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Items: 1 to 50 of 176

1.

Targeting the OXE receptor as a potential novel therapy for asthma.

Powell WS, Rokach J.

Biochem Pharmacol. 2020 Mar 30:113930. doi: 10.1016/j.bcp.2020.113930. [Epub ahead of print] Review.

PMID:
32240653
2.

Novel highly potent OXE receptor antagonists with prolonged plasma lifetimes that are converted to active metabolites in vivo in monkeys.

Ye Q, Chourey S, Reddy CN, Wang R, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Br J Pharmacol. 2020 Jan;177(2):388-401. doi: 10.1111/bph.14874. Epub 2020 Jan 17.

PMID:
31655025
3.

Inhibition of allergen-induced dermal eosinophilia by an oxoeicosanoid receptor antagonist in non-human primates.

Miller LA, Cossette C, Chourey S, Ye Q, Reddy CN, Rokach J, Powell WS.

Br J Pharmacol. 2020 Jan;177(2):360-371. doi: 10.1111/bph.14872. Epub 2020 Jan 17.

PMID:
31655023
4.

Tolerogenic signaling of alveolar macrophages induces lung adaptation to oxidative injury.

Allard B, Panariti A, Pernet E, Downey J, Ano S, Dembele M, Nakada E, Fujii U, McGovern TK, Powell WS, Divangahi M, Martin JG.

J Allergy Clin Immunol. 2019 Oct;144(4):945-961.e9. doi: 10.1016/j.jaci.2019.07.015. Epub 2019 Jul 26.

PMID:
31356919
5.

Leukotriene B4-type I interferon axis regulates macrophage-mediated disease tolerance to influenza infection.

Pernet E, Downey J, Vinh DC, Powell WS, Divangahi M.

Nat Microbiol. 2019 Aug;4(8):1389-1400. doi: 10.1038/s41564-019-0444-3. Epub 2019 May 20.

PMID:
31110361
6.

Novel Highly Potent and Metabolically Resistant Oxoeicosanoid (OXE) Receptor Antagonists That Block the Actions of the Granulocyte Chemoattractant 5-Oxo-6,8,11,14-Eicosatetraenoic Acid (5-oxo-ETE).

Chourey S, Ye Q, Reddy CN, Wang R, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

J Med Chem. 2018 Jul 26;61(14):5934-5948. doi: 10.1021/acs.jmedchem.8b00154. Epub 2018 Jul 17.

PMID:
29972644
7.

Corrigendum to "In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys" [Biochem. Pharmacol. 138 (2017) 107-118].

Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Biochem Pharmacol. 2018 Aug;154:174. doi: 10.1016/j.bcp.2018.04.025. Epub 2018 May 10. No abstract available.

PMID:
29754018
8.

Metabolism and pharmacokinetics of a potent N-acylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) in rats and monkeys.

Reddy CN, Alhamza H, Chourey S, Ye Q, Gore V, Cossette C, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Eur J Pharm Sci. 2018 Mar 30;115:88-99. doi: 10.1016/j.ejps.2018.01.021. Epub 2018 Jan 12.

PMID:
29339225
9.

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists.

Ye Q, Chourey S, Wang R, Chintam NR, Gravel S, Powell WS, Rokach J.

Bioorg Med Chem Lett. 2017 Oct 15;27(20):4770-4776. doi: 10.1016/j.bmcl.2017.08.034. Epub 2017 Aug 19.

PMID:
28943042
10.

In vivo α-hydroxylation of a 2-alkylindole antagonist of the OXE receptor for the eosinophil chemoattractant 5-oxo-6,8,11,14-eicosatetraenoic acid in monkeys.

Chourey S, Ye Q, Reddy CN, Cossette C, Gravel S, Zeller M, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

Biochem Pharmacol. 2017 Aug 15;138:107-118. doi: 10.1016/j.bcp.2017.04.031. Epub 2017 May 3. Erratum in: Biochem Pharmacol. 2018 May 10;154:174.

11.

Design and synthesis of affinity chromatography ligands for the purification of 5-hydroxyeicosanoid dehydrogenase.

Nagendra Reddy C, Ye Q, Patel P, Sivendran S, Chourey S, Wang R, Anumolu JR, Grant GE, Powell WS, Rokach J.

Bioorg Med Chem. 2017 Jan 1;25(1):116-125. doi: 10.1016/j.bmc.2016.10.017. Epub 2016 Oct 15.

PMID:
28340986
12.

Inflammation and airway hyperresponsiveness after chlorine exposure are prolonged by Nrf2 deficiency in mice.

Ano S, Panariti A, Allard B, O'Sullivan M, McGovern TK, Hamamoto Y, Ishii Y, Yamamoto M, Powell WS, Martin JG.

Free Radic Biol Med. 2017 Jan;102:1-15. doi: 10.1016/j.freeradbiomed.2016.11.017. Epub 2016 Nov 13.

PMID:
27847240
13.

Pharmacokinetics and Metabolism of Selective Oxoeicosanoid (OXE) Receptor Antagonists and Their Effects on 5-Oxo-6,8,11,14-eicosatetraenoic Acid (5-Oxo-ETE)-Induced Granulocyte Activation in Monkeys.

Cossette C, Chourey S, Ye Q, Nagendra Reddy C, Gore V, Gravel S, Slobodchikova I, Vuckovic D, Rokach J, Powell WS.

J Med Chem. 2016 Nov 23;59(22):10127-10146. Epub 2016 Nov 7.

PMID:
27766872
14.

CysLT1 Receptor Is Protective against Oxidative Stress in a Model of Irritant-Induced Asthma.

McGovern T, Goldberger M, Chen M, Allard B, Hamamoto Y, Kanaoka Y, Austen KF, Powell WS, Martin JG.

J Immunol. 2016 Jul 1;197(1):266-77. doi: 10.4049/jimmunol.1501084. Epub 2016 May 25.

15.

Biosynthesis and actions of 5-oxoeicosatetraenoic acid (5-oxo-ETE) on feline granulocytes.

Cossette C, Gravel S, Reddy CN, Gore V, Chourey S, Ye Q, Snyder NW, Mesaros CA, Blair IA, Lavoie JP, Reinero CR, Rokach J, Powell WS.

Biochem Pharmacol. 2015 Aug 1;96(3):247-55. doi: 10.1016/j.bcp.2015.05.009. Epub 2015 May 29.

16.

Biosynthesis, biological effects, and receptors of hydroxyeicosatetraenoic acids (HETEs) and oxoeicosatetraenoic acids (oxo-ETEs) derived from arachidonic acid.

Powell WS, Rokach J.

Biochim Biophys Acta. 2015 Apr;1851(4):340-55. doi: 10.1016/j.bbalip.2014.10.008. Epub 2014 Oct 29. Review.

17.

Two Potent OXE-R Antagonists: Assignment of Stereochemistry.

Patel P, Reddy CN, Gore V, Chourey S, Ye Q, Ouedraogo YP, Gravel S, Powell WS, Rokach J.

ACS Med Chem Lett. 2014 May 29;5(7):815-9. doi: 10.1021/ml500161v. eCollection 2014 Jul 10.

18.

Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists.

Gore V, Chourey S, Ye Q, Patel P, Ouedraogo Y, Gravel S, Powell WS, Rokach J.

Bioorg Med Chem Lett. 2014 Aug 1;24(15):3385-8. doi: 10.1016/j.bmcl.2014.05.090. Epub 2014 Jun 4.

PMID:
24948567
19.

Targeted prostaglandin E2 inhibition enhances antiviral immunity through induction of type I interferon and apoptosis in macrophages.

Coulombe F, Jaworska J, Verway M, Tzelepis F, Massoud A, Gillard J, Wong G, Kobinger G, Xing Z, Couture C, Joubert P, Fritz JH, Powell WS, Divangahi M.

Immunity. 2014 Apr 17;40(4):554-68. doi: 10.1016/j.immuni.2014.02.013. Epub 2014 Apr 10.

20.

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7.

Bäck M, Powell WS, Dahlén SE, Drazen JM, Evans JF, Serhan CN, Shimizu T, Yokomizo T, Rovati GE.

Br J Pharmacol. 2014 Aug;171(15):3551-74. doi: 10.1111/bph.12665. Epub 2014 Jul 12. Review.

21.

Inhibition of 5-oxo-6,8,11,14-eicosatetraenoic acid-induced activation of neutrophils and eosinophils by novel indole OXE receptor antagonists.

Gore V, Gravel S, Cossette C, Patel P, Chourey S, Ye Q, Rokach J, Powell WS.

J Med Chem. 2014 Jan 23;57(2):364-77. doi: 10.1021/jm401292m. Epub 2014 Jan 6.

PMID:
24351031
22.

The eosinophil chemoattractant 5-oxo-ETE and the OXE receptor.

Powell WS, Rokach J.

Prog Lipid Res. 2013 Oct;52(4):651-65. doi: 10.1016/j.plipres.2013.09.001. Epub 2013 Sep 19. Review.

23.

5-Oxo-ETE receptor antagonists.

Gore V, Patel P, Chang CT, Sivendran S, Kang N, Ouedraogo YP, Gravel S, Powell WS, Rokach J.

J Med Chem. 2013 May 9;56(9):3725-32. doi: 10.1021/jm400480j. Epub 2013 Apr 26.

24.

Enhanced formation of 5-oxo-6,8,11,14-eicosatetraenoic acid by cancer cells in response to oxidative stress, docosahexaenoic acid and neutrophil-derived 5-hydroxy-6,8,11,14-eicosatetraenoic acid.

Grant GE, Rubino S, Gravel S, Wang X, Patel P, Rokach J, Powell WS.

Carcinogenesis. 2011 Jun;32(6):822-8. doi: 10.1093/carcin/bgr044. Epub 2011 Mar 10.

25.

C20-trifluoro-5-oxo-ETE: a metabolically stable 5-oxo-ETE derivative.

Patel P, Gore V, Powell WS, Rokach J.

Bioorg Med Chem Lett. 2011 Apr 1;21(7):1987-90. doi: 10.1016/j.bmcl.2011.02.021. Epub 2011 Feb 12.

26.

5-oxo-ETE is a major oxidative stress-induced arachidonate metabolite in B lymphocytes.

Grant GE, Gravel S, Guay J, Patel P, Mazer BD, Rokach J, Powell WS.

Free Radic Biol Med. 2011 May 15;50(10):1297-304. doi: 10.1016/j.freeradbiomed.2011.02.010. Epub 2011 Feb 18.

PMID:
21334434
27.

5-oxo-15-HETE: total synthesis and bioactivity.

Patel P, Anumolu JR, Powell WS, Rokach J.

Bioorg Med Chem Lett. 2011 Mar 15;21(6):1857-60. doi: 10.1016/j.bmcl.2011.01.032. Epub 2011 Jan 25.

28.

AEOL10150: a novel therapeutic for rescue treatment after toxic gas lung injury.

McGovern T, Day BJ, White CW, Powell WS, Martin JG.

Free Radic Biol Med. 2011 Mar 1;50(5):602-8. doi: 10.1016/j.freeradbiomed.2010.12.001. Epub 2010 Dec 13.

29.

Dimethylthiourea protects against chlorine induced changes in airway function in a murine model of irritant induced asthma.

McGovern TK, Powell WS, Day BJ, White CW, Govindaraju K, Karmouty-Quintana H, Lavoie N, Tan JJ, Martin JG.

Respir Res. 2010 Oct 6;11:138. doi: 10.1186/1465-9921-11-138.

30.

A new approach to the synthesis of polyunsaturated deuterated isoprostanes: total synthesis of d4-5-epi-8,12-iso-iPF3alpha-VI and d4-8,12-iso-iPF3alpha-VI.

Chang CT, Patel P, Gore V, Song WL, Lawson JA, Powell WS, Fitzgerald GA, Rokach J.

Bioorg Med Chem Lett. 2009 Dec 1;19(23):6755-8. doi: 10.1016/j.bmcl.2009.09.099. Epub 2009 Sep 29.

31.

5-Oxo-ETE and the OXE receptor.

Grant GE, Rokach J, Powell WS.

Prostaglandins Other Lipid Mediat. 2009 Sep;89(3-4):98-104. doi: 10.1016/j.prostaglandins.2009.05.002. Epub 2009 May 18. Review.

32.

Oxidative stress-induced changes in pyridine nucleotides and chemoattractant 5-lipoxygenase products in aging neutrophils.

Graham FD, Erlemann KR, Gravel S, Rokach J, Powell WS.

Free Radic Biol Med. 2009 Jul 1;47(1):62-71. doi: 10.1016/j.freeradbiomed.2009.04.016. Epub 2009 Apr 17.

33.

Substrate selectivity of 5-hydroxyeicosanoid dehydrogenase and its inhibition by 5-hydroxy-Delta6-long-chain fatty acids.

Patel P, Cossette C, Anumolu JR, Erlemann KR, Grant GE, Rokach J, Powell WS.

J Pharmacol Exp Ther. 2009 Apr;329(1):335-41. doi: 10.1124/jpet.108.143453. Epub 2009 Jan 22.

34.

Eicosapentaenoic-acid-derived isoprostanes: synthesis and discovery of two major isoprostanes.

Chang CT, Patel P, Kang N, Lawson JA, Song WL, Powell WS, FitzGerald GA, Rokach J.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5523-7. doi: 10.1016/j.bmcl.2008.09.008. Epub 2008 Sep 6.

35.

Enantio- and stereospecific syntheses of 15(R)-Me-PGD2, a potent and selective DP2-receptor agonist.

Patel P, Lee GJ, Kim S, Grant GE, Powell WS, Rokach J.

J Org Chem. 2008 Sep 19;73(18):7213-8. doi: 10.1021/jo801190m. Epub 2008 Aug 14.

PMID:
18700746
36.

Structural requirements for activation of the 5-oxo-6E,8Z, 11Z,14Z-eicosatetraenoic acid (5-oxo-ETE) receptor: identification of a mead acid metabolite with potent agonist activity.

Patel P, Cossette C, Anumolu JR, Gravel S, Lesimple A, Mamer OA, Rokach J, Powell WS.

J Pharmacol Exp Ther. 2008 May;325(2):698-707. doi: 10.1124/jpet.107.134908. Epub 2008 Feb 21.

PMID:
18292294
37.

Human neutrophils convert the sebum-derived polyunsaturated fatty acid Sebaleic acid to a potent granulocyte chemoattractant.

Cossette C, Patel P, Anumolu JR, Sivendran S, Lee GJ, Gravel S, Graham FD, Lesimple A, Mamer OA, Rokach J, Powell WS.

J Biol Chem. 2008 Apr 25;283(17):11234-43. doi: 10.1074/jbc.M709531200. Epub 2008 Feb 20.

38.

Nitration of respiratory epithelial cells by myeloperoxidase depends on extracellular nitrite.

Govindaraju K, Shan J, Levesque K, Hussain SN, Powell WS, Eidelman DH.

Nitric Oxide. 2008 May;18(3):184-94. doi: 10.1016/j.niox.2008.01.004. Epub 2008 Jan 31.

PMID:
18280259
39.

Reductive Deprotection of Silyl Groups with Wilkinson's Catalyst/Catechol Borane.

Patel P, Chang CT, Kang N, Lee GJ, Powell WS, Rokach J.

Tetrahedron Lett. 2007 Jul 23;48(30):5289-5292.

40.

Airway epithelial cells synthesize the lipid mediator 5-oxo-ETE in response to oxidative stress.

Erlemann KR, Cossette C, Gravel S, Lesimple A, Lee GJ, Saha G, Rokach J, Powell WS.

Free Radic Biol Med. 2007 Mar 1;42(5):654-64. Epub 2006 Dec 14.

41.

Regulation of 5-hydroxyeicosanoid dehydrogenase activity in monocytic cells.

Erlemann KR, Cossette C, Grant GE, Lee GJ, Patel P, Rokach J, Powell WS.

Biochem J. 2007 Apr 1;403(1):157-65.

42.

Human CD4+CD25+ regulatory T lymphocytes inhibit lipopolysaccharide-induced monocyte survival through a Fas/Fas ligand-dependent mechanism.

Venet F, Pachot A, Debard AL, Bohe J, Bienvenu J, Lepape A, Powell WS, Monneret G.

J Immunol. 2006 Nov 1;177(9):6540-7.

43.

Agonist and antagonist effects of 15R-prostaglandin (PG) D2 and 11-methylene-PGD2 on human eosinophils and basophils.

Cossette C, Walsh SE, Kim S, Lee GJ, Lawson JA, Bellone S, Rokach J, Powell WS.

J Pharmacol Exp Ther. 2007 Jan;320(1):173-9. Epub 2006 Oct 13.

PMID:
17041009
44.

Metabolism of 5-hydroxy-6,8,11,14-eicosatetraenoic acid by human endothelial cells.

Erlemann KR, Cossette C, Gravel S, Stamatiou PB, Lee GJ, Rokach J, Powell WS.

Biochem Biophys Res Commun. 2006 Nov 10;350(1):151-6. Epub 2006 Sep 12.

PMID:
16997273
45.

Oxidized derivatives of omega-3 fatty acids: identification of IPF3 alpha-VI in human urine.

Lawson JA, Kim S, Powell WS, FitzGerald GA, Rokach J.

J Lipid Res. 2006 Nov;47(11):2515-24. Epub 2006 Aug 30.

46.

Interleukin-8: novel roles in human airway smooth muscle cell contraction and migration.

Govindaraju V, Michoud MC, Al-Chalabi M, Ferraro P, Powell WS, Martin JG.

Am J Physiol Cell Physiol. 2006 Nov;291(5):C957-65. Epub 2006 Jul 5.

47.

Total synthesis of 8,12-iso-iPF3alpha-VI, an EPA-derived isoprostane: stereoselective introduction of the fifth asymmetric center.

Jacobo SH, Chang CT, Lee GJ, Lawson JA, Powell WS, Pratico D, FitzGerald GA, Rokach J.

J Org Chem. 2006 Feb 17;71(4):1370-9.

PMID:
16468784
48.

Biochemistry, biology and chemistry of the 5-lipoxygenase product 5-oxo-ETE.

Powell WS, Rokach J.

Prog Lipid Res. 2005 Mar-May;44(2-3):154-83. Epub 2005 Apr 20. Review.

PMID:
15893379
49.

Synthesis of 15R-PGD2: a potential DP2 receptor agonist.

Kim S, Bellone S, Maxey KM, Powell WS, Lee GJ, Rokach J.

Bioorg Med Chem Lett. 2005 Apr 1;15(7):1873-6.

PMID:
15780624
50.

iPF2alpha-III-17,18,19,20-d4: total synthesis and metabolism.

Kim S, Powell WS, Lawson JA, Jacobo SH, Pratico D, FitzGerald GA, Maxey K, Rokach J.

Bioorg Med Chem Lett. 2005 Mar 15;15(6):1613-7.

PMID:
15745808

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