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Items: 1 to 50 of 76

1.

Oligomerization of a G protein-coupled receptor in neurons controlled by its structural dynamics.

Møller TC, Hottin J, Clerté C, Zwier JM, Durroux T, Rondard P, Prézeau L, Royer CA, Pin JP, Margeat E, Kniazeff J.

Sci Rep. 2018 Jul 10;8(1):10414. doi: 10.1038/s41598-018-28682-6.

2.

Reversing HIV latency via sphingosine-1-phosphate receptor 1 signaling.

Duquenne C, Gimenez S, Guigues A, Viala B, Boulouis C, Mettling C, Maurel D, Campos N, Doumazane E, Comps-Agrar L, Tazi J, Prézeau L, Psomas C, Corbeau P, François V.

AIDS. 2017 Nov 28;31(18):2443-2454. doi: 10.1097/QAD.0000000000001649.

PMID:
28926402
3.

Pharmacological evidence for a metabotropic glutamate receptor heterodimer in neuronal cells.

Moreno Delgado D, Møller TC, Ster J, Giraldo J, Maurel D, Rovira X, Scholler P, Zwier JM, Perroy J, Durroux T, Trinquet E, Prezeau L, Rondard P, Pin JP.

Elife. 2017 Jun 29;6. pii: e25233. doi: 10.7554/eLife.25233.

4.

The G Protein-Coupled Receptor UT of the Neuropeptide Urotensin II Displays Structural and Functional Chemokine Features.

Castel H, Desrues L, Joubert JE, Tonon MC, Prézeau L, Chabbert M, Morin F, Gandolfo P.

Front Endocrinol (Lausanne). 2017 Apr 25;8:76. doi: 10.3389/fendo.2017.00076. eCollection 2017. Review.

5.

Identification of key phosphorylation sites in PTH1R that determine arrestin3 binding and fine-tune receptor signaling.

Zindel D, Engel S, Bottrill AR, Pin JP, Prézeau L, Tobin AB, Bünemann M, Krasel C, Butcher AJ.

Biochem J. 2016 Nov 15;473(22):4173-4192. Epub 2016 Sep 13.

6.

Functional Characterisation of Eel Dopamine D2 Receptors and Involvement in the Direct Inhibition of Pituitary Gonadotrophins.

Jolly C, Rousseau K, Prézeau L, Vol C, Tomkiewicz J, Dufour S, Pasqualini C.

J Neuroendocrinol. 2016 Sep;28(9). doi: 10.1111/jne.12411.

PMID:
27453551
7.

SGIP1 alters internalization and modulates signaling of activated cannabinoid receptor 1 in a biased manner.

Hájková A, Techlovská Š, Dvořáková M, Chambers JN, Kumpošt J, Hubálková P, Prezeau L, Blahos J.

Neuropharmacology. 2016 Aug;107:201-214. doi: 10.1016/j.neuropharm.2016.03.008. Epub 2016 Mar 9.

8.

Post-endocytotic Deubiquitination and Degradation of the Metabotropic γ-Aminobutyric Acid Receptor by the Ubiquitin-specific Protease 14.

Lahaie N, Kralikova M, Prézeau L, Blahos J, Bouvier M.

J Biol Chem. 2016 Mar 25;291(13):7156-70. doi: 10.1074/jbc.M115.686907. Epub 2016 Jan 27.

9.

A Broad G Protein-Coupled Receptor Internalization Assay that Combines SNAP-Tag Labeling, Diffusion-Enhanced Resonance Energy Transfer, and a Highly Emissive Terbium Cryptate.

Levoye A, Zwier JM, Jaracz-Ros A, Klipfel L, Cottet M, Maurel D, Bdioui S, Balabanian K, Prézeau L, Trinquet E, Durroux T, Bachelerie F.

Front Endocrinol (Lausanne). 2015 Nov 9;6:167. doi: 10.3389/fendo.2015.00167. eCollection 2015.

10.

A proteomic analysis reveals the interaction of GluK1 ionotropic kainate receptor subunits with Go proteins.

Rutkowska-Wlodarczyk I, Aller MI, Valbuena S, Bologna JC, Prézeau L, Lerma J.

J Neurosci. 2015 Apr 1;35(13):5171-9. doi: 10.1523/JNEUROSCI.5059-14.2015.

11.

Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma.

Lecointre C, Desrues L, Joubert JE, Perzo N, Guichet PO, Le Joncour V, Brulé C, Chabbert M, Leduc R, Prézeau L, Laquerrière A, Proust F, Gandolfo P, Morin F, Castel H.

Oncogene. 2015 Sep 24;34(39):5080-94. doi: 10.1038/onc.2014.433. Epub 2015 Jan 19.

PMID:
25597409
12.

Biased signaling regulates the pleiotropic effects of the urotensin II receptor to modulate its cellular behaviors.

Brulé C, Perzo N, Joubert JE, Sainsily X, Leduc R, Castel H, Prézeau L.

FASEB J. 2014 Dec;28(12):5148-62. doi: 10.1096/fj.14-249771. Epub 2014 Sep 2.

PMID:
25183668
13.

Metabotropic glutamate receptor 1 splice variants mGluR1a and mGluR1b combine in mGluR1a/b dimers in vivo.

Techlovská Š, Chambers JN, Dvořáková M, Petralia RS, Wang YX, Hájková A, Nová A, Franková D, Prezeau L, Blahos J.

Neuropharmacology. 2014 Nov;86:329-336. doi: 10.1016/j.neuropharm.2014.08.011. Epub 2014 Aug 23.

14.

The chemokine CXC4 and CC2 receptors form homo- and heterooligomers that can engage their signaling G-protein effectors and βarrestin.

Armando S, Quoyer J, Lukashova V, Maiga A, Percherancier Y, Heveker N, Pin JP, Prézeau L, Bouvier M.

FASEB J. 2014 Oct;28(10):4509-23. doi: 10.1096/fj.13-242446. Epub 2014 Jul 22.

PMID:
25053617
15.

Quantitative phosphoproteomics unravels biased phosphorylation of serotonin 2A receptor at Ser280 by hallucinogenic versus nonhallucinogenic agonists.

Karaki S, Becamel C, Murat S, Mannoury la Cour C, Millan MJ, Prézeau L, Bockaert J, Marin P, Vandermoere F.

Mol Cell Proteomics. 2014 May;13(5):1273-85. doi: 10.1074/mcp.M113.036558. Epub 2014 Mar 17.

16.

Further insights into GPR179: expression, localization, and associated pathogenic mechanisms leading to complete congenital stationary night blindness.

Orhan E, Prézeau L, El Shamieh S, Bujakowska KM, Michiels C, Zagar Y, Vol C, Bhattacharya SS, Sahel JA, Sennlaub F, Audo I, Zeitz C.

Invest Ophthalmol Vis Sci. 2013 Dec 9;54(13):8041-50. doi: 10.1167/iovs.13-12610.

PMID:
24222301
17.

Up-regulation of GABA(B) receptor signaling by constitutive assembly with the K+ channel tetramerization domain-containing protein 12 (KCTD12).

Ivankova K, Turecek R, Fritzius T, Seddik R, Prezeau L, Comps-Agrar L, Pin JP, Fakler B, Besseyrias V, Gassmann M, Bettler B.

J Biol Chem. 2013 Aug 23;288(34):24848-56. doi: 10.1074/jbc.M113.476770. Epub 2013 Jul 10.

18.

Time-resolved Förster resonance energy transfer-based technologies to investigate G protein-coupled receptor machinery: high-throughput screening assays and future development.

Scholler P, Zwier JM, Trinquet E, Rondard P, Pin JP, Prézeau L, Kniazeff J.

Prog Mol Biol Transl Sci. 2013;113:275-312. doi: 10.1016/B978-0-12-386932-6.00007-7. Review.

PMID:
23244793
19.

Sequential inter- and intrasubunit rearrangements during activation of dimeric metabotropic glutamate receptor 1.

Hlavackova V, Zabel U, Frankova D, Bätz J, Hoffmann C, Prezeau L, Pin JP, Blahos J, Lohse MJ.

Sci Signal. 2012 Aug 14;5(237):ra59. doi: 10.1126/scisignal.2002720.

20.

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to G protein-coupled receptor oligomerization.

Comps-Agrar L, Maurel D, Rondard P, Pin JP, Trinquet E, Prézeau L.

Methods Mol Biol. 2011;756:201-14. doi: 10.1007/978-1-61779-160-4_10.

PMID:
21870227
21.

The oligomeric state sets GABA(B) receptor signalling efficacy.

Comps-Agrar L, Kniazeff J, Nørskov-Lauritsen L, Maurel D, Gassmann M, Gregor N, Prézeau L, Bettler B, Durroux T, Trinquet E, Pin JP.

EMBO J. 2011 May 6;30(12):2336-49. doi: 10.1038/emboj.2011.143.

22.

Dimers and beyond: The functional puzzles of class C GPCRs.

Kniazeff J, Prézeau L, Rondard P, Pin JP, Goudet C.

Pharmacol Ther. 2011 Apr;130(1):9-25. doi: 10.1016/j.pharmthera.2011.01.006. Epub 2011 Jan 20. Review.

PMID:
21256155
23.

The complexity of their activation mechanism opens new possibilities for the modulation of mGlu and GABAB class C G protein-coupled receptors.

Rondard P, Goudet C, Kniazeff J, Pin JP, Prézeau L.

Neuropharmacology. 2011 Jan;60(1):82-92. doi: 10.1016/j.neuropharm.2010.08.009. Epub 2010 Aug 14. Review.

PMID:
20713070
24.

The vasoactive peptides urotensin II and urotensin II-related peptide regulate astrocyte activity through common and distinct mechanisms: involvement in cell proliferation.

Jarry M, Diallo M, Lecointre C, Desrues L, Tokay T, Chatenet D, Leprince J, Rossi O, Vaudry H, Tonon MC, Prézeau L, Castel H, Gandolfo P.

Biochem J. 2010 Apr 28;428(1):113-24. doi: 10.1042/BJ20090867.

25.

Functional crosstalk between GPCRs: with or without oligomerization.

Prezeau L, Rives ML, Comps-Agrar L, Maurel D, Kniazeff J, Pin JP.

Curr Opin Pharmacol. 2010 Feb;10(1):6-13. doi: 10.1016/j.coph.2009.10.009. Epub 2009 Dec 3. Review.

PMID:
19962942
26.

G-protein-coupled receptor oligomers: two or more for what? Lessons from mGlu and GABAB receptors.

Pin JP, Comps-Agrar L, Maurel D, Monnier C, Rives ML, Trinquet E, Kniazeff J, Rondard P, Prézeau L.

J Physiol. 2009 Nov 15;587(Pt 22):5337-44. doi: 10.1113/jphysiol.2009.179978. Epub 2009 Sep 1. Review.

27.

Crosstalk between GABAB and mGlu1a receptors reveals new insight into GPCR signal integration.

Rives ML, Vol C, Fukazawa Y, Tinel N, Trinquet E, Ayoub MA, Shigemoto R, Pin JP, Prézeau L.

EMBO J. 2009 Aug 5;28(15):2195-208. doi: 10.1038/emboj.2009.177. Epub 2009 Jul 9.

28.

Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells.

Kumpost J, Syrova Z, Kulihova L, Frankova D, Bologna JC, Hlavackova V, Prezeau L, Kralikova M, Hruskova B, Pin JP, Blahos J.

Neuropharmacology. 2008 Sep;55(4):409-18. doi: 10.1016/j.neuropharm.2008.06.073. Epub 2008 Jul 11.

29.

Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization.

Maurel D, Comps-Agrar L, Brock C, Rives ML, Bourrier E, Ayoub MA, Bazin H, Tinel N, Durroux T, Prézeau L, Trinquet E, Pin JP.

Nat Methods. 2008 Jun;5(6):561-7. doi: 10.1038/nmeth.1213. Epub 2008 May 18.

30.

Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective.

Pin JP, Prézeau L.

Curr Neuropharmacol. 2007 Sep;5(3):195-201. doi: 10.2174/157015907781695919.

31.

Common structural requirements for heptahelical domain function in class A and class C G protein-coupled receptors.

Binet V, Duthey B, Lecaillon J, Vol C, Quoyer J, Labesse G, Pin JP, Prézeau L.

J Biol Chem. 2007 Apr 20;282(16):12154-63. Epub 2007 Feb 19.

32.

Real-time analysis of agonist-induced activation of protease-activated receptor 1/Galphai1 protein complex measured by bioluminescence resonance energy transfer in living cells.

Ayoub MA, Maurel D, Binet V, Fink M, Prézeau L, Ansanay H, Pin JP.

Mol Pharmacol. 2007 May;71(5):1329-40. Epub 2007 Jan 31.

33.

Amino-pyrrolidine tricarboxylic acids give new insight into group III metabotropic glutamate receptor activation mechanism.

Frauli M, Hubert N, Schann S, Triballeau N, Bertrand HO, Acher F, Neuville P, Pin JP, Prézeau L.

Mol Pharmacol. 2007 Mar;71(3):704-12. Epub 2006 Dec 13.

34.

Among the twenty classical L-amino acids, only glutamate directly activates metabotropic glutamate receptors.

Frauli M, Neuville P, Vol C, Pin JP, Prézeau L.

Neuropharmacology. 2006 Feb;50(2):245-53. Epub 2005 Nov 28.

PMID:
16310227
35.

Allosteric functioning of dimeric class C G-protein-coupled receptors.

Pin JP, Kniazeff J, Liu J, Binet V, Goudet C, Rondard P, Prézeau L.

FEBS J. 2005 Jun;272(12):2947-55. Review.

36.

Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators.

Goudet C, Kniazeff J, Hlavackova V, Malhaire F, Maurel D, Acher F, Blahos J, Prézeau L, Pin JP.

J Biol Chem. 2005 Jul 1;280(26):24380-5. Epub 2005 Apr 29.

37.

Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR.

Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prézeau L, Pin JP, Blahos J.

EMBO J. 2005 Feb 9;24(3):499-509. Epub 2005 Jan 20.

38.

Molecular mechanisms of GABA(B) receptor activation: new insights from the mechanism of action of CGP7930, a positive allosteric modulator.

Binet V, Goudet C, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L.

Biochem Soc Trans. 2004 Nov;32(Pt 5):871-2. Review.

PMID:
15494037
39.

Activation mechanism of the heterodimeric GABA(B) receptor.

Pin JP, Kniazeff J, Binet V, Liu J, Maurel D, Galvez T, Duthey B, Havlickova M, Blahos J, Prézeau L, Rondard P.

Biochem Pharmacol. 2004 Oct 15;68(8):1565-72.

PMID:
15451400
40.

Closed state of both binding domains of homodimeric mGlu receptors is required for full activity.

Kniazeff J, Bessis AS, Maurel D, Ansanay H, Prézeau L, Pin JP.

Nat Struct Mol Biol. 2004 Aug;11(8):706-13. Epub 2004 Jul 4.

41.

The activation mechanism of class-C G-protein coupled receptors.

Pin JP, Kniazeff J, Goudet C, Bessis AS, Liu J, Galvez T, Acher F, Rondard P, Prézeau L.

Biol Cell. 2004 Jun;96(5):335-42. Review.

PMID:
15207901
42.

The heptahelical domain of GABA(B2) is activated directly by CGP7930, a positive allosteric modulator of the GABA(B) receptor.

Binet V, Brajon C, Le Corre L, Acher F, Pin JP, Prézeau L.

J Biol Chem. 2004 Jul 9;279(28):29085-91. Epub 2004 May 4.

43.

Heptahelical domain of metabotropic glutamate receptor 5 behaves like rhodopsin-like receptors.

Goudet C, Gaven F, Kniazeff J, Vol C, Liu J, Cohen-Gonsaud M, Acher F, Prézeau L, Pin JP.

Proc Natl Acad Sci U S A. 2004 Jan 6;101(1):378-83. Epub 2003 Dec 22.

44.

The second intracellular loop of metabotropic glutamate receptors recognizes C termini of G-protein alpha-subunits.

Havlickova M, Blahos J, Brabet I, Liu J, Hruskova B, Prézeau L, Pin JP.

J Biol Chem. 2003 Sep 12;278(37):35063-70. Epub 2003 Jun 26.

45.

Evolution, structure, and activation mechanism of family 3/C G-protein-coupled receptors.

Pin JP, Galvez T, Prézeau L.

Pharmacol Ther. 2003 Jun;98(3):325-54. Review.

PMID:
12782243
46.

Closure of the Venus flytrap module of mGlu8 receptor and the activation process: Insights from mutations converting antagonists into agonists.

Bessis AS, Rondard P, Gaven F, Brabet I, Triballeau N, Prezeau L, Acher F, Pin JP.

Proc Natl Acad Sci U S A. 2002 Aug 20;99(17):11097-102. Epub 2002 Jul 31.

47.

The intracellular loops of the GB2 subunit are crucial for G-protein coupling of the heteromeric gamma-aminobutyrate B receptor.

Havlickova M, Prezeau L, Duthey B, Bettler B, Pin JP, Blahos J.

Mol Pharmacol. 2002 Aug;62(2):343-50.

48.

A model for the functioning of family 3 GPCRs.

Parmentier ML, Prézeau L, Bockaert J, Pin JP.

Trends Pharmacol Sci. 2002 Jun;23(6):268-74.

PMID:
12084632
49.

A single subunit (GB2) is required for G-protein activation by the heterodimeric GABA(B) receptor.

Duthey B, Caudron S, Perroy J, Bettler B, Fagni L, Pin JP, Prézeau L.

J Biol Chem. 2002 Feb 1;277(5):3236-41. Epub 2001 Nov 15.

50.

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