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Human papillomavirus 16 promotes microhomology-mediated end-joining.

Leeman JE, Li Y, Bell A, Hussain SS, Majumdar R, Rong-Mullins X, Blecua P, Damerla R, Narang H, Ravindran PT, Lee NY, Riaz N, Powell SN, Higginson DS.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201906120. doi: 10.1073/pnas.1906120116. [Epub ahead of print]


Detection of Early Human Papillomavirus-Associated Cancers by Liquid Biopsy.

Damerla RR, Lee NY, You D, Soni R, Shah R, Reyngold M, Katabi N, Wu V, McBride SM, Tsai CJ, Riaz N, Powell SN, Babady NE, Viale A, Higginson DS.

JCO Precis Oncol. 2019;3. doi: 10.1200/PO.18.00276. Epub 2019 Apr 3.


The implications of genetic testing on radiotherapy decisions: a guide for radiation oncologists.

Bergom C, West CM, Higginson DS, Abazeed ME, Arun B, Bentzen SM, Bernstein JL, Evans JD, Gerber NK, Kerns SL, Keen J, Litton JK, Reiner AS, Riaz N, Rosenstein BS, Sawakuchi GO, Shaitelman SF, Powell SN, Woodward WA.

Int J Radiat Oncol Biol Phys. 2019 Aug 2. pii: S0360-3016(19)33530-8. doi: 10.1016/j.ijrobp.2019.07.026. [Epub ahead of print] Review.


Overall Survival of Breast Cancer Patients With Locoregional Failures Involving Internal Mammary Nodes.

Xu AJ, DeSelm CJ, Ho AY, Gillespie EF, Braunstein LZ, Khan AJ, McCormick B, Powell SN, Cahlon O.

Adv Radiat Oncol. 2019 Mar 1;4(3):447-452. doi: 10.1016/j.adro.2019.02.004. eCollection 2019 Jul-Sep.


Emerging Roles of RAD52 in Genome Maintenance.

Jalan M, Olsen KS, Powell SN.

Cancers (Basel). 2019 Jul 23;11(7). pii: E1038. doi: 10.3390/cancers11071038. Review.


Capitalizing on Cancer Replication Stress by Preventing PAR Chain Turnover: A New Type of Synthetic Lethality.

McDermott N, Buechelmaier ES, Powell SN.

Cancer Cell. 2019 Apr 15;35(4):706. doi: 10.1016/j.ccell.2019.03.013. No abstract available.


Capitalizing on Cancer Replication Stress by Preventing PAR Chain Turnover: A New Type of Synthetic Lethality.

McDermott N, Buechelmaier ES, Powell SN.

Cancer Cell. 2019 Mar 18;35(3):344-346. doi: 10.1016/j.ccell.2019.02.011. Erratum in: Cancer Cell. 2019 Apr 15;35(4):706.


Daily Fractionation of External Beam Accelerated Partial Breast Irradiation to 40 Gy Is Well Tolerated and Locally Effective.

Braunstein LZ, Thor M, Flynn J, Cost Z, Wilgucki M, Rosenbaum S, Zhang Z, Gillespie E, McCormick B, Khan A, Ho A, Cahlon O, Deasy JO, Powell SN.

Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):859-866. doi: 10.1016/j.ijrobp.2019.02.050. Epub 2019 Mar 7.


Long-Term Pulmonary Outcomes of a Feasibility Study of Inverse-Planned, Multibeam Intensity Modulated Radiation Therapy in Node-Positive Breast Cancer Patients Receiving Regional Nodal Irradiation.

Ho AY, Ballangrud A, Li G, Gupta GP, McCormick B, Gewanter R, Gelblum D, Zinovoy M, Mueller B, Mychalczak B, Dutta P, Borofsky K, Parhar P, Reyngold M, Braunstein LZ, Chawla M, Krause K, Freeman N, Siu CT, Cost Z, Arnold BB, Zhang Z, Powell SN.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1100-1108. doi: 10.1016/j.ijrobp.2018.11.045. Epub 2018 Nov 30.


Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury.

Bodo S, Campagne C, Thin TH, Higginson DS, Vargas HA, Hua G, Fuller JD, Ackerstaff E, Russell J, Zhang Z, Klingler S, Cho H, Kaag MG, Mazaheri Y, Rimner A, Manova-Todorova K, Epel B, Zatcky J, Cleary CR, Rao SS, Yamada Y, Zelefsky MJ, Halpern HJ, Koutcher JA, Cordon-Cardo C, Greco C, Haimovitz-Friedman A, Sala E, Powell SN, Kolesnick R, Fuks Z.

J Clin Invest. 2019 Feb 1;129(2):786-801. doi: 10.1172/JCI97631. Epub 2019 Jan 14.


An Antitumor Immune Response Is Evoked by Partial-Volume Single-Dose Radiation in 2 Murine Models.

Markovsky E, Budhu S, Samstein RM, Li H, Russell J, Zhang Z, Drill E, Bodden C, Chen Q, Powell SN, Merghoub T, Wolchok JD, Humm J, Deasy JO, Haimovitz-Friedman A.

Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):697-708. doi: 10.1016/j.ijrobp.2018.10.009. Epub 2018 Oct 18.


The therapeutic significance of mutational signatures from DNA repair deficiency in cancer.

Ma J, Setton J, Lee NY, Riaz N, Powell SN.

Nat Commun. 2018 Aug 17;9(1):3292. doi: 10.1038/s41467-018-05228-y. Review.


A Randomized Trial of Mometasone Furoate 0.1% to Reduce High-Grade Acute Radiation Dermatitis in Breast Cancer Patients Receiving Postmastectomy Radiation.

Ho AY, Olm-Shipman M, Zhang Z, Siu CT, Wilgucki M, Phung A, Arnold BB, Porinchak M, Lacouture M, McCormick B, Powell SN, Gelblum DY.

Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):325-333. doi: 10.1016/j.ijrobp.2018.02.006. Epub 2018 Feb 14. Erratum in: Int J Radiat Oncol Biol Phys. 2018 Sep 1;102(1):231.


Pazopanib radio-sensitization of human sarcoma tumors.

Wang F, Li H, Markovsky E, Glass R, de Stanchina E, Powell SN, Schwartz GK, Haimovitz-Friedman A.

Oncotarget. 2018 Jan 20;9(10):9311-9324. doi: 10.18632/oncotarget.24281. eCollection 2018 Feb 6.


The Landscape of Somatic Genetic Alterations in Breast Cancers From ATM Germline Mutation Carriers.

Weigelt B, Bi R, Kumar R, Blecua P, Mandelker DL, Geyer FC, Pareja F, James PA; kConFab Investigators, Couch FJ, Eccles DM, Blows F, Pharoah P, Li A, Selenica P, Lim RS, Jayakumaran G, Waddell N, Shen R, Norton L, Wen HY, Powell SN, Riaz N, Robson ME, Reis-Filho JS, Chenevix-Trench G.

J Natl Cancer Inst. 2018 Sep 1;110(9):1030-1034. doi: 10.1093/jnci/djy028.


Epidemiological investigation of tattoo-like skin lesions among bottlenose dolphins in Shark Bay, Australia.

Powell SN, Wallen MM, Bansal S, Mann J.

Sci Total Environ. 2018 Jul 15;630:774-780. doi: 10.1016/j.scitotenv.2018.02.202. Epub 2018 Feb 27.


A new role for a tumor-suppressing protein.

Setton JS, Powell SN.

Elife. 2018 Mar 1;7. pii: e35111. doi: 10.7554/eLife.35111.


Chromosomal instability drives metastasis through a cytosolic DNA response.

Bakhoum SF, Ngo B, Laughney AM, Cavallo JA, Murphy CJ, Ly P, Shah P, Sriram RK, Watkins TBK, Taunk NK, Duran M, Pauli C, Shaw C, Chadalavada K, Rajasekhar VK, Genovese G, Venkatesan S, Birkbak NJ, McGranahan N, Lundquist M, LaPlant Q, Healey JH, Elemento O, Chung CH, Lee NY, Imielenski M, Nanjangud G, Pe'er D, Cleveland DW, Powell SN, Lammerding J, Swanton C, Cantley LC.

Nature. 2018 Jan 25;553(7689):467-472. doi: 10.1038/nature25432. Epub 2018 Jan 17.


Impact of an In Situ Component on Outcome After In-Breast Tumor Recurrence in Patients Treated with Breast-Conserving Therapy.

Laird J, Lok B, Siu C, Cahlon O, Khan AJ, McCormick B, Powell SN, Cody H, Wen HY, Ho A, Braunstein LZ.

Ann Surg Oncol. 2018 Jan;25(1):154-163. doi: 10.1245/s10434-017-6209-4. Epub 2017 Nov 1.


Pan-cancer analysis of bi-allelic alterations in homologous recombination DNA repair genes.

Riaz N, Blecua P, Lim RS, Shen R, Higginson DS, Weinhold N, Norton L, Weigelt B, Powell SN, Reis-Filho JS.

Nat Commun. 2017 Oct 11;8(1):857. doi: 10.1038/s41467-017-00921-w.


Mitotic DNA Damage Response: At the Crossroads of Structural and Numerical Cancer Chromosome Instabilities.

Bakhoum SF, Kabeche L, Compton DA, Powell SN, Bastians H.

Trends Cancer. 2017 Mar;3(3):225-234. doi: 10.1016/j.trecan.2017.02.001. Epub 2017 Feb 28. Review.


Bi-allelic alterations in DNA repair genes underpin homologous recombination DNA repair defects in breast cancer.

Mutter RW, Riaz N, Ng CK, Delsite R, Piscuoglio S, Edelweiss M, Martelotto LG, Sakr RA, King TA, Giri DD, Drobnjak M, Brogi E, Bindra R, Bernheim G, Lim RS, Blecua P, Desrichard A, Higginson D, Towers R, Jiang R, Lee W, Weigelt B, Reis-Filho JS, Powell SN.

J Pathol. 2017 Jun;242(2):165-177. doi: 10.1002/path.4890. Epub 2017 Apr 27.


Computational methods using genome-wide association studies to predict radiotherapy complications and to identify correlative molecular processes.

Oh JH, Kerns S, Ostrer H, Powell SN, Rosenstein B, Deasy JO.

Sci Rep. 2017 Feb 24;7:43381. doi: 10.1038/srep43381.


Tumour-specific PI3K inhibition via nanoparticle-targeted delivery in head and neck squamous cell carcinoma.

Mizrachi A, Shamay Y, Shah J, Brook S, Soong J, Rajasekhar VK, Humm JL, Healey JH, Powell SN, Baselga J, Heller DA, Haimovitz-Friedman A, Scaltriti M.

Nat Commun. 2017 Feb 13;8:14292. doi: 10.1038/ncomms14292.


The EMSY threonine 207 phospho-site is required for EMSYdriven suppression of DNA damage repair.

Jelinic P, Eccles LA, Tseng J, Cybulska P, Wielgos M, Powell SN, Levine DA.

Oncotarget. 2017 Feb 21;8(8):13792-13804. doi: 10.18632/oncotarget.14637.


Genomic analysis of exceptional responders to radiotherapy reveals somatic mutations in ATM.

Ma J, Setton J, Morris L, Albornoz PB, Barker C, Lok BH, Sherman E, Katabi N, Beal K, Ganly I, Powell SN, Lee N, Chan TA, Riaz N.

Oncotarget. 2017 Feb 7;8(6):10312-10323. doi: 10.18632/oncotarget.14400.


BRCA1 loses the ring but lords over resistance.

Powell SN.

J Clin Invest. 2016 Aug 1;126(8):2802-4. doi: 10.1172/JCI89209. Epub 2016 Jul 25.


PARP Inhibitor Activity Correlates with SLFN11 Expression and Demonstrates Synergy with Temozolomide in Small Cell Lung Cancer.

Lok BH, Gardner EE, Schneeberger VE, Ni A, Desmeules P, Rekhtman N, de Stanchina E, Teicher BA, Riaz N, Powell SN, Poirier JT, Rudin CM.

Clin Cancer Res. 2017 Jan 15;23(2):523-535. doi: 10.1158/1078-0432.CCR-16-1040. Epub 2016 Jul 20.


Valproic acid causes radiosensitivity of breast cancer cells via disrupting the DNA repair pathway.

Luo Y, Wang H, Zhao X, Dong C, Zhang F, Guo G, Guo G, Wang X, Powell SN, Feng Z.

Toxicol Res (Camb). 2016 Feb 18;5(3):859-870. doi: 10.1039/c5tx00476d. eCollection 2016 May 1.


Taselisib (GDC-0032), a Potent β-Sparing Small Molecule Inhibitor of PI3K, Radiosensitizes Head and Neck Squamous Carcinomas Containing Activating PIK3CA Alterations.

Zumsteg ZS, Morse N, Krigsfeld G, Gupta G, Higginson DS, Lee NY, Morris L, Ganly I, Shiao SL, Powell SN, Chung CH, Scaltriti M, Baselga J.

Clin Cancer Res. 2016 Apr 15;22(8):2009-19. doi: 10.1158/1078-0432.CCR-15-2245. Epub 2015 Nov 20.


Detection of Internal Mammary Adenopathy in Patients With Breast Cancer by PET/CT and MRI.

Jochelson MS, Lebron L, Jacobs SS, Zheng J, Moskowitz CS, Powell SN, Sacchini V, Ulaner GA, Morris EA, Dershaw DD.

AJR Am J Roentgenol. 2015 Oct;205(4):899-904. doi: 10.2214/AJR.14.13804.


p53 suppresses hyper-recombination by modulating BRCA1 function.

Dong C, Zhang F, Luo Y, Wang H, Zhao X, Guo G, Powell SN, Feng Z.

DNA Repair (Amst). 2015 Sep;33:60-9. doi: 10.1016/j.dnarep.2015.06.005. Epub 2015 Jun 24.


The Effect of Molecular Subtype and Residual Disease on Locoregional Recurrence in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy and Postmastectomy Radiation.

Yang TJ, Morrow M, Modi S, Zhang Z, Krause K, Siu C, McCormick B, Powell SN, Ho AY.

Ann Surg Oncol. 2015 Dec;22 Suppl 3:S495-501. doi: 10.1245/s10434-015-4697-7. Epub 2015 Jul 1.


BRCA1 and BRCA2 protect against oxidative DNA damage converted into double-strand breaks during DNA replication.

Fridlich R, Annamalai D, Roy R, Bernheim G, Powell SN.

DNA Repair (Amst). 2015 Jun;30:11-20. doi: 10.1016/j.dnarep.2015.03.002. Epub 2015 Mar 17.


The Effect of Adjuvant Trastuzumab on Locoregional Recurrence of Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer Treated with Mastectomy.

Lanning RM, Morrow M, Riaz N, McArthur HL, Dang C, Moo TA, El-Tamer M, Krause K, Siu C, Hsu M, Zhang Z, Pei X, McCormick B, Powell SN, Ho A.

Ann Surg Oncol. 2015 Aug;22(8):2517-25. doi: 10.1245/s10434-014-4321-2. Epub 2015 Jan 7.


Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.

Goglia AG, Delsite R, Luz AN, Shahbazian D, Salem AF, Sundaram RK, Chiaravalli J, Hendrikx PJ, Wilshire JA, Jasin M, Kluger HM, Glickman JF, Powell SN, Bindra RS.

Mol Cancer Ther. 2015 Feb;14(2):326-42. doi: 10.1158/1535-7163.MCT-14-0765. Epub 2014 Dec 15.


Clinical Assessment of 2D/3D Registration Accuracy in 4 Major Anatomic Sites Using On-Board 2D Kilovoltage Images for 6D Patient Setup.

Li G, Yang TJ, Furtado H, Birkfellner W, Ballangrud Å, Powell SN, Mechalakos J.

Technol Cancer Res Treat. 2015 Jun;14(3):305-14. doi: 10.1177/1533034614547454. Epub 2014 Sep 15.


Long-term cosmetic outcomes and toxicities of proton beam therapy compared with photon-based 3-dimensional conformal accelerated partial-breast irradiation: a phase 1 trial.

Galland-Girodet S, Pashtan I, MacDonald SM, Ancukiewicz M, Hirsch AE, Kachnic LA, Specht M, Gadd M, Smith BL, Powell SN, Recht A, Taghian AG.

Int J Radiat Oncol Biol Phys. 2014 Nov 1;90(3):493-500. doi: 10.1016/j.ijrobp.2014.04.008. Epub 2014 May 29.


Axitinib sensitization of high Single Dose Radiotherapy.

Rao SS, Thompson C, Cheng J, Haimovitz-Friedman A, Powell SN, Fuks Z, Kolesnick RN.

Radiother Oncol. 2014 Apr;111(1):88-93. doi: 10.1016/j.radonc.2014.02.010. Epub 2014 Apr 29.


Bilateral implant reconstruction does not affect the quality of postmastectomy radiation therapy.

Ho AY, Patel N, Ohri N, Morrow M, Mehrara BJ, Disa JJ, Cordeiro PG, Shi W, Zhang Z, Gelblum D, Nerbun CT, Woch KM, Ballangrud A, McCormick B, Powell SN.

Med Dosim. 2014 Spring;39(1):18-22. doi: 10.1016/j.meddos.2013.08.008. Epub 2013 Nov 14.


Androgen receptor signaling regulates DNA repair in prostate cancers.

Polkinghorn WR, Parker JS, Lee MX, Kass EM, Spratt DE, Iaquinta PJ, Arora VK, Yen WF, Cai L, Zheng D, Carver BS, Chen Y, Watson PA, Shah NP, Fujisawa S, Goglia AG, Gopalan A, Hieronymus H, Wongvipat J, Scardino PT, Zelefsky MJ, Jasin M, Chaudhuri J, Powell SN, Sawyers CL.

Cancer Discov. 2013 Nov;3(11):1245-53. doi: 10.1158/2159-8290.CD-13-0172. Epub 2013 Sep 11.


Localized therapy for male breast cancer: functional advantages with comparable outcomes using breast conservation.

Fogh S, Kachnic LA, Goldberg SI, Taghian AG, Powell SN, Hirsch AE.

Clin Breast Cancer. 2013 Oct;13(5):344-9. doi: 10.1016/j.clbc.2013.05.004. Epub 2013 Jul 26.


Tumor bed delineation for external beam accelerated partial breast irradiation: a systematic review.

Yang TJ, Tao R, Elkhuizen PH, van Vliet-Vroegindeweij C, Li G, Powell SN.

Radiother Oncol. 2013 Aug;108(2):181-9. doi: 10.1016/j.radonc.2013.05.028. Epub 2013 Jun 24. Review.


Black race as a prognostic factor in triple-negative breast cancer patients treated with breast-conserving therapy: a large, single-institution retrospective analysis.

Perez CA, Zumsteg ZS, Gupta G, Morrow M, Arnold B, Patil SM, Traina TA, Robson ME, Wen YH, McCormick B, Powell SN, Ho AY.

Breast Cancer Res Treat. 2013 Jun;139(2):497-506. doi: 10.1007/s10549-013-2550-x. Epub 2013 May 5.


Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells.

Bindra RS, Goglia AG, Jasin M, Powell SN.

Nucleic Acids Res. 2013 Jun;41(11):e115. doi: 10.1093/nar/gkt255. Epub 2013 Apr 12.


Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest.

Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Pandita TK.

Mol Cell Biol. 2013 Mar;33(6):1210-22. doi: 10.1128/MCB.01676-12. Epub 2013 Jan 14. Erratum in: Mol Cell Biol. 2013 Aug;33(16):3390.


Rad51 paralog complexes BCDX2 and CX3 act at different stages in the BRCA1-BRCA2-dependent homologous recombination pathway.

Chun J, Buechelmaier ES, Powell SN.

Mol Cell Biol. 2013 Jan;33(2):387-95. doi: 10.1128/MCB.00465-12. Epub 2012 Nov 12.


Molecular pathways: understanding the role of Rad52 in homologous recombination for therapeutic advancement.

Lok BH, Powell SN.

Clin Cancer Res. 2012 Dec 1;18(23):6400-6. doi: 10.1158/1078-0432.CCR-11-3150. Epub 2012 Oct 15. Review.


RAD52 inactivation is synthetically lethal with deficiencies in BRCA1 and PALB2 in addition to BRCA2 through RAD51-mediated homologous recombination.

Lok BH, Carley AC, Tchang B, Powell SN.

Oncogene. 2013 Jul 25;32(30):3552-8. doi: 10.1038/onc.2012.391. Epub 2012 Sep 10.

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