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Items: 16


Biomarkers of phenethyl isothiocyanate-mediated mammary cancer chemoprevention in a clinically relevant mouse model.

Singh SV, Kim SH, Sehrawat A, Arlotti JA, Hahm ER, Sakao K, Beumer JH, Jankowitz RC, Chandra-Kuntal K, Lee J, Powolny AA, Dhir R.

J Natl Cancer Inst. 2012 Aug 22;104(16):1228-39. doi: 10.1093/jnci/djs321. Epub 2012 Aug 2.


Chemopreventative potential of the cruciferous vegetable constituent phenethyl isothiocyanate in a mouse model of prostate cancer.

Powolny AA, Bommareddy A, Hahm ER, Normolle DP, Beumer JH, Nelson JB, Singh SV.

J Natl Cancer Inst. 2011 Apr 6;103(7):571-84. doi: 10.1093/jnci/djr029. Epub 2011 Feb 17.


The garlic constituent diallyl trisulfide increases the lifespan of C. elegans via skn-1 activation.

Powolny AA, Singh SV, Melov S, Hubbard A, Fisher AL.

Exp Gerontol. 2011 Jun;46(6):441-52. doi: 10.1016/j.exger.2011.01.005. Epub 2011 Feb 2.


Phenethyl isothiocyanate inhibits oxidative phosphorylation to trigger reactive oxygen species-mediated death of human prostate cancer cells.

Xiao D, Powolny AA, Moura MB, Kelley EE, Bommareddy A, Kim SH, Hahm ER, Normolle D, Van Houten B, Singh SV.

J Biol Chem. 2010 Aug 20;285(34):26558-69. doi: 10.1074/jbc.M109.063255. Epub 2010 Jun 22.


Cellular responses to cancer chemopreventive agent D,L-sulforaphane in human prostate cancer cells are initiated by mitochondrial reactive oxygen species.

Xiao D, Powolny AA, Antosiewicz J, Hahm ER, Bommareddy A, Zeng Y, Desai D, Amin S, Herman-Antosiewicz A, Singh SV.

Pharm Res. 2009 Jul;26(7):1729-38. doi: 10.1007/s11095-009-9883-5. Epub 2009 Apr 21.


Atg5 regulates phenethyl isothiocyanate-induced autophagic and apoptotic cell death in human prostate cancer cells.

Bommareddy A, Hahm ER, Xiao D, Powolny AA, Fisher AL, Jiang Y, Singh SV.

Cancer Res. 2009 Apr 15;69(8):3704-12. doi: 10.1158/0008-5472.CAN-08-4344. Epub 2009 Mar 31.


Sulforaphane inhibits prostate carcinogenesis and pulmonary metastasis in TRAMP mice in association with increased cytotoxicity of natural killer cells.

Singh SV, Warin R, Xiao D, Powolny AA, Stan SD, Arlotti JA, Zeng Y, Hahm ER, Marynowski SW, Bommareddy A, Desai D, Amin S, Parise RA, Beumer JH, Chambers WH.

Cancer Res. 2009 Mar 1;69(5):2117-25. doi: 10.1158/0008-5472.CAN-08-3502. Epub 2009 Feb 17.


Garlic constituent diallyl trisulfide prevents development of poorly differentiated prostate cancer and pulmonary metastasis multiplicity in TRAMP mice.

Singh SV, Powolny AA, Stan SD, Xiao D, Arlotti JA, Warin R, Hahm ER, Marynowski SW, Bommareddy A, Potter DM, Dhir R.

Cancer Res. 2008 Nov 15;68(22):9503-11. doi: 10.1158/0008-5472.CAN-08-1677.


Benzyl isothiocyanate targets mitochondrial respiratory chain to trigger reactive oxygen species-dependent apoptosis in human breast cancer cells.

Xiao D, Powolny AA, Singh SV.

J Biol Chem. 2008 Oct 31;283(44):30151-63. doi: 10.1074/jbc.M802529200. Epub 2008 Sep 3.


Role of reactive oxygen intermediates in cellular responses to dietary cancer chemopreventive agents.

Antosiewicz J, Ziolkowski W, Kar S, Powolny AA, Singh SV.

Planta Med. 2008 Oct;74(13):1570-9. doi: 10.1055/s-2008-1081307. Epub 2008 Jul 31. Review.


Multitargeted prevention and therapy of cancer by diallyl trisulfide and related Allium vegetable-derived organosulfur compounds.

Powolny AA, Singh SV.

Cancer Lett. 2008 Oct 8;269(2):305-14. doi: 10.1016/j.canlet.2008.05.027. Epub 2008 Jun 24. Review.


Plumbagin-induced apoptosis in human prostate cancer cells is associated with modulation of cellular redox status and generation of reactive oxygen species.

Powolny AA, Singh SV.

Pharm Res. 2008 Sep;25(9):2171-80. doi: 10.1007/s11095-008-9533-3. Epub 2008 Jan 23.


Molecular targets of cancer chemoprevention by garlic-derived organosulfides.

Herman-Antosiewicz A, Powolny AA, Singh SV.

Acta Pharmacol Sin. 2007 Sep;28(9):1355-64. Review.


Mitochondria-mediated apoptosis by diallyl trisulfide in human prostate cancer cells is associated with generation of reactive oxygen species and regulated by Bax/Bak.

Kim YA, Xiao D, Xiao H, Powolny AA, Lew KL, Reilly ML, Zeng Y, Wang Z, Singh SV.

Mol Cancer Ther. 2007 May;6(5):1599-609.

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