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Single-molecule long-read sequencing reveals the chromatin basis of gene expression.

Wang Y, Wang A, Liu Z, Thurman AL, Powers LS, Zou M, Zhao Y, Hefel A, Li Y, Zabner J, Au KF.

Genome Res. 2019 Aug;29(8):1329-1342. doi: 10.1101/gr.251116.119. Epub 2019 Jun 14.


Widespread airway distribution and short-term phenotypic correction of cystic fibrosis pigs following aerosol delivery of piggyBac/adenovirus.

Cooney AL, Singh BK, Loza LM, Thornell IM, Hippee CE, Powers LS, Ostedgaard LS, Meyerholz DK, Wohlford-Lenane C, Stoltz DA, B McCray P Jr, Sinn PL.

Nucleic Acids Res. 2018 Oct 12;46(18):9591-9600. doi: 10.1093/nar/gky773.


Postnatal airway growth in cystic fibrosis piglets.

Adam RJ, Abou Alaiwa MH, Bouzek DC, Cook DP, Gansemer ND, Taft PJ, Powers LS, Stroik MR, Hoegger MJ, McMenimen JD, Hoffman EA, Zabner J, Welsh MJ, Meyerholz DK, Stoltz DA.

J Appl Physiol (1985). 2017 Sep 1;123(3):526-533. doi: 10.1152/japplphysiol.00263.2017. Epub 2017 Jun 15.


Gel-forming mucins form distinct morphologic structures in airways.

Ostedgaard LS, Moninger TO, McMenimen JD, Sawin NM, Parker CP, Thornell IM, Powers LS, Gansemer ND, Bouzek DC, Cook DP, Meyerholz DK, Abou Alaiwa MH, Stoltz DA, Welsh MJ.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):6842-6847. doi: 10.1073/pnas.1703228114. Epub 2017 Jun 12.


Acid-Sensing Ion Channel 1a Contributes to Airway Hyperreactivity in Mice.

Reznikov LR, Meyerholz DK, Adam RJ, Abou Alaiwa M, Jaffer O, Michalski AS, Powers LS, Price MP, Stoltz DA, Welsh MJ.

PLoS One. 2016 Nov 7;11(11):e0166089. doi: 10.1371/journal.pone.0166089. eCollection 2016.


CFTR gene transfer with AAV improves early cystic fibrosis pig phenotypes.

Steines B, Dickey DD, Bergen J, Excoffon KJ, Weinstein JR, Li X, Yan Z, Abou Alaiwa MH, Shah VS, Bouzek DC, Powers LS, Gansemer ND, Ostedgaard LS, Engelhardt JF, Stoltz DA, Welsh MJ, Sinn PL, Schaffer DV, Zabner J.

JCI Insight. 2016 Sep 8;1(14):e88728. doi: 10.1172/jci.insight.88728.


Lentiviral-mediated phenotypic correction of cystic fibrosis pigs.

Cooney AL, Abou Alaiwa MH, Shah VS, Bouzek DC, Stroik MR, Powers LS, Gansemer ND, Meyerholz DK, Welsh MJ, Stoltz DA, Sinn PL, McCray PB Jr.

JCI Insight. 2016 Sep 8;1(14). pii: 88730. doi: 10.1172/jci.insight.88730.


Interferon-γ Inhibits Ebola Virus Infection.

Rhein BA, Powers LS, Rogers K, Anantpadma M, Singh BK, Sakurai Y, Bair T, Miller-Hunt C, Sinn P, Davey RA, Monick MM, Maury W.

PLoS Pathog. 2015 Nov 12;11(11):e1005263. doi: 10.1371/journal.ppat.1005263. eCollection 2015.


Effects of prenatal inhalation exposure to copper nanoparticles on murine dams and offspring.

Adamcakova-Dodd A, Monick MM, Powers LS, Gibson-Corley KN, Thorne PS.

Part Fibre Toxicol. 2015 Oct 6;12:30. doi: 10.1186/s12989-015-0105-5.


Characterization of fusion genes and the significantly expressed fusion isoforms in breast cancer by hybrid sequencing.

Weirather JL, Afshar PT, Clark TA, Tseng E, Powers LS, Underwood JG, Zabner J, Korlach J, Wong WH, Au KF.

Nucleic Acids Res. 2015 Oct 15;43(18):e116. doi: 10.1093/nar/gkv562. Epub 2015 Jun 3.


Effects of vitamin D supplementation on alveolar macrophage gene expression: preliminary results of a randomized, controlled trial.

Gerke AK, Pezzulo AA, Tang F, Cavanaugh JE, Bair TB, Phillips E, Powers LS, Monick MM.

Multidiscip Respir Med. 2014 Mar 26;9(1):18. doi: 10.1186/2049-6958-9-18.


A microRNA processing defect in smokers' macrophages is linked to SUMOylation of the endonuclease DICER.

Gross TJ, Powers LS, Boudreau RL, Brink B, Reisetter A, Goel K, Gerke AK, Hassan IH, Monick MM.

J Biol Chem. 2014 May 2;289(18):12823-34. doi: 10.1074/jbc.M114.565473. Epub 2014 Mar 25.


Inositol-requiring enzyme 1 inhibits respiratory syncytial virus replication.

Hassan I, Gaines KS, Hottel WJ, Wishy RM, Miller SE, Powers LS, Rutkowski DT, Monick MM.

J Biol Chem. 2014 Mar 14;289(11):7537-46. doi: 10.1074/jbc.M113.510594. Epub 2014 Feb 4.


Epigenetic silencing of the human NOS2 gene: rethinking the role of nitric oxide in human macrophage inflammatory responses.

Gross TJ, Kremens K, Powers LS, Brink B, Knutson T, Domann FE, Philibert RA, Milhem MM, Monick MM.

J Immunol. 2014 Mar 1;192(5):2326-38. doi: 10.4049/jimmunol.1301758. Epub 2014 Jan 29.


Effects of Eyjafjallajökull volcanic ash on innate immune system responses and bacterial growth in vitro.

Monick MM, Baltrusaitis J, Powers LS, Borcherding JA, Caraballo JC, Mudunkotuwa I, Peate DW, Walters K, Thompson JM, Grassian VH, Gudmundsson G, Comellas AP.

Environ Health Perspect. 2013 Jun;121(6):691-8. doi: 10.1289/ehp.1206004. Epub 2013 Mar 11.


Cigarette smoking decreases global microRNA expression in human alveolar macrophages.

Graff JW, Powers LS, Dickson AM, Kim J, Reisetter AC, Hassan IH, Kremens K, Gross TJ, Wilson ME, Monick MM.

PLoS One. 2012;7(8):e44066. doi: 10.1371/journal.pone.0044066. Epub 2012 Aug 29.


Rapid microbial quantification of disinfected contact lens surfaces.

Powers LS, Snyder RW, Wardell LJ.

Curr Eye Res. 2012 Sep;37(9):850-2. doi: 10.3109/02713683.2012.681095. Epub 2012 Jun 6.


Coordinated DNA methylation and gene expression changes in smoker alveolar macrophages: specific effects on VEGF receptor 1 expression.

Philibert RA, Sears RA, Powers LS, Nash E, Bair T, Gerke AK, Hassan I, Thomas CP, Gross TJ, Monick MM.

J Leukoc Biol. 2012 Sep;92(3):621-31. doi: 10.1189/jlb.1211632. Epub 2012 Mar 16.


Influenza A viral replication is blocked by inhibition of the inositol-requiring enzyme 1 (IRE1) stress pathway.

Hassan IH, Zhang MS, Powers LS, Shao JQ, Baltrusaitis J, Rutkowski DT, Legge K, Monick MM.

J Biol Chem. 2012 Feb 10;287(7):4679-89. doi: 10.1074/jbc.M111.284695. Epub 2011 Dec 22.


Identification of an autophagy defect in smokers' alveolar macrophages.

Monick MM, Powers LS, Walters K, Lovan N, Zhang M, Gerke A, Hansdottir S, Hunninghake GW.

J Immunol. 2010 Nov 1;185(9):5425-35. doi: 10.4049/jimmunol.1001603. Epub 2010 Oct 4.


Affinity capture mass spectrometry of biomarker proteins using peptide ligands from biopanning.

Johnson EM, Ellis WR Jr, Powers LS, Wysocki VH.

Anal Chem. 2009 Aug 1;81(15):5999-6005. doi: 10.1021/ac900868q.


Molecular basis of the Bohr effect in arthropod hemocyanin.

Hirota S, Kawahara T, Beltramini M, Di Muro P, Magliozzo RS, Peisach J, Powers LS, Tanaka N, Nagao S, Bubacco L.

J Biol Chem. 2008 Nov 14;283(46):31941-8. doi: 10.1074/jbc.M803433200. Epub 2008 Aug 25.


Constitutive ERK MAPK activity regulates macrophage ATP production and mitochondrial integrity.

Monick MM, Powers LS, Barrett CW, Hinde S, Ashare A, Groskreutz DJ, Nyunoya T, Coleman M, Spitz DR, Hunninghake GW.

J Immunol. 2008 Jun 1;180(11):7485-96.


Respiratory syncytial virus decreases p53 protein to prolong survival of airway epithelial cells.

Groskreutz DJ, Monick MM, Yarovinsky TO, Powers LS, Quelle DE, Varga SM, Look DC, Hunninghake GW.

J Immunol. 2007 Sep 1;179(5):2741-7.


Respiratory syncytial virus synergizes with Th2 cytokines to induce optimal levels of TARC/CCL17.

Monick MM, Powers LS, Hassan I, Groskreutz D, Yarovinsky TO, Barrett CW, Castilow EM, Tifrea D, Varga SM, Hunninghake GW.

J Immunol. 2007 Aug 1;179(3):1648-58.


Pseudomonas aeruginosa delays Kupffer cell death via stabilization of the X-chromosome-linked inhibitor of apoptosis protein.

Ashare A, Monick MM, Nymon AB, Morrison JM, Noble M, Powers LS, Yarovinsky TO, Yahr TL, Hunninghake GW.

J Immunol. 2007 Jul 1;179(1):505-13.


Active ERK contributes to protein translation by preventing JNK-dependent inhibition of protein phosphatase 1.

Monick MM, Powers LS, Gross TJ, Flaherty DM, Barrett CW, Hunninghake GW.

J Immunol. 2006 Aug 1;177(3):1636-45.


Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells.

Groskreutz DJ, Monick MM, Powers LS, Yarovinsky TO, Look DC, Hunninghake GW.

J Immunol. 2006 Feb 1;176(3):1733-40.


Severe bacteremia results in a loss of hepatic bacterial clearance.

Ashare A, Monick MM, Powers LS, Yarovinsky T, Hunninghake GW.

Am J Respir Crit Care Med. 2006 Mar 15;173(6):644-52. Epub 2006 Jan 6.


Macrophages survive hyperoxia via prolonged ERK activation due to phosphatase down-regulation.

Nyunoya T, Monick MM, Powers LS, Yarovinsky TO, Hunninghake GW.

J Biol Chem. 2005 Jul 15;280(28):26295-302. Epub 2005 May 18.


Anti-inflammatory response is associated with mortality and severity of infection in sepsis.

Ashare A, Powers LS, Butler NS, Doerschug KC, Monick MM, Hunninghake GW.

Am J Physiol Lung Cell Mol Physiol. 2005 Apr;288(4):L633-40. Epub 2004 Dec 3.


Activation of the epidermal growth factor receptor by respiratory syncytial virus results in increased inflammation and delayed apoptosis.

Monick MM, Cameron K, Staber J, Powers LS, Yarovinsky TO, Koland JG, Hunninghake GW.

J Biol Chem. 2005 Jan 21;280(3):2147-58. Epub 2004 Nov 12.


Extracellular signal-regulated kinase activation delays hyperoxia-induced epithelial cell death in conditions of Akt downregulation.

Truong SV, Monick MM, Yarovinsky TO, Powers LS, Nyunoya T, Hunninghake GW.

Am J Respir Cell Mol Biol. 2004 Dec;31(6):611-8. Epub 2004 Aug 12.


Cooperative prosurvival activity by ERK and Akt in human alveolar macrophages is dependent on high levels of acid ceramidase activity.

Monick MM, Mallampalli RK, Bradford M, McCoy D, Gross TJ, Flaherty DM, Powers LS, Cameron K, Kelly S, Merrill AH Jr, Hunninghake GW.

J Immunol. 2004 Jul 1;173(1):123-35.


Real-time detection of microbial contamination.

Kim HY, Estes CR, Duncan AG, Wade BD, Cleary FC, Lloyd CR, Ellis WR Jr, Powers LS.

IEEE Eng Med Biol Mag. 2004 Jan-Feb;23(1):122-9. Review. No abstract available.


Adenovirus vectors activate survival pathways in lung epithelial cells.

Flaherty DM, Hinde SL, Monick MM, Powers LS, Bradford MA, Yarovinsky T, Hunninghake GW.

Am J Physiol Lung Cell Mol Physiol. 2004 Aug;287(2):L393-401. Epub 2004 Apr 23.


Antibiotics delay but do not prevent bacteremia and lung injury in murine sepsis.

Doerschug KC, Powers LS, Monick MM, Thorne PS, Hunninghake GW.

Crit Care Med. 2004 Feb;32(2):489-94.


Sphingosine kinase mediates activation of extracellular signal-related kinase and Akt by respiratory syncytial virus.

Monick MM, Cameron K, Powers LS, Butler NS, McCoy D, Mallampalli RK, Hunninghake GW.

Am J Respir Cell Mol Biol. 2004 Jun;30(6):844-52. Epub 2004 Jan 23.


Intracellular thiols contribute to Th2 function via a positive role in IL-4 production.

Monick MM, Samavati L, Butler NS, Mohning M, Powers LS, Yarovinsky T, Spitz DR, Hunninghake GW.

J Immunol. 2003 Nov 15;171(10):5107-15.


Respiratory syncytial virus up-regulates TLR4 and sensitizes airway epithelial cells to endotoxin.

Monick MM, Yarovinsky TO, Powers LS, Butler NS, Carter AB, Gudmundsson G, Hunninghake GW.

J Biol Chem. 2003 Dec 26;278(52):53035-44. Epub 2003 Oct 17.


US agriculture is vulnerable to bioterrorism.

Moon HW, Kirk-Baer C, Ascher M, Cook RJ, Franz DR, Hoy M, Husnik DF, Jensen HH, Keller KH, Lederberg J, Madden LV, Powers LS, Steinberg AD, Strating A, Smith RE, Kuzma J, Grossblatt N, Holliday L, Sweatt D, Strongin S.

J Vet Med Educ. 2003 Summer;30(2):96-104. No abstract available.


Inhibition of Rho family GTPases results in increased TNF-alpha production after lipopolysaccharide exposure.

Monick MM, Powers LS, Butler NS, Hunninghake GW.

J Immunol. 2003 Sep 1;171(5):2625-30.


Adenoviral infection decreases mortality from lipopolysaccharide-induced liver failure via induction of TNF-alpha tolerance.

Yarovinsky TO, Powers LS, Butler NS, Bradford MA, Monick MM, Hunninghake GW.

J Immunol. 2003 Sep 1;171(5):2453-60.


Hyperoxia induces macrophage cell cycle arrest by adhesion-dependent induction of p21Cip1 and activation of the retinoblastoma protein.

Nyunoya T, Powers LS, Yarovinsky TO, Butler NS, Monick MM, Hunninghake GW.

J Biol Chem. 2003 Sep 19;278(38):36099-106. Epub 2003 Jul 7.


Role of repeated lung injury and genetic background in bleomycin-induced fibrosis.

Chung MP, Monick MM, Hamzeh NY, Butler NS, Powers LS, Hunninghake GW.

Am J Respir Cell Mol Biol. 2003 Sep;29(3 Pt 1):375-80. Epub 2003 Apr 3.


Bidentate ligation of heme analogues; novel biomimetics of peroxidase active site.

Ashkenasy G, Margulies D, Felder CE, Shanzer A, Powers LS.

Chemistry. 2002 Sep 2;8(17):4017-26.


Altered IL-4 mRNA stability correlates with Th1 and Th2 bias and susceptibility to hypersensitivity pneumonitis in two inbred strains of mice.

Butler NS, Monick MM, Yarovinsky TO, Powers LS, Hunninghake GW.

J Immunol. 2002 Oct 1;169(7):3700-9.


Asbestos stimulation triggers differential cytokine release from human monocytes and alveolar macrophages.

Geist LJ, Powers LS, Monick MM, Hunninghake GW.

Exp Lung Res. 2000 Jan-Feb;26(1):41-56.


Variable airway responsiveness to inhaled lipopolysaccharide.

Kline JN, Cowden JD, Hunninghake GW, Schutte BC, Watt JL, Wohlford-Lenane CL, Powers LS, Jones MP, Schwartz DA.

Am J Respir Crit Care Med. 1999 Jul;160(1):297-303.


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