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Items: 1 to 50 of 252

1.

Effect of the point mutation H54N on the ferroxidase process of Rana catesbeiana H' ferritin.

Pozzi C, Di Pisa F, Lalli D, Rosa C, Turano P, Mangani S.

J Inorg Biochem. 2019 Aug;197:110697. doi: 10.1016/j.jinorgbio.2019.110697. Epub 2019 May 7.

PMID:
31075719
2.

Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS).

Pozzi C, Lopresti L, Tassone G, Mangani S.

Molecules. 2019 Apr 25;24(8). pii: E1638. doi: 10.3390/molecules24081638. Review.

3.

Structural Insights into the Development of Cycloguanil Derivatives as Trypanosoma brucei Pteridine-Reductase-1 Inhibitors.

Landi G, Linciano P, Borsari C, Bertolacini CP, Moraes CB, Cordeiro-da-Silva A, Gul S, Witt G, Kuzikov M, Costi MP, Pozzi C, Mangani S.

ACS Infect Dis. 2019 Jul 12;5(7):1105-1114. doi: 10.1021/acsinfecdis.8b00358. Epub 2019 May 1.

PMID:
31012301
4.

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R.

Pozzi C, Lopresti L, Santucci M, Costi MP, Mangani S.

Biomolecules. 2019 Apr 3;9(4). pii: E134. doi: 10.3390/biom9040134.

5.

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors.

Pozzi C, Ferrari S, Luciani R, Costi MP, Mangani S.

Molecules. 2019 Apr 7;24(7). pii: E1362. doi: 10.3390/molecules24071362.

6.

Metagenomic analysis of colorectal cancer datasets identifies cross-cohort microbial diagnostic signatures and a link with choline degradation.

Thomas AM, Manghi P, Asnicar F, Pasolli E, Armanini F, Zolfo M, Beghini F, Manara S, Karcher N, Pozzi C, Gandini S, Serrano D, Tarallo S, Francavilla A, Gallo G, Trompetto M, Ferrero G, Mizutani S, Shiroma H, Shiba S, Shibata T, Yachida S, Yamada T, Wirbel J, Schrotz-King P, Ulrich CM, Brenner H, Arumugam M, Bork P, Zeller G, Cordero F, Dias-Neto E, Setubal JC, Tett A, Pardini B, Rescigno M, Waldron L, Naccarati A, Segata N.

Nat Med. 2019 Apr;25(4):667-678. doi: 10.1038/s41591-019-0405-7. Epub 2019 Apr 1.

PMID:
30936548
7.

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities.

Pozzi C, Ferrari S, Luciani R, Tassone G, Costi MP, Mangani S.

Molecules. 2019 Mar 31;24(7). pii: E1257. doi: 10.3390/molecules24071257.

8.

Enhancement of Benzothiazoles as Pteridine Reductase-1 Inhibitors for the Treatment of Trypanosomatidic Infections.

Linciano P, Pozzi C, Iacono LD, di Pisa F, Landi G, Bonucci A, Gul S, Kuzikov M, Ellinger B, Witt G, Santarem N, Baptista C, Franco C, Moraes CB, Müller W, Wittig U, Luciani R, Sesenna A, Quotadamo A, Ferrari S, Pöhner I, Cordeiro-da-Silva A, Mangani S, Costantino L, Costi MP.

J Med Chem. 2019 Apr 25;62(8):3989-4012. doi: 10.1021/acs.jmedchem.8b02021. Epub 2019 Apr 9.

PMID:
30908048
9.

The association of HLA-G polymorphisms and the synergistic effect of sMICA and sHLA-G with chronic kidney disease and allograft acceptance.

Hauer V, Risti M, Miranda BLM, da Silva JS, Cidral AL, Pozzi CM, Contieri FLC, Sadissou IA, Donadi EA, Augusto DG, Bicalho MDG.

PLoS One. 2019 Feb 22;14(2):e0212750. doi: 10.1371/journal.pone.0212750. eCollection 2019.

10.

Association between delirium, adverse clinical events and functional outcomes in older patients admitted to rehabilitation settings after a hip fracture: A multicenter retrospective cohort study.

Morandi A, Mazzone A, Bernardini B, Suardi T, Prina R, Pozzi C, Gentile S, Trabucchi M, Bellelli G.

Geriatr Gerontol Int. 2019 May;19(5):404-408. doi: 10.1111/ggi.13628. Epub 2019 Feb 20.

PMID:
30788897
11.

Accelerating Drug Discovery Efforts for Trypanosomatidic Infections Using an Integrated Transnational Academic Drug Discovery Platform.

Moraes CB, Witt G, Kuzikov M, Ellinger B, Calogeropoulou T, Prousis KC, Mangani S, Di Pisa F, Landi G, Iacono LD, Pozzi C, Freitas-Junior LH, Dos Santos Pascoalino B, Bertolacini CP, Behrens B, Keminer O, Leu J, Wolf M, Reinshagen J, Cordeiro-da-Silva A, Santarem N, Venturelli A, Wrigley S, Karunakaran D, Kebede B, Pöhner I, Müller W, Panecka-Hofman J, Wade RC, Fenske M, Clos J, Alunda JM, Corral MJ, Uliassi E, Bolognesi ML, Linciano P, Quotadamo A, Ferrari S, Santucci M, Borsari C, Costi MP, Gul S.

SLAS Discov. 2019 Mar;24(3):346-361. doi: 10.1177/2472555218823171.

12.

Radium-223 in patients with metastatic castration-resistant prostate cancer: Efficacy and safety in clinical practice.

Prelaj A, Rebuzzi SE, Buzzacchino F, Pozzi C, Ferrara C, Frantellizzi V, Follacchio GA, Civitelli L, De Vincentis G, Tomao S, Bianco V.

Oncol Lett. 2019 Feb;17(2):1467-1476. doi: 10.3892/ol.2018.9785. Epub 2018 Nov 30.

13.

A pilot study of community-based occupational therapy for persons with dementia (COTID-IT Program) and their caregivers: evidence for applicability in Italy.

Pozzi C, Lanzoni A, Lucchi E, Bergamini L, Bevilacqua P, Manni B, Garzetta G, Barbieri S, Khazri S, Chattat R, Graff M, Fabbo A, Morandi A.

Aging Clin Exp Res. 2018 Nov 28. doi: 10.1007/s40520-018-1078-7. [Epub ahead of print]

PMID:
30488182
14.

SAR Studies Leading to the Identification of a Novel Series of Metallo-β-lactamase Inhibitors for the Treatment of Carbapenem-Resistant Enterobacteriaceae Infections That Display Efficacy in an Animal Infection Model.

Leiris S, Coelho A, Castandet J, Bayet M, Lozano C, Bougnon J, Bousquet J, Everett M, Lemonnier M, Sprynski N, Zalacain M, Pallin TD, Cramp MC, Jennings N, Raphy G, Jones MW, Pattipati R, Shankar B, Sivasubrahmanyam R, Soodhagani AK, Juventhala RR, Pottabathini N, Pothukanuri S, Benvenuti M, Pozzi C, Mangani S, De Luca F, Cerboni G, Docquier JD, Davies DT.

ACS Infect Dis. 2019 Jan 11;5(1):131-140. doi: 10.1021/acsinfecdis.8b00246. Epub 2018 Nov 30.

15.

Probing the role of Arg97 in Heat shock protein 90 N-terminal domain from the parasite Leishmania braziliensis through site-directed mutagenesis on the human counterpart.

Tassone G, Mangani S, Botta M, Pozzi C.

Biochim Biophys Acta Proteins Proteom. 2018 Nov;1866(11):1190-1198. doi: 10.1016/j.bbapap.2018.09.005. Epub 2018 Sep 21.

PMID:
30248409
16.

The structure of the human glutaminyl cyclase-SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders.

Pozzi C, Di Pisa F, Benvenuti M, Mangani S.

J Biol Inorg Chem. 2018 Dec;23(8):1219-1226. doi: 10.1007/s00775-018-1605-1. Epub 2018 Aug 21.

PMID:
30132075
17.

Atomic-Resolution Structure of a Class C β-Lactamase and Its Complex with Avibactam.

Pozzi C, Di Pisa F, De Luca F, Benvenuti M, Docquier JD, Mangani S.

ChemMedChem. 2018 Jul 18;13(14):1437-1446. doi: 10.1002/cmdc.201800213. Epub 2018 Jun 20.

PMID:
29786960
18.

Human Thymidylate Synthase Inhibitors Halting Ovarian Cancer Growth.

Ferrari S, Severi L, Pozzi C, Quotadamo A, Ponterini G, Losi L, Marverti G, Costi MP.

Vitam Horm. 2018;107:473-513. doi: 10.1016/bs.vh.2017.12.002. Epub 2018 Feb 12. Review.

PMID:
29544641
19.

Evaluation of Real Time PCR Aspergillus spp. in bronchoalveolar lavage samples.

Grancini A, Orlandi A, Lunghi G, Consonni D, Pozzi C, Rossetti V, Palleschi A, Fracchiolla N, Melada E, Savioli M, Arghittu M, Maiavacca R, Prigitano A.

New Microbiol. 2018 Jan;41(1):67-70.

20.

In Silico Identification and In Vitro Evaluation of Natural Inhibitors of Leishmania major Pteridine Reductase I.

Herrmann FC, Sivakumar N, Jose J, Costi MP, Pozzi C, Schmidt TJ.

Molecules. 2017 Dec 6;22(12). pii: E2166. doi: 10.3390/molecules22122166.

21.

Preliminary Evidence of a Positive Effect of Occupational Therapy in Patients With Delirium Superimposed on Dementia.

Pozzi C, Lucchi E, Lanzoni A, Gentile S, Trabucchi M, Bellelli G, Morandi A.

J Am Med Dir Assoc. 2017 Dec 1;18(12):1091-1092. doi: 10.1016/j.jamda.2017.09.005. Epub 2017 Oct 15. No abstract available.

PMID:
29042265
22.

Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery.

Linciano P, Dawson A, Pöhner I, Costa DM, Sá MS, Cordeiro-da-Silva A, Luciani R, Gul S, Witt G, Ellinger B, Kuzikov M, Gribbon P, Reinshagen J, Wolf M, Behrens B, Hannaert V, Michels PAM, Nerini E, Pozzi C, di Pisa F, Landi G, Santarem N, Ferrari S, Saxena P, Lazzari S, Cannazza G, Freitas-Junior LH, Moraes CB, Pascoalino BS, Alcântara LM, Bertolacini CP, Fontana V, Wittig U, Müller W, Wade RC, Hunter WN, Mangani S, Costantino L, Costi MP.

ACS Omega. 2017 Sep 30;2(9):5666-5683. doi: 10.1021/acsomega.7b00473. Epub 2017 Sep 11.

23.

Why older people stop to drive? A cohort study of older patients admitted to a rehabilitation setting.

Pozzi C, Lucchi E, Lanzoni A, Gentile S, Morghen S, Trabucchi M, Bellelli G, Morandi A.

Aging Clin Exp Res. 2018 May;30(5):543-546. doi: 10.1007/s40520-017-0804-x. Epub 2017 Aug 8.

PMID:
28791624
24.

Sudden Death in End Stage Renal Disease: Comparing Hemodialysis versus Peritoneal Dialysis.

Genovesi S, Porcu L, Luise MC, Riva H, Nava E, Contaldo G, Stella A, Pozzi C, Ondei P, Minoretti C, Gallieni M, Pontoriero G, Conte F, Torri V, Bertoli S, Vincenti A.

Blood Purif. 2017;44(1):77-88. doi: 10.1159/000464347. Epub 2017 Apr 1.

25.

Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity.

Di Pisa F, Landi G, Dello Iacono L, Pozzi C, Borsari C, Ferrari S, Santucci M, Santarem N, Cordeiro-da-Silva A, Moraes CB, Alcantara LM, Fontana V, Freitas-Junior LH, Gul S, Kuzikov M, Behrens B, Pöhner I, Wade RC, Costi MP, Mangani S.

Molecules. 2017 Mar 8;22(3). pii: E426. doi: 10.3390/molecules22030426.

26.

Chemistry at the protein-mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo)Tris[(μ2-peroxo)] triiron(III) cluster.

Pozzi C, Ciambellotti S, Bernacchioni C, Di Pisa F, Mangani S, Turano P.

Proc Natl Acad Sci U S A. 2017 Mar 7;114(10):2580-2585. doi: 10.1073/pnas.1614302114. Epub 2017 Feb 15.

27.

Vaccines for Staphylococcus aureus and Target Populations.

Pozzi C, Olaniyi R, Liljeroos L, Galgani I, Rappuoli R, Bagnoli F.

Curr Top Microbiol Immunol. 2017;409:491-528. doi: 10.1007/82_2016_54.

PMID:
28197738
28.

Mycoplasma hominis Induces Mediastinitis after a Tonsillar Abscess.

Grancini A, Colosimo M, Restelli A, Colombo R, Maraschini A, Pozzi C, Breda G, Protti A, Arghittu M, Gallelli L, Maiavacca R.

Case Rep Infect Dis. 2016;2016:9531715. Epub 2016 Nov 10.

29.

Effect of oral anticoagulant therapy on mortality in end-stage renal disease patients with atrial fibrillation: a prospective study.

Genovesi S, Rebora P, Gallieni M, Stella A, Badiali F, Conte F, Pasquali S, Bertoli S, Ondei P, Bonforte G, Pozzi C, Rossi E, Valsecchi MG, Santoro A.

J Nephrol. 2017 Aug;30(4):573-581. doi: 10.1007/s40620-016-0364-8. Epub 2016 Nov 11.

30.

Opponent's comments.

Pozzi C.

Nephrol Dial Transplant. 2016 Nov;31(11):1775-1776. No abstract available.

PMID:
27807128
31.

Pro: STOP immunosuppression in IgA nephropathy?

Pozzi C.

Nephrol Dial Transplant. 2016 Nov;31(11):1766-1770. Epub 2016 Aug 11.

PMID:
27515694
32.

Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory-Iron-Binding Sites in the Catalytic Cavity.

Bernacchioni C, Pozzi C, Di Pisa F, Mangani S, Turano P.

Chemistry. 2016 Nov 2;22(45):16213-16219. doi: 10.1002/chem.201602842. Epub 2016 Sep 21.

PMID:
27650996
33.

Staphylococcus aureus-Associated Skin and Soft Tissue Infections: Anatomical Localization, Epidemiology, Therapy and Potential Prophylaxis.

Olaniyi R, Pozzi C, Grimaldi L, Bagnoli F.

Curr Top Microbiol Immunol. 2017;409:199-227. doi: 10.1007/82_2016_32.

PMID:
27744506
34.

Crystal Structure of the Pseudomonas aeruginosa BEL-1 Extended-Spectrum β-Lactamase and Its Complexes with Moxalactam and Imipenem.

Pozzi C, De Luca F, Benvenuti M, Poirel L, Nordmann P, Rossolini GM, Mangani S, Docquier JD.

Antimicrob Agents Chemother. 2016 Nov 21;60(12):7189-7199. Print 2016 Dec.

35.

X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors.

Catalano A, Luciani R, Carocci A, Cortesi D, Pozzi C, Borsari C, Ferrari S, Mangani S.

Eur J Med Chem. 2016 Nov 10;123:649-664. doi: 10.1016/j.ejmech.2016.07.066. Epub 2016 Jul 29.

PMID:
27517810
36.

Corticosteroid Treatment Influences TA-Proteinuria and Renal Survival in IgA Nephropathy.

Sarcina C, Tinelli C, Ferrario F, Visciano B, Pani A, De Silvestri A, De Simone I, Del Vecchio L, Terraneo V, Furiani S, Santagostino G, Corghi E, Pozzi C.

PLoS One. 2016 Jul 14;11(7):e0158584. doi: 10.1371/journal.pone.0158584. eCollection 2016.

37.

Profiling of Flavonol Derivatives for the Development of Antitrypanosomatidic Drugs.

Borsari C, Luciani R, Pozzi C, Poehner I, Henrich S, Trande M, Cordeiro-da-Silva A, Santarem N, Baptista C, Tait A, Di Pisa F, Dello Iacono L, Landi G, Gul S, Wolf M, Kuzikov M, Ellinger B, Reinshagen J, Witt G, Gribbon P, Kohler M, Keminer O, Behrens B, Costantino L, Tejera Nevado P, Bifeld E, Eick J, Clos J, Torrado J, Jiménez-Antón MD, Corral MJ, Alunda JM, Pellati F, Wade RC, Ferrari S, Mangani S, Costi MP.

J Med Chem. 2016 Aug 25;59(16):7598-616. doi: 10.1021/acs.jmedchem.6b00698. Epub 2016 Aug 5.

PMID:
27411733
38.

The EGFR-specific antibody cetuximab combined with chemotherapy triggers immunogenic cell death.

Pozzi C, Cuomo A, Spadoni I, Magni E, Silvola A, Conte A, Sigismund S, Ravenda PS, Bonaldi T, Zampino MG, Cancelliere C, Di Fiore PP, Bardelli A, Penna G, Rescigno M.

Nat Med. 2016 Jun;22(6):624-31. doi: 10.1038/nm.4078. Epub 2016 May 2.

PMID:
27135741
39.

Changes in Proteinuria and Side Effects of Corticosteroids Alone or in Combination with Azathioprine at Different Stages of IgA Nephropathy.

Sarcina C, Tinelli C, Ferrario F, Pani A, De Silvestri A, Scaini P, Del Vecchio L, Alberghini E, Buzzi L, Baragetti I, Pozzi C.

Clin J Am Soc Nephrol. 2016 Jun 6;11(6):973-81. doi: 10.2215/CJN.02300215. Epub 2016 Apr 29. Erratum in: Clin J Am Soc Nephrol. 2016 Sep 7;11(9):1721.

40.

Auto-Assembling Detoxified Staphylococcus aureus Alpha-Hemolysin Mimicking the Wild-Type Cytolytic Toxin.

Fiaschi L, Di Palo B, Scarselli M, Pozzi C, Tomaszewski K, Galletti B, Nardi-Dei V, Arcidiacono L, Mishra RP, Mori E, Pallaoro M, Falugi F, Torre A, Fontana MR, Soriani M, Bubeck Wardenburg J, Grandi G, Rappuoli R, Ferlenghi I, Bagnoli F.

Clin Vaccine Immunol. 2016 Jun 6;23(6):442-50. doi: 10.1128/CVI.00091-16. Print 2016 Jun.

41.

Staphylococcus aureus coagulase R domain, a new evasion mechanism and vaccine target.

Pozzi C, Bagnoli F, Rappuoli R.

J Exp Med. 2016 Mar 7;213(3):292. doi: 10.1084/jem.2133insight1. No abstract available.

42.

Treatment of IgA nephropathy with renal insufficiency.

Pozzi C, Sarcina C, Ferrario F.

J Nephrol. 2016 Aug;29(4):551-8. doi: 10.1007/s40620-015-0257-2. Epub 2016 Jan 7. Review.

PMID:
26743078
43.

Impact of European medicines agency recommendations for hypersensitivity reactions on intravenous iron prescription in haemodialysis centres of the Lombardy region.

Rivera RF, Guido D, Del Vecchio L, Corghi E, D'Amico M, Camerini C, Spotti D, Galassi A, Pozzi C, Cancarini G, Pontoriero G, Locatelli F.

J Nephrol. 2016 Oct;29(5):673-81. doi: 10.1007/s40620-015-0254-5. Epub 2015 Dec 29.

PMID:
26715394
44.

Treatment of IgA nephropathy.

Pozzi C.

J Nephrol. 2016 Feb;29(1):21-5. doi: 10.1007/s40620-015-0248-3. Epub 2015 Nov 17. Review.

PMID:
26577268
45.

Iron binding to human heavy-chain ferritin.

Pozzi C, Di Pisa F, Bernacchioni C, Ciambellotti S, Turano P, Mangani S.

Acta Crystallogr D Biol Crystallogr. 2015 Sep;71(Pt 9):1909-20. doi: 10.1107/S1399004715013073. Epub 2015 Aug 25.

PMID:
26327381
46.

The soluble Y115E-Y117E variant of human glutaminyl cyclase is a valid target for X-ray and NMR screening of inhibitors against Alzheimer disease.

DiPisa F, Pozzi C, Benvenuti M, Andreini M, Marconi G, Mangani S.

Acta Crystallogr F Struct Biol Commun. 2015 Aug;71(Pt 8):986-92. doi: 10.1107/S2053230X15010389. Epub 2015 Jul 28.

47.

The Genetic Basis of Composite Spike Form in Barley and 'Miracle-Wheat'.

Poursarebani N, Seidensticker T, Koppolu R, Trautewig C, Gawroński P, Bini F, Govind G, Rutten T, Sakuma S, Tagiri A, Wolde GM, Youssef HM, Battal A, Ciannamea S, Fusca T, Nussbaumer T, Pozzi C, Börner A, Lundqvist U, Komatsuda T, Salvi S, Tuberosa R, Uauy C, Sreenivasulu N, Rossini L, Schnurbusch T.

Genetics. 2015 Sep;201(1):155-65. doi: 10.1534/genetics.115.176628. Epub 2015 Jul 7.

48.

Phagocyte subsets and lymphocyte clonal deletion behind ineffective immune response to Staphylococcus aureus.

Pozzi C, Lofano G, Mancini F, Soldaini E, Speziale P, De Gregorio E, Rappuoli R, Bertholet S, Grandi G, Bagnoli F.

FEMS Microbiol Rev. 2015 Sep;39(5):750-63. doi: 10.1093/femsre/fuv024. Epub 2015 May 19. Review.

PMID:
25994610
49.

Time-lapse anomalous X-ray diffraction shows how Fe(2+) substrate ions move through ferritin protein nanocages to oxidoreductase sites.

Pozzi C, Di Pisa F, Lalli D, Rosa C, Theil E, Turano P, Mangani S.

Acta Crystallogr D Biol Crystallogr. 2015 Apr;71(Pt 4):941-53. doi: 10.1107/S1399004715002333. Epub 2015 Mar 27.

50.

Mortality, sudden death and indication for cardioverter defibrillator implantation in a dialysis population.

Genovesi S, Porcu L, Luise MC, Riva H, Nava E, Stella A, Pozzi C, Ondei P, Minoretti C, Gallieni M, Pontoriero G, Conte F, Torri V, Vincenti A.

Int J Cardiol. 2015;186:170-7. doi: 10.1016/j.ijcard.2015.03.178. Epub 2015 Mar 17.

PMID:
25819895

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