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An oncolytic adenovirus targeting TGFβ inhibits pro-tumorigenic signals and produces immune activation: A novel approach to enhance anti-PD-1 and anti-CTLA-4 therapy.

Seth P, Yang Y, Xu W, Peng D, Wang H, Zhang X, Wang H, Xiao F, Zhu Y, Ji Y, Gulukota K, Helseth DL Jr, Mangold KA, Sullivan M, Kaul K, Wang CH, Prabhakar BS, Li J, Wu X, Wang L.

Hum Gene Ther. 2019 May 24. doi: 10.1089/hum.2019.059. [Epub ahead of print]


MADD silencing enhances anti-tumor activity of TRAIL in anaplastic thyroid cancer.

Saini S, Sripada L, Tulla K, Qiao G, Kunda N, Maker AV, Prabhakar BS.

Endocr Relat Cancer. 2019 Jun 1;26(6):551-563. doi: 10.1530/ERC-18-0517.


Protein Aggregation Capture on Microparticles Enables Multipurpose Proteomics Sample Preparation.

Batth TS, Tollenaere MAX, Rüther P, Gonzalez-Franquesa A, Prabhakar BS, Bekker-Jensen S, Deshmukh AS, Olsen JV.

Mol Cell Proteomics. 2019 May;18(5):1027-1035. doi: 10.1074/mcp.TIR118.001270. Epub 2019 Mar 4.


Loss of MADD expression inhibits cellular growth and metastasis in anaplastic thyroid cancer.

Saini S, Sripada L, Tulla K, Kumar P, Yue F, Kunda N, Maker AV, Prabhakar BS.

Cell Death Dis. 2019 Feb 13;10(2):145. doi: 10.1038/s41419-019-1351-5.


Cancer immunotherapy with check point inhibitor can cause autoimmune adverse events due to loss of Treg homeostasis.

Kumar P, Saini S, Prabhakar BS.

Semin Cancer Biol. 2019 Feb 1. pii: S1044-579X(18)30189-5. doi: 10.1016/j.semcancer.2019.01.006. [Epub ahead of print] Review.


Molecular aberrations and signaling cascades implicated in the pathogenesis of anaplastic thyroid cancer.

Saini S, Maker AV, Burman KD, Prabhakar BS.

Biochim Biophys Acta Rev Cancer. 2018 Dec 31. pii: S0304-419X(18)30141-0. doi: 10.1016/j.bbcan.2018.12.003. [Epub ahead of print] Review.


Vaccination With Mitoxantrone-Treated Primary Colon Cancer Cells Enhances Tumor-Infiltrating Lymphocytes and Clinical Responses in Colorectal Liver Metastases.

Qin J, Kunda NM, Qiao G, Tulla K, Prabhakar BS, Maker AV.

J Surg Res. 2019 Jan;233:57-64. doi: 10.1016/j.jss.2018.07.068. Epub 2018 Aug 17.


Restoring self-tolerance in autoimmune diseases by enhancing regulatory T-cells.

Kumar P, Saini S, Khan S, Surendra Lele S, Prabhakar BS.

Cell Immunol. 2019 May;339:41-49. doi: 10.1016/j.cellimm.2018.09.008. Epub 2018 Sep 29.


Therapeutic advances in anaplastic thyroid cancer: a current perspective.

Saini S, Tulla K, Maker AV, Burman KD, Prabhakar BS.

Mol Cancer. 2018 Oct 23;17(1):154. doi: 10.1186/s12943-018-0903-0. Review.


Identification of a Novel OX40L+ Dendritic Cell Subset That Selectively Expands Regulatory T cells.

Marinelarena A, Bhattacharya P, Kumar P, Maker AV, Prabhakar BS.

Sci Rep. 2018 Oct 8;8(1):14940. doi: 10.1038/s41598-018-33307-z.


A comprehensive review on the role of co-signaling receptors and Treg homeostasis in autoimmunity and tumor immunity.

Kumar P, Bhattacharya P, Prabhakar BS.

J Autoimmun. 2018 Dec;95:77-99. doi: 10.1016/j.jaut.2018.08.007. Epub 2018 Aug 31. Review.


A single high-fat meal alters human soluble RAGE profiles and PBMC RAGE expression with no effect of prior aerobic exercise.

Fuller KNZ, Valentine RJ, Miranda ER, Kumar P, Prabhakar BS, Haus JM.

Physiol Rep. 2018 Jul;6(14):e13811. doi: 10.14814/phy2.13811.


Implementing a STEMI system of care in urban Bangalore: Rationale and Study Design for heart rescue India.

Ramesh A, LaBresh KA, Begeman R, Bobrow B, Campbell T, Chaudhury N, Edison M, Erickson TB, Manning JD, Prabhakar BS, Kotini-Shah P, Shetty N, Williams PA, Vanden Hoek T.

Contemp Clin Trials Commun. 2018 Apr 5;10:105-110. doi: 10.1016/j.conctc.2018.04.002. eCollection 2018 Jun.


Critical role of OX40 signaling in the TCR-independent phase of human and murine thymic Treg generation.

Kumar P, Marinelarena A, Raghunathan D, Ragothaman VK, Saini S, Bhattacharya P, Fan J, Epstein AL, Maker AV, Prabhakar BS.

Cell Mol Immunol. 2019 Feb;16(2):138-153. doi: 10.1038/cmi.2018.8. Epub 2018 Mar 26.


Mitochondrial protein 18 (MTP18) plays a pro-apoptotic role in chemotherapy-induced gastric cancer cell apoptosis.

Aung LHH, Li R, Prabhakar BS, Maker AV, Li P.

Oncotarget. 2017 Apr 28;8(34):56582-56597. doi: 10.18632/oncotarget.17508. eCollection 2017 Aug 22.


PKC-ѳ is dispensable for OX40L-induced TCR-independent Treg proliferation but contributes by enabling IL-2 production from effector T-cells.

Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Bhattacharya P, Sun Z, Epstein AL, Maker AV, Prabhakar BS.

Sci Rep. 2017 Jul 26;7(1):6594. doi: 10.1038/s41598-017-05254-8.


The epigenetic drug Trichostatin A ameliorates experimental autoimmune encephalomyelitis via T cell tolerance induction and impaired influx of T cells into the spinal cord.

Jayaraman A, Soni A, Prabhakar BS, Holterman M, Jayaraman S.

Neurobiol Dis. 2017 Dec;108:1-12. doi: 10.1016/j.nbd.2017.07.015. Epub 2017 Jul 20.


Knockdown of Mtfp1 can minimize doxorubicin cardiotoxicity by inhibiting Dnm1l-mediated mitochondrial fission.

Aung LHH, Li R, Prabhakar BS, Li P.

J Cell Mol Med. 2017 Dec;21(12):3394-3404. doi: 10.1111/jcmm.13250. Epub 2017 Jun 23.


Regulatory T cells in multiple sclerosis and myasthenia gravis.

Danikowski KM, Jayaraman S, Prabhakar BS.

J Neuroinflammation. 2017 Jun 9;14(1):117. doi: 10.1186/s12974-017-0892-8. Review.


LIGHT Elevation Enhances Immune Eradication of Colon Cancer Metastases.

Qiao G, Qin J, Kunda N, Calata JF, Mahmud DL, Gann P, Fu YX, Rosenberg SA, Prabhakar BS, Maker AV.

Cancer Res. 2017 Apr 15;77(8):1880-1891. doi: 10.1158/0008-5472.CAN-16-1655. Epub 2017 Mar 1.


Colon cancer cell treatment with rose bengal generates a protective immune response via immunogenic cell death.

Qin J, Kunda N, Qiao G, Calata JF, Pardiwala K, Prabhakar BS, Maker AV.

Cell Death Dis. 2017 Feb 2;8(2):e2584. doi: 10.1038/cddis.2016.473.


An Engineered Herpesvirus Activates Dendritic Cells and Induces Protective Immunity.

Ma Y, Chen M, Jin H, Prabhakar BS, Valyi-Nagy T, He B.

Sci Rep. 2017 Feb 2;7:41461. doi: 10.1038/srep41461.


Soluble OX40L and JAG1 Induce Selective Proliferation of Functional Regulatory T-Cells Independent of canonical TCR signaling.

Kumar P, Alharshawi K, Bhattacharya P, Marinelarena A, Haddad C, Sun Z, Chiba S, Epstein AL, Prabhakar BS.

Sci Rep. 2017 Jan 3;7:39751. doi: 10.1038/srep39751.


Targeting the metabolic pathway of human colon cancer overcomes resistance to TRAIL-induced apoptosis.

Carr RM, Qiao G, Qin J, Jayaraman S, Prabhakar BS, Maker AV.

Cell Death Discov. 2016 Sep 12;2:16067. doi: 10.1038/cddiscovery.2016.67. eCollection 2016.


The mitochondrial ubiquitin ligase plays an anti-apoptotic role in cardiomyocytes by regulating mitochondrial fission.

Wang J, Aung LH, Prabhakar BS, Li P.

J Cell Mol Med. 2016 Dec;20(12):2278-2288. doi: 10.1111/jcmm.12914. Epub 2016 Jul 22.


Age-dependent divergent effects of OX40L treatment on the development of diabetes in NOD mice.

Haddad CS, Bhattacharya P, Alharshawi K, Marinelarena A, Kumar P, El-Sayed O, Elshabrawy HA, Epstein AL, Prabhakar BS.

Autoimmunity. 2016 Aug;49(5):298-311. doi: 10.1080/08916934.2016.1183657. Epub 2016 May 31.


Intravaginal Zinc Oxide Tetrapod Nanoparticles as Novel Immunoprotective Agents against Genital Herpes.

Antoine TE, Hadigal SR, Yakoub AM, Mishra YK, Bhattacharya P, Haddad C, Valyi-Nagy T, Adelung R, Prabhakar BS, Shukla D.

J Immunol. 2016 Jun 1;196(11):4566-75. doi: 10.4049/jimmunol.1502373. Epub 2016 Apr 27.


Deleted in Breast Cancer 1 Suppresses B Cell Activation through RelB and Is Regulated by IKKα Phosphorylation.

Kong S, Dong H, Song J, Thiruppathi M, Prabhakar BS, Qiu Q, Lin Z, Chini E, Zhang B, Fang D.

J Immunol. 2015 Oct 15;195(8):3685-93. doi: 10.4049/jimmunol.1500713. Epub 2015 Sep 16.


GM-CSF: An immune modulatory cytokine that can suppress autoimmunity.

Bhattacharya P, Thiruppathi M, Elshabrawy HA, Alharshawi K, Kumar P, Prabhakar BS.

Cytokine. 2015 Oct;75(2):261-71. doi: 10.1016/j.cyto.2015.05.030. Epub 2015 Jun 22. Review.


Alternative splicing as a biomarker and potential target for drug discovery.

Le KQ, Prabhakar BS, Hong WJ, Li LC.

Acta Pharmacol Sin. 2015 Oct;36(10):1212-8. doi: 10.1038/aps.2015.43. Epub 2015 Jun 15. Review.


Ebola virus outbreak, updates on current therapeutic strategies.

Elshabrawy HA, Erickson TB, Prabhakar BS.

Rev Med Virol. 2015 Jul;25(4):241-53. doi: 10.1002/rmv.1841. Epub 2015 May 11. Review.


Dual Role of GM-CSF as a Pro-Inflammatory and a Regulatory Cytokine: Implications for Immune Therapy.

Bhattacharya P, Budnick I, Singh M, Thiruppathi M, Alharshawi K, Elshabrawy H, Holterman MJ, Prabhakar BS.

J Interferon Cytokine Res. 2015 Aug;35(8):585-99. doi: 10.1089/jir.2014.0149. Epub 2015 Mar 24. Review.


DBC1 is a suppressor of B cell activation by negatively regulating alternative NF-κB transcriptional activity.

Kong S, Thiruppathi M, Qiu Q, Lin Z, Dong H, Chini EN, Prabhakar BS, Fang D.

J Immunol. 2014 Dec 1;193(11):5515-24. doi: 10.4049/jimmunol.1401798. Epub 2014 Oct 31.


A novel pancreatic β-cell targeting bispecific-antibody (BsAb) can prevent the development of type 1 diabetes in NOD mice.

Bhattacharya P, Fan J, Haddad C, Essani A, Gopisetty A, Elshabrawy HA, Vasu C, Prabhakar BS.

Clin Immunol. 2014 Jul;153(1):187-98. doi: 10.1016/j.clim.2014.04.014. Epub 2014 May 2.


Ad5/48 hexon oncolytic virus expressing sTGFβRIIFc produces reduced hepatic and systemic toxicities and inhibits prostate cancer bone metastases.

Xu W, Zhang Z, Yang Y, Hu Z, Wang CH, Morgan M, Wu Y, Hutten R, Xiao X, Stock S, Guise T, Prabhakar BS, Brendler C, Seth P.

Mol Ther. 2014 Aug;22(8):1504-1517. doi: 10.1038/mt.2014.80. Epub 2014 May 5.


Identification of a broad-spectrum antiviral small molecule against severe acute respiratory syndrome coronavirus and Ebola, Hendra, and Nipah viruses by using a novel high-throughput screening assay.

Elshabrawy HA, Fan J, Haddad CS, Ratia K, Broder CC, Caffrey M, Prabhakar BS.

J Virol. 2014 Apr;88(8):4353-65. doi: 10.1128/JVI.03050-13. Epub 2014 Feb 5.


Recombinant IgG2a Fc (M045) multimers effectively suppress experimental autoimmune myasthenia gravis.

Thiruppathi M, Sheng JR, Li L, Prabhakar BS, Meriggioli MN.

J Autoimmun. 2014 Aug;52:64-73. doi: 10.1016/j.jaut.2013.12.014. Epub 2014 Jan 2.


IG20/MADD plays a critical role in glucose-induced insulin secretion.

Li LC, Wang Y, Carr R, Haddad CS, Li Z, Qian L, Oberholzer J, Maker AV, Wang Q, Prabhakar BS.

Diabetes. 2014 May;63(5):1612-23. doi: 10.2337/db13-0707. Epub 2013 Dec 30.


MADD is a downstream target of PTEN in triggering apoptosis.

Jayarama S, Li LC, Ganesh L, Mardi D, Kanteti P, Hay N, Li P, Prabhakar BS.

J Cell Biochem. 2014 Feb;115(2):261-70. doi: 10.1002/jcb.24657.


OX40L/Jagged1 cosignaling by GM-CSF-induced bone marrow-derived dendritic cells is required for the expansion of functional regulatory T cells.

Gopisetty A, Bhattacharya P, Haddad C, Bruno JC Jr, Vasu C, Miele L, Prabhakar BS.

J Immunol. 2013 Jun 1;190(11):5516-25. doi: 10.4049/jimmunol.1202298. Epub 2013 Apr 29.


The novel role of IL-7 ligation to IL-7 receptor in myeloid cells of rheumatoid arthritis and collagen-induced arthritis.

Chen Z, Kim SJ, Chamberlain ND, Pickens SR, Volin MV, Volkov S, Arami S, Christman JW, Prabhakar BS, Swedler W, Mehta A, Sweiss N, Shahrara S.

J Immunol. 2013 May 15;190(10):5256-66. doi: 10.4049/jimmunol.1201675. Epub 2013 Apr 19.


MADD knock-down enhances doxorubicin and TRAIL induced apoptosis in breast cancer cells.

Turner A, Li LC, Pilli T, Qian L, Wiley EL, Setty S, Christov K, Ganesh L, Maker AV, Li P, Kanteti P, Das Gupta TK, Prabhakar BS.

PLoS One. 2013;8(2):e56817. doi: 10.1371/journal.pone.0056817. Epub 2013 Feb 15.


Functional defect in regulatory T cells in myasthenia gravis.

Thiruppathi M, Rowin J, Li Jiang Q, Sheng JR, Prabhakar BS, Meriggioli MN.

Ann N Y Acad Sci. 2012 Dec;1274:68-76. doi: 10.1111/j.1749-6632.2012.06840.x. Review.


Human monoclonal antibodies against highly conserved HR1 and HR2 domains of the SARS-CoV spike protein are more broadly neutralizing.

Elshabrawy HA, Coughlin MM, Baker SC, Prabhakar BS.

PLoS One. 2012;7(11):e50366. doi: 10.1371/journal.pone.0050366. Epub 2012 Nov 21.


Impaired regulatory function in circulating CD4(+)CD25(high)CD127(low/-) T cells in patients with myasthenia gravis.

Thiruppathi M, Rowin J, Ganesh B, Sheng JR, Prabhakar BS, Meriggioli MN.

Clin Immunol. 2012 Dec;145(3):209-23. doi: 10.1016/j.clim.2012.09.012. Epub 2012 Oct 7.


Expression of the ring ligase PRAJA2 in thyroid cancer.

Cantara S, D'Angeli F, Toti P, Lignitto L, Castagna MG, Capuano S, Prabhakar BS, Feliciello A, Pacini F.

J Clin Endocrinol Metab. 2012 Nov;97(11):4253-9. doi: 10.1210/jc.2012-2360. Epub 2012 Sep 4.


Granulocyte macrophage colony-stimulating factor treatment of a patient in myasthenic crisis: effects on regulatory T cells.

Rowin J, Thiruppathi M, Arhebamen E, Sheng J, Prabhakar BS, Meriggioli MN.

Muscle Nerve. 2012 Sep;46(3):449-53. doi: 10.1002/mus.23488.


Control of mitochondrial activity by miRNAs.

Li P, Jiao J, Gao G, Prabhakar BS.

J Cell Biochem. 2012 Apr;113(4):1104-10. doi: 10.1002/jcb.24004. Review.


GM-CSF-induced regulatory T cells selectively inhibit anti-acetylcholine receptor-specific immune responses in experimental myasthenia gravis.

Sheng JR, Muthusamy T, Prabhakar BS, Meriggioli MN.

J Neuroimmunol. 2011 Dec 15;240-241:65-73. doi: 10.1016/j.jneuroim.2011.10.010. Epub 2011 Nov 17.

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