, Shay AE, Basrur V, Conlon K, Prabhu KS.

J Am Soc Mass Spectrom. 2019 Jul;30(7):1276-1283. doi: 10.1007/s13361-019-02192-9. Epub 2019 Apr 9.


Greensporone A, a Fungal Secondary Metabolite Suppressed Constitutively Activated AKT via ROS Generation and Induced Apoptosis in Leukemic Cell Lines.

Prabhu KS, Siveen KS, Kuttikrishnan S, Jochebeth A, Ali TA, Elareer NR, Iskandarani A, Quaiyoom Khan A, Merhi M, Dermime S, El-Elimat T, Oberlies NH, Alali FQ, Steinhoff M, Uddin S.

Biomolecules. 2019 Mar 29;9(4). pii: E126. doi: 10.3390/biom9040126.


Evaluation of cationic channel TRPV2 as a novel biomarker and therapeutic target in Leukemia-Implications concerning the resolution of pulmonary inflammation.

Siveen KS, Prabhu KS, Parray AS, Merhi M, Arredouani A, Chikri M, Uddin S, Dermime S, Mohammad RM, Steinhoff M, Janahi IA, Azizi F.

Sci Rep. 2019 Feb 7;9(1):1554. doi: 10.1038/s41598-018-37469-8.


Curcumin-Mediated Degradation of S-Phase Kinase Protein 2 Induces Cytotoxic Effects in Human Papillomavirus-Positive and Negative Squamous Carcinoma Cells.

Khan AQ, Siveen KS, Prabhu KS, Kuttikrishnan S, Akhtar S, Shaar A, Raza A, Mraiche F, Dermime S, Uddin S.

Front Oncol. 2018 Oct 2;8:399. doi: 10.3389/fonc.2018.00399. eCollection 2018.


Monocyte-derived macrophages expand the murine stress erythropoietic niche during the recovery from anemia.

Liao C, Prabhu KS, Paulson RF.

Blood. 2018 Dec 13;132(24):2580-2593. doi: 10.1182/blood-2018-06-856831. Epub 2018 Oct 15.


Sanguinarine suppresses growth and induces apoptosis in childhood acute lymphoblastic leukemia.

Kuttikrishnan S, Siveen KS, Prabhu KS, Khan AQ, Akhtar S, Mateo JM, Merhi M, Taha R, Omri HE, Mraiche F, Dermime S, Uddin S.

Leuk Lymphoma. 2019 Mar;60(3):782-794. doi: 10.1080/10428194.2018.1494270. Epub 2018 Sep 6.


Greensporone C, a Freshwater Fungal Secondary Metabolite Induces Mitochondrial-Mediated Apoptotic Cell Death in Leukemic Cell Lines.

Prabhu KS, Siveen KS, Kuttikrishnan S, Iskandarani AN, Khan AQ, Merhi M, Omri HE, Dermime S, El-Elimat T, Oberlies NH, Alali FQ, Uddin S.

Front Pharmacol. 2018 Jul 16;9:720. doi: 10.3389/fphar.2018.00720. eCollection 2018.


Accelerated lipid catabolism and autophagy are cancer survival mechanisms under inhibited glutaminolysis.

Halama A, Kulinski M, Dib SS, Zaghlool SB, Siveen KS, Iskandarani A, Zierer J, Prabhu KS, Satheesh NJ, Bhagwat AM, Uddin S, Kastenmüller G, Elemento O, Gross SS, Suhre K.

Cancer Lett. 2018 Aug 28;430:133-147. doi: 10.1016/j.canlet.2018.05.017. Epub 2018 May 17.


The intricate role of selenium and selenoproteins in erythropoiesis.

Liao C, Carlson BA, Paulson RF, Prabhu KS.

Free Radic Biol Med. 2018 Nov 1;127:165-171. doi: 10.1016/j.freeradbiomed.2018.04.578. Epub 2018 Apr 30. Review.


Assessment of genetic diversity in ragi [Eleusine coracana (L.) Gaertn] using morphological, RAPD and SSR markers.

Prabhu KS, Das AB, Dikshit N.

Z Naturforsch C J Biosci. 2018 Apr 25;73(5-6):165-176. doi: 10.1515/znc-2017-0182.


Bioaccessible selenium sourced from Se-rich mustard cake facilitates protection from TBHP induced cytotoxicity in melanoma cells.

Jaiswal SK, Prakash R, Prabhu KS, Tejo Prakash N.

Food Funct. 2018 Apr 25;9(4):1998-2004. doi: 10.1039/c7fo01644a.


Embelin: a benzoquinone possesses therapeutic potential for the treatment of human cancer.

Prabhu KS, Achkar IW, Kuttikrishnan S, Akhtar S, Khan AQ, Siveen KS, Uddin S.

Future Med Chem. 2018 Apr 1;10(8):961-976. doi: 10.4155/fmc-2017-0198. Epub 2018 Apr 5. Review.


Selenoproteins regulate stress erythroid progenitors and spleen microenvironment during stress erythropoiesis.

Liao C, Hardison RC, Kennett MJ, Carlson BA, Paulson RF, Prabhu KS.

Blood. 2018 Jun 7;131(23):2568-2580. doi: 10.1182/blood-2017-08-800607. Epub 2018 Apr 3.


RAS-mediated oncogenic signaling pathways in human malignancies.

Khan AQ, Kuttikrishnan S, Siveen KS, Prabhu KS, Shanmugakonar M, Al-Naemi HA, Haris M, Dermime S, Uddin S.

Semin Cancer Biol. 2019 Feb;54:1-13. doi: 10.1016/j.semcancer.2018.03.001. Epub 2018 Mar 7. Review.


Selenium and Selenoproteins in Gut Inflammation-A Review.

Nettleford SK, Prabhu KS.

Antioxidants (Basel). 2018 Mar 1;7(3). pii: E36. doi: 10.3390/antiox7030036. Review.


Role of Non Receptor Tyrosine Kinases in Hematological Malignances and its Targeting by Natural Products.

Siveen KS, Prabhu KS, Achkar IW, Kuttikrishnan S, Shyam S, Khan AQ, Merhi M, Dermime S, Uddin S.

Mol Cancer. 2018 Feb 19;17(1):31. doi: 10.1186/s12943-018-0788-y. Review.


The Regulation of Pathways of Inflammation and Resolution in Immune Cells and Cancer Stem Cells by Selenium.

Diwakar BT, Korwar AM, Paulson RF, Prabhu KS.

Adv Cancer Res. 2017;136:153-172. doi: 10.1016/bs.acr.2017.07.003. Epub 2017 Aug 31. Review.


Targeting of X-linked inhibitor of apoptosis protein and PI3-kinase/AKT signaling by embelin suppresses growth of leukemic cells.

Prabhu KS, Siveen KS, Kuttikrishnan S, Iskandarani A, Tsakou M, Achkar IW, Therachiyil L, Krishnankutty R, Parray A, Kulinski M, Merhi M, Dermime S, Mohammad RM, Uddin S.

PLoS One. 2017 Jul 13;12(7):e0180895. doi: 10.1371/journal.pone.0180895. eCollection 2017.


IL-4 up-regulates cyclooxygenase-1 expression in macrophages.

Shay AE, Diwakar BT, Guan BJ, Narayan V, Urban JF Jr, Prabhu KS.

J Biol Chem. 2017 Sep 1;292(35):14544-14555. doi: 10.1074/jbc.M117.785014. Epub 2017 Jul 6.


Potential therapeutic targets of Guggulsterone in cancer.

Bhat AA, Prabhu KS, Kuttikrishnan S, Krishnankutty R, Babu J, Mohammad RM, Uddin S.

Nutr Metab (Lond). 2017 Feb 28;14:23. doi: 10.1186/s12986-017-0180-8. eCollection 2017. Review.


Activation of PPARγ by endogenous prostaglandin J2 mediates the antileukemic effect of selenium in murine leukemia.

Finch ER, Tukaramrao DB, Goodfield LL, Quickel MD, Paulson RF, Prabhu KS.

Blood. 2017 Mar 30;129(13):1802-1810. doi: 10.1182/blood-2016-08-736405. Epub 2017 Jan 23.


Selenium supplementation through Se-rich dietary matrices can upregulate the anti-inflammatory responses in lipopolysaccharide-stimulated murine macrophages.

Dhanjal NIK, Sharma S, Prabhu KS, Prakash NT.

Food Agric Immunol. 2017;28(6):1374-1392. doi: 10.1080/09540105.2017.1343805. Epub 2017 Jul 19.



Prabhu KS, Lei XG.

Adv Nutr. 2016 Mar 15;7(2):415-7. doi: 10.3945/an.115.010785. Print 2016 Mar. No abstract available.


Bortezomib-mediated downregulation of S-phase kinase protein-2 (SKP2) causes apoptotic cell death in chronic myelogenous leukemia cells.

Iskandarani A, Bhat AA, Siveen KS, Prabhu KS, Kuttikrishnan S, Khan MA, Krishnankutty R, Kulinski M, Nasr RR, Mohammad RM, Uddin S.

J Transl Med. 2016 Mar 9;14:69. doi: 10.1186/s12967-016-0823-y.


Selenoprotein Expression in Macrophages Is Critical for Optimal Clearance of Parasitic Helminth Nippostrongylus brasiliensis.

Nelson SM, Shay AE, James JL, Carlson BA, Urban JF Jr, Prabhu KS.

J Biol Chem. 2016 Feb 5;291(6):2787-98. doi: 10.1074/jbc.M115.684738. Epub 2015 Dec 7.


Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia.

Finch ER, Kudva AK, Quickel MD, Goodfield LL, Kennett MJ, Whelan J, Paulson RF, Prabhu KS.

Cancer Prev Res (Phila). 2015 Oct;8(10):989-99. doi: 10.1158/1940-6207.CAPR-15-0050. Epub 2015 Aug 19.


Reduction of Tetrathionate by Mammalian Thioredoxin Reductase.

Narayan V, Kudva AK, Prabhu KS.

Biochemistry. 2015 Aug 25;54(33):5121-4. doi: 10.1021/acs.biochem.5b00620. Epub 2015 Aug 13.


Selenium and inflammatory bowel disease.

Kudva AK, Shay AE, Prabhu KS.

Am J Physiol Gastrointest Liver Physiol. 2015 Jul 15;309(2):G71-7. doi: 10.1152/ajpgi.00379.2014. Epub 2015 Jun 4. Review.


Epigenetic regulation of inflammatory gene expression in macrophages by selenium.

Narayan V, Ravindra KC, Liao C, Kaushal N, Carlson BA, Prabhu KS.

J Nutr Biochem. 2015 Feb;26(2):138-45. doi: 10.1016/j.jnutbio.2014.09.009. Epub 2014 Oct 24.


Crucial role of macrophage selenoproteins in experimental colitis.

Kaushal N, Kudva AK, Patterson AD, Chiaro C, Kennett MJ, Desai D, Amin S, Carlson BA, Cantorna MT, Prabhu KS.

J Immunol. 2014 Oct 1;193(7):3683-92. doi: 10.4049/jimmunol.1400347. Epub 2014 Sep 3.


Total synthesis of Δ¹²-prostaglandin J₃, a highly potent and selective antileukemic agent.

Nicolaou KC, Heretsch P, ElMarrouni A, Hale CR, Pulukuri KK, Kudva AK, Narayan V, Prabhu KS.

Angew Chem Int Ed Engl. 2014 Sep 22;53(39):10443-7. doi: 10.1002/anie.201404917. Epub 2014 Aug 5.


Selenium suppresses leukemia through the action of endogenous eicosanoids.

Gandhi UH, Kaushal N, Hegde S, Finch ER, Kudva AK, Kennett MJ, Jordan CT, Paulson RF, Prabhu KS.

Cancer Res. 2014 Jul 15;74(14):3890-901. doi: 10.1158/0008-5472.CAN-13-3694. Epub 2014 May 28.


The microbiome and obesity-an established risk for certain types of cancer.

Rogers CJ, Prabhu KS, Vijay-Kumar M.

Cancer J. 2014 May-Jun;20(3):176-80. doi: 10.1097/PPO.0000000000000049. Review.


Evaluation of the stability, bioavailability, and hypersensitivity of the omega-3 derived anti-leukemic prostaglandin: Δ(12)-prostaglandin J3.

Kudva AK, Kaushal N, Mohinta S, Kennett MJ, August A, Paulson RF, Prabhu KS.

PLoS One. 2013 Dec 2;8(12):e80622. doi: 10.1371/journal.pone.0080622. eCollection 2013.


Dietary selenium supplementation modifies breast tumor growth and metastasis.

Chen YC, Prabhu KS, Das A, Mastro AM.

Int J Cancer. 2013 Nov;133(9):2054-64. doi: 10.1002/ijc.28224. Epub 2013 Jul 6.

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