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Multiple clinically relevant immunotherapies prolong the function of microencapsulated porcine islet xenografts in diabetic NOD mice without the use of anti-CD154 mAb.

Safley SA, Barber GF, Holdcraft RW, Gazda LS, Duncanson S, Poznansky MC, Sambanis A, Weber CJ.

Xenotransplantation. 2020 Jan 6:e12577. doi: 10.1111/xen.12577. [Epub ahead of print]


Coxiella burnetii Epitope-Specific T-Cell Responses in Patients with Chronic Q Fever.

Scholzen A, Richard G, Moise L, Hartman E, Bleeker-Rovers CP, Reeves PM, Raju Paul S, Martin WD, De Groot AS, Poznansky MC, Sluder AE, Garritsen A.

Infect Immun. 2019 Sep 19;87(10). pii: e00213-19. doi: 10.1128/IAI.00213-19. Print 2019 Oct.


CD90low MSCs modulate intratumoral immunity to confer antitumor activity in a mouse model of ovarian cancer.

Zeng Y, Li B, Li T, Liu W, Ran C, Penson RT, Poznansky MC, Du Y, Chen H.

Oncotarget. 2019 Jul 8;10(43):4479-4491. doi: 10.18632/oncotarget.27065. eCollection 2019 Jul 8.


Preliminary Studies of the Impact of CXCL12 on the Foreign Body Reaction to Pancreatic Islets Microencapsulated in Alginate in Nonhuman Primates.

Sremac M, Lei J, Penson MFE, Schuetz C, Lakey JRT, Papas KK, Varde PS, Hering B, de Vos P, Brauns T, Markmann J, Poznansky MC.

Transplant Direct. 2019 Apr 15;5(5):e447. doi: 10.1097/TXD.0000000000000890. eCollection 2019 May. Erratum in: Transplant Direct. 2019 Jun 21;5(7):e471.


Intraparenchymal Application of Mature B Lymphocytes Improves Structural and Functional Outcome after Contusion Traumatic Brain Injury.

Sîrbulescu RF, Chung JY, Edmiston WJ , III, Poznansky SA, Poznansky MC, Whalen MJ.

J Neurotrauma. 2019 Sep 1;36(17):2579-2589. doi: 10.1089/neu.2018.6368. Epub 2019 May 23.


Promiscuous Coxiella burnetii CD4 Epitope Clusters Associated With Human Recall Responses Are Candidates for a Novel T-Cell Targeted Multi-Epitope Q Fever Vaccine.

Scholzen A, Richard G, Moise L, Baeten LA, Reeves PM, Martin WD, Brauns TA, Boyle CM, Raju Paul S, Bucala R, Bowen RA, Garritsen A, De Groot AS, Sluder AE, Poznansky MC.

Front Immunol. 2019 Feb 15;10:207. doi: 10.3389/fimmu.2019.00207. eCollection 2019.


Dual blockade of CXCL12-CXCR4 and PD-1-PD-L1 pathways prolongs survival of ovarian tumor-bearing mice by prevention of immunosuppression in the tumor microenvironment.

Zeng Y, Li B, Liang Y, Reeves PM, Qu X, Ran C, Liu Q, Callahan MV, Sluder AE, Gelfand JA, Chen H, Poznansky MC.

FASEB J. 2019 May;33(5):6596-6608. doi: 10.1096/fj.201802067RR. Epub 2019 Feb 25.


Alginate-microencapsulation of human stem cell-derived β cells with CXCL12 prolongs their survival and function in immunocompetent mice without systemic immunosuppression.

Alagpulinsa DA, Cao JJL, Driscoll RK, Sîrbulescu RF, Penson MFE, Sremac M, Engquist EN, Brauns TA, Markmann JF, Melton DA, Poznansky MC.

Am J Transplant. 2019 Jul;19(7):1930-1940. doi: 10.1111/ajt.15308. Epub 2019 Mar 25.


Brief Exposure of Skin to Near-Infrared Laser Modulates Mast Cell Function and Augments the Immune Response.

Kimizuka Y, Katagiri W, Locascio JJ, Shigeta A, Sasaki Y, Shibata M, Morse K, Sîrbulescu RF, Miyatake M, Reeves P, Suematsu M, Gelfand J, Brauns T, Poznansky MC, Tsukada K, Kashiwagi S.

J Immunol. 2018 Dec 15;201(12):3587-3603. doi: 10.4049/jimmunol.1701687. Epub 2018 Nov 12.


Standardized guinea pig model for Q fever vaccine reactogenicity.

Baeten LA, Podell BK, Sluder AE, Garritsen A, Bowen RA, Poznansky MC.

PLoS One. 2018 Oct 12;13(10):e0205882. doi: 10.1371/journal.pone.0205882. eCollection 2018.


A pilot clinical trial of a near-infrared laser vaccine adjuvant: safety, tolerability, and cutaneous immune cell trafficking.

Gelfand JA, Nazarian RM, Kashiwagi S, Brauns T, Martin B, Kimizuka Y, Korek S, Botvinick E, Elkins K, Thomas L, Locascio J, Parry B, Kelly KM, Poznansky MC.

FASEB J. 2019 Feb;33(2):3074-3081. doi: 10.1096/fj.201801095R. Epub 2018 Sep 7.


Harnessing CXCL12 signaling to protect and preserve functional β-cell mass and for cell replacement in type 1 diabetes.

Alagpulinsa DA, Cao JJL, Sobell D, Poznansky MC.

Pharmacol Ther. 2019 Jan;193:63-74. doi: 10.1016/j.pharmthera.2018.08.011. Epub 2018 Aug 24. Review.


Correction: Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice.

Reeves PM, Abbaslou MA, Kools FRW, Vutipongsatorn K, Tong X, Gavegnano C, Schinazi RF, Poznansky MC.

Oncotarget. 2018 Jul 13;9(54):30472. doi: 10.18632/oncotarget.25791. eCollection 2018 Jul 13.


Epigenetic Regulation of CXCL12 Plays a Critical Role in Mediating Tumor Progression and the Immune Response In Osteosarcoma.

Li B, Wang Z, Wu H, Xue M, Lin P, Wang S, Lin N, Huang X, Pan W, Liu M, Yan X, Qu H, Sun L, Li H, Wu Y, Teng W, Wang Z, Zhou X, Chen H, Poznansky MC, Ye Z.

Cancer Res. 2018 Jul 15;78(14):3938-3953. doi: 10.1158/0008-5472.CAN-17-3801. Epub 2018 May 7.


AMD3100 Augments the Efficacy of Mesothelin-Targeted, Immune-Activating VIC-008 in Mesothelioma by Modulating Intratumoral Immunosuppression.

Li B, Zeng Y, Reeves PM, Ran C, Liu Q, Qu X, Liang Y, Liu Z, Yuan J, Leblanc PR, Ye Z, Sluder AE, Gelfand JA, Brauns TA, Chen H, Poznansky MC.

Cancer Immunol Res. 2018 May;6(5):539-551. doi: 10.1158/2326-6066.CIR-17-0530. Epub 2018 Mar 6.


Ruxolitinib sensitizes ovarian cancer to reduced dose Taxol, limits tumor growth and improves survival in immune competent mice.

Reeves PM, Abbaslou MA, Kools FRW, Vutipongsatorn K, Tong X, Gavegnano C, Schinazi RF, Poznansky MC.

Oncotarget. 2017 Oct 4;8(55):94040-94053. doi: 10.18632/oncotarget.21541. eCollection 2017 Nov 7. Erratum in: Oncotarget. 2018 Jul 13;9(54):30472. Gavegano, Christina [corrected to Gavegnano, Christina].


Application and utility of mass cytometry in vaccine development.

Reeves PM, Sluder AE, Paul SR, Scholzen A, Kashiwagi S, Poznansky MC.

FASEB J. 2018 Jan;32(1):5-15. doi: 10.1096/fj.201700325R. Epub 2017 Nov 1. Review.


PD-1 Expression in Head and Neck Squamous Cell Carcinomas Derives Primarily from Functionally Anergic CD4+ TILs in the Presence of PD-L1+ TAMs.

Mattox AK, Lee J, Westra WH, Pierce RH, Ghossein R, Faquin WC, Diefenbach TJ, Morris LG, Lin DT, Wirth LJ, Lefranc-Torres A, Ishida E, Chakravarty PD, Johnson L, Zeng YC, Chen H, Poznansky MC, Iyengar NM, Pai SI.

Cancer Res. 2017 Nov 15;77(22):6365-6374. doi: 10.1158/0008-5472.CAN-16-3453. Epub 2017 Sep 25.


Q-vaxcelerate: A distributed development approach for a new Coxiella burnetii vaccine.

Reeves PM, Paul SR, Sluder AE, Brauns TA, Poznansky MC.

Hum Vaccin Immunother. 2017 Dec 2;13(12):2977-2981. doi: 10.1080/21645515.2017.1371377. Epub 2017 Sep 21. Review.


Mature B cells accelerate wound healing after acute and chronic diabetic skin lesions.

Sîrbulescu RF, Boehm CK, Soon E, Wilks MQ, Ilieş I, Yuan H, Maxner B, Chronos N, Kaittanis C, Normandin MD, El Fakhri G, Orgill DP, Sluder AE, Poznansky MC.

Wound Repair Regen. 2017 Sep;25(5):774-791. doi: 10.1111/wrr.12584. Epub 2017 Oct 17.


CXCR4 blockade with AMD3100 enhances Taxol chemotherapy to limit ovarian cancer cell growth.

Reeves PM, Abbaslou MA, Kools FRW, Poznansky MC.

Anticancer Drugs. 2017 Oct;28(9):935-942. doi: 10.1097/CAD.0000000000000518.


Near-Infrared 1064 nm Laser Modulates Migratory Dendritic Cells To Augment the Immune Response to Intradermal Influenza Vaccine.

Morse K, Kimizuka Y, Chan MPK, Shibata M, Shimaoka Y, Takeuchi S, Forbes B, Nirschl C, Li B, Zeng Y, Bronson RT, Katagiri W, Shigeta A, Sîrbulescu RF, Chen H, Tan RYY, Tsukada K, Brauns T, Gelfand J, Sluder A, Locascio JJ, Poznansky MC, Anandasabapathy N, Kashiwagi S.

J Immunol. 2017 Aug 15;199(4):1319-1332. doi: 10.4049/jimmunol.1601873. Epub 2017 Jul 14.


Semiconductor diode laser device adjuvanting intradermal vaccine.

Kimizuka Y, Callahan JJ, Huang Z, Morse K, Katagiri W, Shigeta A, Bronson R, Takeuchi S, Shimaoka Y, Chan MPK, Zeng Y, Li B, Chen H, Tan RYY, Dwyer C, Mulley T, Leblanc P, Goudie C, Gelfand J, Tsukada K, Brauns T, Poznansky MC, Bean D, Kashiwagi S.

Vaccine. 2017 Apr 25;35(18):2404-2412. doi: 10.1016/j.vaccine.2017.03.036. Epub 2017 Mar 30.


Biomechanically primed liver microtumor array as a high-throughput mechanopharmacological screening platform for stroma-reprogrammed combinatorial therapy.

Zhu L, Fan X, Wang B, Liu L, Yan X, Zhou L, Zeng Y, Poznansky MC, Wang L, Chen H, Du Y.

Biomaterials. 2017 Apr;124:12-24. doi: 10.1016/j.biomaterials.2017.01.030. Epub 2017 Jan 27.


Adult-Onset Still's Disease: Still a Serious Health Problem (a Case Report and Literature Review).

Agha-Abbaslou M, Bensaci AM, Dike O, Poznansky MC, Hyat A.

Am J Case Rep. 2017 Feb 3;18:119-124. Review.


Classification of Laser Vaccine Adjuvants.

Kashiwagi S, Brauns T, Poznansky MC.

J Vaccines Vaccin. 2016 Feb;7(1). pii: 307. Epub 2016 Feb 12.


A Critical Reappraisal of Prolonged Neutropenia as a Risk Factor for Invasive Pulmonary Aspergillosis.

Abers MS, Ghebremichael MS, Timmons AK, Warren HS, Poznansky MC, Vyas JM.

Open Forum Infect Dis. 2016 Feb 12;3(1):ofw036. doi: 10.1093/ofid/ofw036. eCollection 2016 Jan.


Human Neutrophils Are Primed by Chemoattractant Gradients for Blocking the Growth of Aspergillus fumigatus.

Jones CN, Dimisko L, Forrest K, Judice K, Poznansky MC, Markmann JF, Vyas JM, Irimia D.

J Infect Dis. 2016 Feb 1;213(3):465-75. doi: 10.1093/infdis/jiv419. Epub 2015 Aug 12.


Alginate encapsulant incorporating CXCL12 supports long-term allo- and xenoislet transplantation without systemic immune suppression.

Chen T, Yuan J, Duncanson S, Hibert ML, Kodish BC, Mylavaganam G, Maker M, Li H, Sremac M, Santosuosso M, Forbes B, Kashiwagi S, Cao J, Lei J, Thomas M, Hartono C, Sachs D, Markmann J, Sambanis A, Poznansky MC.

Am J Transplant. 2015 Mar;15(3):618-27. doi: 10.1111/ajt.13049.


VaxCelerate II: rapid development of a self-assembling vaccine for Lassa fever.

Leblanc P, Moise L, Luza C, Chantaralawan K, Lezeau L, Yuan J, Field M, Richer D, Boyle C, Martin WD, Fishman JB, Berg EA, Baker D, Zeigler B, Mais DE, Taylor W, Coleman R, Warren HS, Gelfand JA, De Groot AS, Brauns T, Poznansky MC.

Hum Vaccin Immunother. 2014;10(10):3022-38. doi: 10.4161/hv.34413. Review.


Laser vaccine adjuvants. History, progress, and potential.

Kashiwagi S, Brauns T, Gelfand J, Poznansky MC.

Hum Vaccin Immunother. 2014;10(7):1892-907. doi: 10.4161/hv.28840. Review.


A novel mycobacterial Hsp70-containing fusion protein targeting mesothelin augments antitumor immunity and prolongs survival in murine models of ovarian cancer and mesothelioma.

Yuan J, Kashiwagi S, Reeves P, Nezivar J, Yang Y, Arrifin NH, Nguyen M, Jean-Mary G, Tong X, Uppal P, Korochkina S, Forbes B, Chen T, Righi E, Bronson R, Chen H, Orsulic S, Brauns T, Leblanc P, Scholler N, Dranoff G, Gelfand J, Poznansky MC.

J Hematol Oncol. 2014 Feb 24;7:15. doi: 10.1186/1756-8722-7-15.


Near-infrared laser adjuvant for influenza vaccine.

Kashiwagi S, Yuan J, Forbes B, Hibert ML, Lee EL, Whicher L, Goudie C, Yang Y, Chen T, Edelblute B, Collette B, Edington L, Trussler J, Nezivar J, Leblanc P, Bronson R, Tsukada K, Suematsu M, Dover J, Brauns T, Gelfand J, Poznansky MC.

PLoS One. 2013 Dec 11;8(12):e82899. doi: 10.1371/journal.pone.0082899. eCollection 2013.


Vascular normalizing doses of antiangiogenic treatment reprogram the immunosuppressive tumor microenvironment and enhance immunotherapy.

Huang Y, Yuan J, Righi E, Kamoun WS, Ancukiewicz M, Nezivar J, Santosuosso M, Martin JD, Martin MR, Vianello F, Leblanc P, Munn LL, Huang P, Duda DG, Fukumura D, Jain RK, Poznansky MC.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17561-6. doi: 10.1073/pnas.1215397109. Epub 2012 Oct 8.


Accelerated vaccine development against emerging infectious diseases.

Leblanc PR, Yuan J, Brauns T, Gelfand JA, Poznansky MC.

Hum Vaccin Immunother. 2012 Jul;8(7):1010-2. doi: 10.4161/hv.20805. Epub 2012 Jul 1.


Vaccination of oncology patients: an effective tool and an opportunity not to be missed.

Kotton CN, Poznansky MC.

Oncologist. 2012;17(1):1-2. doi: 10.1634/theoncologist.2011-0383. Epub 2012 Jan 12. No abstract available.


CXCL12/CXCR4 blockade induces multimodal antitumor effects that prolong survival in an immunocompetent mouse model of ovarian cancer.

Righi E, Kashiwagi S, Yuan J, Santosuosso M, Leblanc P, Ingraham R, Forbes B, Edelblute B, Collette B, Xing D, Kowalski M, Mingari MC, Vianello F, Birrer M, Orsulic S, Dranoff G, Poznansky MC.

Cancer Res. 2011 Aug 15;71(16):5522-5534. doi: 10.1158/0008-5472.CAN-10-3143. Epub 2011 Jul 8.


R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.

Santosuosso M, Righi E, Hill ED, Leblanc PR, Kodish B, Mylvaganam HN, Siddappa NB, Stevceva L, Hu SL, Ghebremichael M, Chenine AL, Hovav AH, Ruprecht RM, Poznansky MC.

PLoS One. 2011 Apr 5;6(4):e18465. doi: 10.1371/journal.pone.0018465.


R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.

Siddappa NB, Watkins JD, Wassermann KJ, Song R, Wang W, Kramer VG, Lakhashe S, Santosuosso M, Poznansky MC, Novembre FJ, Villinger F, Else JG, Montefiori DC, Rasmussen RA, Ruprecht RM.

PLoS One. 2010 Jul 21;5(7):e11689. doi: 10.1371/journal.pone.0011689.


Methods for quantitation of leukocyte chemotaxis and fugetaxis.

Vianello F, Righi E, Poznansky MC.

Methods Mol Biol. 2010;616:115-24. doi: 10.1007/978-1-60761-461-6_8.


Relative transmissibility of an R5 clade C simian-human immunodeficiency virus across different mucosae in macaques parallels the relative risks of sexual HIV-1 transmission in humans via different routes.

Chenine AL, Siddappa NB, Kramer VG, Sciaranghella G, Rasmussen RA, Lee SJ, Santosuosso M, Poznansky MC, Velu V, Amara RR, Souder C, Anderson DC, Villinger F, Else JG, Novembre FJ, Strobert E, O'Neil SP, Secor WE, Ruprecht RM.

J Infect Dis. 2010 Apr 15;201(8):1155-63. doi: 10.1086/651274.


Bone marrow-derived B cells preserve ventricular function after acute myocardial infarction.

Goodchild TT, Robinson KA, Pang W, Tondato F, Cui J, Arrington J, Godwin L, Ungs M, Carlesso N, Weich N, Poznansky MC, Chronos NA.

JACC Cardiovasc Interv. 2009 Oct;2(10):1005-16. doi: 10.1016/j.jcin.2009.08.010.


Correlation of CXCL12 expression and FoxP3+ cell infiltration with human papillomavirus infection and clinicopathological progression of cervical cancer.

Jaafar F, Righi E, Lindstrom V, Linton C, Nohadani M, Van Noorden S, Lloyd T, Poznansky J, Stamp G, Dina R, Coleman DV, Poznansky MC.

Am J Pathol. 2009 Oct;175(4):1525-35. doi: 10.2353/ajpath.2009.090295.


Dynamic alterations in chemokine gradients induce transendothelial shuttling of human T cells under physiologic shear conditions.

Lee JY, Buzney CD, Poznansky MC, Sackstein R.

J Leukoc Biol. 2009 Dec;86(6):1285-94. doi: 10.1189/jlb.0309214. Erratum in: J Leukoc Biol. 2010 Mar;87(3):534. Erratum in: J Leukoc Biol. 2010 Mar;87(3):534.


HIV-1 envelope protein gp120 is present at high concentrations in secondary lymphoid organs of individuals with chronic HIV-1 infection.

Santosuosso M, Righi E, Lindstrom V, Leblanc PR, Poznansky MC.

J Infect Dis. 2009 Oct 1;200(7):1050-3. doi: 10.1086/605695.


X4 human immunodeficiency virus type 1 gp120 down-modulates expression and immunogenicity of codelivered antigens.

Hovav AH, Santosuosso M, Bivas-Benita M, Plair A, Cheng A, Elnekave M, Righi E, Chen T, Kashiwagi S, Panas MW, Xiang SH, Furmanov K, Letvin NL, Poznansky MC.

J Virol. 2009 Nov;83(21):10941-50. doi: 10.1128/JVI.00394-09. Epub 2009 Aug 19.


The efficacy of T cell-mediated immune responses is reduced by the envelope protein of the chimeric HIV-1/SIV-KB9 virus in vivo.

Stevceva L, Yoon V, Carville A, Pacheco B, Santosuosso M, Korioth-Schmitz B, Mansfield K, Poznansky MC.

J Immunol. 2008 Oct 15;181(8):5510-21.


Reverse leukocyte migration can be attractive or repulsive.

Huttenlocher A, Poznansky MC.

Trends Cell Biol. 2008 Jun;18(6):298-306. doi: 10.1016/j.tcb.2008.04.001. Epub 2008 May 9. Review.


Generation of a tissue-engineered thymic organoid.

Vianello F, Poznansky MC.

Methods Mol Biol. 2007;380:163-70. Review.


Immune responses to HIV Gp120 that facilitate viral escape.

Stevceva L, Yoon V, Anastasiades D, Poznansky MC.

Curr HIV Res. 2007 Jan;5(1):47-54. Review.


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