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Items: 1 to 50 of 79

1.

Genetic risk variants for membranous nephropathy: extension of and association with other chronic kidney disease aetiologies.

Sekula P, Li Y, Stanescu HC, Wuttke M, Ekici AB, Bockenhauer D, Walz G, Powis SH, Kielstein JT, Brenchley P; GCKD Investigators, Eckardt KU, Kronenberg F, Kleta R, Köttgen A.

Nephrol Dial Transplant. 2017 Feb 1;32(2):325-332. doi: 10.1093/ndt/gfw001. Epub 2016 Feb 4.

2.

Inflammatory stress reduces the effectiveness of statins in the kidney by disrupting HMGCoA reductase feedback regulation.

Chen Y, Zhao L, Li Q, Wheeler DC, Varghese Z, Moorhead JF, Powis SH, Ruan XZ.

Nephrol Dial Transplant. 2014 Oct;29(10):1864-78. doi: 10.1093/ndt/gfu203. Epub 2014 Jun 3.

PMID:
24895437
3.

Inflammatory stress induces statin resistance by disrupting 3-hydroxy-3-methylglutaryl-CoA reductase feedback regulation.

Chen Y, Ku H, Zhao L, Wheeler DC, Li LC, Li Q, Varghese Z, Moorhead JF, Powis SH, Huang A, Ruan XZ.

Arterioscler Thromb Vasc Biol. 2014 Feb;34(2):365-76. doi: 10.1161/ATVBAHA.113.301301. Epub 2013 Nov 14.

PMID:
24233489
4.

Chronic inflammation exacerbates glucose metabolism disorders in C57BL/6J mice fed with high-fat diet.

Wu Y, Wu T, Wu J, Zhao L, Li Q, Varghese Z, Moorhead JF, Powis SH, Chen Y, Ruan XZ.

J Endocrinol. 2013 Oct 28;219(3):195-204. doi: 10.1530/JOE-13-0160. Print 2013 Dec.

PMID:
24029730
5.

Phospholipase A2 receptor (PLA2R1) sequence variants in idiopathic membranous nephropathy.

Coenen MJ, Hofstra JM, Debiec H, Stanescu HC, Medlar AJ, Stengel B, Boland-Augé A, Groothuismink JM, Bockenhauer D, Powis SH, Mathieson PW, Brenchley PE, Kleta R, Wetzels JF, Ronco P.

J Am Soc Nephrol. 2013 Mar;24(4):677-83. doi: 10.1681/ASN.2012070730. Epub 2013 Feb 21.

6.

Inflammatory stress exacerbates lipid-mediated renal injury in ApoE/CD36/SRA triple knockout mice.

Xu ZE, Chen Y, Huang A, Varghese Z, Moorhead JF, Yan F, Powis SH, Li Q, Ruan XZ.

Am J Physiol Renal Physiol. 2011 Oct;301(4):F713-22. doi: 10.1152/ajprenal.00341.2010. Epub 2011 Jul 27.

7.

Inflammatory stress exacerbates ectopic lipid deposition in C57BL/6J mice.

Mei M, Zhao L, Li Q, Chen Y, Huang A, Varghese Z, Moorhead JF, Zhang S, Powis SH, Li Q, Ruan XZ.

Lipids Health Dis. 2011 Jun 30;10:110. doi: 10.1186/1476-511X-10-110.

8.

Advanced glycation end products (AGEs) increase human mesangial foam cell formation by increasing Golgi SCAP glycosylation in vitro.

Yuan Y, Zhao L, Chen Y, Moorhead JF, Varghese Z, Powis SH, Minogue S, Sun Z, Ruan XZ.

Am J Physiol Renal Physiol. 2011 Jul;301(1):F236-43. doi: 10.1152/ajprenal.00646.2010. Epub 2011 Apr 20.

9.

Risk HLA-DQA1 and PLA(2)R1 alleles in idiopathic membranous nephropathy.

Stanescu HC, Arcos-Burgos M, Medlar A, Bockenhauer D, Kottgen A, Dragomirescu L, Voinescu C, Patel N, Pearce K, Hubank M, Stephens HA, Laundy V, Padmanabhan S, Zawadzka A, Hofstra JM, Coenen MJ, den Heijer M, Kiemeney LA, Bacq-Daian D, Stengel B, Powis SH, Brenchley P, Feehally J, Rees AJ, Debiec H, Wetzels JF, Ronco P, Mathieson PW, Kleta R.

N Engl J Med. 2011 Feb 17;364(7):616-26. doi: 10.1056/NEJMoa1009742.

10.

Use of perfluorodecalin for pancreatic islet culture prior to transplantation: a liquid-liquid interface culture system--preliminary report.

Juszczak MT, Elsadig A, Kumar A, Muzyamba M, Pawelec K, Powis SH, Press M.

Cell Transplant. 2011;20(2):323-32. doi: 10.3727/096368910X514189. Epub 2010 Aug 17.

PMID:
20719067
11.

Sirolimus inhibits endogenous cholesterol synthesis induced by inflammatory stress in human vascular smooth muscle cells.

Ma KL, Varghese Z, Ku Y, Powis SH, Chen Y, Moorhead JF, Ruan XZ.

Am J Physiol Heart Circ Physiol. 2010 Jun;298(6):H1646-51. doi: 10.1152/ajpheart.00492.2009. Epub 2010 Mar 26.

12.

Highly selective intraportal transplantation of pancreatic islets.

Juszczak MT, Kooner P, Pawelec K, Jones GL, Hughes SJ, Kumar A, Powis SH, Press M.

J Surg Res. 2009 Dec;157(2):216-22. doi: 10.1016/j.jss.2008.09.026. Epub 2008 Nov 4.

PMID:
19482293
13.

Time course of islet loss after intraportal transplantation.

Pawelec K, Juszczak MT, Kumar A, Powis SH, Press M.

Ann N Y Acad Sci. 2008 Dec;1150:230-3. doi: 10.1196/annals.1447.016.

PMID:
19120301
14.

Introducing 'nephron clinical guidelines'.

Cunningham J, Connolly J, Powis SH, El Nahas M.

Nephron Clin Pract. 2008;110(2):c114. doi: 10.1159/000162713. Epub 2008 Oct 16. No abstract available.

15.

Inflammatory stress exacerbates lipid accumulation in hepatic cells and fatty livers of apolipoprotein E knockout mice.

Ma KL, Ruan XZ, Powis SH, Chen Y, Moorhead JF, Varghese Z.

Hepatology. 2008 Sep;48(3):770-81. doi: 10.1002/hep.22423.

PMID:
18752326
16.

Mesangial matrix-activated monocytes express functional scavenger receptors and accumulate intracellular lipid.

Rahman EU, Ruan XZ, Chana RS, Brunskill NJ, Gaya J, Powis SH, Varghese Z, Moorhead JF, Wheeler DC.

Nephrol Dial Transplant. 2008 Jun;23(6):1876-85. doi: 10.1093/ndt/gfm901. Epub 2008 Feb 14.

PMID:
18281317
17.

Interpreting regulatory authority guidance on immunosuppressive therapy for renal transplantation: a response to the UK's National Institute for Clinical Excellence (NICE).

Warrens AN, Baboolal K, Buist L, Dudley C, Koffman G, Lipkin G, Parrott N, Powis SH, Sweny P, Raftery M.

Clin Nephrol. 2008 Feb;69(2):67-76. Review.

PMID:
18218299
18.

Sirolimus modifies cholesterol homeostasis in hepatic cells: a potential molecular mechanism for sirolimus-associated dyslipidemia.

Ma KL, Ruan XZ, Powis SH, Chen Y, Moorhead JF, Varghese Z.

Transplantation. 2007 Oct 27;84(8):1029-36.

PMID:
17989609
19.

Time course and quantification of pancreatic islet revascularization following intraportal transplantation.

Jones GL, Juszczak MT, Hughes SJ, Kooner P, Powis SH, Press M.

Cell Transplant. 2007;16(5):505-16.

PMID:
17708340
20.

Inflammatory cytokines disrupt LDL-receptor feedback regulation and cause statin resistance: a comparative study in human hepatic cells and mesangial cells.

Chen Y, Ruan XZ, Li Q, Huang A, Moorhead JF, Powis SH, Varghese Z.

Am J Physiol Renal Physiol. 2007 Sep;293(3):F680-7. Epub 2007 Jul 18.

21.

Plasma concentrations of mycophenolic acid acyl glucuronide are not associated with diarrhea in renal transplant recipients.

Heller T, van Gelder T, Budde K, de Fijter JW, Kuypers D, Arns W, Schmidt J, Rostaing L, Powis SH, Claesson K, Macphee IA, Pohanka E, Engelmayer J, Brandhorst G, Oellerich M, Armstrong VW.

Am J Transplant. 2007 Jul;7(7):1822-31. Epub 2007 May 26.

22.

Anti-atherosclerotic effects of sirolimus on human vascular smooth muscle cells.

Ma KL, Ruan XZ, Powis SH, Moorhead JF, Varghese Z.

Am J Physiol Heart Circ Physiol. 2007 Jun;292(6):H2721-8. Epub 2007 Feb 23.

23.

Platelet-activating factor (PAF) increase intracellular lipid accumulation by increasing both LDL and scavenger receptors in human mesangial cells.

Fragopoulou E, Iatrou C, Antonopoulou S, Ruan XZ, Fernando RL, Powis SH, Moorhead JF, Varghese Z.

J Lab Clin Med. 2006 Jun;147(6):281-9.

PMID:
16750665
24.

Mechanisms of dysregulation of low-density lipoprotein receptor expression in vascular smooth muscle cells by inflammatory cytokines.

Ruan XZ, Moorhead JF, Tao JL, Ma KL, Wheeler DC, Powis SH, Varghese Z.

Arterioscler Thromb Vasc Biol. 2006 May;26(5):1150-5. Epub 2006 Mar 16.

PMID:
16543490
25.

Nuclear receptors and their coregulators in kidney.

Ruan XZ, Varghese Z, Powis SH, Moorhead JF.

Kidney Int. 2005 Dec;68(6):2444-61. Review.

26.

Low plasma protein nitrotyrosine levels distinguish primary Raynaud's phenomenon from scleroderma.

Kingdon EJ, Mani AR, Frost MT, Denton CP, Powis SH, Black CM, Moore KP.

Ann Rheum Dis. 2006 Jul;65(7):952-4. Epub 2005 Nov 24.

27.
28.

Effects of sirolimus on mesangial cell cholesterol homeostasis: a novel mechanism for its action against lipid-mediated injury in renal allografts.

Varghese Z, Fernando R, Moorhead JF, Powis SH, Ruan XZ.

Am J Physiol Renal Physiol. 2005 Jul;289(1):F43-8. Epub 2005 Mar 15.

29.

EPA and DHA reduce LPS-induced inflammation responses in HK-2 cells: evidence for a PPAR-gamma-dependent mechanism.

Li H, Ruan XZ, Powis SH, Fernando R, Mon WY, Wheeler DC, Moorhead JF, Varghese Z.

Kidney Int. 2005 Mar;67(3):867-74.

30.

Effect of inspired oxygen on portal and hepatic oxygenation: effective arterialization of portal blood by hyperoxia.

Hughes SJ, Yang W, Juszczak M, Jones GL, Powis SH, Seifalian AM, Press M.

Cell Transplant. 2004;13(7-8):801-8.

PMID:
15690982
31.

Effect of donor treatment with heparinoids on graft function after intraportal transplantation of a marginal islet mass: an experimental study.

Juszczak MT, Hughes SJ, Jones GL, Powis SH, Press M.

Transplant Proc. 2004 Dec;36(10):3117-20.

PMID:
15686709
32.

Renovascular disease is associated with low producer genotypes of the anti-inflammatory cytokine interleukin-10.

George S, Ruan XZ, Navarrete C, Turner D, Reynard M, Sweny P, Hamilton G, Wheeler DC, Powis SH, Moorhead JF, Varghese Z.

Tissue Antigens. 2004 May;63(5):470-5.

PMID:
15104679
33.

Regulation of lipoprotein trafficking in the kidney: role of inflammatory mediators and transcription factors.

Ruan XZ, Moorhead JF, Fernando R, Wheeler DC, Powis SH, Varghese Z.

Biochem Soc Trans. 2004 Feb;32(Pt 1):88-91.

PMID:
14748720
34.

Halting chronic allograft nephropathy--do we already have the drugs?

Powis SH.

Nephron Clin Pract. 2003;95(3):c73-4. No abstract available.

PMID:
14646365
35.

Hyperoxia improves the survival of intraportally transplanted syngeneic pancreatic islets.

Hughes SJ, Davies SE, Powis SH, Press M.

Transplantation. 2003 Jun 27;75(12):1954-9.

PMID:
12829893
36.

PPAR agonists protect mesangial cells from interleukin 1beta-induced intracellular lipid accumulation by activating the ABCA1 cholesterol efflux pathway.

Ruan XZ, Moorhead JF, Fernando R, Wheeler DC, Powis SH, Varghese Z.

J Am Soc Nephrol. 2003 Mar;14(3):593-600.

37.

Dialysis induces cyclosporine a resistance: induction therapy with bolus ATG-Fresenius increases cyclosporine sensistivity.

Abudher MN, Davenport A, Fernando ON, Powis SH, Moorhead JF, Varghese Z.

Transplant Proc. 2003 Feb;35(1):210-4. No abstract available.

PMID:
12591368
38.

Calculated glomerular filtration rate is a useful screening tool to identify scleroderma patients with renal impairment.

Kingdon EJ, Knight CJ, Dustan K, Irwin AG, Thomas M, Powis SH, Burns A, Hilson AJ, Black CM.

Rheumatology (Oxford). 2003 Jan;42(1):26-33.

PMID:
12509609
39.

Typing alleles of TAP1 and TAP2.

Powis SH.

Methods Mol Biol. 2003;210:249-58. No abstract available.

PMID:
12412459
40.

ANCA +ve vasculitis after autologous PBSC transplantation.

Kingdon EJ, Johnston RE, Pawson R, Prentice HG, Potter MN, Burns A, Powis SH.

Nephrol Dial Transplant. 2002 Feb;17(2):285-7. No abstract available.

PMID:
11812882
41.
42.

The safety and efficacy of MMF in lupus nephritis: a pilot study.

Kingdon EJ, McLean AG, Psimenou E, Davenport A, Powis SH, Sweny P, Burns A.

Lupus. 2001;10(9):606-11.

PMID:
11678448
43.

Glomeruloid haemangioma and POEMS syndrome.

Kingdon EJ, Phillips BB, Jarmulowicz M, Powis SH, Vanderpump MP.

Nephrol Dial Transplant. 2001 Oct;16(10):2105-7. No abstract available.

PMID:
11572909
44.

Surviving native beta-cells determine outcome of syngeneic intraportal islet transplantation.

Hughes SJ, Powis SH, Press M.

Cell Transplant. 2001 Mar-Apr;10(2):145-51.

PMID:
11332628
45.

FK506 and CsA differ in their effect on intracellular cytokine expression following kidney transplantation.

Zamauskaite A, Cohen S, Sweny P, Madrigal A, Varghese Z, McLean A, Powis SH.

Transplant Proc. 2001 Feb-Mar;33(1-2):1046-7. No abstract available.

PMID:
11267184
46.

Significance of cytokine gene polymorphism in renal transplantation.

George S, Turner D, Reynard M, Navarrete C, Rizvi I, Fernando ON, Powis SH, Moorhead JF, Varghese Z.

Transplant Proc. 2001 Feb-Mar;33(1-2):483-4. No abstract available.

PMID:
11266919
47.

Functional characterization of HLA-F and binding of HLA-F tetramers to ILT2 and ILT4 receptors.

Lepin EJ, Bastin JM, Allan DS, Roncador G, Braud VM, Mason DY, van der Merwe PA, McMichael AJ, Bell JI, Powis SH, O'Callaghan CA.

Eur J Immunol. 2000 Dec;30(12):3552-61.

48.

Identification of a novel psoriasis susceptibility locus at 1p and evidence of epistasis between PSORS1 and candidate loci.

Veal CD, Clough RL, Barber RC, Mason S, Tillman D, Ferry B, Jones AB, Ameen M, Balendran N, Powis SH, Burden AD, Barker JN, Trembath RC.

J Med Genet. 2001 Jan;38(1):7-13.

49.

Sample sequencing of the human major histocompatibility complex class I region identifies further new genes.

Goldsworthy M, Wilkinson JM, Balendran N, Powis SH.

Immunogenetics. 2000 Jul;51(8-9):615-23.

PMID:
10941832
50.

Large-scale chromatin organization of the major histocompatibility complex and other regions of human chromosome 6 and its response to interferon in interphase nuclei.

Volpi EV, Chevret E, Jones T, Vatcheva R, Williamson J, Beck S, Campbell RD, Goldsworthy M, Powis SH, Ragoussis J, Trowsdale J, Sheer D.

J Cell Sci. 2000 May;113 ( Pt 9):1565-76.

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