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Discovery of a Thiadiazole-Pyridazine Based Allosteric Glutaminase 1 Inhibitor Series That Demonstrates Oral Bioavailability and Activity in Tumor Xenograft Models.

Finlay MRV, Anderton M, Bailey A, Boyd S, Brookfield J, Cairnduff C, Charles MD, Cheasty A, Critchlow SE, Culshaw J, Ekwuru T, Hollingsworth I, Jones N, Leroux F, Littleson MM, McCarron HB, McKelvie J, Mooney L, Nissink JWM, Perkins D, Powell S, Quesada MJ, Raubo P, Sabin V, Smith J, Smith PD, Stark A, Ting A, Wang P, Wilson Z, Winter-Holt J, Wood JM, Wrigley G, Yu G, Zhang P.

J Med Chem. 2019 Jun 14. doi: 10.1021/acs.jmedchem.9b00260. [Epub ahead of print]


Clinical practice guideline on peri- and postoperative care of arteriovenous fistulas and grafts for haemodialysis in adults.

Gallieni M, Hollenbeck M, Inston N, Kumwenda M, Powell S, Tordoir J, Al Shakarchi J, Berger P, Bolignano D, Cassidy D, Chan TY, Dhondt A, Drechsler C, Ecder T, Finocchiaro P, Haller M, Hanko J, Heye S, Ibeas J, Jemcov T, Kershaw S, Khawaja A, Labriola L, Lomonte C, Malovrh M, Marti I Monros A, Matthew S, McGrogan D, Meyer T, Mikros S, Nistor I, Planken N, Roca-Tey R, Ross R, Troxler M, van der Veer S, Vanholder R, Vermassen F, Welander G, Wilmink T, Koobasi M, Fox J, Van Biesen W, Nagler E.

Nephrol Dial Transplant. 2019 Jun 1;34(Supplement_2):ii1-ii42. doi: 10.1093/ndt/gfz072. No abstract available.


Three-dimensional quantitative photoacoustic tomography using an adjoint radiance Monte Carlo model and gradient descent.

Buchmann J, Kaplan B, Powell S, Prohaska S, Laufer J.

J Biomed Opt. 2019 Jun;24(6):1-13. doi: 10.1117/1.JBO.24.6.066001.


Validity of energy expenditure estimation methods during 10 days of military training.

Siddall AG, Powell SD, Needham-Beck SC, Edwards VC, Thompson JES, Kefyalew SS, Singh PA, Orford ER, Venables MC, Jackson S, Greeves JP, Blacker SD, Myers SD.

Scand J Med Sci Sports. 2019 May 28. doi: 10.1111/sms.13488. [Epub ahead of print]


Self-reported health impacts of caregiving by age and income among participants of the Canadian 2012 General Social Survey.

Ysseldyk R, Kuran N, Powell S, Villeneuve PJ.

Health Promot Chronic Dis Prev Can. 2019 May;39(5):169-177. doi: 10.24095/hpcdp.39.5.01. English, French.


A systematic review and meta-analysis of antimicrobial resistance in paediatric acute otitis media.

Mather MW, Drinnan M, Perry JD, Powell S, Wilson JA, Powell J.

Int J Pediatr Otorhinolaryngol. 2019 Aug;123:102-109. doi: 10.1016/j.ijporl.2019.04.041. Epub 2019 May 6.


Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.

Ordonez LD, Hay T, McEwen R, Polanska UM, Hughes A, Delpuech O, Cadogan E, Powell S, Dry J, Tornillo G, Silcock L, Leo E, O'Connor MJ, Clarke AR, Smalley MJ.

Oncotarget. 2019 Apr 5;10(27):2586-2606. doi: 10.18632/oncotarget.26830. eCollection 2019 Apr 5.


Biorelevant dissolution testing of a weak base: Interlaboratory reproducibility and investigation of parameters controlling in vitro precipitation.

Berben P, Ashworth L, Beato S, Bevernage J, Bruel JL, Butler J, Dressman J, Schäfer K, Hutchins P, Klumpp L, Mann J, Nicolai J, Ojala K, Patel S, Powell S, Rosenblatt K, Tomaszewska I, Williams J, Augustijns P.

Eur J Pharm Biopharm. 2019 Jul;140:141-148. doi: 10.1016/j.ejpb.2019.04.017. Epub 2019 Apr 30.


Improved neuropsychological outcomes following proton therapy relative to x-ray therapy for pediatric brain tumor patients.

Gross JP, Powell S, Zelko F, Hartsell W, Goldman S, Fangusaro J, Lulla RR, Smiley NP, Chang JH, Gondi V.

Neuro Oncol. 2019 Apr 17. pii: noz070. doi: 10.1093/neuonc/noz070. [Epub ahead of print]


Safety of Intratracheal Administration of Human Umbilical Cord Blood Derived Mesenchymal Stromal Cells in Extremely Low Birth Weight Preterm Infants.

Powell SB, Silvestri JM.

J Pediatr. 2019 Apr 13. pii: S0022-3476(19)30261-6. doi: 10.1016/j.jpeds.2019.02.029. [Epub ahead of print]


Capitalizing on Cancer Replication Stress by Preventing PAR Chain Turnover: A New Type of Synthetic Lethality.

McDermott N, Buechelmaier ES, Powell SN.

Cancer Cell. 2019 Apr 15;35(4):706. doi: 10.1016/j.ccell.2019.03.013. No abstract available.


Social Determinants of Health: A Timely Topic for Case Management.

Powell SK.

Prof Case Manag. 2019 May/Jun;24(3):111-113. doi: 10.1097/NCM.0000000000000367.


Emergent SO(5) Symmetry at the Columnar Ordering Transition in the Classical Cubic Dimer Model.

Sreejith GJ, Powell S, Nahum A.

Phys Rev Lett. 2019 Mar 1;122(8):080601. doi: 10.1103/PhysRevLett.122.080601.


Experiential Learning to Engage Millennial Learners in an Undergraduate Nursing Research Course.

Powell SB, Engelke MK.

Nurs Educ Perspect. 2019 Mar 26. doi: 10.1097/01.NEP.0000000000000483. [Epub ahead of print]


Real-Time Temperature Mapping in Ultra-Low Freezers as a Standard Quality Assessment.

Powell S, Molinolo A, Masmila E, Kaushal S.

Biopreserv Biobank. 2019 Apr;17(2):139-142. doi: 10.1089/bio.2018.0108. Epub 2019 Mar 26.


Capitalizing on Cancer Replication Stress by Preventing PAR Chain Turnover: A New Type of Synthetic Lethality.

McDermott N, Buechelmaier ES, Powell SN.

Cancer Cell. 2019 Mar 18;35(3):344-346. doi: 10.1016/j.ccell.2019.02.011. Erratum in: Cancer Cell. 2019 Apr 15;35(4):706.


Pembrolizumab in combination with ipilimumab as second-line or later therapy for advanced non-small-cell lung cancer: KEYNOTE-021 cohorts D and H.

Gubens MA, Sequist LV, Stevenson JP, Powell SF, Villaruz LC, Gadgeel SM, Langer CJ, Patnaik A, Borghaei H, Jalal SI, Fiore J, Saraf S, Raftopoulos H, Gandhi L.

Lung Cancer. 2019 Apr;130:59-66. doi: 10.1016/j.lungcan.2018.12.015. Epub 2018 Dec 17.


Correction to: DNA copy number evolution in Drosophila cell lines.

Lee H, McManus CJ, Cho DY, Eaton M, Renda F, Somma MP, Cherbas L, May G, Powell S, Zhang D, Zhan L, Resch A, Andrews J, Celniker SE, Cherbas P, Przytycka TM, Gatti M, Oliver B, Graveley B, MacAlpine D.

Genome Biol. 2019 Mar 11;20(1):53. doi: 10.1186/s13059-019-1668-5.


Daily Fractionation of External Beam Accelerated Partial Breast Irradiation to 40 Gy Is Well Tolerated and Locally Effective.

Braunstein LZ, Thor M, Flynn J, Cost Z, Wilgucki M, Rosenbaum S, Zhang Z, Gillespie E, McCormick B, Khan A, Ho A, Cahlon O, Deasy JO, Powell SN.

Int J Radiat Oncol Biol Phys. 2019 Jul 15;104(4):859-866. doi: 10.1016/j.ijrobp.2019.02.050. Epub 2019 Mar 7.


Polarisation signals: a new currency for communication.

Marshall NJ, Powell SB, Cronin TW, Caldwell RL, Johnsen S, Gruev V, Chiou TS, Roberts NW, How MJ.

J Exp Biol. 2019 Feb 7;222(Pt 3). pii: jeb134213. doi: 10.1242/jeb.134213. Review.


Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex.

Amodeo DA, Lai CY, Hassan O, Mukamel EA, Behrens MM, Powell SB.

Neurobiol Dis. 2019 May;125:211-218. doi: 10.1016/j.nbd.2019.01.025. Epub 2019 Feb 2.


Black spot gill syndrome in the northern shrimp, Pandalus borealis, caused by the parasitic ciliate Synophrya sp.

Lee RF, Walker AN, Landers SC, Walters TL, Powell SA, Frischer ME.

J Invertebr Pathol. 2019 Feb;161:40-46. doi: 10.1016/j.jip.2019.01.003. Epub 2019 Jan 23.


A Comparison of Homogenization vs. Enzymatic Lysis for Microbiome Profiling in Clinical Endoscopic Biopsy Tissue Samples.

Zhang C, Thakkar PV, Powell SE, Sharma P, Vennelaganti S, Betel D, Shah MA.

Front Microbiol. 2019 Jan 8;9:3246. doi: 10.3389/fmicb.2018.03246. eCollection 2018.


The incidence of anxiety symptoms in boys with 47,XXY (Klinefelter syndrome) and the possible impact of timing of diagnosis and hormonal replacement therapy.

Samango-Sprouse C, Lasutschinkow P, Powell S, Sadeghin T, Gropman A.

Am J Med Genet A. 2019 Mar;179(3):423-428. doi: 10.1002/ajmg.a.61038. Epub 2019 Jan 13.


Long-term psychological distress of Bosnian war survivors: an 11-year follow-up of former displaced persons, returnees, and stayers.

Comtesse H, Powell S, Soldo A, Hagl M, Rosner R.

BMC Psychiatry. 2019 Jan 3;19(1):1. doi: 10.1186/s12888-018-1996-0.


Favorable Response to Pembrolizumab in a Patient With Metastatic Castration-Resistant Prostate Cancer Progressing While Receiving Enzalutamide.

Dib EG, Antonarakis ES, Wasco MJ, Powell SF.

Clin Genitourin Cancer. 2019 Apr;17(2):e365-e368. doi: 10.1016/j.clgc.2018.11.021. Epub 2018 Dec 6. No abstract available.


Neuron-specific signatures in the chromosomal connectome associated with schizophrenia risk.

Rajarajan P, Borrman T, Liao W, Schrode N, Flaherty E, Casiño C, Powell S, Yashaswini C, LaMarca EA, Kassim B, Javidfar B, Espeso-Gil S, Li A, Won H, Geschwind DH, Ho SM, MacDonald M, Hoffman GE, Roussos P, Zhang B, Hahn CG, Weng Z, Brennand KJ, Akbarian S.

Science. 2018 Dec 14;362(6420). pii: eaat4311. doi: 10.1126/science.aat4311.


A Mixed-Methods Assessment of a Peer-Enforced Tobacco- and Smoke-Free Policy at a Large Urban University.

Gatto A, Powell SE, Walters EF, Zamani S, Sales LB, DeBate R.

J Community Health. 2019 Apr;44(2):365-376. doi: 10.1007/s10900-018-0593-y.


Long-Term Pulmonary Outcomes of a Feasibility Study of Inverse-Planned, Multibeam Intensity Modulated Radiation Therapy in Node-Positive Breast Cancer Patients Receiving Regional Nodal Irradiation.

Ho AY, Ballangrud A, Li G, Gupta GP, McCormick B, Gewanter R, Gelblum D, Zinovoy M, Mueller B, Mychalczak B, Dutta P, Borofsky K, Parhar P, Reyngold M, Braunstein LZ, Chawla M, Krause K, Freeman N, Siu CT, Cost Z, Arnold BB, Zhang Z, Powell SN.

Int J Radiat Oncol Biol Phys. 2019 Apr 1;103(5):1100-1108. doi: 10.1016/j.ijrobp.2018.11.045. Epub 2018 Nov 30.


Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins.

Sartor GC, Malvezzi AM, Kumar A, Andrade NS, Wiedner HJ, Vilca SJ, Janczura KJ, Bagheri A, Al-Ali H, Powell SK, Brown PT, Volmar CH, Foster TC, Zeier Z, Wahlestedt C.

J Neurosci. 2019 Jan 23;39(4):612-626. doi: 10.1523/JNEUROSCI.1604-18.2018. Epub 2018 Nov 30.


Teaching Genomic Pathology: Translating Team-Based Learning to a Virtual Environment Using Computer-Based Simulation.

Haspel RL, Ali AM, Huang GC, Smith MH, Atkinson JB, Chabot-Richards DS, Elliott RM, Kaul KL, Powell SZ, Rao A, Rinder HM, Vanderbilt CM, Wilcox R.

Arch Pathol Lab Med. 2019 Apr;143(4):513-517. doi: 10.5858/arpa.2018-0153-OA. Epub 2018 Nov 30.


ATRX protein loss and deregulation of PI3K/AKT pathway is frequent in pilocytic astrocytoma with anaplastic features.

Olar A, Tran D, Mehta VP, Reinhardt A, Manekia JH, Garnovskaya M, Ellezam B, Luthra R, Sulman EP, Mohila CA, Campbell GA, Powell SZ, Fuller GN, Aldape KD, Adesina AM.

Clin Neuropathol. 2019 Mar/Apr;38(2):59-73. doi: 10.5414/NP301105.


Choosing Medicare Advantage Plans Versus Traditional Fee-for-Service: Is This Change the Tipping Point?

Powell SK.

Prof Case Manag. 2019 Jan/Feb;24(1):1-3. doi: 10.1097/NCM.0000000000000338.


Single-dose radiotherapy disables tumor cell homologous recombination via ischemia/reperfusion injury.

Bodo S, Campagne C, Thin TH, Higginson DS, Vargas HA, Hua G, Fuller JD, Ackerstaff E, Russell J, Zhang Z, Klingler S, Cho H, Kaag MG, Mazaheri Y, Rimner A, Manova-Todorova K, Epel B, Zatcky J, Cleary CR, Rao SS, Yamada Y, Zelefsky MJ, Halpern HJ, Koutcher JA, Cordon-Cardo C, Greco C, Haimovitz-Friedman A, Sala E, Powell SN, Kolesnick R, Fuks Z.

J Clin Invest. 2019 Feb 1;129(2):786-801. doi: 10.1172/JCI97631. Epub 2019 Jan 14.


Due Process in Medical Education: Legal Considerations.

Conran RM, Elzie CA, Knollmann-Ritschel BE, Domen RE, Powell SZ.

Acad Pathol. 2018 Nov 14;5:2374289518807460. doi: 10.1177/2374289518807460. eCollection 2018 Jan-Dec.


Chronic treatment with a metabotropic mGlu2/3 receptor agonist diminishes behavioral response to a phenethylamine hallucinogen.

Halberstadt AL, van der Zee JVF, Chatha M, Geyer MA, Powell SB.

Psychopharmacology (Berl). 2019 Feb;236(2):821-830. doi: 10.1007/s00213-018-5118-y. Epub 2018 Nov 17.


Early outcomes of breast cancer patients treated with post-mastectomy uniform scanning proton therapy.

Luo L, Cuaron J, Braunstein L, Gillespie E, Kahn A, McCormick B, Mah D, Chon B, Tsai H, Powell S, Cahlon O.

Radiother Oncol. 2019 Mar;132:250-256. doi: 10.1016/j.radonc.2018.10.002. Epub 2018 Nov 7.


Solar-powered radio tags reveal patterns of post-fledging site visitation in adult and juvenile Tree Swallows Tachycineta bicolor.

Pegan TM, Craig DP, Gulson-Castillo ER, Gabrielson RM, Bezner Kerr W, MacCurdy R, Powell SP, Winkler DW.

PLoS One. 2018 Nov 8;13(11):e0206258. doi: 10.1371/journal.pone.0206258. eCollection 2018.


A 3-Dimensional Mapping Analysis of Regional Nodal Recurrences in Breast Cancer.

DeSelm C, Yang TJ, Cahlon O, Tisnado J, Khan A, Gillespie E, Powell S, Ho A.

Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):583-591. doi: 10.1016/j.ijrobp.2018.10.021. Epub 2018 Oct 24.


Atretic anomalous left subclavian artery as part of an unusual vascular ring.

Powell SK, Patel JK, Ebenroth ES.

Cardiol Young. 2019 Jan;29(1):85-87. doi: 10.1017/S1047951118001737. Epub 2018 Oct 26.


An Antitumor Immune Response Is Evoked by Partial-Volume Single-Dose Radiation in 2 Murine Models.

Markovsky E, Budhu S, Samstein RM, Li H, Russell J, Zhang Z, Drill E, Bodden C, Chen Q, Powell SN, Merghoub T, Wolchok JD, Humm J, Deasy JO, Haimovitz-Friedman A.

Int J Radiat Oncol Biol Phys. 2019 Mar 1;103(3):697-708. doi: 10.1016/j.ijrobp.2018.10.009. Epub 2018 Oct 18.


A Patient With EGFR-Mutated Lung Cancer Progressing on Erlotinib: Evaluating for a T790M Mutation With Limited Tissue.

Wynja E, Hove J, Powell SF.

Oncology (Williston Park). 2018 Oct 15;32(10):499-500, 504. No abstract available.


Use of Physical Activity Monitors in Rheumatic Populations.

Pellegrini CA, Powell SM, Mook N, DeVivo K, Ehrlich-Jones L.

Curr Rheumatol Rep. 2018 Oct 6;20(12):73. doi: 10.1007/s11926-018-0786-5. Review.


A review of adenotonsillar hypertrophy and adenotonsillectomy in children after solid organ transplantation.

Roberts J, Powell J, Mather MW, Powell S, Brodlie M.

Int J Pediatr Otorhinolaryngol. 2018 Nov;114:29-35. doi: 10.1016/j.ijporl.2018.08.020. Epub 2018 Aug 23. Review.


A spread spectrum approach to time-domain near-infrared diffuse optical imaging using inexpensive optical transceiver modules.

Papadimitriou KI, Dempsey LA, Hebden JC, Arridge SR, Powell S.

Biomed Opt Express. 2018 May 10;9(6):2648-2663. doi: 10.1364/BOE.9.002648. eCollection 2018 Jun 1.


Supraorbital Nerve and Cavernous Sinus Invasion with Poorly Differentiated Carcinoma of Unknown Primary.

Patel SN, Nakawah MO, Sadaka A, Berry S, Ortiz Gomez J, Powell S, Lee AG.

Neuroophthalmology. 2018 Jan 9;42(5):312-315. doi: 10.1080/01658107.2017.1401093. eCollection 2018 Oct.


Trainee Responses to Hurricane Harvey: Correlating Volunteerism With Burnout.

Yeo CJJ, Román GC, Kusnerik D, Burt T, Mersinger D, Thomas S, Boone T, Powell SZ.

Front Public Health. 2018 Aug 28;6:224. doi: 10.3389/fpubh.2018.00224. eCollection 2018.


Effective Word-Problem Instruction: Using Schemas to Facilitate Mathematical Reasoning.

Powell SR, Fuchs LS.

Teach Except Child. 2018 Sep;51(1):31-42. doi: 10.1177/0040059918777250. Epub 2018 Jun 7. No abstract available.


Neurocognitive and Psychosocial Outcomes in Pediatric Brain Tumor Survivors.

Stavinoha PL, Askins MA, Powell SK, Pillay Smiley N, Robert RS.

Bioengineering (Basel). 2018 Sep 11;5(3). pii: E73. doi: 10.3390/bioengineering5030073. Review.

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