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Items: 1 to 50 of 164

1.

Gut-Proglucagon-Derived Peptides Are Essential for Regulating Glucose Homeostasis in Mice.

Song Y, Koehler JA, Baggio LL, Powers AC, Sandoval DA, Drucker DJ.

Cell Metab. 2019 Aug 30. pii: S1550-4131(19)30438-3. doi: 10.1016/j.cmet.2019.08.009. [Epub ahead of print]

PMID:
31495689
2.

Modeling Monogenic Diabetes using Human ESCs Reveals Developmental and Metabolic Deficiencies Caused by Mutations in HNF1A.

Cardenas-Diaz FL, Osorio-Quintero C, Diaz-Miranda MA, Kishore S, Leavens K, Jobaliya C, Stanescu D, Ortiz-Gonzalez X, Yoon C, Chen CS, Haliyur R, Brissova M, Powers AC, French DL, Gadue P.

Cell Stem Cell. 2019 Aug 1;25(2):273-289.e5. doi: 10.1016/j.stem.2019.07.007.

PMID:
31374199
3.

NIH Initiative to Improve Understanding of the Pancreas, Islet, and Autoimmunity in Type 1 Diabetes: The Human Pancreas Analysis Program (HPAP).

Kaestner KH, Powers AC, Naji A; HPAP Consortium, Atkinson MA.

Diabetes. 2019 Jul;68(7):1394-1402. doi: 10.2337/db19-0058. Epub 2019 May 24. Review.

PMID:
31127054
4.

Maternal Western-style diet affects offspring islet composition and function in a non-human primate model of maternal over-nutrition.

Elsakr JM, Dunn JC, Tennant K, Zhao SK, Kroeten K, Pasek RC, Takahashi DL, Dean TA, Velez Edwards DR, McCurdy CE, Aagaard KM, Powers AC, Friedman JE, Kievit P, Gannon M.

Mol Metab. 2019 Jul;25:73-82. doi: 10.1016/j.molmet.2019.03.010. Epub 2019 Apr 12.

5.

Imaging mass spectrometry enables molecular profiling of mouse and human pancreatic tissue.

Prentice BM, Hart NJ, Phillips N, Haliyur R, Judd A, Armandala R, Spraggins JM, Lowe CL, Boyd KL, Stein RW, Wright CV, Norris JL, Powers AC, Brissova M, Caprioli RM.

Diabetologia. 2019 Jun;62(6):1036-1047. doi: 10.1007/s00125-019-4855-8. Epub 2019 Apr 6.

PMID:
30955045
6.

HLA Class II Antigen Processing and Presentation Pathway Components Demonstrated by Transcriptome and Protein Analyses of Islet β-Cells From Donors With Type 1 Diabetes.

Russell MA, Redick SD, Blodgett DM, Richardson SJ, Leete P, Krogvold L, Dahl-Jørgensen K, Bottino R, Brissova M, Spaeth JM, Babon JAB, Haliyur R, Powers AC, Yang C, Kent SC, Derr AG, Kucukural A, Garber MG, Morgan NG, Harlan DM.

Diabetes. 2019 May;68(5):988-1001. doi: 10.2337/db18-0686. Epub 2019 Mar 4.

PMID:
30833470
7.

New-Onset Post-Transplant Diabetes Mellitus after Allogeneic Hematopoietic Cell Transplant Is Initiated by Insulin Resistance, Not Immunosuppressive Medications.

Engelhardt BG, Savani U, Jung DK, Powers AC, Jagasia M, Chen H, Winnick JJ, Tamboli RA, Crowe JE Jr, Abumrad NN.

Biol Blood Marrow Transplant. 2019 Jun;25(6):1225-1231. doi: 10.1016/j.bbmt.2019.02.001. Epub 2019 Feb 7.

PMID:
30738170
8.

Multiplexed In Situ Imaging Mass Cytometry Analysis of the Human Endocrine Pancreas and Immune System in Type 1 Diabetes.

Wang YJ, Traum D, Schug J, Gao L, Liu C; HPAP Consortium, Atkinson MA, Powers AC, Feldman MD, Naji A, Chang KM, Kaestner KH.

Cell Metab. 2019 Mar 5;29(3):769-783.e4. doi: 10.1016/j.cmet.2019.01.003. Epub 2019 Jan 31.

PMID:
30713110
9.

Pancreas Volume Declines During the First Year After Diagnosis of Type 1 Diabetes and Exhibits Altered Diffusion at Disease Onset.

Virostko J, Williams J, Hilmes M, Bowman C, Wright JJ, Du L, Kang H, Russell WE, Powers AC, Moore DJ.

Diabetes Care. 2019 Feb;42(2):248-257. doi: 10.2337/dc18-1507. Epub 2018 Dec 14.

PMID:
30552135
10.

Use of human islets to understand islet biology and diabetes: progress, challenges and suggestions.

Hart NJ, Powers AC.

Diabetologia. 2019 Feb;62(2):212-222. doi: 10.1007/s00125-018-4772-2. Epub 2018 Dec 14. Review.

PMID:
30547228
11.

Human islets expressing HNF1A variant have defective β cell transcriptional regulatory networks.

Haliyur R, Tong X, Sanyoura M, Shrestha S, Lindner J, Saunders DC, Aramandla R, Poffenberger G, Redick SD, Bottino R, Prasad N, Levy SE, Blind RD, Harlan DM, Philipson LH, Stein RW, Brissova M, Powers AC.

J Clin Invest. 2019 Jan 2;129(1):246-251. doi: 10.1172/JCI121994. Epub 2018 Dec 3.

12.

Ectonucleoside Triphosphate Diphosphohydrolase-3 Antibody Targets Adult Human Pancreatic β Cells for In Vitro and In Vivo Analysis.

Saunders DC, Brissova M, Phillips N, Shrestha S, Walker JT, Aramandla R, Poffenberger G, Flaherty DK, Weller KP, Pelletier J, Cooper T, Goff MT, Virostko J, Shostak A, Dean ED, Greiner DL, Shultz LD, Prasad N, Levy SE, Carnahan RH, Dai C, Sévigny J, Powers AC.

Cell Metab. 2019 Mar 5;29(3):745-754.e4. doi: 10.1016/j.cmet.2018.10.007. Epub 2018 Nov 15.

PMID:
30449685
13.

Examining How the MAFB Transcription Factor Affects Islet β-Cell Function Postnatally.

Cyphert HA, Walker EM, Hang Y, Dhawan S, Haliyur R, Bonatakis L, Avrahami D, Brissova M, Kaestner KH, Bhushan A, Powers AC, Stein R.

Diabetes. 2019 Feb;68(2):337-348. doi: 10.2337/db18-0903. Epub 2018 Nov 13.

14.

Increased Reporting of Immune Checkpoint Inhibitor-Associated Diabetes.

Wright JJ, Salem JE, Johnson DB, Lebrun-Vignes B, Stamatouli A, Thomas JW, Herold KC, Moslehi J, Powers AC.

Diabetes Care. 2018 Dec;41(12):e150-e151. doi: 10.2337/dc18-1465. Epub 2018 Oct 10. No abstract available.

PMID:
30305348
15.

β-Cell DNA Damage Response Promotes Islet Inflammation in Type 1 Diabetes.

Horwitz E, Krogvold L, Zhitomirsky S, Swisa A, Fischman M, Lax T, Dahan T, Hurvitz N, Weinberg-Corem N, Klochendler A, Powers AC, Brissova M, Jörns A, Lenzen S, Glaser B, Dahl-Jørgensen K, Dor Y.

Diabetes. 2018 Nov;67(11):2305-2318. doi: 10.2337/db17-1006. Epub 2018 Aug 27.

16.

Erratum. Insulin Access and Affordability Working Group: Conclusions and Recommendations. Diabetes Care 2018;41;1299-1311.

Cefalu WT, Dawes DE, Gavlak G, Goldman D, Herman WH, Van Nuys K, Powers AC, Taylor SI, Yatvin AL; Insulin Access and Affordability Working Group.

Diabetes Care. 2018 Aug;41(8):1831. doi: 10.2337/dc18-er08. Epub 2018 Jun 28. No abstract available.

17.

Insulin Access and Affordability Working Group: Conclusions and Recommendations.

Cefalu WT, Dawes DE, Gavlak G, Goldman D, Herman WH, Van Nuys K, Powers AC, Taylor SI, Yatvin AL; Insulin Access and Affordability Working Group.

Diabetes Care. 2018 Jun;41(6):1299-1311. doi: 10.2337/dci18-0019. Epub 2018 May 8. Review. No abstract available. Erratum in: Diabetes Care. 2018 Aug;41(8):1831.

PMID:
29739814
18.

The Interface of Pancreatic Cancer With Diabetes, Obesity, and Inflammation: Research Gaps and Opportunities: Summary of a National Institute of Diabetes and Digestive and Kidney Diseases Workshop.

Abbruzzese JL, Andersen DK, Borrebaeck CAK, Chari ST, Costello E, Cruz-Monserrate Z, Eibl G, Engleman EG, Fisher WE, Habtezion A, Kim SK, Korc M, Logsdon C, Lyssiotis CA, Pandol SJ, Rustgi A, Wolfe BM, Zheng L, Powers AC.

Pancreas. 2018 May/Jun;47(5):516-525. doi: 10.1097/MPA.0000000000001037.

19.

Cystic fibrosis-related diabetes is caused by islet loss and inflammation.

Hart NJ, Aramandla R, Poffenberger G, Fayolle C, Thames AH, Bautista A, Spigelman AF, Babon JAB, DeNicola ME, Dadi PK, Bush WS, Balamurugan AN, Brissova M, Dai C, Prasad N, Bottino R, Jacobson DA, Drumm ML, Kent SC, MacDonald PE, Powers AC.

JCI Insight. 2018 Apr 19;3(8). pii: 98240. doi: 10.1172/jci.insight.98240. eCollection 2018 Apr 19.

20.

Modifying Enzymes Are Elicited by ER Stress, Generating Epitopes That Are Selectively Recognized by CD4+ T Cells in Patients With Type 1 Diabetes.

Marre ML, McGinty JW, Chow IT, DeNicola ME, Beck NW, Kent SC, Powers AC, Bottino R, Harlan DM, Greenbaum CJ, Kwok WW, Piganelli JD, James EA.

Diabetes. 2018 Jul;67(7):1356-1368. doi: 10.2337/db17-1166. Epub 2018 Apr 13.

21.

α Cell Function and Gene Expression Are Compromised in Type 1 Diabetes.

Brissova M, Haliyur R, Saunders D, Shrestha S, Dai C, Blodgett DM, Bottino R, Campbell-Thompson M, Aramandla R, Poffenberger G, Lindner J, Pan FC, von Herrath MG, Greiner DL, Shultz LD, Sanyoura M, Philipson LH, Atkinson M, Harlan DM, Levy SE, Prasad N, Stein R, Powers AC.

Cell Rep. 2018 Mar 6;22(10):2667-2676. doi: 10.1016/j.celrep.2018.02.032.

22.

Suppression of Insulin Production and Secretion by a Decretin Hormone.

Alfa RW, Park S, Skelly KR, Poffenberger G, Jain N, Gu X, Kockel L, Wang J, Liu Y, Powers AC, Kim SK.

Cell Metab. 2018 Feb 6;27(2):479. doi: 10.1016/j.cmet.2018.01.003. No abstract available.

23.

The obesity epidemic and rising diabetes incidence in a low-income racially diverse southern US cohort.

Conway BN, Han X, Munro HM, Gross AL, Shu XO, Hargreaves MK, Zheng W, Powers AC, Blot WJ.

PLoS One. 2018 Jan 11;13(1):e0190993. doi: 10.1371/journal.pone.0190993. eCollection 2018.

24.

Structural abnormalities in islets from very young children with cystic fibrosis may contribute to cystic fibrosis-related diabetes.

Bogdani M, Blackman SM, Ridaura C, Bellocq JP, Powers AC, Aguilar-Bryan L.

Sci Rep. 2017 Dec 8;7(1):17231. doi: 10.1038/s41598-017-17404-z.

25.

Loss of mTORC1 signaling alters pancreatic α cell mass and impairs glucagon secretion.

Bozadjieva N, Blandino-Rosano M, Chase J, Dai XQ, Cummings K, Gimeno J, Dean D, Powers AC, Gittes GK, Rüegg MA, Hall MN, MacDonald PE, Bernal-Mizrachi E.

J Clin Invest. 2017 Dec 1;127(12):4379-4393. doi: 10.1172/JCI90004. Epub 2017 Nov 6.

26.

β-Cell Replacement in Mice Using Human Type 1 Diabetes Nuclear Transfer Embryonic Stem Cells.

Sui L, Danzl N, Campbell SR, Viola R, Williams D, Xing Y, Wang Y, Phillips N, Poffenberger G, Johannesson B, Oberholzer J, Powers AC, Leibel RL, Chen X, Sykes M, Egli D.

Diabetes. 2018 Jan;67(1):26-35. doi: 10.2337/db17-0120. Epub 2017 Sep 20.

27.

Age-dependent human β cell proliferation induced by glucagon-like peptide 1 and calcineurin signaling.

Dai C, Hang Y, Shostak A, Poffenberger G, Hart N, Prasad N, Phillips N, Levy SE, Greiner DL, Shultz LD, Bottino R, Kim SK, Powers AC.

J Clin Invest. 2017 Oct 2;127(10):3835-3844. doi: 10.1172/JCI91761. Epub 2017 Sep 18.

28.

Signals in the pancreatic islet microenvironment influence β-cell proliferation.

Aamodt KI, Powers AC.

Diabetes Obes Metab. 2017 Sep;19 Suppl 1:124-136. doi: 10.1111/dom.13031. Review.

29.

Glycoprotein 2 is a specific cell surface marker of human pancreatic progenitors.

Cogger KF, Sinha A, Sarangi F, McGaugh EC, Saunders D, Dorrell C, Mejia-Guerrero S, Aghazadeh Y, Rourke JL, Screaton RA, Grompe M, Streeter PR, Powers AC, Brissova M, Kislinger T, Nostro MC.

Nat Commun. 2017 Aug 24;8(1):331. doi: 10.1038/s41467-017-00561-0.

30.

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JAB, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Aug 4;23(8):1004. doi: 10.1038/nm0817-1004a. No abstract available.

31.

Interrupted Glucagon Signaling Reveals Hepatic α Cell Axis and Role for L-Glutamine in α Cell Proliferation.

Dean ED, Li M, Prasad N, Wisniewski SN, Von Deylen A, Spaeth J, Maddison L, Botros A, Sedgeman LR, Bozadjieva N, Ilkayeva O, Coldren A, Poffenberger G, Shostak A, Semich MC, Aamodt KI, Phillips N, Yan H, Bernal-Mizrachi E, Corbin JD, Vickers KC, Levy SE, Dai C, Newgard C, Gu W, Stein R, Chen W, Powers AC.

Cell Metab. 2017 Jun 6;25(6):1362-1373.e5. doi: 10.1016/j.cmet.2017.05.011.

32.

Age-Dependent Decline in the Coordinated [Ca2+] and Insulin Secretory Dynamics in Human Pancreatic Islets.

Westacott MJ, Farnsworth NL, St Clair JR, Poffenberger G, Heintz A, Ludin NW, Hart NJ, Powers AC, Benninger RKP.

Diabetes. 2017 Sep;66(9):2436-2445. doi: 10.2337/db17-0137. Epub 2017 Jun 6.

33.

Corrigendum: Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2017 Feb 7;23(2):264. doi: 10.1038/nm0217-264a. No abstract available.

PMID:
28170374
34.

Re-addressing the 2013 consensus guidelines for the diagnosis of insulitis in human type 1 diabetes: is change necessary?

Campbell-Thompson ML, Atkinson MA, Butler AE, Giepmans BN, von Herrath MG, Hyöty H, Kay TW, Morgan NG, Powers AC, Pugliese A, Richardson SJ, In't Veld PA.

Diabetologia. 2017 Apr;60(4):753-755. doi: 10.1007/s00125-016-4195-x. Epub 2017 Jan 9. No abstract available.

35.

Type 1 Diabetes Prevention: A Goal Dependent on Accepting a Diagnosis of an Asymptomatic Disease.

Ziegler AG, Bonifacio E, Powers AC, Todd JA, Harrison LC, Atkinson MA.

Diabetes. 2016 Nov;65(11):3233-3239.

36.

Analysis of self-antigen specificity of islet-infiltrating T cells from human donors with type 1 diabetes.

Babon JA, DeNicola ME, Blodgett DM, Crèvecoeur I, Buttrick TS, Maehr R, Bottino R, Naji A, Kaddis J, Elyaman W, James EA, Haliyur R, Brissova M, Overbergh L, Mathieu C, Delong T, Haskins K, Pugliese A, Campbell-Thompson M, Mathews C, Atkinson MA, Powers AC, Harlan DM, Kent SC.

Nat Med. 2016 Dec;22(12):1482-1487. doi: 10.1038/nm.4203. Epub 2016 Oct 31. Erratum in: Nat Med. 2017 Feb 7;23 (2):264. Nat Med. 2017 Aug 4;23 (8):1004.

37.

Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.

Bonifacio E, Mathieu C, Nepom GT, Ziegler AG, Anhalt H, Haller MJ, Harrison LC, Hebrok M, Kushner JA, Norris JM, Peakman M, Powers AC, Todd JA, Atkinson MA.

Diabetologia. 2017 Jan;60(1):35-38. Epub 2016 Oct 26.

38.

Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.

Wang YJ, Golson ML, Schug J, Traum D, Liu C, Vivek K, Dorrell C, Naji A, Powers AC, Chang KM, Grompe M, Kaestner KH.

Cell Metab. 2016 Oct 11;24(4):616-626. doi: 10.1016/j.cmet.2016.09.007.

39.

Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regeneration.

Aamodt KI, Aramandla R, Brown JJ, Fiaschi-Taesch N, Wang P, Stewart AF, Brissova M, Powers AC.

Am J Physiol Endocrinol Metab. 2016 Nov 1;311(5):E859-E868. doi: 10.1152/ajpendo.00515.2015. Epub 2016 Sep 13.

40.

Use of the Electronic Medical Record to Assess Pancreas Size in Type 1 Diabetes.

Virostko J, Hilmes M, Eitel K, Moore DJ, Powers AC.

PLoS One. 2016 Jul 8;11(7):e0158825. doi: 10.1371/journal.pone.0158825. eCollection 2016.

41.

G6PC2 Modulates Fasting Blood Glucose In Male Mice in Response to Stress.

Boortz KA, Syring KE, Dai C, Pound LD, Oeser JK, Jacobson DA, Wang JC, McGuinness OP, Powers AC, O'Brien RM.

Endocrinology. 2016 Aug;157(8):3002-8. doi: 10.1210/en.2016-1245. Epub 2016 Jun 14.

42.

Hyperglycemic clamp-derived disposition index is negatively associated with metabolic syndrome severity in obese subjects.

Shah SS, Ramirez CE, Powers AC, Yu C, Shibao CA, Luther JM.

Metabolism. 2016 Jun;65(6):835-42. doi: 10.1016/j.metabol.2016.02.011. Epub 2016 Feb 26.

43.

Replicative capacity of β-cells and type 1 diabetes.

Saunders D, Powers AC.

J Autoimmun. 2016 Jul;71:59-68. doi: 10.1016/j.jaut.2016.03.014. Epub 2016 Apr 28. Review.

44.

Age-Dependent Pancreatic Gene Regulation Reveals Mechanisms Governing Human β Cell Function.

Arda HE, Li L, Tsai J, Torre EA, Rosli Y, Peiris H, Spitale RC, Dai C, Gu X, Qu K, Wang P, Wang J, Grompe M, Scharfmann R, Snyder MS, Bottino R, Powers AC, Chang HY, Kim SK.

Cell Metab. 2016 May 10;23(5):909-20. doi: 10.1016/j.cmet.2016.04.002. Epub 2016 Apr 28.

45.

Blockade of glucagon signaling prevents or reverses diabetes onset only if residual β-cells persist.

Damond N, Thorel F, Moyers JS, Charron MJ, Vuguin PM, Powers AC, Herrera PL.

Elife. 2016 Apr 19;5. pii: e13828. doi: 10.7554/eLife.13828.

46.

Stress-impaired transcription factor expression and insulin secretion in transplanted human islets.

Dai C, Kayton NS, Shostak A, Poffenberger G, Cyphert HA, Aramandla R, Thompson C, Papagiannis IG, Emfinger C, Shiota M, Stafford JM, Greiner DL, Herrera PL, Shultz LD, Stein R, Powers AC.

J Clin Invest. 2016 May 2;126(5):1857-70. doi: 10.1172/JCI83657. Epub 2016 Apr 11.

47.

Affordable Care Act Implementation: Challenges and Opportunities to Impact Patients With Diabetes.

Powers AC, Wexler JA, Lash RW, Dyer MC, Becker MN, Vigersky RA.

J Clin Endocrinol Metab. 2016 Apr;101(4):1315-7. doi: 10.1210/jc.2016-1047. Epub 2016 Mar 23. No abstract available.

48.

p16(Ink4a)-induced senescence of pancreatic beta cells enhances insulin secretion.

Helman A, Klochendler A, Azazmeh N, Gabai Y, Horwitz E, Anzi S, Swisa A, Condiotti R, Granit RZ, Nevo Y, Fixler Y, Shreibman D, Zamir A, Tornovsky-Babeay S, Dai C, Glaser B, Powers AC, Shapiro AM, Magnuson MA, Dor Y, Ben-Porath I.

Nat Med. 2016 Apr;22(4):412-20. doi: 10.1038/nm.4054. Epub 2016 Mar 7.

49.

Pathogenic CD4 T cells in type 1 diabetes recognize epitopes formed by peptide fusion.

Delong T, Wiles TA, Baker RL, Bradley B, Barbour G, Reisdorph R, Armstrong M, Powell RL, Reisdorph N, Kumar N, Elso CM, DeNicola M, Bottino R, Powers AC, Harlan DM, Kent SC, Mannering SI, Haskins K.

Science. 2016 Feb 12;351(6274):711-4. doi: 10.1126/science.aad2791.

50.

The MAFB transcription factor impacts islet α-cell function in rodents and represents a unique signature of primate islet β-cells.

Conrad E, Dai C, Spaeth J, Guo M, Cyphert HA, Scoville D, Carroll J, Yu WM, Goodrich LV, Harlan DM, Grove KL, Roberts CT Jr, Powers AC, Gu G, Stein R.

Am J Physiol Endocrinol Metab. 2016 Jan 1;310(1):E91-E102. doi: 10.1152/ajpendo.00285.2015. Epub 2015 Nov 10.

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