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Alpha kinase 1 controls intestinal inflammation by suppressing the IL-12/Th1 axis.

Ryzhakov G, West NR, Franchini F, Clare S, Ilott NE, Sansom SN, Bullers SJ, Pearson C, Costain A, Vaughan-Jackson A, Goettel JA, Ermann J, Horwitz BH, Buti L, Lu X, Mukhopadhyay S, Snapper SB, Powrie F.

Nat Commun. 2018 Sep 18;9(1):3797. doi: 10.1038/s41467-018-06085-5.


Interleukin-22 promotes phagolysosomal fusion to induce protection against Salmonella enterica Typhimurium in human epithelial cells.

Forbester JL, Lees EA, Goulding D, Forrest S, Yeung A, Speak A, Clare S, Coomber EL, Mukhopadhyay S, Kraiczy J, Schreiber F, Lawley TD, Hancock REW, Uhlig HH, Zilbauer M, Powrie F, Dougan G.

Proc Natl Acad Sci U S A. 2018 Oct 2;115(40):10118-10123. doi: 10.1073/pnas.1811866115. Epub 2018 Sep 14.


Innate Lymphoid Cells: 10 Years On.

Vivier E, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie ANJ, Mebius RE, Powrie F, Spits H.

Cell. 2018 Aug 23;174(5):1054-1066. doi: 10.1016/j.cell.2018.07.017. Review.


Foxp3+ T reg cells control psoriasiform inflammation by restraining an IFN-I-driven CD8+ T cell response.

Stockenhuber K, Hegazy AN, West NR, Ilott NE, Stockenhuber A, Bullers SJ, Thornton EE, Arnold IC, Tucci A, Waldmann H, Ogg GS, Powrie F.

J Exp Med. 2018 Aug 6;215(8):1987-1998. doi: 10.1084/jem.20172094. Epub 2018 Jul 6.


Consequences of Identifying XIAP Deficiency in an Adult Patient With Inflammatory Bowel Disease.

Quaranta M, Wilson R, Gonçalves Serra E, Pandey S, Schwerd T, Gilmour K, Klenerman P, Powrie F, Keshav S, Travis SPL, Anderson CA, Uhlig HH.

Gastroenterology. 2018 Jul;155(1):231-234. doi: 10.1053/j.gastro.2018.03.069. Epub 2018 Jun 9. No abstract available.


Translating Immunology into Therapeutic Concepts for Inflammatory Bowel Disease.

Uhlig HH, Powrie F.

Annu Rev Immunol. 2018 Apr 26;36:755-781. doi: 10.1146/annurev-immunol-042617-053055.


Helicobacter hepaticus polysaccharide induces an anti-inflammatory response in intestinal macrophages.

Danne C, Powrie F.

Microb Cell. 2018 Mar 22;5(4):208-211. doi: 10.15698/mic2018.04.626.


A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages.

Danne C, Ryzhakov G, Martínez-López M, Ilott NE, Franchini F, Cuskin F, Lowe EC, Bullers SJ, Arthur JSC, Powrie F.

Cell Host Microbe. 2017 Dec 13;22(6):733-745.e5. doi: 10.1016/j.chom.2017.11.002.


Unique transcriptome signatures and GM-CSF expression in lymphocytes from patients with spondyloarthritis.

Al-Mossawi MH, Chen L, Fang H, Ridley A, de Wit J, Yager N, Hammitzsch A, Pulyakhina I, Fairfax BP, Simone D, Yi Y, Bandyopadhyay S, Doig K, Gundle R, Kendrick B, Powrie F, Knight JC, Bowness P.

Nat Commun. 2017 Nov 15;8(1):1510. doi: 10.1038/s41467-017-01771-2.


NOX1 loss-of-function genetic variants in patients with inflammatory bowel disease.

Schwerd T, Bryant RV, Pandey S, Capitani M, Meran L, Cazier JB, Jung J, Mondal K, Parkes M, Mathew CG, Fiedler K, McCarthy DJ; WGS500 Consortium; Oxford IBD cohort study investigators; COLORS in IBD group investigators; UK IBD Genetics Consortium, Sullivan PB, Rodrigues A, Travis SPL, Moore C, Sambrook J, Ouwehand WH, Roberts DJ, Danesh J; INTERVAL Study, Russell RK, Wilson DC, Kelsen JR, Cornall R, Denson LA, Kugathasan S, Knaus UG, Serra EG, Anderson CA, Duerr RH, McGovern DP, Cho J, Powrie F, Li VS, Muise AM, Uhlig HH.

Mucosal Immunol. 2018 Mar;11(2):562-574. doi: 10.1038/mi.2017.74. Epub 2017 Nov 1.


Circulating and Tissue-Resident CD4+ T Cells With Reactivity to Intestinal Microbiota Are Abundant in Healthy Individuals and Function Is Altered During Inflammation.

Hegazy AN, West NR, Stubbington MJT, Wendt E, Suijker KIM, Datsi A, This S, Danne C, Campion S, Duncan SH, Owens BMJ, Uhlig HH, McMichael A; Oxford IBD Cohort Investigators, Bergthaler A, Teichmann SA, Keshav S, Powrie F.

Gastroenterology. 2017 Nov;153(5):1320-1337.e16. doi: 10.1053/j.gastro.2017.07.047. Epub 2017 Aug 4.


Erratum: Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M, Görtz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F, Brodmerkel C, Cieluch C, Rahman N, Müller-Newen G, Owens RJ, Kühl AA, Maloy KJ, Plevy SE; Oxford IBD Cohort Investigators, Keshav S, Travis SPL, Powrie F.

Nat Med. 2017 Jun 6;23(6):788. doi: 10.1038/nm0617-788d. No abstract available.


Th1 and Innate Lymphoid Cells Accumulate in Primary Sclerosing Cholangitis-associated Inflammatory Bowel Disease.

Gwela A, Siddhanathi P, Chapman RW, Travis S, Powrie F, Arancibia-Cárcamo CV, Geremia A.

J Crohns Colitis. 2017 Sep 1;11(9):1124-1134. doi: 10.1093/ecco-jcc/jjx050.


Oncostatin M drives intestinal inflammation and predicts response to tumor necrosis factor-neutralizing therapy in patients with inflammatory bowel disease.

West NR, Hegazy AN, Owens BMJ, Bullers SJ, Linggi B, Buonocore S, Coccia M, Görtz D, This S, Stockenhuber K, Pott J, Friedrich M, Ryzhakov G, Baribaud F, Brodmerkel C, Cieluch C, Rahman N, Müller-Newen G, Owens RJ, Kühl AA, Maloy KJ, Plevy SE; Oxford IBD Cohort Investigators, Keshav S, Travis SPL, Powrie F.

Nat Med. 2017 May;23(5):579-589. doi: 10.1038/nm.4307. Epub 2017 Apr 3. Erratum in: Nat Med. 2017 Jun 6;23 (6):788.


Inflammatory cues enhance TGFβ activation by distinct subsets of human intestinal dendritic cells via integrin αvβ8.

Fenton TM, Kelly A, Shuttleworth EE, Smedley C, Atakilit A, Powrie F, Campbell S, Nishimura SL, Sheppard D, Levison S, Worthington JJ, Lehtinen MJ, Travis MA.

Mucosal Immunol. 2017 May;10(3):624-634. doi: 10.1038/mi.2016.94. Epub 2016 Oct 26.


Immune dysregulation in patients with PTEN hamartoma tumor syndrome: Analysis of FOXP3 regulatory T cells.

Chen HH, Händel N, Ngeow J, Muller J, Hühn M, Yang HT, Heindl M, Berbers RM, Hegazy AN, Kionke J, Yehia L, Sack U, Bläser F, Rensing-Ehl A, Reifenberger J, Keith J, Travis S, Merkenschlager A, Kiess W, Wittekind C, Walker L, Ehl S, Aretz S, Dustin ML, Eng C, Powrie F, Uhlig HH.

J Allergy Clin Immunol. 2017 Feb;139(2):607-620.e15. doi: 10.1016/j.jaci.2016.03.059. Epub 2016 Jun 18.


T-bet is a key modulator of IL-23-driven pathogenic CD4(+) T cell responses in the intestine.

Krausgruber T, Schiering C, Adelmann K, Harrison OJ, Chomka A, Pearson C, Ahern PP, Shale M, Oukka M, Powrie F.

Nat Commun. 2016 May 19;7:11627. doi: 10.1038/ncomms11627.


Integrative Phosphoproteomics Links IL-23R Signaling with Metabolic Adaptation in Lymphocytes.

Lochmatter C, Fischer R, Charles PD, Yu Z, Powrie F, Kessler BM.

Sci Rep. 2016 Apr 15;6:24491. doi: 10.1038/srep24491.


Defining the microbial transcriptional response to colitis through integrated host and microbiome profiling.

Ilott NE, Bollrath J, Danne C, Schiering C, Shale M, Adelmann K, Krausgruber T, Heger A, Sims D, Powrie F.

ISME J. 2016 Oct;10(10):2389-404. doi: 10.1038/ismej.2016.40. Epub 2016 Mar 22.


Impaired antibacterial autophagy links granulomatous intestinal inflammation in Niemann-Pick disease type C1 and XIAP deficiency with NOD2 variants in Crohn's disease.

Schwerd T, Pandey S, Yang HT, Bagola K, Jameson E, Jung J, Lachmann RH, Shah N, Patel SY, Booth C, Runz H, Düker G, Bettels R, Rohrbach M, Kugathasan S, Chapel H, Keshav S, Elkadri A, Platt N, Muise AM, Koletzko S, Xavier RJ, Marquardt T, Powrie F, Wraith JE, Gyrd-Hansen M, Platt FM, Uhlig HH.

Gut. 2017 Jun;66(6):1060-1073. doi: 10.1136/gutjnl-2015-310382. Epub 2016 Mar 7.


ILC3 GM-CSF production and mobilisation orchestrate acute intestinal inflammation.

Pearson C, Thornton EE, McKenzie B, Schaupp AL, Huskens N, Griseri T, West N, Tung S, Seddon BP, Uhlig HH, Powrie F.

Elife. 2016 Jan 18;5:e10066. doi: 10.7554/eLife.10066.


Immunotherapy Not Working? Check Your Microbiota.

West NR, Powrie F.

Cancer Cell. 2015 Dec 14;28(6):687-689. doi: 10.1016/j.ccell.2015.11.010.


RORγt inhibitors suppress T(H)17 responses in inflammatory arthritis and inflammatory bowel disease.

de Wit J, Al-Mossawi MH, Hühn MH, Arancibia-Cárcamo CV, Doig K, Kendrick B, Gundle R, Taylor P, Mcclanahan T, Murphy E, Zhang H, Barr K, Miller JR, Hu X, Aicher TD, Morgan RW, Glick GD, Zaller D, Correll C, Powrie F, Bowness P.

J Allergy Clin Immunol. 2016 Mar;137(3):960-3. doi: 10.1016/j.jaci.2015.09.048. Epub 2015 Nov 21. No abstract available.


Emerging cytokine networks in colorectal cancer.

West NR, McCuaig S, Franchini F, Powrie F.

Nat Rev Immunol. 2015 Oct;15(10):615-29. doi: 10.1038/nri3896. Epub 2015 Sep 11. Review.


MICROBIOME. Microbiota RORgulates intestinal suppressor T cells.

Hegazy AN, Powrie F.

Science. 2015 Aug 28;349(6251):929-30. doi: 10.1126/science.aad0865. No abstract available.


CD11c(+) monocyte/macrophages promote chronic Helicobacter hepaticus-induced intestinal inflammation through the production of IL-23.

Arnold IC, Mathisen S, Schulthess J, Danne C, Hegazy AN, Powrie F.

Mucosal Immunol. 2016 Mar;9(2):352-63. doi: 10.1038/mi.2015.65. Epub 2015 Aug 5.


Transcriptional profiling of macrophages derived from monocytes and iPS cells identifies a conserved response to LPS and novel alternative transcription.

Alasoo K, Martinez FO, Hale C, Gordon S, Powrie F, Dougan G, Mukhopadhyay S, Gaffney DJ.

Sci Rep. 2015 Jul 30;5:12524. doi: 10.1038/srep12524.


CD161(int)CD8+ T cells: a novel population of highly functional, memory CD8+ T cells enriched within the gut.

Fergusson JR, Hühn MH, Swadling L, Walker LJ, Kurioka A, Llibre A, Bertoletti A, Holländer G, Newell EW, Davis MM, Sverremark-Ekström E, Powrie F, Capone S, Folgori A, Barnes E, Willberg CB, Ussher JE, Klenerman P.

Mucosal Immunol. 2016 Mar;9(2):401-13. doi: 10.1038/mi.2015.69. Epub 2015 Jul 29.


Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis.

Griseri T, Arnold IC, Pearson C, Krausgruber T, Schiering C, Franchini F, Schulthess J, McKenzie BS, Crocker PR, Powrie F.

Immunity. 2015 Jul 21;43(1):187-99. doi: 10.1016/j.immuni.2015.07.008.


Factors influencing success of clinical genome sequencing across a broad spectrum of disorders.

Taylor JC, Martin HC, Lise S, Broxholme J, Cazier JB, Rimmer A, Kanapin A, Lunter G, Fiddy S, Allan C, Aricescu AR, Attar M, Babbs C, Becq J, Beeson D, Bento C, Bignell P, Blair E, Buckle VJ, Bull K, Cais O, Cario H, Chapel H, Copley RR, Cornall R, Craft J, Dahan K, Davenport EE, Dendrou C, Devuyst O, Fenwick AL, Flint J, Fugger L, Gilbert RD, Goriely A, Green A, Greger IH, Grocock R, Gruszczyk AV, Hastings R, Hatton E, Higgs D, Hill A, Holmes C, Howard M, Hughes L, Humburg P, Johnson D, Karpe F, Kingsbury Z, Kini U, Knight JC, Krohn J, Lamble S, Langman C, Lonie L, Luck J, McCarthy D, McGowan SJ, McMullin MF, Miller KA, Murray L, Németh AH, Nesbit MA, Nutt D, Ormondroyd E, Oturai AB, Pagnamenta A, Patel SY, Percy M, Petousi N, Piazza P, Piret SE, Polanco-Echeverry G, Popitsch N, Powrie F, Pugh C, Quek L, Robbins PA, Robson K, Russo A, Sahgal N, van Schouwenburg PA, Schuh A, Silverman E, Simmons A, Sørensen PS, Sweeney E, Taylor J, Thakker RV, Tomlinson I, Trebes A, Twigg SR, Uhlig HH, Vyas P, Vyse T, Wall SA, Watkins H, Whyte MP, Witty L, Wright B, Yau C, Buck D, Humphray S, Ratcliffe PJ, Bell JI, Wilkie AO, Bentley D, Donnelly P, McVean G.

Nat Genet. 2015 Jul;47(7):717-726. doi: 10.1038/ng.3304. Epub 2015 May 18.


Induced pluripotent stem cell derived macrophages as a cellular system to study salmonella and other pathogens.

Hale C, Yeung A, Goulding D, Pickard D, Alasoo K, Powrie F, Dougan G, Mukhopadhyay S.

PLoS One. 2015 May 6;10(5):e0124307. doi: 10.1371/journal.pone.0124307. eCollection 2015.


Helicobacter hepaticus infection in BALB/c mice abolishes subunit-vaccine-induced protection against M. tuberculosis.

Arnold IC, Hutchings C, Kondova I, Hey A, Powrie F, Beverley P, Tchilian E.

Vaccine. 2015 Apr 8;33(15):1808-14. doi: 10.1016/j.vaccine.2015.02.041. Epub 2015 Mar 4.


The alarmin IL-33 promotes regulatory T-cell function in the intestine.

Schiering C, Krausgruber T, Chomka A, Fröhlich A, Adelmann K, Wohlfert EA, Pott J, Griseri T, Bollrath J, Hegazy AN, Harrison OJ, Owens BMJ, Löhning M, Belkaid Y, Fallon PG, Powrie F.

Nature. 2014 Sep 25;513(7519):564-568. doi: 10.1038/nature13577. Epub 2014 Jul 16.


A mouse model of HIES reveals pro- and anti-inflammatory functions of STAT3.

Steward-Tharp SM, Laurence A, Kanno Y, Kotlyar A, Villarino AV, Sciume G, Kuchen S, Resch W, Wohlfert EA, Jiang K, Hirahara K, Vahedi G, Sun HW, Feigenbaum L, Milner JD, Holland SM, Casellas R, Powrie F, O'Shea JJ.

Blood. 2014 May 8;123(19):2978-87. doi: 10.1182/blood-2013-09-523167. Epub 2014 Mar 14.


Mutations in tetratricopeptide repeat domain 7A result in a severe form of very early onset inflammatory bowel disease.

Avitzur Y, Guo C, Mastropaolo LA, Bahrami E, Chen H, Zhao Z, Elkadri A, Dhillon S, Murchie R, Fattouh R, Huynh H, Walker JL, Wales PW, Cutz E, Kakuta Y, Dudley J, Kammermeier J, Powrie F, Shah N, Walz C, Nathrath M, Kotlarz D, Puchaka J, Krieger JR, Racek T, Kirchner T, Walters TD, Brumell JH, Griffiths AM, Rezaei N, Rashtian P, Najafi M, Monajemzadeh M, Pelsue S, McGovern DP, Uhlig HH, Schadt E, Klein C, Snapper SB, Muise AM.

Gastroenterology. 2014 Apr;146(4):1028-39. doi: 10.1053/j.gastro.2014.01.015. Epub 2014 Jan 11.


Controlling the frontier: regulatory T-cells and intestinal homeostasis.

Bollrath J, Powrie FM.

Semin Immunol. 2013 Nov 30;25(5):352-7. doi: 10.1016/j.smim.2013.09.002. Epub 2013 Oct 31. Review.


Immunology. Feed your Tregs more fiber.

Bollrath J, Powrie F.

Science. 2013 Aug 2;341(6145):463-4. doi: 10.1126/science.1242674. No abstract available.


Regulatory T cells and immune tolerance in the intestine.

Harrison OJ, Powrie FM.

Cold Spring Harb Perspect Biol. 2013 Jul 1;5(7). pii: a018341. doi: 10.1101/cshperspect.a018341. Review. Erratum in: Cold Spring Harb Perspect Biol. 2013 Aug;5(8):a021022.


Innate lymphoid cells sustain colon cancer through production of interleukin-22 in a mouse model.

Kirchberger S, Royston DJ, Boulard O, Thornton E, Franchini F, Szabady RL, Harrison O, Powrie F.

J Exp Med. 2013 May 6;210(5):917-31.


Regulation of Foxp3+ inducible regulatory T cell stability by SOCS2.

Knosp CA, Schiering C, Spence S, Carroll HP, Nel HJ, Osbourn M, Jackson R, Lyubomska O, Malissen B, Ingram R, Fitzgerald DC, Powrie F, Fallon PG, Johnston JA, Kissenpfennig A.

J Immunol. 2013 Apr 1;190(7):3235-45. doi: 10.4049/jimmunol.1201396. Epub 2013 Mar 1.


CD4(+) T-cell subsets in intestinal inflammation.

Shale M, Schiering C, Powrie F.

Immunol Rev. 2013 Mar;252(1):164-82. doi: 10.1111/imr.12039. Review.


Gender equality: is it real?

Simon K, Athanassakis I, Powrie F, Montoya M.

Eur J Immunol. 2012 Dec;42(12):3095-6. No abstract available.


Innate lymphoid cells--a proposal for uniform nomenclature.

Spits H, Artis D, Colonna M, Diefenbach A, Di Santo JP, Eberl G, Koyasu S, Locksley RM, McKenzie AN, Mebius RE, Powrie F, Vivier E.

Nat Rev Immunol. 2013 Feb;13(2):145-9. doi: 10.1038/nri3365. Review.


Environmental effects on protection against Mycobacterium tuberculosis after immunization with Ad85A.

Beverley P, Ronan E, Lee L, Arnold I, Bolinger B, Powrie F, Tchilian E.

Vaccine. 2013 Feb 4;31(7):1086-93. doi: 10.1016/j.vaccine.2012.12.024. Epub 2012 Dec 21.


Early and nonreversible decrease of CD161++ /MAIT cells in HIV infection.

Cosgrove C, Ussher JE, Rauch A, Gärtner K, Kurioka A, Hühn MH, Adelmann K, Kang YH, Fergusson JR, Simmonds P, Goulder P, Hansen TH, Fox J, Günthard HF, Khanna N, Powrie F, Steel A, Gazzard B, Phillips RE, Frater J, Uhlig H, Klenerman P.

Blood. 2013 Feb 7;121(6):951-61. doi: 10.1182/blood-2012-06-436436. Epub 2012 Dec 18.


Dysregulated hematopoietic stem and progenitor cell activity promotes interleukin-23-driven chronic intestinal inflammation.

Griseri T, McKenzie BS, Schiering C, Powrie F.

Immunity. 2012 Dec 14;37(6):1116-29. doi: 10.1016/j.immuni.2012.08.025. Epub 2012 Nov 29.


CTLA-4 promotes Foxp3 induction and regulatory T cell accumulation in the intestinal lamina propria.

Barnes MJ, Griseri T, Johnson AM, Young W, Powrie F, Izcue A.

Mucosal Immunol. 2013 Mar;6(2):324-34. doi: 10.1038/mi.2012.75. Epub 2012 Aug 22.


IL-1β mediates chronic intestinal inflammation by promoting the accumulation of IL-17A secreting innate lymphoid cells and CD4(+) Th17 cells.

Coccia M, Harrison OJ, Schiering C, Asquith MJ, Becher B, Powrie F, Maloy KJ.

J Exp Med. 2012 Aug 27;209(9):1595-609. doi: 10.1084/jem.20111453. Epub 2012 Aug 13.


Immunology: Malnutrition promotes rogue bacteria.

Izcue A, Powrie F.

Nature. 2012 Jul 25;487(7408):437-9. doi: 10.1038/487437a. No abstract available.


Identification of a genetic locus controlling bacteria-driven colitis and associated cancer through effects on innate inflammation.

Boulard O, Kirchberger S, Royston DJ, Maloy KJ, Powrie FM.

J Exp Med. 2012 Jul 2;209(7):1309-24. doi: 10.1084/jem.20120239. Epub 2012 Jun 25.

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