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Items: 19

1.

Selective oral ROCK2 inhibitor down-regulates IL-21 and IL-17 secretion in human T cells via STAT3-dependent mechanism.

Zanin-Zhorov A, Weiss JM, Nyuydzefe MS, Chen W, Scher JU, Mo R, Depoil D, Rao N, Liu B, Wei J, Lucas S, Koslow M, Roche M, Schueller O, Weiss S, Poyurovsky MV, Tonra J, Hippen KL, Dustin ML, Blazar BR, Liu CJ, Waksal SD.

Proc Natl Acad Sci U S A. 2014 Nov 25;111(47):16814-9. doi: 10.1073/pnas.1414189111. Epub 2014 Nov 10.

2.

Selective ROCK2 Inhibition In Focal Cerebral Ischemia.

Lee JH, Zheng Y, von Bornstadt D, Wei Y, Balcioglu A, Daneshmand A, Yalcin N, Yu E, Herisson F, Atalay YB, Kim MH, Ahn YJ, Balkaya M, Sweetnam P, Schueller O, Poyurovsky MV, Kim HH, Lo EH, Furie KL, Ayata C.

Ann Clin Transl Neurol. 2014 Jan 1;1(1):2-14.

3.

Gata3/Ruvbl2 complex regulates T helper 2 cell proliferation via repression of Cdkn2c expression.

Hosokawa H, Tanaka T, Kato M, Shinoda K, Tohyama H, Hanazawa A, Tamaki Y, Hirahara K, Yagi R, Sakikawa I, Morita A, Nagira M, Poyurovsky MV, Suzuki Y, Motohashi S, Nakayama T.

Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18626-31. doi: 10.1073/pnas.1311100110. Epub 2013 Oct 28.

4.

Discovery of Mdm2-MdmX E3 ligase inhibitors using a cell-based ubiquitination assay.

Herman AG, Hayano M, Poyurovsky MV, Shimada K, Skouta R, Prives C, Stockwell BR.

Cancer Discov. 2011 Sep;1(4):312-25. doi: 10.1158/2159-8290.CD-11-0104. Epub 2011 Jul 28.

5.

Length matters: C-terminal tails regulate Mdm2-MdmX complexes.

Poyurovsky MV.

Cell Cycle. 2012 Apr 15;11(8):1485. doi: 10.4161/cc.20047. No abstract available.

6.

MdmX is required for p53 interaction with and full induction of the Mdm2 promoter after cellular stress.

Biderman L, Poyurovsky MV, Assia Y, Manley JL, Prives C.

Mol Cell Biol. 2012 Apr;32(7):1214-25. doi: 10.1128/MCB.06150-11. Epub 2012 Jan 30.

7.

APC/C(Cdc20) targets E2F1 for degradation in prometaphase.

Peart MJ, Poyurovsky MV, Kass EM, Urist M, Verschuren EW, Summers MK, Jackson PK, Prives C.

Cell Cycle. 2010 Oct 1;9(19):3956-64. Epub 2010 Oct 26.

8.

Deconstructing nucleotide binding activity of the Mdm2 RING domain.

Priest C, Prives C, Poyurovsky MV.

Nucleic Acids Res. 2010 Nov;38(21):7587-98. doi: 10.1093/nar/gkq669. Epub 2010 Jul 29.

9.

P53 and aging: A fresh look at an old paradigm.

Poyurovsky MV, Prives C.

Aging (Albany NY). 2010 Jul;2(7):380-2. No abstract available.

10.

The C terminus of p53 binds the N-terminal domain of MDM2.

Poyurovsky MV, Katz C, Laptenko O, Beckerman R, Lokshin M, Ahn J, Byeon IJ, Gabizon R, Mattia M, Zupnick A, Brown LM, Friedler A, Prives C.

Nat Struct Mol Biol. 2010 Aug;17(8):982-9. doi: 10.1038/nsmb.1872. Epub 2010 Jul 18. Erratum in: Nat Struct Mol Biol. 2011 Apr;18(4):516.

11.

Phosphate-activated glutaminase (GLS2), a p53-inducible regulator of glutamine metabolism and reactive oxygen species.

Suzuki S, Tanaka T, Poyurovsky MV, Nagano H, Mayama T, Ohkubo S, Lokshin M, Hosokawa H, Nakayama T, Suzuki Y, Sugano S, Sato E, Nagao T, Yokote K, Tatsuno I, Prives C.

Proc Natl Acad Sci U S A. 2010 Apr 20;107(16):7461-6. doi: 10.1073/pnas.1002459107. Epub 2010 Mar 29.

12.

Ribosomal protein S7 is both a regulator and a substrate of MDM2.

Zhu Y, Poyurovsky MV, Li Y, Biderman L, Stahl J, Jacq X, Prives C.

Mol Cell. 2009 Aug 14;35(3):316-26. doi: 10.1016/j.molcel.2009.07.014.

13.

Dissection of the sequence-specific DNA binding and exonuclease activities reveals a superactive yet apoptotically impaired mutant p53 protein.

Ahn J, Poyurovsky MV, Baptiste N, Beckerman R, Cain C, Mattia M, McKinney K, Zhou J, Zupnick A, Gottifredi V, Prives C.

Cell Cycle. 2009 May 15;8(10):1603-15.

14.

Mdm2 and PCAF increase Chk2 ubiquitination and degradation independently of their intrinsic E3 ligase activities.

Kass EM, Poyurovsky MV, Zhu Y, Prives C.

Cell Cycle. 2009 Feb 1;8(3):430-7. Epub 2009 Feb 12.

PMID:
19176998
15.

The Mdm2 RING domain C-terminus is required for supramolecular assembly and ubiquitin ligase activity.

Poyurovsky MV, Priest C, Kentsis A, Borden KL, Pan ZQ, Pavletich N, Prives C.

EMBO J. 2007 Jan 10;26(1):90-101. Epub 2006 Dec 14.

16.

Unleashing the power of p53: lessons from mice and men.

Poyurovsky MV, Prives C.

Genes Dev. 2006 Jan 15;20(2):125-31. Review. No abstract available.

17.

p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2.

Urist M, Tanaka T, Poyurovsky MV, Prives C.

Genes Dev. 2004 Dec 15;18(24):3041-54.

18.

Decreased p21 levels are required for efficient restart of DNA synthesis after S phase block.

Gottifredi V, McKinney K, Poyurovsky MV, Prives C.

J Biol Chem. 2004 Feb 13;279(7):5802-10. Epub 2003 Nov 3.

19.

Nucleotide binding by the Mdm2 RING domain facilitates Arf-independent Mdm2 nucleolar localization.

Poyurovsky MV, Jacq X, Ma C, Karni-Schmidt O, Parker PJ, Chalfie M, Manley JL, Prives C.

Mol Cell. 2003 Oct;12(4):875-87.

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